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UniProtKB/Swiss-Prot entry A0KKW8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDL_AERHH
Primary accession number A0KKW8
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on December 12, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 18)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase
Synonyms EC 6.3.2.4
D-alanylalanine synthetase
D-Ala-D-Ala ligase
Gene name
Name: ddl
OrderedLocusNames: AHA_2404
From
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [TaxID: 380703] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales; Aeromonadaceae; Aeromonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.00621-06; PubMed=16980456 [NCBI, ExPASy, EBI, Israel, Japan]
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
J. Bacteriol. 188:8272-8282(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000462; ABK38135.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_856919.1; -.
3D structure databases
ModBase A0KKW8.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS A0KKW8.
Genome annotation databases
GeneID 4488463; -.
GenomeReviews CP000462_GR; AHA_2404.
KEGG aha:AHA_2404; -.
TIGR AHA_2404; -.
Other
ProtoNet A0KKW8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   329  329     D-alanine--D-alanine ligase. PRO_1000030422
DOMAIN   120   326  207     ATP-grasp. 
NP_BIND   150   205  56     ATP (By similarity). 
METAL   280   280        Magnesium or manganese 1 (By similarity). 
METAL   293   293        Magnesium or manganese 1 (By similarity). 
METAL   293   293        Magnesium or manganese 2 (By similarity). 
METAL   295   295        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 329 AA [This is the length of the unprocessed precursor] Molecular weight: 36343 Da [This is the MW of the unprocessed precursor] CRC64: BC5B5747304BD548 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKNIHVLLLC GGGGSEHEVS LRSANFLEKQ LSLLPGVEVT RVEMFADRWL SADGRECKLG 

        70         80         90        100        110        120 
LDKLLSFDSV ARPVDYVVPC IHGYPGETGD LQSFLELAGL PYLGCDAEAS KICFNKISTK 

       130        140        150        160        170        180 
LWLSAIGIPN TPYLFLTEQN DAALSEAKAA LAKWGKVFIK AASQGSSVGC YSASNEADLV 

       190        200        210        220        230        240 
KGIADAFGYS EQVLIEKAVK PRELEVAVYQ YGDELVATYP GEICVPQDKF YTYEEKYSSA 

       250        260        270        280        290        300 
SHTETALRAE GLTQAQADAI HEYALKAFRQ LKLTHLSRID FFLTEEGEIL LNEINTFPGM 

       310        320 
TSISMFPKLL EHHGHRFADY LEQILRKAV
A0KKW8 in FASTA format

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