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HAMAP: Proteus mirabilis (strain HI4320) complete proteome

General information

Species:  Proteus mirabilis (strain HI4320)
Species code: PROMH
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Proteus (TaxID: 529507) [NEWT/ NCBI]
Description: The gram-negative enteric bacterium Proteus mirabilis, a human commensal bacterium, is a frequent cause of urinary tract infections in individuals with long-term indwelling catheters or with complicated urinary tracts (e.g., due to spinal cord injury or anatomic abnormality). Infection may lead to acute pyelonephritis, fever, bacteremia, the formation of kidney and bladder stones or the encrustation or obstruction of indwelling urinary catheters. It is highly motile and differentiates from short vegetative swimmer cells to an elongated, highly flagellated swarmer form. It has strong adherence abilities, which enable it to infect the bladder, kidney and even penetrate into the bloodstream.
Strain HI4320 was isolated from the urine of a nursing home patient with a long-term (>30 days) indwelling urinary catheter. It is not only able to degrade urine but analysis of the genome suggests it may also be able to synthesize it. The genome encodes 17 types of fimbriae, more than in any other bacterium sequenced to date, highlighting the importance of adherence to this organism. This strain is considered a low-passage clinical isolate (adapted from PubMed 18375554).
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: Animal commensal in Mammalia; Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of PROMH entries in the UniProt Knowledgebase: 3661 (480 in UniProtKB/Swiss-Prot + 3181 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    HI4320
Genome structure:
• Chromosome EMBL accession number AM942759 (circular; 4,063,606 bp) (download entry) (download Genome Reviews).
• Plasmid pHI4320 EMBL accession number AM942760 (circular; 36,289 bp) (download entry) (download Genome Reviews).
Reference(s):
[1] PubMed=18375554; [ NCBI , EBI , Israel , Japan ]
Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T. ;
"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility.";
J. Bacteriol. 190:4027-4037(2008).
Web links:
Official genome site(s):
http://www.sanger.ac.uk/Projects/P_mirabilis/
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=12624
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Pmir_HI4320
PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p12624_Pro_mirab
 EBI Proteome Analysis page



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