Species code:	STRPG
Taxonomy:	Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus (TaxID: 160491) [NEWT/ NCBI]
Description:	The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. This strain of S.pyogenes is an M5 serotype isolated from a patient with acute rheumatic fever in 1952, which contains 5 prophages. Of the 12 available completely sequenced S.pyogenes genomes (February 2007), it is most closely related to the M18 serotype strain MGAS8232 (STRP8) and the M6 strain MGAS10394 (STRP6). Strain comparisons indicate that intrachromosomal recombination contributes to the divergence of S.pyogenes and of their integrated prophages.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of STRPG entries in the UniProt Knowledgebase: 1736 (302 in UniProtKB/Swiss-Prot + 1434 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number AM295007 (circular; 1,841,271 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] PubMed=17012393; [ NCBI , EBI , Israel , Japan ] Holden M.T.G., Scott A., Cherevach I., Chillingworth T., Churcher C., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S., Mungall K., Quail M.A., Price C., Rabbinowitsch E., Sharp S., Skelton J., Whitehead S., Barrell B.G., Kehoe M., Parkhill J. ; "Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain Manfredo."; J. Bacteriol. 189:1473-1477(2007).
Web links:	Official genome site(s): http://www.sanger.ac.uk/Projects/S_pyogenes/ Other web sites: CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?KLSO=ASC&KLSK=ORGANISMSORT&kingdom=Bacteria&KLquickSearch=streptococcus&GLgenus=Streptococcus&GLSHWPLA=on&GLSHWMERG=on&GLspecies=pyogenes&GLsu Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid160491%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_MANFREDO NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=1314.1;page=SearchResult  EBI Proteome Analysis page

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