Species code:	STRPF
Taxonomy:	Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus (TaxID: 370554) [NEWT/ NCBI]
Description:	The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. Serotype M3 strains cause a higher rate of lethal infections than strains of other M types. In addition, serotype M3 and other GAS strains can undergo rapid shifts in disease frequency and display epidemic behaviour. This is a serotype M4 strain of S.pyogenes.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of STRPF entries in the UniProt Knowledgebase: 1964 (278 in UniProtKB/Swiss-Prot + 1686 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number CP000262 (circular; 1,937,111 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] PubMed=16636287; [ NCBI , EBI , Israel , Japan ] Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. ; "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."; Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
Web links:	CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLsupStrain=MGAS10750 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid370554%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_MGAS10750 NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=370554.3;page=SearchResult PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p16366_Str_pyoge  EBI Proteome Analysis page

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