FUNCTION: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity).
CATALYTIC ACTIVITY: Chorismate = 4-hydroxybenzoate + pyruvate.
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the ubiC family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000462; ABK37637.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_854713.1; -.

3D structure databases

ModBase

A0KEP8.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008813;	Molecular function: chorismate lyase activity (inferred from electronic annotation from HAMAP).
GO:0042866;	Biological process: pyruvate biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0006744;	Biological process: ubiquinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01632; -; 1.
PBIL [Tree]

InterPro

IPR007440; Chor_lyase.
Graphical view of domain structure.

Pfam

PF04345; Chor_lyase; 1.
Pfam graphical view of domain structure.

Genome annotation databases

GeneID

4486810; -.

GenomeReviews

CP000462_GR; AHA_0180.

KEGG

aha:AHA_0180; -.

TIGR

AHA_0180; -.

Other

ProtoNet

A0KEP8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Lyase; Pyruvate; Ubiquinone biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 178`	`178`	`Probable chorismate--pyruvate lyase.`	`PRO_1000069740`
`BINDING`	`37 37`		`Substrate; via amide nitrogen (By similarity).`
`BINDING`	`78 78`		`Substrate (By similarity).`
`BINDING`	`114 114`		`Substrate; via amide nitrogen (By similarity).`

Sequence information

Length: 178 AA [This is the length of the unprocessed precursor]

Molecular weight: 20132 Da [This is the MW of the unprocessed precursor]

CRC64: 7BD810730997C01E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKSELTVPLA RLVPWQTPAQ CEPPEALLPW LLEADSMTRR LRRHNRHFSV QLFGNRSVAL 

        70         80         90        100        110        120 
DADEQQLVVA EQPMGLCREV ILHGDHGPAV LGWTLFAEAA LQESGLRELG EQPLGERIFG 

       130        140        150        160        170 
DEPARRDHLQ LACFEIASNP WCPAGTVWGR RSRLFLGQWP LLVHELFLPS LSCNKELE

A0KEP8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools