Species code:	SALTO
Taxonomy:	Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micromonosporineae; Micromonosporaceae; Salinispora (TaxID: 369723) [NEWT/ NCBI]
Description:	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) is an aerobic seawater-requiring marine actinomycete isolated from coarse beach sand off the Bahamas. The genus Salinispora is distinct from other actinomycetes however in that it resides in ocean sediments and is the first bacterium of its type to require seawater for growth thus providing opportunities to study marine adaptations in Gram-positive bacteria. One significant feature of S. tropica is its ability to produce structurally unique secondary metabolites. This observation supports the exploitation of marine actinomycetes as a source of new medicines. The metabolites observed from S. tropica include salinosporamide A, a potent inhibitor of the 20S proteasome that is currently in human clinical trials for the treatment of cancer. Interestingly, we have observed that the three closely related Salinispora species produce dramatically different suites of secondary metabolites. These metabolites represent the single most significant phenotypic difference observed among the three species and raise questions about the ecological roles and evolutionary significance of secondary metabolites.
Properties:	Presence of flagella: No Interaction: No Number of membranes: 1 Number of inteins:0
Statistics:	Number of SALTO entries in the UniProt Knowledgebase: 4522 (177 in UniProtKB/Swiss-Prot + 4345 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number CP000667 (circular; 5,183,331 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Jensen P.R., Moore B.S., Udwary D.W., Richardson P. ; "Complete sequence of Salinispora tropica CNB-440."; Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
Web links:	Official genome site(s): http://genome.jgi-psf.org/finished_microbes/saltr/saltr.home.html Other web sites: Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=16342 Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/project.php?pid=16342 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Stro_CNB440  EBI Proteome Analysis page

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