The UniProtKB/Swiss-Prot
Protein Knowledgebase is a manually annotated protein sequence database
which provides a wealth of information regarding protein variety, protein
function and associated disorders. An article in
C. R. Biologies
gives an overview on cellular processes that can lead to sequence variety
and structural diversity in eukaryotes, as well as how such processes are
annotated in UniProtKB/Swiss-Prot. The many examples given therein
can be accessed below: the Swiss-Prot examples (dark blue) are linked via
their accession numbers to the most recent version of the database entries
(UniProt web site view); the same entry in the original Swiss-Prot
raw format is provided.
Terms in light blue indicate the annotation topics, under which the information
of interest can be found in the Swiss-Prot entry. Other links provide lists of
further examples via queries, using specific keywords, combination of keywords and/or other annotation.
Note: The ongoing evolution of the database can lead to changes in the annotation, thus
the examples might differ soon from those printed in the corresponding article.
Recent changes and
forthcoming changes
of Swiss-Prot are announced. Details on the format of Swiss-Prot
entries are provided in the user manual.
Formation of the nascent protein sequence
Alternative promoter usage
Alternative products (CC),
Ontologies (KW): Alternative promoter usage,
Sequence annotation (FT): Alternative sequence
Proteins attached to the membrane by a lipophil group
General annotation (CC): Subcellular location (lipid-anchor),
Ontologies (KW): Lipoprotein; GPI-anchor;
Prenylation; Myristate;
Palmitate,
Sequence annotation (FT): Lipidation
A same mutation causes different phenotypes
General annotation (CC): Function, Involvement in disease,
Ontologies (KW): Disease mutation ,
Sequence annotation (FT): Natural variant
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