PROSITE entry PS51839

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51839
Entry name [info]	4FE4S_HC3
Accession [info]	PS51839
Entry type [info]	MATRIX
Date [info]	27-SEP-2017 CREATED; 26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51839
Associated ProRule [info]	PRU01184

Name and characterization of the entry

Description [info]

His(Cys)3-ligated-type [4Fe-4S] domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=40;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8934792; R2=0.0111744; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2196.2661133; R2=1.4897637; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=592; H_SCORE=3078; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=413; H_SCORE=2812; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -6,  1,-26,  5, 15,-22,-19, -8,-16,  6,-12, -9, -4,-11,  3,  4, -5, -7,-12,-26,-14,  8;
/M: SY='V';  M=  5,-23,-13,-26,-22, -3,-23,-24, 17,-20, 12,  6,-22,-24,-21,-19, -6,  1, 26,-27,-10,-22;
/M: SY='K';  M=-10,  0,-26,  0,  6,-23,-18, -6,-20, 22,-19, -9,  3,-15,  7, 19, -6, -7,-15,-25,-11,  6;
/M: SY='E';  M= -5, 10,-26, 13, 22,-28,-15, -5,-26, 15,-23,-16,  6, -9,  9,  7,  1, -6,-21,-28,-16, 15;
/M: SY='A';  M= 13,-15,-17,-23,-14,  5,-15,-15, -3,-10, -2,  0,-12,-17,-13,-13, -3, -3,  0,-13, -1,-13;
/M: SY='R';  M=-16, -9,-30,-10,  3,-24,-22,  0,-19, 19,-16, -4, -2,-17, 21, 44, -8,-10,-18,-20, -9,  8;
/M: SY='K';  M= -5, -1,-26,  0, 14,-27,-18, -3,-23, 22,-22,-10, -1,-10, 12, 13, -2, -5,-17,-24,-12, 12;
/M: SY='S';  M=  3, -1,-19, -1,  8,-24,  6,-12,-23, -6,-22,-16,  2,-11, -2,-10,  9, -2,-18,-29,-21,  2;
/M: SY='V';  M=  1,-22,-19,-26,-20, -7,-20,-21, 14,-12,  6,  8,-18,-22,-16,-10,-11, -6, 19,-23, -9,-20;
/M: SY='M';  M= -8,-27,-19,-31,-24,  3,-28,-17, 26,-21, 26, 31,-25,-25,-16,-18,-21, -8, 22,-22, -2,-20;
/M: SY='E';  M= -7, 16,-27, 26, 38,-31,-15, -3,-30,  7,-23,-21,  5, -4, 11, -2,  4, -7,-26,-32,-19, 25;
/M: SY='F';  M=-12,-22,-25,-25,-14, 13,-24,-14, -4,-11,  9,  3,-18,-24,-10, -1,-19,-11, -7,  3,  6,-11;
/M: SY='L';  M=-10,-28,-22,-31,-21,  6,-31,-21, 25,-28, 39, 20,-26,-26,-17,-21,-25, -8, 13,-20, -1,-20;
/M: SY='L';  M=-11,-29,-20,-31,-21, 14,-29,-17, 18,-27, 42, 24,-28,-29,-19,-19,-28,-10,  9,-18,  2,-19;
/M: SY='T';  M=  2, -4,-20, -5, -1,-14,-13,-13, -6,-11, -7, -6, -6,-14, -7,-14,  2,  3, -2,-25, -9, -5;
/M: SY='N';  M=-11, 25,-24, 16,  8,-22,-10,  2,-17,  4,-24,-16, 33,-15,  2, -1,  3, -4,-23,-34,-17,  5;
/M: SY='H';  M=-18, -1,-30, -1, -2,-21,-13, 91,-31,-11,-21, -2,  9,-20,  8, -2, -9,-20,-30,-29, 16, -2;
/M: SY='P';  M=-10,-11,-34, -6,  6,-25,-19,-12,-16, -7,-20,-10,-11, 52, -4,-14, -9, -9,-24,-29,-23, -2;
/M: SY='H';  M=-10,-18,-23,-20,-13,  4,-25, 18, -2,-19, 17,  9,-14,-25,-11,-12,-19,-13, -5,-20,  8,-13;
/M: SY='D';  M=-13, 24,-27, 33,  7,-21,-13,  2,-27,  2,-23,-20, 11,-15, -1, -6, -1, -7,-22,-23,  1,  2;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P';  M= -7,-17,-30,-13, -7,-20,-13,-20,-14,-14,-14,-12,-16, 41,-13,-18, -6,  1,-18,-27,-21,-13;
/M: SY='V';  M= -4,-24,-18,-27,-23,  0,-28,-25, 20,-20,  4,  6,-21,-13,-22,-20, -7,  2, 25,-26, -8,-23;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='D';  M= -9, 30,-27, 40, 28,-33,-11, -1,-32,  2,-25,-24, 15, -8,  6, -7,  2, -8,-27,-35,-20, 17;
/M: SY='E';  M=-10, -1,-29,  0, 17,-20,-20,  2,-22, 16,-19, -9, -2,-12, 17, 13, -6, -9,-22,-15,  2, 16;
/I:         I=-5; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='G';  M= -4,  5,-25, -1, -9,-25, 30, -9,-31, -5,-29,-19, 17,-18, -8, -2,  6, -9,-26,-28,-23, -9;
/I:         I=-15; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='G';  M=  2, -8,-29, -8,-11,-29, 57,-18,-37,-16,-28,-19, -1,-17,-15,-18,  1,-18,-28,-21,-28,-13;
/M: SY='E';  M= -9, 16,-26, 16, 18,-26, -7,  6,-28,  5,-24,-18, 18,-12,  6,  6,  2, -7,-26,-32,-17, 11;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M=-13, 13,-30, 21, 33,-30,-18, 18,-30,  3,-22,-16,  5, -2, 15, -2, -2,-10,-29,-31,-12, 23;
/M: SY='L';  M=-11,-30,-22,-33,-23, 15,-32,-22, 23,-30, 41, 18,-27,-28,-22,-22,-27,-10, 12,-17,  3,-23;
/M: SY='Q';  M=-12, -3,-29, -3, 12,-31,-21, 25,-18,  2,-13,  2, -1,-14, 42,  5, -5,-12,-26,-22, -3, 26;
/M: SY='D';  M= -9, 30,-25, 31, 13,-29, -9, -1,-28,  7,-27,-21, 24,-12,  2, -1,  3, -4,-25,-34,-18,  7;
/M: SY='M';  M= -4,-16,-20,-21,-12, -9,-23,-12,  9,-11,  8, 16,-14,-18,  0, -9, -8,  2,  5,-22, -6, -7;
/M: SY='T';  M= 11,-12, -7,-19,-16,-12, -9,-19, -3,-13, -6,  0,-10,-17,-14,-16,  6, 13,  7,-27,-14,-15;
/M: SY='M';  M=-10,-11,-23,-11, -7, -5,-25, -9,  7, -8,  2, 10,-14,-20, -8,-11,-12, -8,  7,-19,  3, -9;
/M: SY='K';  M=  0, -8,-23,-10,  3,-16,-13, -6,-11,  6, -9,  6, -8,-14,  4,  2, -5, -7, -9,-20, -8,  3;
/M: SY='Y';  M=-10,-21,-23,-26,-22, 14,-25, -9,  6,-17,  3,  5,-19,-25,-17,-15,-14, -3,  5, 10, 21,-20;
/M: SY='G';  M= -4, -3,-30, -1, -9,-30, 44,-16,-37, -5,-29,-19,  2,-17,-12,-10, -1,-16,-28,-22,-25,-11;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	66 in 66 different sequences
Number of true positive hits	66 in 66 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	4Fe-4S His(Cys)3-ligated-type
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

66 sequences

FDHA_MOOTH  (P77908), FDHL_BACSU  (Q795Y4), FDHL_STAA3  (Q2FEI5),

FDHL_STAA8  (Q2FVV9), FDHL_STAAB  (Q2YYT1), FDHL_STAAC  (Q5HDP9), 
FDHL_STAAM  (Q931G2), FDHL_STAAN  (Q99RW4), FDHL_STAAR  (Q6GEC4), 
FDHL_STAAS  (Q6G711), FDHL_STAAW  (Q7A057), FDHL_STAHJ  (Q4L8G8), 
FDHL_STAS1  (Q49ZN0), HNDD_SOLFR  (Q46508), HOXU_CUPNH  (P22318), 
HYDA_THEMA  (O52683), NDUS1_ACACA (Q37373), NDUS1_ARATH (Q9FGI6), 
NDUS1_BOVIN (P15690), NDUS1_CANAL (A0A1D8PU51), NDUS1_DICCI (Q2LCP5), 
NDUS1_DICDI (Q34312), NDUS1_DROME (Q94511), NDUS1_GORGO (Q0MQG1), 
NDUS1_HUMAN (P28331), NDUS1_MACFA (Q4R6K9), NDUS1_MOUSE (Q91VD9), 
NDUS1_NEUCR (P24918), NDUS1_PANTR (Q0MQG2), NDUS1_PONAB (P0CB67), 
NDUS1_PONPY (P0CB68), NDUS1_RAT   (Q66HF1), NDUS1_RECAM (O21241), 
NDUS1_SOLTU (Q43644), NQO3_PARDE  (P29915), NQO3_THET8  (Q56223), 
NUOG2_RHIME (P56914), NUOG_BLOFL  (Q7VRV7), NUOG_BUCAI  (P57257), 
NUOG_BUCAP  (Q8K9Y2), NUOG_BUCBP  (Q89AU1), NUOG_ECO57  (Q8XCX2), 
NUOG_ECOL6  (Q8FFJ9), NUOG_ECOLI  (P33602), NUOG_MYCBO  (P59962), 
NUOG_MYCTO  (P9WIV8), NUOG_MYCTU  (P9WIV9), NUOG_PSEAE  (Q9I0J6), 
NUOG_PSEFL  (Q9KGW3), NUOG_PSEPK  (Q88FH2), NUOG_PSESM  (Q87ZQ4), 
NUOG_RICBR  (Q1RKD2), NUOG_RICCN  (Q92G92), NUOG_RICFE  (Q4UK22), 
NUOG_RICPR  (Q9ZCF6), NUOG_RICTY  (Q68VV2), NUOG_SALTI  (P0A1Y5), 
NUOG_SALTY  (P0A1Y4), NUOG_SHEON  (Q8EI34), NUOG_SHIFL  (Q7UC56), 
NUOG_STRCO  (Q9XAR0), NUOG_YERPE  (Q8ZDL2), PHF1_CLOPA  (P29166), 
SFRA_GEOSK  (D7AF63), SFRA_GEOSL  (Q74FU6), YJGC_BACSU  (O34720)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

187 PDB

1C4A; 1C4C; 1FEH; 2FUG; 2YBB; 3C8Y; 3I9V; 3IAM; 3IAS; 3M9S; 4HEA; 4XDC;
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