Species code:	MYCLE
Taxonomy:	Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium (TaxID: 1769) [NEWT/ NCBI]
Description:	A very slow-growing, acid-fast, obligate intracellular bacterium, which is non-motile and rod-shaped. It is responsible for leprosy. Leprosy is primarily a granulomatous disease of the peripheral nerves and mucosa of the upper respiratory tract; skin lesions are the primary external symptom. Left untreated, leprosy can be progressive, causing permanent damage to the skin, nerves, limbs and eyes. Contrary to popular belief, leprosy does not actually cause body parts to simply fall off. People who have leprosy used to be forced to live in isolated colonies. It is now commonly believed that many of the people who were segregated into these communities were presumed to have leprosy, when they actually had syphilis. Leprosy is not highly infectious, as approximately 95% of people are immune; syphilis is more contagious. Before the 1940's leprosy was considered incurable until the development of the drug dapsone. M.leprae has however started to develop resistance to dapsone and so a new multiple-drug therapy (MDT) containing three drugs: dapsone, rifampicin and clofazimine is administered (adapted in part from Wikipedia).
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia (intracellular obligate) Number of membranes: 1 Number of inteins: 3 in 3 different sequences
Statistics:	Number of MYCLE entries in the UniProt Knowledgebase: 1603 (654 in UniProtKB/Swiss-Prot + 949 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number AL450380 (circular; 3,268,203 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] MEDLINE=21128732; PubMed=11234002; [ NCBI , EBI , Israel , Japan ] Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. ; "Massive gene decay in the leprosy bacillus."; Nature 409:1007-1011(2001).
Web links:	Official genome site(s): http://www.sanger.ac.uk/Projects/M_leprae/ Other web sites: CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Mycobacterium&GLspecies=leprae&GLstrain=TN Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid272631%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mlep_TN Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Mycobacterium_leprae.html Leproma: http://genolist.pasteur.fr/Leproma/ PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p90_Myc_lepra TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=ntml01  EBI Proteome Analysis page

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