Species code:	STAAE
Taxonomy:	Bacteria; Firmicutes; Bacillales; Staphylococcus (TaxID: 426430) [NEWT/ NCBI]
Description:	Gram-positive nonmotile coccus that grows in aerobic and anaerobic conditions, in which it forms grape-like clusters. Staphylococcus aureus is one of the major causes of community- acquired and hospital-acquired infections. It produces numerous toxins including superantigens that cause unique disease entities such as toxic-shock syndrome and staphylococcal scarlet fever. Staphylococcus aureus (strain Newman) was isolated in 1952 from a human infection and has been used extensively in animal models of staphylococcal disease due to its robust virulence phenotype. It possesses four integrated prophages and two large pathogenicity islands. The two major pathogenicity islands vSa alpha and vSa beta are present as well as vSa gamma and vSa4. The vSa4 of the strain Newman, unlike the one in strain N315, lacks virulent determinants and codes for one integrase and three proteins of unknown function. Many virulence genes are encoded by prophages and it is likely that the virulence of the strain Newman largely rely on them. Staphylococcus aureus (strain Newman) has few insertion sequences and lacks known antibiotic-resistance determinants. The fibronectin-binding proteins, FnbA and FnbB are present but lack the C-terminal cell wall sorting signal.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of STAAE entries in the UniProt Knowledgebase: 2583 (488 in UniProtKB/Swiss-Prot + 2095 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number AP009351 (circular; 2,878,897 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] PubMed=17951380; [ NCBI , EBI , Israel , Japan ] Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K. ; "Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."; J. Bacteriol. 190:300-310(2008).
Web links:	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid426430%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Saur_Newman NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=426430.6;page=SearchResult  EBI Proteome Analysis page

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