Species code:	ACTPJ
Taxonomy:	Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Actinobacillus (TaxID: 434271) [NEWT/ NCBI]
Description:	Actinobacillus pleuropneumoniae serotype 3 (strain JL03) is a Gram-negative, non-motile, facultatively anaerobic Pasteurellaceae. It is the etiologic agent of porcine contagious pleuropneumonia, an infectious respiratory disease of swine. Actinobacillus pleuropneumoniae strain JL03 is an isolate of serotype 3 which is prevalent in China. Its genome is made up of a single circular chromosome encoding 2097 CDSs. It possesses a complete set of genes coding for enzymes of glycolysis, gluconeogenesis and non-oxidative pentose phosphate pathways. Genes coding for the key enzymes of the TCA cycle, citrate synthase, aconitase and isocitrate dehydrogenase as well as the genes coding for malate synthase and isocitrate lyase, essential for the glyoxylate pathway, are missing. The pore-forming Apx toxins, responsible for the hemorrhagic lesions of the disease, are encoded in an operon apxCABD. Different serotypes secrete different sets of Apx toxins, causing variations in their hemolytic and cytotoxic activities. The absence of apxICABD in strain JL03 confirms that it has the moderate toxicity specific to serotype 3. Actinobacillus pleuropneumoniae can use porcine transferrin, hemoglobin and ferrichrome. Approximately 2.6 % of the genome (55 genes) are involved in iron uptake.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of ACTPJ entries in the UniProt Knowledgebase: 2026 (25 in UniProtKB/Swiss-Prot + 2001 in UniProtKB/TrEMBL)

Genome structure	Chromosome EMBL accession number CP000687 (circular; 2,242,062 bp) (download entry) (download Genome Reviews).
References	[1] PubMed=18197260; [ NCBI , EBI , Israel , Japan ] Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T., Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. ; "Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China."; PLoS ONE 3:E1450-E1450(2008).
Web links	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=19135 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Aple_JL03  EBI Proteome Analysis page

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