FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.
SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).
SIMILARITY: Belongs to the archaeal DNA polymerase II family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000477; ABK15029.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_843669.1; -.

3D structure databases

ModBase

A0B8K5.

Ontologies

GO:0008408;	Molecular function: 3'-5' exonuclease activity (inferred from electronic annotation from HAMAP).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0000738;	Biological process: DNA catabolic process, exonucleolytic (inferred from electronic annotation from HAMAP).
GO:0006261;	Biological process: DNA-dependent DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00324; -; 1.
PBIL [Tree]

InterPro

IPR004475; PolC_DP2.
IPR016033; PolC_DP2_N.
IPR013083; Znf_RING/FYVE/PHD.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.40.10; Znf_RING/FYVE/PHD; 1.

Pfam

PF03833; PolC_DP2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF016275; PolC_DP2; 1.

TIGRFAMs

TIGR00354; polC; 1.

BLOCKS

A0B8K5.

Genome annotation databases

GeneID

4463181; -.

GenomeReviews

CP000477_GR; Mthe_1250.

KEGG

mtp:Mthe_1250; -.

NMPDR

fig|349307.7.peg.1296; -.

CMR

A0B8K5; Mthe_1250.

Other

ProtoNet

A0B8K5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1109`	`1109`		`DNA polymerase II large subunit.`	`PRO_0000294691`

Sequence information

Length: 1109 AA [This is the length of the unprocessed precursor]

Molecular weight: 122895 Da [This is the MW of the unprocessed precursor]

CRC64: 9CAFADACAC8D75C2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSAEYFERLE RGLREEMEIA RRARSKGLDP ETDVEIPIAV DLAERVEKLV SIPGVAERIR 

        70         80         90        100        110        120 
EFEVQGLSRE EAALAIGRDF AEGRLGKGAS RLDAIDMAIR TSVALLTEGV VAAPIEGIAR 

       130        140        150        160        170        180 
VGLGKNDDGS EYLKVYYAGP IRSAGGTAQA LSVLVADYVR RSMGIAPYKP TDEEIERYVE 

       190        200        210        220        230        240 
EIGLYKRLQH LQYTPSDDEI RTIIRNCPVC IDGEPTEEEE VSGYRDLPRV ETNRVRGGIA 

       250        260        270        280        290        300 
LVSAEGIALK RPKIKKHVSK LGIDGWGWLD VLGGEKKDGG GSSGKFLRDL IAGRPVFSHP 

       310        320        330        340        350        360 
SRPGGFRLRY GRSRNTGLAA AGINPATMMV LNQFLAPGTQ IKVEQPGKAA AVAPVSSIEG 

       370        380        390        400        410        420 
PTVRLTNGDV VRIDDPSSFP WISSPEALRR NISKIIDLGE ILVSFGDFME NNRPLAPASY 

       430        440        450        460        470        480 
TFEWWAEEFR RAGGDPAGME HVDGRTAIRL SRDFGVPLHP DHTYLWHDIT LDELDLLADA 

       490        500        510        520        530        540 
ASDGEIDGDA LLMDMREDVK EVLEKLLVHH KVRDGMIVVE DALPLLLCLG VDETGRRWRR 

       550        560        570        580        590        600 
EDLNADNALS AVNQLSGLVI RARAPTRIGC RMGRPEKSDR REMRPPPHVL FPTGSEGGKS 

       610        620        630        640        650        660 
RLVNEAAEHG FIEVVVERRR CPSCGKEGFA FRCECGAHTE RVRACLSCGV RADDKCPRCG 

       670        680        690        700        710        720 
TETSAATRMR IDVKGTLARA LESLGERVDN IRGVMGLTSR DSTPEPLEKG VLRAKHGVFI 

       730        740        750        760        770        780 
FKDGTSRYDL TDLPLTHFRP REIGTSVDAL LDLGYTHDIH GKPLESDDQI LELKVQDVVL 

       790        800        810        820        830        840 
CRNAGDWLLR VSKFIDDLLV KFYGLEPYYN AERPEDLIGR LMIGLAPHTS AGVLCRLIGF 

       850        860        870        880        890        900 
TRASAGYAHP YFHAAKRRNC DGDEDCVMLL MDALLNFSRS YLPEKRGGKM DAPLVLTTRI 

       910        920        930        940        950        960 
NPAEVDKEAH NLDLSFIYPL EFYEATLRNA NPKDVEGLID LVSKRLGSEG QYCGFGFTHD 

       970        980        990       1000       1010       1020 
TDDIAGGPRN SSYKTLETMI DKMKSQLELA KLIRAVDATD VAERVINSHF LPDLMGNLRA 

      1030       1040       1050       1060       1070       1080 
FSRQSVRCVK CNAKYRRPPL SESCPKCGGR LVLTVHEGSV RKYLEVSMKV AEEYGVSSYT 

      1090       1100 
RQRLELIQME IESLFRSDKV KQTGLADFV

A0B8K5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools