Species code:	STRP3
Taxonomy:	Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus (TaxID: 301448) [NEWT/ NCBI]
Description:	The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. Serotype M3 strains cause a higher rate of lethal infections than strains of other M types. In addition, serotype M3 and other GAS strains can undergo rapid shifts in disease frequency and display epidemic behaviour. Serotype M3 strains are a common cause of severe invasive infections with unusually high rates of morbidity and mortality. The strain MGAS315 has been isolated from a patient with streptococcal toxic shock syndrome.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of STRP3 entries in the UniProt Knowledgebase: 1859 (411 in UniProtKB/Swiss-Prot + 1448 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number AE014074 (circular; 1,900,521 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] MEDLINE=22133808; PubMed=12122206; [ NCBI , EBI , Israel , Japan ] Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M. ; "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."; Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
Web links:	CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLstrain=MGAS315 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=311 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_MGAS315 Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Streptococcus_pyogenes.html NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=198466.1;page=SearchResult PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p311_Str_pyoge TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=ntsp04  EBI Proteome Analysis page

Genome structure:	Chromosome EMBL accession number BA000034 (circular; 1,894,275 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] MEDLINE=22683278; PubMed=12799345; [ NCBI , EBI , Israel , Japan ] Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S. ; "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution."; Genome Res. 13:1042-1055(2003).
Web links:	Official genome site(s): http://genome.gen-info.osaka-u.ac.jp/bacteria/spyo/index.html Other web sites: CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLstrain=SSI1 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=301 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_SSI1 NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=193567.1;page=SearchResult PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p301_Str_pyoge TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=ntsp06  EBI Proteome Analysis page

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