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HAMAP: Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) complete proteome

General information

Species:  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Species code: SHIB3
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Shigella (TaxID: 344609) [NEWT/ NCBI]
Description: Shigella is a Gram-negative, non-sporulating, facultative anaerobe bacterium that causes dysentery or shigellosis in man. Shigella are highly invasive in the colon and the rectum, and are able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. Shigella was recognized as the etiologic agent for bacillary dysentery in the 1890's, and adopted as a genus in the 1950's and subgrouped into four species. However, a recent genetic study argues that Shigella emerged from multiple independent origins of E.coli 35,000-270,000 years ago and may not constitute a genus. S.boydii is mainly epidemic to the Indian subcontinent. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.
Shigella boydii BS512 was originally isolated from a 12-year-old boy in Arizona, USA. It is serotype 18 and is a member of Group 1 as determined by sequence analysis. The virulence of S. boydii BS512 has been verified through in vitro experimentation via invasion of HeLa cells.
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of SHIB3 entries in the UniProt Knowledgebase: 4140 (696 in UniProtKB/Swiss-Prot + 3444 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    CDC 3083-94 / BS512
Genome structure:
• Chromosome EMBL accession number CP001063 (circular; 4,615,997 bp) (download entry) (download Genome Reviews).
• Plasmid pBS512_211 EMBL accession number CP001062 (circular; 210,919 bp) (download entry) (download Genome Reviews).
• Plasmid pBS512_33 EMBL accession number CP001059 (circular; 33,103 bp) (download entry) (download Genome Reviews).
• Plasmid pBS512_7 EMBL accession number CP001061 (linear; 7,437 bp) (download entry) (download Genome Reviews).
• Plasmid pBS512_5 EMBL accession number CP001060 (circular; 5,114 bp) (download entry) (download Genome Reviews).
Reference(s):
[1] Rasko D.A., Rosovitz M., Maurelli A.T., Myers G., Seshadri R., Cer R., Jiang L., Ravel J., Sebastian Y. ;
"Complete sequence of Shigella boydii serotype 18 strain BS512.";
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
Web links:
Official genome site(s):
http://msc.jcvi.org/e_coli_and_shigella/index.shtml
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=15637
ERIC: http://www.ericbrc.org/portal/eric/shigellaboydiibs512
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Sboy_CDC308394
 EBI Proteome Analysis page



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