CAMEO continuously evaluates the accuracy and reliability of protein structure prediction methods in a fully automated manner. CAMEO currently assesses predictions in two categories (3D protein structure modeling and ligand binding site residue predictions). The project is open to everyone and has been used by several method developer groups to benchmark and monitor their servers and new developments.
Estimating the quality of predicted structural models is a crucial step in homology modeling. Scoring functions analyze different structural features of the protein models in order to generate a quality estimate. QMEAN consists of four statistical potential terms (two non-bonded interaction terms, a torsion angle term and a solvation term) and two components describing the agreement between predicted and observed secondary structure and solvent accessibility.