HPI The UniProtKB/Swiss-Prot Human Proteome Initiative

Publications

Boeckmann B, Blatter MC, Famiglietti L, Hinz U, Lane L, Roechert B, Bairoch A.
Protein variety and functional diversity: Swiss-Prot annotation in its biological context.
We all know that the dogma 'one gene, one protein' is obsolete. A functional protein and, likewise, a protein's ultimate function depend not only on the underlying genetic information but also on the ongoing conditions of the cellular system. Frequently the transcript, like the polypeptide, is processed in multiple ways, but only one or a few out of a multitude of possible variants are produced at a time. An overview on processes that can lead to sequence variety and structural diversity in eukaryotes is given. The UniProtKB/Swiss-Prot protein knowledgebase provides a wealth of information regarding protein variety, function and associated disorders. Examples for such annotation are shown and further ones are available at http://www.expasy.org/sprot/tutorial/examples_CRB.
C R Biol. 328:882-99(2005)
PubMed: 16286078.

O'Donovan C, Apweiler R, Bairoch A.
The human proteomics initiative (HPI).
The availability of the human genome sequence has enabled the exploration and exploitation of the human genome and proteome to begin. Research has now focussed on the annotation of the genome and in particular of the proteome. With expert annotation extracted from the literature by biologists as the foundation, it has been possible to expand into the areas of data mining and automatic annotation. With further development and integration of pattern recognition methods and the application of alignments clustering, proteome analysis can now be provided in a meaningful way. These various approaches have been integrated to attach, extract and combine as much relevant information as possible to the proteome. This resource should be valuable to users from both research and industry.
Trends Biotechnol. 19:178-81(2001)
PubMed: 11301130.