Species code:	HELAH
Taxonomy:	Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter (TaxID: 382638) [NEWT/ NCBI]
Description:	Helicobacter acinonychis strain Sheeba is the causative agent of severe gastritis in large felines such as tigers, lions and cheetahs. H. acinonychis arose 200000 years ago via a host jump of H.pylori from early humans. Its genome is made up of one chromosome and one plasmid. It possesses a large number of highly fragmented genes, many encoding outer membrane proteins. These genes could have been destroyed in order to bypass deleterious responses from the feline host immune system. Five genes are present that are involved in sialylation of cell surface carbohydrates and that were probably acquired by horizontal gene transfer.
Properties:	Presence of flagella: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of HELAH entries in the UniProt Knowledgebase: 1596 (252 in UniProtKB/Swiss-Prot + 1344 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome EMBL accession number AM260522 (circular; 1,553,927 bp) (download entry) (download Genome Reviews). • Plasmid pHac1 EMBL accession number AM260523 (circular; 3,661 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] PubMed=16789826; [ NCBI , EBI , Israel , Japan ] Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G., Gressmann H., Achtman M., Schuster S.C. ; "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines."; PLoS Genet. 2:1097-1110(2006).
Web links:	CampyDB: http://xbase.bham.ac.uk/campydb/genome.pl?id=1104 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid382638%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Haci_SHEEBA PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p17251_Hel_acino  EBI Proteome Analysis page

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