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UniProtKB/Swiss-Prot entry A0KEM1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ILVC_AERHH
Primary accession number A0KEM1
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on December 12, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 17)
Name and origin of the protein
Protein name Ketol-acid reductoisomerase
Synonyms EC 1.1.1.86
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene name
Name: ilvC
OrderedLocusNames: AHA_0153
From
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [TaxID: 380703] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales; Aeromonadaceae; Aeromonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.00621-06; PubMed=16980456 [NCBI, ExPASy, EBI, Israel, Japan]
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
J. Bacteriol. 188:8272-8282(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000462; ABK38758.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_854686.1; -.
3D structure databases
ModBase A0KEM1.
Ontologies
GO
GO:0004455; Molecular function: ketol-acid reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0009097; Biological process: isoleucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0009099; Biological process: valine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00435; -; 1.
PBIL [Tree]
InterPro IPR013023; AcH_isomrdctse.
IPR000506; AcH_isomrdctse_C.
IPR013116; IlvN.
IPR014359; KetolA_reductoisomerase_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR21371; AcH_isomrdctse; 1.
Pfam PF01450; IlvC; 1.
PF07991; IlvN; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000116; IlvC_gammaproteo; 1.
TIGRFAMs TIGR00465; ilvC; 1.
BLOCKS A0KEM1.
Genome annotation databases
GeneID 4490334; -.
GenomeReviews CP000462_GR; AHA_0153.
KEGG aha:AHA_0153; -.
TIGR AHA_0153; -.
Other
ProtoNet A0KEM1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   493  493     Ketol-acid reductoisomerase. PRO_1000050474
ACT_SITE   132   132        Potential. 
Sequence information
Length: 493 AA [This is the length of the unprocessed precursor] Molecular weight: 53827 Da [This is the MW of the unprocessed precursor] CRC64: 116A6F2DC97F78C6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MANYFNTLNL RQQLAQLGKC RFMQREEFAD GCNVLKGKKV VIVGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LDISYALRKA AITEKRASWQ KATDNGFAVG TYEELIPTAD LVLNLTPDKQ HSDVVKTVMP 

       130        140        150        160        170        180 
LMKQGAALGY SHGFNVVEEG QQIRADITVV MVAPKCPGTE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPKGEGMAI AKAWASATGG DRAGVLESSF VAEVKSDLMG EQTILCGMLQ AGSLLCYDKL 

       250        260        270        280        290        300 
VAEGTDPAYA GKLIQFGWET ITEALKQGGI SLMMDRLSNP AKLRAFELSE QLKTLMRPLF 

       310        320        330        340        350        360 
EKHMDDIIAG EFSRGMMADW AEDDAKLFGW REETGKSAFE NAPAFAGKIA EQEYFDNGVV 

       370        380        390        400        410        420 
MVAMVKAGVE LAFETMVASG IYEESAYYES LHELPLIANT VARKRLYEMN VVISDTAEYG 

       430        440        450        460        470        480 
NYLFANAAVP LLREHFMPTL KAGDLGASKA EGQSVDNLAL LAANEATRNH PIEKIGQVLR 

       490 
GYMKDMKRIA VGG
A0KEM1 in FASTA format

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