Species code:	STRP1
Taxonomy:	Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus (TaxID: 301447) [NEWT/ NCBI]
Description:	The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. Serotype M3 strains cause a higher rate of lethal infections than strains of other M types. In addition, serotype M3 and other GAS strains can undergo rapid shifts in disease frequency and display epidemic behaviour. Strict human pathogen responsible for a wide variety of diseases, including pharyngitis, scarlet fever, impetigo, septicemia, toxic shock syndrome, flesh-eating disease, rheumatic fever and acute glomerulonephritis. MGAS5005 was isolated in 1996 from the cerebrospinal fluid of an infected patient in Ontario, Canada, and has been used extensively in studies of GAS pathogenesis.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of STRP1 entries in the UniProt Knowledgebase: 1693 (418 in UniProtKB/Swiss-Prot + 1275 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number AE004092 (circular; 1,852,441 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] MEDLINE=21192684; PubMed=11296296; [ NCBI , EBI , Israel , Japan ] Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. ; "Complete genome sequence of an M1 strain of Streptococcus pyogenes."; Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
Web links:	Official genome site(s): http://www.genome.ou.edu/strep.html Other web sites: CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLstrain=SF370 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=269 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_SF370 Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Streptococcus_pyogenes.html NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=160490.1;page=SearchResult PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p269_Str_pyoge TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=ntsp01  EBI Proteome Analysis page

Genome structure:	Chromosome EMBL accession number CP000017 (circular; 1,838,554 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] PubMed=16088826; [ NCBI , EBI , Israel , Japan ] Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. ; "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."; J. Infect. Dis. 192:771-782(2005).
Web links:	CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLstrain=MGAS5005 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=13888 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_MGAS5005 NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=293653.3;page=SearchResult  EBI Proteome Analysis page

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