PROSITE entry PS51870
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General information about the entry
| Entry name [info] | APP_E2 |
| Accession [info] | PS51870 |
| Entry type [info] | MATRIX |
| Date [info] |
10-OCT-2018 CREATED;
26-FEB-2020 DATA UPDATE; 27-MAR-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00204 |
| Associated ProRule [info] | PRU01218 |
Name and characterization of the entry
| Description [info] | Amyloid precursor protein (APP) E2 domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=199; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=194; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2405782; R2=0.0084607; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=22663.1796875; R2=16.1209831; PRIORITY=1; TEXT='Heuristic 0.5%'; /CUT_OFF: LEVEL=0; SCORE=1036; H_SCORE=39365; N_SCORE=11.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=504; H_SCORE=30788; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-36; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='Y'; M= -21, -74, -1, 17, -60, 33, 23, -69, 17, -15, -61, 22, -68, 5, -57, 9, 18, -68, -67, 54; /M: SY='Q'; M= -61, -74, 42, -55, 36, -71, -60, -2, -11, 5, -53, -2, -73, 47, -9, 15, -56, 29, -70, 14; /M: SY='D'; M= -63, -77, 97, -39, -75, -63, -52, -77, -52, -24, -71, 29, -69, 28, 4, 16, -55, -75, -87, 5; /M: SY='P'; M= -60, -79, -66, -58, -70, -9, 47, 23, -61, -24, 22, -61, 81, 46, -65, 8, -3, -8, -79, -64; /M: SY='Y'; M= -22, -81, -68, -66, -29, -16, -42, -14, -59, -56, -52, -67, -79, 39, -4, -62, -64, -61, -36, 120; /M: SY='F'; M= -68, -72, -70, -3, 89, 5, -62, -51, -10, 32, -49, 24, -79, -69, -67, -66, -63, -56, -54, 13; /I: I=-30; MI=0; MD=-77; IM=0; DM=-77; /M: SY='E'; M= -19, -75, -53, 58, 6, -13, -60, -65, 12, -29, -63, -58, 23, -48, 36, 32, -55, 6, -75, -63; /M: SY='H'; M= -21, -74, -61, 19, -62, -21, 50, 28, 17, 11, 40, -1, 11, -55, -9, -5, -5, -10, -79, -60; /M: SY='P'; M= 31, -73, -56, 24, 22, 11, -60, -70, -58, -70, -65, 32, 54, 8, -64, 11, 1, -67, -70, 12; /M: SY='D'; M= 20, -73, 69, -1, -81, 35, -59, -78, 0, -78, -71, 11, -65, 5, -60, 17, 14, -71, -84, -70; /I: I=-28; MD=-71; /M: SY='P'; M= 4, -80, 46, -56, 22, -71, -61, -66, 8, 1, -61, -61, 64, -61, -3, -17, -61, -67, -68, 42; D=-28; /I: I=-28; MI=-71; MD=-71; IM=-71; DM=-71; /M: SY='N'; M= 14, -75, 34, 20, 0, 27, 16, -78, 29, -76, -70, 35, -69, -54, 0, -53, 6, -73, -81, -66; D=-28; /I: I=-28; DM=-71; /M: SY='N'; M= -19, 46, 5, -11, -76, -2, -51, -75, -51, -78, -69, 98, -70, -53, -7, 10, 20, -72, -91, -71; /I: I=-28; MI=0; MD=-71; IM=0; DM=-71; /M: SY='E'; M= -60, -80, 22, 104, -80, -74, -54, -80, -44, -27, -70, -55, -57, -37, -53, -13, -59, -74, -81, -72; /M: SY='H'; M= -23, -80, -54, -52, -69, -70, 140, -84, 3, -69, -55, -44, -70, -46, 16, -58, -66, -82, -96, -41; /M: SY='E'; M= 35, -73, -2, 70, -79, -63, 24, -77, 36, -74, -67, -52, -61, 15, -49, 27, -54, -69, -79, -67; /M: SY='H'; M= 16, -73, -53, 23, -66, -65, 68, -68, 36, -3, 12, 48, -68, -48, 18, -5, -56, -66, -77, 6; /M: SY='Y'; M= -74, -76, -79, -79, 97, -80, -50, -52, -72, -46, -50, -75, -85, -74, -69, -70, -66, -57, -34, 103; /M: SY='K'; M= -7, -73, -64, -53, -63, -73, 19, -56, 56, 35, -50, -57, -70, 33, 37, -57, 23, -16, -76, -60; /M: SY='N'; M= 22, -73, 37, 43, -76, -64, -56, -73, 27, -23, -65, 47, -66, -47, 34, -51, 14, -68, -82, -68; /M: SY='A'; M= 95, -63, -67, -57, -77, -50, -67, -66, -60, -67, -61, -61, -66, 27, -64, -41, -53, -53, -75, -70; /M: SY='Q'; M= -62, -80, -52, 43, -77, -72, -53, -72, 58, -4, -59, -53, -66, 82, 39, -56, -61, -71, -74, -64; /M: SY='Q'; M= -19, -75, 28, -2, -76, -67, -55, -68, 57, -65, 60, -49, -65, 75, -43, 3, 14, -66, -77, -63; /M: SY='R'; M= 27, -76, 15, -3, -76, -19, -58, -67, 1, -69, -62, -55, -70, 39, 79, -55, -60, 9, -78, -65; /M: SY='M'; M= -65, -69, -84, -75, -44, -83, -64, -32, -74, 76, 93, -79, -80, -67, -72, -75, -62, -11, -72, -52; /M: SY='E'; M= -59, -79, 1, 91, -82, -71, -54, -81, 23, -76, -70, -53, -59, 35, 2, 2, -3, -74, -79, -70; /M: SY='E'; M= -60, -77, 19, 68, -79, -72, -56, -73, 51, -72, -66, -51, -61, 52, -3, -53, 27, -17, -79, -67; /M: SY='R'; M= -60, -76, -59, -51, -74, -18, 21, -67, 36, -69, -61, 15, -70, 39, 77, -6, 1, 13, -79, -62; /M: SY='H'; M= -67, -82, -51, 28, -68, -72, 131, -83, -51, -69, -56, -47, -68, 43, 6, -58, -66, -82, -87, 11; /M: SY='R'; M= -64, -80, -62, -50, -74, -75, 51, -68, 26, -68, -59, -55, -73, 44, 93, -59, -62, 14, -78, -59; /M: SY='N'; M= -16, -74, 27, 55, -76, -62, 35, -76, -48, -30, -67, 57, 3, -46, 21, 36, -53, -72, -85, -67; /M: SY='K'; M= -63, -79, -55, 4, -79, -71, -55, -80, 92, -77, -65, -50, -65, 33, 53, -57, -59, -75, -73, -65; /M: SY='M'; M= -58, -70, -77, -75, -3, -80, -73, 58, -71, -37, 77, 3, -74, -70, -73, -64, 13, 62, -78, -56; /M: SY='T'; M= 32, -65, 20, -56, -74, -59, -62, -66, -57, -71, -65, 44, 22, -58, -65, 17, 79, -59, -86, -69; /M: SY='K'; M= -1, -78, -59, 1, -73, -70, -60, -72, 85, -73, -64, -54, -66, 5, 43, -57, -60, -14, 69, -61; /M: SY='V'; M= -15, -68, -77, -14, -53, -81, -76, 21, -71, 21, 48, -74, -76, -70, -73, -65, -8, 78, -81, -59; /M: SY='M'; M= -61, -70, -81, -71, -52, -77, -59, 19, 10, -3, 130, -69, -71, -59, -61, -70, -59, 8, -74, -52; /M: SY='K'; M= -63, -78, 17, -41, -80, -68, -55, -79, 92, -78, -66, 10, -65, 46, 27, -55, -58, -76, -75, -65; /M: SY='E'; M= -60, -81, 24, 100, -82, -74, -54, -76, -43, -74, -70, -54, -58, 39, -52, -56, -60, -14, -81, -71; /M: SY='W'; M= -75, -99,-102, -80, -40, -74,-101, -71, -72, -27, -71, -96, -79, -72, -76, -82, -87, -85, 177, -28; /M: SY='S'; M= 29, -70, 17, 14, -77, -57, -57, -72, -4, -30, -65, 8, -65, 58, -54, 66, -48, -66, -80, -66; /M: SY='E'; M= 24, -77, 37, 95, -82, -68, -55, -81, -46, -76, -72, 7, -59, -40, -55, -53, -58, -73, -82, -73; /M: SY='A'; M= 80, -64, -73, -65, -60, -59, -69, -50, -67, 49, -46, -69, -72, -63, -70, -51, -56, -47, -74, -64; /M: SY='E'; M= -63, -82, 49, 76, -76, -73, -51, -81, -39, -75, -69, -52, -64, 41, 59, -57, -62, -77, -76, 14; /M: SY='E'; M= -14, -77, 55, 59, -79, -10, 22, -78, -47, -29, -68, 38, -65, 29, 15, -7, -57, -74, -85, -67; /M: SY='R'; M= -66, -82, -59, -47, -76, -73, 83, -82, 22, -73, -61, -51, -71, 60, 89, -58, -65, -78, -79, -56; /M: SY='Y'; M= 28, -74, -73, -72, -32, -73, -50, -4, -67, -51, -49, -72, -79, -64, -66, -61, -59, 38, -42, 111; /M: SY='Q'; M= -60, -76, -49, 37, -77, -67, -53, -70, 56, -28, -61, 43, -66, 74, 4, -7, -56, -14, -77, -65; /M: SY='E'; M= -60, -76, 4, 81, -79, -70, 29, -79, 37, -75, -68, 27, -60, 15, -47, -52, 28, -73, -82, -67; /M: SY='M'; M= -63, -69, -84, -75, -46, -81, -63, -32, -72, 63, 109, -77, -78, -65, -70, -73, -60, 16, -74, -52; /I: I=-22; MD=-57; /M: SY='K'; M= -72, -88, -69, -57, -86, -81, -67, -86, 80, -82, 21, -61, -77, -52, 48, -10, -68, -82, -84, -74; D=-22; /I: I=-22; MD=-57; /M: SY='K'; M= 15, -84, -66, 29, -85, -77, -75, 8, 31, -77, -73, 25, -79, -63, -65, 5, -66, -6, -93, -81; D=-22; /I: I=-22; MI=0; MD=-57; IM=0; DM=-57; /M: SY='K'; M= -75, -88, 31, -58, -90, -79, -69, -21, 57, -86, -78, 31, -79, 26, -55, -64, 24, -80, -95, -80; D=-22; /I: I=-22; DM=-57; /M: SY='D'; M= -77, -90, 89, -3, -11, -77, -65, -12, -9, -84, -82, 15, -78, 1, -69, -67, -68, -82, -99, -75; D=-22; /I: I=-22; DM=-57; /M: SY='P'; M= -65, -87, -63, -55, -83, -68, 15, -74, -13, -82, -69, 6, 117, -61, -6, -60, -3, -77, -81, -77; /M: SY='K'; M= 23, -72, -52, 26, -76, -19, -58, -73, 79, -26, -64, 26, -64, -45, -39, 9, -54, -68, -76, -68; /M: SY='A'; M= 76, -66, -65, -61, -67, 31, -64, -67, -62, -68, -62, -58, -67, 10, -66, -44, 27, -58, -69, 34; /M: SY='A'; M= 81, -67, 52, 35, -79, -55, -63, -71, -57, -71, -66, -55, -65, -53, -64, -46, -54, -60, -81, -71; /I: I=-22; MD=-57; /M: SY='E'; M= -69, -88, -2, 82, -86, -82, -63, -81, -3, -26, 21, -65, 3, 33, -59, -66, -69, -79, -87, -77; D=-22; /I: I=-22; MD=-57; /M: SY='K'; M= -19, -89, -71, 9, -89, -86, -75, -80, 52, -35, -75, -69, -80, 32, -8, -68, 23, -22, -92, -81; D=-22; /I: I=-22; MI=0; MD=-57; IM=0; DM=-57; /M: SY='M'; M= -72, -80, -85, -76, 59, -85, -68, -52, 6, 14, 80, -77, -84, 0, -69, -14, -68, -12, -67, 17; D=-22; /I: I=-22; DM=-57; /M: SY='K'; M= 9, -75, -55, -3, -75, -66, -54, -73, 67, -70, 39, 42, -68, -43, 65, -55, -58, -69, -77, -65; /M: SY='Q'; M= -60, -78, -53, 0, -81, -21, -55, -73, 82, -73, -62, 0, -65, 83, -33, -54, -58, -16, -74, -65; /M: SY='E'; M= -1, -78, 26, 82, -80, -71, -55, -79, -40, -74, -69, -53, -61, 10, 52, -53, 18, -72, -81, -69; /M: SY='M'; M= -63, -70, -82, -76, 3, -81, -65, 51, -71, 35, 108, -72, -74, -66, -71, -69, 13, -36, -72, -51; /M: SY='T'; M= -54, -65, -58, -62, -64, -65, -62, -52, -9, -5, 42, 41, -66, -58, -62, 28, 81, 10, -85, -63; /M: SY='E'; M= 22, -75, -47, 69, -77, 14, 16, -19, -8, -27, -63, -1, -63, 52, -54, -10, -58, -67, -78, -67; /M: SY='R'; M= -64, -79, -61, -52, -73, -74, 75, -72, 36, -70, -60, -53, -72, -43, 92, -12, -62, 0, -80, -57; /M: SY='F'; M= -74, -73, -85, -81, 111, -82, -61, -48, -76, -16, 21, -76, -85, -81, -73, -73, -67, -54, -40, 58; /M: SY='Q'; M= -60, -81, -49, 46, -84, -69, -50, -77, 0, -73, -62, 7, -65, 105, 35, -51, -5, -75, -76, -64; /M: SY='K'; M= 6, -71, -53, 6, -76, -62, -57, -70, 63, -73, -64, 32, -65, 29, 3, 39, 15, -22, -79, -66; /M: SY='T'; M= -57, -66, -62, -65, -61, -72, -68, 38, -59, 6, -51, 7, -65, -63, -6, -45, 95, -43, -83, -62; /M: SY='Y'; M= -62, -72, -77, -17, 6, -83, -63, 26, -72, 31, -41, -76, -80, -69, -72, -69, -58, 60, -58, 76; /M: SY='Q'; M= 44, -73, -5, 14, -80, -3, -57, -74, 32, -73, -64, 22, -65, 68, 4, -48, 4, -68, -77, -68; /M: SY='A'; M= 71, -62, -58, -59, -74, -52, -63, -66, -58, -70, -63, 37, -65, -56, -64, 42, 46, -56, -81, -69; /M: SY='L'; M= -65, -70, -81, -75, -40, -82, -63, 3, -74, 77, 36, -78, -81, -68, -72, -12, -61, -10, -65, 43; /M: SY='E'; M= -59, -81, -34, 106, -84, -15, -54, -84, -7, -77, -72, -56, -57, 15, -50, -56, -61, -77, -79, -73; /M: SY='Q'; M= -20, -79, 26, 74, -84, -68, -52, -78, -4, -74, -66, 8, -61, 83, -48, -51, 6, -74, -80, -68; /M: SY='E'; M= -60, -82, -33, 106, -84, -75, -52, -83, -41, -76, -71, -56, -57, 49, -50, -55, -61, -77, -79, -72; /M: SY='N'; M= -15, -70, 3, 9, -67, 32, -53, -69, -55, -74, -67, 81, -69, -54, -62, 24, 0, -12, -77, 30; /M: SY='K'; M= 27, -70, 7, -9, -71, -63, -60, -9, 54, -21, -60, 26, -67, 3, -3, 15, 8, -11, -79, -66; /M: SY='E'; M= 40, -71, -3, 53, -74, 33, 21, -66, -57, -22, -63, -55, -65, -52, -63, 25, -55, 2, -80, -68; /M: SY='E'; M= -60, -81, -34, 105, -81, -76, -54, -11, -42, -72, -68, -57, -57, 38, -51, -56, -61, -71, -79, -71; /M: SY='K'; M= -63, -78, -57, -45, -77, -72, -57, -79, 91, -76, -65, -50, -66, -41, 69, -56, 6, -73, -74, -64; /M: SY='Q'; M= -63, -81, 18, 38, -76, -72, 46, -12, 42, -27, -60, -51, -66, 68, 49, -57, -61, -70, -78, -61; /M: SY='Q'; M= -60, -83, -53, 27, -86, 1, -50, -79, -38, -73, -61, -52, -67, 112, 47, -51, -63, -78, -74, -63; /M: SY='L'; M= -67, -72, -83, -76, -44, -85, -72, 49, -77, 77, -32, -81, 20, -71, -77, -75, -62, -36, -72, -56; /M: SY='E'; M= 7, -74, -56, 57, -67, 0, -64, 31, -52, -25, -56, -61, -67, -51, 36, 8, -56, 26, -78, -66; /M: SY='A'; M= 57, -70, -2, 52, -79, 18, -61, -74, -52, -73, -67, -54, -63, 3, 1, 18, 1, -64, -78, -71; /M: SY='V'; M= 21, -67, -69, 8, -56, -74, -70, 0, -66, 28, 45, -67, -71, -64, -69, -56, 44, 51, -80, -61; /M: SY='H'; M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37; /M: SY='Q'; M= 0, -80, -5, 35, -79, -68, -53, -69, -46, 0, -57, -55, 22, 107, -49, -52, -61, -70, -75, -64; /M: SY='Q'; M= -1, -79, 18, 34, -83, -20, -52, -70, -45, -70, -61, 10, -66, 106, -48, -50, -59, -6, -77, -65; /M: SY='R'; M= -67, 45, -63, -53, -74, -76, 75, -83, -31, -73, -62, -54, -76, -43, 104, -61, -66, -77, -81, -58; /M: SY='V'; M= -56, -69, -84, -79, -52, -86, -85, 55, -76, -6, -40, -78, -78, -77, -78, -68, -53, 88, -83, -60; /M: SY='Q'; M= -4, -74, -56, 31, -67, -70, -56, -53, 0, 18, 45, 24, -69, 82, -52, -56, -58, 12, -76, -62; /M: SY='A'; M= 66, -62, -61, -60, -72, -55, -66, -60, -60, -66, -61, 11, -65, -58, -65, 45, 54, 1, -81, -68; /M: SY='H'; M= -7, -74, -1, 19, -68, -65, 79, 32, -55, -59, 45, 58, -68, 31, -58, 5, -55, -57, -85, -57; /M: SY='L'; M= -67, -72, -85, -79, 34, -86, -72, 56, -78, 69, 25, -80, -81, -73, -76, -76, -62, -34, -67, -48; /M: SY='N'; M= 20, -67, -40, -57, -77, -51, -46, -75, -47, -80, -68, 115, -72, -50, 10, -45, -48, -74, -91, -71; /M: SY='E'; M= -61, -77, 49, 72, -79, -68, -53, -71, 11, -71, 13, 40, -63, 36, -51, -53, -1, -15, -84, -69; /M: SY='R'; M= -63, -79, 17, -45, -77, -70, -54, -77, 69, -73, 13, -50, -68, 29, 78, -4, -59, -74, -76, -64; /M: SY='K'; M= -62, -77, -59, -46, -73, -73, -60, -1, 95, -69, -61, -52, -66, -43, 42, -59, -58, 1, -74, -64; /M: SY='R'; M= -67, -81, -62, -53, -72, -75, -53, -75, 0, -10, -60, 15, -75, -42, 108, -61, -64, -72, -76, -62; /M: SY='E'; M= 11, -71, 18, 44, -71, -67, -60, -9, -3, -61, 23, 27, -65, 29, -57, -11, 31, 24, -83, -66; /M: SY='A'; M= 85, -62, -66, -61, -69, -53, -67, -60, -63, 9, -56, 4, -68, -59, -67, 5, 0, -52, -77, -68; /M: SY='M'; M= -21, -70, -77, -73, -49, 0, -60, -1, -68, 36, 111, -68, -73, -62, -68, -64, 20, -44, -69, 23; /M: SY='H'; M= 17, -75, 52, 46, -77, -67, 83, -78, 40, -74, -66, -47, -63, -46, -49, -52, 16, -72, -86, -60; /M: SY='C'; M= -13, 79, 32, 19, -75, 27, 17, -76, 34, -29, -67, 4, -69, -55, -57, 2, 1, -70, -84, -69; /M: SY='Y'; M= -72, -79, -74, -76, 62, -79, -43, -53, -69, -14, -48, -74, -84, -66, -66, -68, -66, -59, -31, 121; /M: SY='M'; M= -63, -72, -70, -62, -54, -77, -59, -3, -50, 36, 66, -63, -73, 14, 60, -59, 46, -50, -72, 14; /M: SY='Q'; M= 30, -73, 17, -1, -73, -63, -59, 27, 22, -65, -60, 22, -67, 48, 20, 16, -6, -57, -79, -65; /M: SY='A'; M= 73, -64, -64, -11, -66, -55, -65, -58, -61, -22, -58, -59, -67, -57, -66, 42, 9, 4, -74, 12; /M: SY='L'; M= -66, -70, -84, -77, -40, -86, -68, 15, -77, 83, -30, -82, -83, -71, -75, -76, -62, 4, -69, 12; /I: I=-15; MI=0; MD=-39; IM=0; DM=-39; /M: SY='Q'; M= -64, -82, 42, 12, -79, -24, 27, -72, -52, -10, -65, -55, -73, 61, 35, 11, -6, -20, -86, -67; D=-15; /I: I=-15; DM=-39; /M: SY='E'; M= -1, -76, 1, 47, 16, -76, -67, -56, -58, -23, -62, 2, -73, -58, 18, -13, 0, 36, -82, -64; D=-15; /I: I=-15; DM=-39; /M: SY='D'; M= -58, -76, 48, 37, -78, -18, -59, -67, 10, -72, -67, -2, 46, 35, -56, 14, 19, 7, -84, -70; /M: SY='P'; M= -60, -79, -62, -52, -70, -68, -62, -9, 58, -25, -60, -59, 79, 28, -49, 27, -55, -14, -73, 5; /M: SY='P'; M= -1, -82, 1, -56, -76, -8, -66, -15, -62, -2, -62, -2, 105, 9, -71, -60, -59, -67, -79, -74; /M: SY='N'; M= -61, -74, 31, -5, -81, -59, 17, -78, 35, -79, -67, 86, -68, 69, -46, -6, -53, -78, -85, -66; /M: SY='P'; M= 35, -71, -65, -58, -74, -11, -67, -58, 28, -68, -62, -59, 64, -57, -6, 32, -7, 27, -79, -70; /M: SY='H'; M= 8, -78, 8, 48, -76, -69, 104, -81, 33, -73, -63, -49, 0, -44, 24, -56, -62, -76, -85, -55; /M: SY='R'; M= -16, -79, -53, 22, -78, -70, -53, -80, 57, -76, -65, 24, -68, 30, 81, -56, -60, -75, -76, -65; /M: SY='I'; M= -59, -72, -85, -81, -50, -88, -84, 82, -77, 4, -37, -78, -77, -76, -79, -71, -55, 67, -79, -58; /M: SY='L'; M= -64, -72, -69, 29, -48, -83, -65, 4, -66, 75, -35, -74, -76, 31, -67, -70, -62, -4, -73, -57; /M: SY='K'; M= -63, -80, -54, 1, -79, -71, 55, -80, 79, -75, -63, -49, -66, 60, 51, -56, -61, -77, -76, -60; /M: SY='C'; M= 69, 79, -67, -64, -67, -58, -68, -65, -63, -66, -62, -58, -69, -63, -69, -8, 56, -55, -77, 17; /M: SY='L'; M= -15, -68, -83, -75, -43, -83, -69, -32, -76, 84, 23, -81, -82, -70, -74, -73, -61, 8, -72, -54; /M: SY='K'; M= -64, -80, -56, 0, -77, -73, 28, -12, 76, -72, -62, -51, -67, 49, 65, -57, -61, -71, -75, -62; /M: SY='R'; M= 45, -73, -62, -53, -74, -7, 48, -17, 53, -71, -62, -54, -68, -48, 59, -6, -58, -64, -77, -63; /M: SY='Y'; M= -70, 30, -76, -76, 42, -80, -47, -50, -70, 31, -45, -75, -84, -67, -67, -69, -65, -55, -37, 113; /M: SY='I'; M= -63, -73, -85, -81, 1, -88, -80, 80, -78, 40, -35, -79, -78, -75, -79, -73, -58, 41, -73, -54; /M: SY='R'; M= -13, -81, -61, -49, -76, -73, 53, -81, 23, -74, -62, -54, -72, 30, 100, -58, -64, -75, -77, -59; /M: SY='A'; M= 81, -63, -69, -63, -69, -54, -69, -10, -64, -59, 16, -62, -68, -60, -68, 29, -50, 22, -78, -67; /M: SY='E'; M= -61, 46, -42, 95, -69, -79, -59, -1, -50, 21, -58, -62, -62, -43, -58, -61, -61, -61, -79, -69; /M: SY='Q'; M= -14, -80, -40, 83, -83, -68, 23, -80, -43, -74, -65, 25, -61, 84, -48, -52, -59, -76, -79, -66; /M: SY='K'; M= -15, -76, -55, -44, -77, -68, 43, -79, 98, -77, -65, 7, -65, -41, 21, -56, -58, -74, -75, -63; /M: SY='D'; M= -8, -79, 110, 23, -86, -63, -54, -84, -53, -82, -80, 6, -66, -52, -62, -54, -57, -79, -98, -71; /M: SY='R'; M= -66, -83, -62, -49, -77, -76, -52, -82, 5, -75, -63, -55, -74, 29, 111, -60, -65, -76, -75, -62; /M: SY='M'; M= -16, -69, -71, -64, -54, -73, 16, -42, -59, 23, 78, -63, -72, 19, 13, -7, 32, 32, -74, 16; /M: SY='H'; M= -68, -81, -54, -54, -68, -13, 147, -86, -59, -69, -55, -43, -70, -48, -53, -58, -68, -86,-101, -38; /M: SY='T'; M= 23, -64, -64, -63, -59, -63, -61, -55, -61, -1, 61, -55, -66, -58, -65, 45, 72, -52, -74, 22; /M: SY='L'; M= -63, -71, -85, -78, -45, -86, -73, 59, -77, 62, 47, -79, -79, -72, -76, -74, -59, 30, -74, -55; /M: SY='N'; M= 4, -72, -50, -54, -75, -61, 18, -76, 17, -76, -65, 79, -71, -46, 72, -7, 7, -72, -83, -65; /M: SY='H'; M= -16, -80, -55, -53, -69, -70, 142, -85, -53, -69, -55, -45, -70, -47, 22, -58, -67, -82, -98, -40; /M: SY='Y'; M= -73, -80, -76, -76, 68, -79, -45, -55, -69, -50, -51, -74, -84, -67, -66, -69, -67, -61, 56, 119; /M: SY='R'; M= -62, -81, -49, 58, -81, -73, -53, -81, 58, -75, -65, -53, -64, 61, 64, -56, -61, -76, -75, -66; /M: SY='H'; M= -69, -81, -54, -53, -68, -71, 147, -86, -55, -69, -54, -43, -70, -47, 1, -59, -68, -85,-101, -38; /M: SY='L'; M= -14, -68, -81, -75, -47, -82, -74, 6, -75, 68, -35, -78, -79, -72, -75, -68, -3, 54, -77, -57; /M: SY='L'; M= -15, -72, -70, -62, -55, -75, 53, -49, 0, 57, -43, -63, -76, -55, 55, 6, -60, -10, -76, -56; /M: SY='N'; M= 16, -74, 23, 15, -66, -14, 24, -75, 5, -73, -65, 49, -69, -49, 45, -3, -4, -70, -72, 41; /M: SY='T'; M= -52, -66, -60, -59, -66, -65, -63, -53, -56, -1, -56, 7, -66, 27, -2, 49, 75, 19, -83, -64; /M: SY='D'; M= -63, -77, 101, -40, -9, 10, -54, -79, -54, -77, 9, 25, -68, -55, -4, -1, -56, -77, -90, -66; /I: I=-24; MI=0; MD=-61; IM=0; DM=-61; /M: SY='P'; M= -64, -84, -63, 10, -68, -12, -63, -12, -6, -26, -62, -66, 100, -58, 19, -61, -9, -68, -71, 28; /M: SY='E'; M= -16, -77, 0, 64, -74, -70, -54, -72, 38, 1, -62, 33, -65, 29, 37, -56, -59, -70, -78, -67; /M: SY='K'; M= 29, -75, 2, 62, -79, -20, -58, -75, 67, -72, 14, -53, -62, 7, -42, -53, -58, -69, -76, -68; /M: SY='A'; M= 97, -61, -67, -60, -75, -50, -69, -65, -62, -67, -61, -62, -66, -59, -67, -41, -8, -52, -76, -71; /M: SY='E'; M= 46, -71, 29, 60, -75, -62, -58, -70, -5, -5, -63, 7, -64, 15, -56, 15, -54, -64, -80, -69; /M: SY='Q'; M= 28, -72, -7, -49, -76, -62, 28, -69, 20, -71, -62, 27, -68, 61, 39, 16, 15, -18, -80, -63; /M: SY='M'; M= -63, -74, -8, 29, 22, -77, 35, 34, -64, 15, 78, -65, -72, -59, -66, -11, -59, -6, -66, 38; /M: SY='R'; M= -65, -80, -56, 17, -72, -74, -54, -80, 73, -75, -65, -53, -68, -40, 85, -59, -62, -75, -71, 11; /M: SY='P'; M= -15, -77, 35, -3, 15, 3, -62, -75, 11, -76, -69, -54, 74, -55, 7, 40, -54, -72, -76, -65; /M: SY='Q'; M= -20, -76, 0, 30, 10, -68, 52, 7, -49, -16, -57, -53, -68, 67, 22, 36, -56, -62, -75, -56; /M: SY='L'; M= -13, -68, -78, -74, -50, -80, -73, 32, -72, 54, 26, -72, -75, -70, -74, -63, 37, 44, -77, -58; /M: SY='L'; M= 5, -71, -76, -67, -47, -77, -64, 16, -8, 59, 23, -72, -77, 32, -65, -66, -60, 19, -68, 29; /M: SY='H'; M= -59, -75, 37, 34, -77, -68, 80, -75, -8, -71, -63, -46, -63, 65, -52, -5, 55, -71, -86, -59; /M: SY='H'; M= -66, -80, -54, -51, -72, -19, 128, -84, 23, -72, -58, 11, -70, 8, 36, -57, -65, -82, -91, -46; /M: SY='L'; M= -67, -69, -85, -77, -40, -86, -68, -32, -78, 92, -28, -84, -84, -71, -75, -77, -63, -39, -71, -53; /M: SY='H'; M= -61, -76, 1, -49, -72, -69, 60, -70, 57, -24, -60, 8, -69, 14, 57, 13, -8, -17, -80, -60; /M: SY='D'; M= -62, -73, 68, -4, -55, -74, -59, -48, -61, 18, -53, -55, -72, 10, -65, -59, 24, 40, -72, 50; /M: SY='I'; M= -14, -73, -80, -77, -50, -81, -78, 85, -75, 34, -37, -72, -74, -71, -77, -4, -1, 1, -75, -58; /M: SY='D'; M= -63, -78, 94, 53, -82, -64, -53, -20, -51, -78, -75, 42, -65, -48, -60, -6, -55, -75, -93, -70; /M: SY='E'; M= -63, -78, -54, 56, -65, -77, -56, -60, 25, 41, -51, -60, -68, 52, 47, -61, -62, -62, -74, -62; /M: SY='R'; M= 6, -76, -63, 4, -69, -72, 18, -63, -36, -24, 40, -59, -72, -46, 92, -12, -60, 2, -78, -61; /M: SY='M'; M= -20, -71, -75, 10, -53, -81, -73, 65, -69, 8, 70, -72, -72, -66, -72, -66, -9, 47, -78, -58; /M: SY='N'; M= -7, -70, 10, -53, -6, -55, -47, -75, -3, -78, -67, 107, -72, 13, 20, -47, -51, -75, -86, -66; /M: SY='Q'; M= -15, -82, -54, 28, -82, -11, -52, -77, -40, -73, -62, -53, -67, 107, 38, -11, -61, -76, 44, -61; /M: SY='S'; M= 25, -63, -59, -59, -71, -54, -62, -66, -58, -68, 22, -48, -63, -53, -63, 85, 55, -58, -82, -66; /M: SY='M'; M= -64, -72, -81, -15, -47, -85, -70, 62, -74, 56, 73, -77, -76, -67, -74, -73, -60, 6, -74, -55; /M: SY='A'; M= 55, -70, 42, 34, -71, -59, -59, -65, -56, -29, -63, -54, -66, 27, -61, 32, -52, -13, -77, 6; /M: SY='M'; M= -63, -70, -82, -72, -47, -77, -61, -38, -67, 56, 113, -73, -76, -61, -9, -10, -61, -44, 51, -51; /M: SY='L'; M= -67, -69, -83, -75, -41, -86, -67, -33, -74, 90, -29, -82, -84, -69, -10, -77, -63, -40, -71, -54; /M: SY='D'; M= -16, -76, 56, -5, 3, -65, -53, -74, 18, -73, -67, 51, -69, 38, 34, -53, 3, -73, 39, 10; /M: SY='R'; M= -64, -79, 23, -48, -69, -69, 18, -78, 41, -75, -65, 34, -71, 9, 81, -8, -59, -75, -73, 29; /M: SY='H'; M= -61, -71, -2, -67, 42, -76, 46, -8, -65, 24, -47, -63, -76, -64, -3, 6, 16, 36, -65, 42; /M: SY='P'; M= -65, -90, -66, -55, -84, -67, 15, -74, -62, -83, -70, -70, 124, -64, -73, -8, -58, -78, -80, -79; /M: SY='E'; M= -13, -77, 27, 77, -74, -67, 62, -80, -48, -74, -67, 0, -62, 34, -54, 23, -56, -75, -79, 9; /M: SY='L'; M= -64, -71, -84, -78, -43, -87, -73, 56, -77, 65, -33, -80, -80, -73, -76, -74, -59, 37, -71, 7; /M: SY='A'; M= 56, -70, 25, 44, -62, -60, -56, -69, -55, -69, -64, -55, -65, 4, -61, 25, -5, -62, -67, 55; /M: SY='E'; M= 8, -72, 19, 41, -75, -64, -58, -65, 11, -69, -64, -1, -65, 35, 23, 36, 8, 12, -81, -67; /M: SY='K'; M= -12, -76, 17, 24, -80, -66, -56, -77, 76, -75, -66, -48, -63, 52, 0, 14, 1, -72, -77, -66; /M: SY='V'; M= -61, -71, -83, -77, 21, -85, -76, 56, -16, 36, 19, -77, -78, -73, -73, -71, -57, 60, -73, -53; /M: SY='R'; M= -59, -77, -63, -55, -5, 49, -60, -74, 55, -23, 12, -53, -69, 9, 59, -9, -62, -72, -72, -63; /M: SY='P'; M= 29, -76, -4, -6, 33, -67, -65, -14, -59, -64, 15, -63, 83, 7, -11, -55, 19, -61, -72, -61; /M: SY='E'; M= 20, -74, 1, 45, -70, -70, -60, 12, 23, -3, -56, -57, -66, 43, 20, -54, 13, -17, -77, -65; /M: SY='I'; M= -20, -72, -82, -78, -52, -1, -75, 72, -74, 4, 71, -73, -74, -71, -76, -68, -58, 44, -76, -58; /M: SY='D'; M= -13, -77, 62, 36, -77, 27, 16, -17, -3, -67, 16, -50, -66, 45, -57, -55, -59, 5, -83, -66; /M: SY='E'; M= 10, -76, 60, 73, -82, -17, -56, -79, -4, -76, -72, -49, -61, 14, -55, 9, 1, -72, -83, -71; /M: SY='F'; M= -70, -73, -9, -76, 87, -82, -62, 0, -74, 33, -44, -75, -83, -75, -73, -72, -64, 6, -48, 63; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 18 in 18 different sequences |
| Number of true positive hits | 18 in 18 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 7 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | DOMAIN |
| Feature description [info] | E2 |
| Version [info] | 3 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
18 sequences
A4_CAEEL(Q10651), A4_CAVPO(Q60495), A4_DORPE(Q06BR2), A4_DROME(P14599), A4_HUMAN(P05067), A4_MACFA(P53601), A4_MOUSE(P12023), A4_PANTR(Q5IS80), A4_PIG (P79307), A4_RAT (P08592), A4_SAISC(Q95241), A4_TAKRU(O93279), A4_TETFL(O73683), APLP1_HUMAN (P51693), APLP1_MOUSE (Q03157), APLP2_HUMAN (Q06481), APLP2_MOUSE (Q06335), APLP2_RAT (P15943)» more
|
| UniProtKB/Swiss-Prot 'Partial' sequences |
7 sequences
A4_BOVIN(Q28053), A4_CANLF(Q28280), A4_FELCA(P86906), A4_MACMU(P29216), A4_RABIT(Q28748), A4_SHEEP(Q28757), A4_URSMA(Q29149)» more |
| PDB [Detailed view] |
17 PDB
1TKN; 3K66; 3K6B; 3NYJ; 3NYL; 3PMR; 3Q7G; 3Q7L; 3QMK; 3UMH; 3UMI; 3UMK; 4RD9; 4RDA; 4YN0; 5BUO; 5TPT » more |