FUNCTION: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities (By similarity).
CATALYTIC ACTIVITY: Guanosine 5'-triphosphate,3'-diphosphate + H₂O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.
PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2 .
SIMILARITY: Belongs to the gppA/ppx family. GppA subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

CP000462; ABK39541.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_854621.1; -.

3D structure databases

ModBase

A0KEG8.

Ontologies

GO:0008894;	Molecular function: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01550; -; 1.
PBIL [Tree]

InterPro

IPR003695; Ppx_GppA.
Graphical view of domain structure.

Pfam

PF02541; Ppx-GppA; 1.
Pfam graphical view of domain structure.

Genome annotation databases

GeneID

4490991; -.

GenomeReviews

CP000462_GR; AHA_0096.

KEGG

aha:AHA_0096; -.

TIGR

AHA_0096; -.

Other

ProtoNet

A0KEG8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Hydrolase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 496`	`496`		`Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.`	`PRO_0000314491`

Sequence information

Length: 496 AA [This is the length of the unprocessed precursor]

Molecular weight: 55133 Da [This is the MW of the unprocessed precursor]

CRC64: 3166C56CE0D4D7B0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHNSPLYAAI DLGSNSFHML VVREVAGALR TVTKVKRKVR LAAGLDPEFR LSRAAMERGW 

        70         80         90        100        110        120 
DCLRLFSEQL QDIPADNIRV VGTATLRLAT NVDEFLSEAE RVLNHSIEII SGEEEAKTIY 

       130        140        150        160        170        180 
EGVSWTSAGE GNRLVIDIGG ASTELVIGEH SEAKLLNSLH MGCVTWLNNH FGDGELSEAR 

       190        200        210        220        230        240 
FKQAIAAAKA VLEKVAEDYR ALGWRTCVGA SGTVQALQEI MLAQGKSERV TLPKLQELMG 

       250        260        270        280        290        300 
QAIACGKLDQ LQLEGLAAER LTVFPSGLAI LIAIFETLGI ESMTLAGGAL REGLIYGLLG 

       310        320        330        340        350        360 
NNHDCDARDR TADSLINRYQ LDKEHAERVR DTAVEAFNQL QPAWRLSKRY GRPILRYAAL 

       370        380        390        400        410        420 
LHEIGLCIEY KKAPQHAAYI IDNIDMPGFT PAQKKLLSAL LFNQRDEFKL EPLEKQGAVT 

       430        440        450        460        470        480 
GRQAIRLARI LRIALILCMR RTQGTVPRFT LEADEDALTL TLPSGWLDEH YLRASELRFE 

       490 
VERQQKMGWP TRLLEA

A0KEG8 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools