Species code:	METST
Taxonomy:	Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanosphaera (TaxID: 339860) [NEWT/ NCBI]
Description:	Methanosphaera stadtmanae, the first human archaeal commensal whose genome has been sequenced, thrives in the human intestine, where methanol is a product of pectin degradation by Bacteroides species and other anaerobic bacteria. This human intestinal inhabitant can generate methane only by reduction of methanol with H2 and is dependent on acetate as a carbon source. It has the most restricted energy metabolism of all methanogenic archaea. The genome lacks 37 CDS present in the genomes of all other methanogens. Among these are the CDS for synthesis of molybdopterin (which is required for the enzyme catalyzing the first step of methanogenesis from CO2 + H2) and for synthesis of the CO dehydrogenase/acetyl-coenzyme A synthase complex, which explains why M. stadtmanae cannot reduce CO2 to methane or oxidize methanol to CO2 and why this archaeon is dependent on acetate for biosynthesis of cell components.
Properties:	Presence of flagella: No Interaction: Animal commensal in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of METST entries in the UniProt Knowledgebase: 1533 (205 in UniProtKB/Swiss-Prot + 1328 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number CP000102 (circular; 1,767,403 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] PubMed=16385054; [ NCBI , EBI , Israel , Japan ] Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K. ; "The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis."; J. Bacteriol. 188:642-658(2006).
Web links:	Official genome site(s): http://www.g2l.bio.uni-goettingen.de/projects/c_proj_mst.html Other web sites: CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Archaea&GLgenus=Methanosphaera&GLspecies=stadtmanae&GLstrain=DSM3091 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid339860%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Msta_DSM3091 PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p15579_Met_stadt  EBI Proteome Analysis page

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