General information about the entry |
View entry in simple text format |
Entry name | CXCL7_HUMAN |
Primary accession number | P02775 |
integrated into SWISS-2DPAGE on | August 1, 1993 (release 0) |
2D Annotations were last modified on | December 30, 2004 (version 1) |
General Annotations were last modified on | May 19, 2011 (version 15) |
Name and origin of the protein |
Description | RecName: Full=Platelet basic protein; Short=PBP; AltName: Full=C-X-C motif chemokine 7; AltName: Full=Leukocyte-derived growth factor; Short=LDGF; AltName: Full=Macrophage-derived growth factor; Short=MDGF; AltName: Full=Small-inducible cytokine B7; Contains: RecName: Full=Connective tissue-activating peptide III; Short=CTAP-III; AltName: Full=LA-PF4; AltName: Full=Low-affinity platelet factor IV; Contains: RecName: Full=TC-2; Contains: RecName: Full=Connective tissue-activating peptide III(1-81); Short=CTAP-III(1-81); Contains: RecName: Full=Beta-thromboglobulin; Short=Beta-TG; Contains: RecName: Full=Neutrophil-activating peptide 2(74); Short=NAP-2(74); Contains: RecName: Full=Neutrophil-activating peptide 2(73); Short=NAP-2(73); Contains: RecName: Full=Neutrophil-activating peptide 2; Short=NAP-2; Contains: RecName: Full=TC-1; Contains: RecName: Full=Neutrophil-activating peptide 2(1-66); Short=NAP-2(1-66); Contains: RecName: Full=Neutrophil-activating peptide 2(1-63); Short=NAP-2(1-63); Flags: Precursor;. |
Gene name | Name=PPBP Synonyms=CTAP3, CXCL7, SCYB7, TGB1, THBGB1
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Annotated species | Homo sapiens (Human) [TaxID: 9606] |
Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
References |
[1] |
MAPPING ON GEL MEDLINE=93092937; PubMed=1459097; [NCBI, Expasy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F. ''''''Plasma protein map: an update by microsequencing'';'';'' Electrophoresis 13(1):707-714(1992)
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Comments |
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2D PAGE maps for identified proteins
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How to interpret a protein
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PLASMA_HUMAN {Plasma} Homo sapiens (Human)
Tissue: Plasma
map experimental info protein estimated location
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PLASMA_HUMAN
MAP LOCATIONS:
MAPPING (identification): MICROSEQUENCING [1].
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Copyright |
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). |
Cross-references |
UniProtKB/Swiss-Prot | P02775; CXCL7_HUMAN. |
2D PAGE maps for identified proteins
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- How to interpret a protein map
- You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
- Warning 1: the displayed region reflects
an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information.
It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
- Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
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External data extracted from UniProtKB/Swiss-Prot |
Extracted from UniProtKB/Swiss-Prot, release: 2011_10 |
Entry name | CXCL7_HUMAN |
Primary accession number | P02775 |
Secondary accession number(s) | B2R5F3 Q6IBJ8 |
Sequence was last modified on | November 1, 1991 (version 3) |
Annotations were last modified on | September 21, 2011 (version 136) |
Name and origin of the protein |
Description | RecName: Full=Platelet basic protein; Short=PBP; AltName: Full=C-X-C motif chemokine 7; AltName: Full=Leukocyte-derived growth factor; Short=LDGF; AltName: Full=Macrophage-derived growth factor; Short=MDGF; AltName: Full=Small-inducible cytokine B7; Contains: RecName: Full=Connective tissue-activating peptide III; Short=CTAP-III; AltName: Full=LA-PF4; AltName: Full=Low-affinity platelet factor IV; Contains: RecName: Full=TC-2; Contains: RecName: Full=Connective tissue-activating peptide III(1-81); Short=CTAP-III(1-81); Contains: RecName: Full=Beta-thromboglobulin; Short=Beta-TG; Contains: RecName: Full=Neutrophil-activating peptide 2(74); Short=NAP-2(74); Contains: RecName: Full=Neutrophil-activating peptide 2(73); Short=NAP-2(73); Contains: RecName: Full=Neutrophil-activating peptide 2; Short=NAP-2; Contains: RecName: Full=TC-1; Contains: RecName: Full=Neutrophil-activating peptide 2(1-66); Short=NAP-2(1-66); Contains: RecName: Full=Neutrophil-activating peptide 2(1-63); Short=NAP-2(1-63); Flags: Precursor; |
Gene name | Name=PPBP Synonyms=CTAP3, CXCL7, SCYB7, TGB1, THBGB1 |
Encoded on | Name=PPBP; Synonyms=CTAP3, CXCL7, SCYB7, TGB1, THBGB1 |
Keywords | 3D-structure; Antibiotic; Antimicrobial; Chemotaxis; Cleavage on pair of basic residues; Complete proteome; Cytokine; Direct protein sequencing; Disulfide bond; Growth factor; Mitogen; Reference proteome; Secreted; Signal. |
Copyright |
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License |
Cross-references |
EMBL | M54995; AAA62836.1; -; mRNA |
EMBL | AF349466; AAK29642.1; -; Genomic_DNA |
EMBL | CR456805; CAG33086.1; -; mRNA |
EMBL | AC097709; AAY41004.1; -; Genomic_DNA |
EMBL | AK312166; BAG35100.1; -; mRNA |
EMBL | CH471057; EAX05695.1; -; Genomic_DNA |
EMBL | BC028217; AAH28217.1; -; mRNA |
IPI | IPI00022445; -; . |
PIR | A39546; TGHU; . |
RefSeq | NP_002695.1; NM_002704.3; . |
UniGene | Hs.2164; -; . |
PDB | 1F9P; X-ray; 1.93 A; A=44-128 |
PDB | 1NAP; X-ray; 1.90 A; A/B/C/D=59-128 |
PDB | 1TVX; X-ray; 1.75 A; A/B/C/D=54-128 |
PDBsum | 1F9P; -; . |
PDBsum | 1NAP; -; . |
PDBsum | 1TVX; -; . |
ProteinModelPortal | P02775; -; . |
SMR | P02775; 44-124; . |
DIP | DIP-5913N; -; . |
IntAct | P02775; 11; . |
MINT | MINT-1393871; -; . |
STRING | P02775; -; . |
SWISS-2DPAGE | P02775; -; . |
PeptideAtlas | P02775; -; . |
PRIDE | P02775; -; . |
Ensembl | ENST00000296028; ENSP00000296028; ENSG00000163736; . |
GeneID | 5473; -; . |
KEGG | hsa:5473; -; . |
UCSC | uc003hhj.1; human; . |
CTD | 5473; -; . |
GeneCards | GC04M070663; -; . |
H-InvDB | HIX0004284; -; . |
HGNC | HGNC:9240; PPBP; . |
HPA | CAB017624; -; . |
HPA | HPA008354; -; . |
MIM | 121010; gene; . |
neXtProt | NX_P02775; -; . |
PharmGKB | PA33561; -; . |
eggNOG | prNOG20711; -; . |
GeneTree | ENSGT00530000062901; -; . |
HOGENOM | HBG506700; -; . |
HOVERGEN | HBG107789; -; . |
InParanoid | P02775; -; . |
OMA | AELRCMC; -; . |
OrthoDB | EOG4Z8XZ6; -; . |
PhylomeDB | P02775; -; . |
Reactome | REACT_14797; Signaling by GPCR; . |
Reactome | REACT_604; Hemostasis; . |
NextBio | 21188; -; . |
PMAP-CutDB | P02775; -; . |
ArrayExpress | P02775; -; . |
Bgee | P02775; -; . |
CleanEx | HS_PPBP; -; . |
Genevestigator | P02775; -; . |
GermOnline | ENSG00000163736; Homo sapiens; . |
GO | GO:0005615; C:extracellular space; IEA:UniProtKB-KW; . |
GO | GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . |
GO | GO:0008009; F:chemokine activity; IEA:InterPro; . |
GO | GO:0005355; F:glucose transmembrane transporter activity; TAS:ProtInc; . |
GO | GO:0008083; F:growth factor activity; IEA:UniProtKB-KW; . |
GO | GO:0006935; P:chemotaxis; IEA:UniProtKB-KW; . |
GO | GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW; . |
GO | GO:0006955; P:immune response; IEA:InterPro; . |
GO | GO:0030168; P:platelet activation; TAS:Reactome; . |
GO | GO:0002576; P:platelet degranulation; TAS:Reactome; . |
GO | GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW; . |
InterPro | IPR001089; Chemokine_CXC; . |
InterPro | IPR018048; Chemokine_CXC_CS; . |
InterPro | IPR002473; Chemokine_CXCL8/IL8; . |
InterPro | IPR001811; Chemokine_IL8-like_dom; . |
Pfam | PF00048; IL8; 1; . |
PRINTS | PR00436; INTERLEUKIN8; . |
PRINTS | PR00437; SMALLCYTKCXC; . |
SMART | SM00199; SCY; 1; . |
SUPFAM | SSF54117; Chemokine_IL8; 1; . |
PROSITE | PS00471; SMALL_CYTOKINES_CXC; 1; . |