Species code:	STRP8
Taxonomy:	Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus (TaxID: 301451) [NEWT/ NCBI]
Description:	The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. Serotype M3 strains cause a higher rate of lethal infections than strains of other M types. In addition, serotype M3 and other GAS strains can undergo rapid shifts in disease frequency and display epidemic behaviour. Strict human pathogen responsible for a wide variety of diseases, including pharyngitis, scarlet fever, impetigo, septicemia, toxic shock syndrome, flesh-eating disease, rheumatic fever and acute glomerulonephritis. Strain MGAS8232 is a serotype M18 organism isolated from a patient with acute rheumatic fever.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of STRP8 entries in the UniProt Knowledgebase: 1835 (411 in UniProtKB/Swiss-Prot + 1424 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number AE009949 (circular; 1,895,017 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] MEDLINE=21927593; PubMed=11917108; [ NCBI , EBI , Israel , Japan ] Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. ; "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."; Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
Web links:	CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLstrain=MGAS8232 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid186103%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_MGAS8232 Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Streptococcus_pyogenes.html NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=186103.1;page=SearchResult PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p286_Str_pyoge TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=ntsp03  EBI Proteome Analysis page

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