PROSITE entry PS51793

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51793
Entry name [info]	MIS18
Accession [info]	PS51793
Entry type [info]	MATRIX
Date [info]	01-APR-2016 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51793
Associated ProRule [info]	PRU01129

Name and characterization of the entry

Description [info]

Mis18 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=100;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=95;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6446862; R2=0.0087206; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=16942.8417969; R2=3.3786802; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=959; H_SCORE=20183; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=443; H_SCORE=18440; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-40; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -14,  81,  -3, -88,-103, -99, -98, -14, -94, -12, -17, -95,  98,  19,-101,  -6, -28, -45,-112,-103;
/M: SY='M';  M=  23,  22, -39, -27,  36, -26,-101,  38, -15,  24,  42, -99,-105, -97,-100, -50, -88,  34,-101, -84;
/M: SY='V';  M= -42, -98,-110,-105, -84,-112,-112,  42, -29, -38, -73,-103,-106,-104,-103, -93,  14,  94,-114, -91;
/M: SY='F';  M=-102,-101,-117,-112, 115,-114, -99, -14,-108,  20, -75,-108,-115,-115,-106,-104, -95,   4, -77, -56;
/M: SY='Q';  M= -89,   1, -86, -20,-105, -97,  13, -49, -75,  -8, -85, -15, -98, 122, -76,   6, -89,-100,-102,  -4;
/M: SY='C';  M= -91, 156,-108,-109,-102,-106,-109,-108,-104, -99, -99, -15,-121,-112, -41, -93, -91, -96,-130,-111;
/M: SY='K';  M=  35, -28, -47, -21,-102,  11, -91, -21,  45, -17, -90, -27, -98,  13,  36,  32, -30, -42,-106, -96;
/M: SY='N';  M= -17, -19, -83, -42,-104,  18,  58,-105,  24,-104, -94,  59, -98,  36,  10,  38,  10, -53,-111, -29;
/M: SY='C';  M= -91, 158,-111,-111,-101,-107,-111,-108,-107, -99, -99, -97,-122,-115,-113, -94, -91, -96,-131,-112;
/M: SY='R';  M= -43,-106, -19, -22,   1, -61,  32, -98,  40,   6, -89,  54,-102, -30,  62, -36, -90, -99,  60,   1;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='T';  M=  23, -97, -91, -40, -97, -39, -93, -86, -11,  -4, -86,  12, -97, -32,  40,  13,  68,  17,-111, -95;
/M: SY='I';  M= -91,-105,-112,-107,  -6,-115,-112,  85,-105, -18, -71,-107,  42,-105,-109,-100, -86,  60,-106, -88;
/M: SY='L';  M= -48, -99,-114,-108,   6,-115,-106,  43,-107,  63, -65,-110,-110,-104,-106,-102, -88,  61,-104, -84;
/M: SY='G';  M=  38,  -6, -93, -98,-107,  79, -98, -41, -95,-106, -99, -82, -97, -91,-101,  45,   5, -97,-107,-103;
/M: SY='D';  M= -98,-111, 123, -62,-116, -95, -84, -21, -86,-111,-110, -66, -97, -85, -94, -86, -87,-108,-132,-100;
/M: SY='S';  M= -73, -93, -86, -88,-103, -37, -91,-100, -87,-104, -98, -75, -93, -81, -92, 103,  60, -92,-113, -96;
/M: SY='F';  M= -62,  16,-100, -42,  59,-105, -95, -11, -97,  48, -14,  35,-107, -98, -31, -26,  25,  17, -98, -33;
/M: SY='S';  M=  45, -98, -35, -31, -30, -53,  57,-100, -16, -48, -92, -21, -96,  37, -87,  71,   3, -94,-110, -91;
/M: SY='W';  M= -50,-106,-114, -45,  32,-110,-102, -14,-103,  59,  -9,-112, -24,-101,-104, -59, -96,   4, 121,  22;
/M: SY='C';  M= -15,  71, -43, -44,   0,-106,-101, -12, -44,  21,  -4, -15,-107,   1,-100, -21, -14,  65,-108, -23;
/M: SY='C';  M=  21,  75,  29,  20, -29,  38,  16, -28, -92, -50, -96,   8,-100, -89, -98,  11, -19, -97,  55, -95;
/M: SY='S';  M=  14,-101,   2,  -5, -23, -38,  17,   3, -88, -53, -89,   2,  -9,  15, -32,  50,  27,  -9,  14,  28;
/M: SY='D';  M= -92,-105,  63,  10, -98, -44,  24, -92,   7,   5, -89,  44, -23,  33, -26, -39,   0,   3,-111,   4;
/M: SY='E';  M= -30,-104,  36,  60,-104, -98, -87, -19,   6, -56,   4,  13, -95,  41,  -8,  22,  -8,  10,-112, -96;
/M: SY='E';  M=  19,-105,  49,  59,-106, -48,   8,   6, -78,-100, -96, -12, -95, -19,  38,  27, -22, -94,-113, -97;
/M: SY='L';  M= -91,-102, -10,  -4,  29,-103,  -5, -11, -89,  49, -11, -92,  -1, -28,  23,  32,  16, -34,-101, -30;
/M: SY='N';  M= -89,-103,  -2,  12, -96,  25,   0, -92,  22,  32,   5,  37,-100,   9,  22,  22, -87, -44,-108, -93;
/M: SY='C';  M=   2,  51, -27, -99,   9,  -3, -99,  30, -98,  23,   3, -94, -23, -31,-102,   9,  32,  13,-104,  -4;
/M: SY='I';  M=  -2, -10,-110,-105,  32,-111,   2,  68, -19,  35,   7,-102,-106,-100,-102, -97, -20,  26,-101, -81;
/M: SY='T';  M= -40,  17, -99, -99,  16, -43,-100,  16, -95,   1, -80, -27,-101, -97, -44,  19,  69,  45,-106, -11;
/M: SY='L';  M= -24,  45,-104, -16,  13,-107,   7, -13,-101,  60,   2, -26,-108, -97,-102,   5, -87,  39,-105, -85;
/M: SY='S';  M= -52,  17,   7, -87,   4, -98,   8, -12,  39,  -8, -12,  -4,-101, -84,  33,  45,   1,   0,-104,   4;
/M: SY='S';  M=  18,  -9,   3, -43, -28, -25, -90, -96,  27,   6, -90,  -5, -26, -83,   4,  67, -12, -92,-106, -15;
/M: SY='V';  M=  36, -98, -96,   3, -92, -98, -98,   4, -44, -37, -27, -26,-101,   2,   1,  20,  -6,  65,-109, -23;
/I:         I=-8; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='T';  M= -28,-107,-107,-107,-106, -27,-112, -42, -35, -14, -96, -42,-109,-105,-109,  21,  69,  29,-126,-107; D=-8;
/I:         I=-8; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='D';  M=-107,-124,  43, -29,-127, -38,  -7,-116,  -2,-122,-118, -29, -17, -27,-109,  20,  19,  -7,-138,-118; D=-8;
/I:         I=-8; DM=-19;
/M: SY='N';  M= -32,-115,  -3, -56,  -2, -32,-100,  -9,  -4,-112,-107,  68,-115, -15, -19,  14, -28, -36,-125,-107; D=-8;
/I:         I=-8; DM=-19;
/M: SY='V';  M= -49,  10,-101,-101, -97, -43,-104,  16, -41, -23, -86,  34,  -7,   1,-102,  20,  10,  60,-119,-100; D=-8;
/I:         I=-8; DM=-19;
/M: SY='V';  M=  -9,-106,   6,  22, -97,-106,-101,  29, -51, -56,  15, -96,-105,   2, -25,  28, -41,  50,-115, -29; D=-8;
/I:         I=-8; DM=-19;
/M: SY='V';  M= -92,  -1,-113,-109, -89,-117,-113,  50, -60,  -3, -77, -43,-111, -37, -35, -30,  -3,  74,-117, -96; D=-8;
/I:         I=-8; DM=-19;
/M: SY='D';  M= -54,  -8,  48,   7,-106,  -2, -96,   9, -15, -24, -10, -17, -15,   2, -18,  36, -15, -23,-117,-101; D=-8;
/I:         I=-8; DM=-19;
/M: SY='E';  M= -68,-127, -13,  44,-124, -55,-114,-115, -19, -25, -12,-109, -17, -16, -55,-107,  31, -28,-134,-120; D=-8;
/I:         I=-8; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='W';  M=  31,-114,   3,  29,-113,  -2,  31, -48,   7,-112,-106, -25, -21, -92, -24,  -9, -27, -45,  53,-103; D=-8;
/I:         I=-8; DM=-19;
/M: SY='E';  M= -10,-104,  21,  47, -13, -98,   1, -20,  20, -58, -91, -27,  22,  24,  -9,   6,  27,   0,-108, -32;
/M: SY='R';  M= -92,  -7, -91,  28,  16,-104,   9,  12,  13,  19,  14,  -4, -13,  29,  31,  -8, -33,   4,-104, -86;
/M: SY='Q';  M= -42,-104, -44,  -9, -25, -36,  40,  13,  21,  18,  43,  11,-101,  44,  11, -10, -25,   3,-107, -87;
/M: SY='T';  M= -21,-100,  40, -40,  17,-101, -96,  31, -41,   2,   8, -87,-100, -17, -14,  26,  43,  21,-107, -87;
/I:         I=-15; MD=-37;
/M: SY='S';  M= -23, -22, -22, -89, -19,  23, -10,-103,  14, -58, -98,  36,  -4, -25, -29,  71,  -7, -48,-111, -97; D=-15;
/I:         I=-15; MD=-37;
/M: SY='S';  M= -42,  17,  30,   0,-102, -95, -29,  16,  26, -34, -93,  23, -98, -24, -37,  56,  29, -50,-115, -97; D=-15;
/I:         I=-15; MD=-37;
/M: SY='E';  M= -15,-105,   5,  42,-108, -29, -27,-101,  36,-104, -97,  16,  29,  -6,   3,  17,  28,  -7,-113,-100; D=-15;
/I:         I=-15; MD=-37;
/M: SY='G';  M= -24,-106,  -5, -15,-107,  69,  22, -23, -30, -45, -98, -83,  21, -90, -33,  34,   7,-101,-110,-101; D=-15;
/I:         I=-15; MD=-37;
/M: SY='W';  M=  -3,  16,  19,  14,  18, -18, -94, -17, -14, -39, -28, -27,  14,   5, -19,  15,   2,   1,  34,  10; D=-15;
/I:         I=-15; MD=-37;
/M: SY='D';  M= -42,-107,  88,  15, -35,   6,  -5,-102, -87,   2, -15, -27, -99, -32, -16, -26,  21,-100,-118, -96; D=-15;
/I:         I=-15; MD=-37;
/M: SY='C';  M=  20,  40, -89,  39, -95,   1, -91, -50,   6, -22,  39, -24, -99,  -5, -91,  30,   0, -27,-104,  26; D=-15;
/I:         I=-15; MD=-37;
/M: SY='G';  M= -50,-107,  -4,  22,-107,  74,  16, -23,  15, -24, -98,  22, -37, -87, -93,  -7, -92,-103,-110,-101; D=-15;
/I:         I=-15; MD=-37;
/M: SY='C';  M= -39, 111, -23, -95, -19, -93, -97,-104, -93,-103,-100,  18,-104, -93, -33,  71,  30, -96,-119,-100; D=-15;
/I:         I=-15; MD=-37;
/M: SY='T';  M= -24, -99, -96, -34,  -1, -55, -98,   0, -27, -29,  15, -24,   7, -93, -98,  35,  64,  33,-107,   1; D=-15;
/I:         I=-15; MD=-37;
/M: SY='Y';  M=  -8,-108,-104,-104,  50,-106,  27, -29, -99, -33, -81,-100,-112, -95, -97, -11, -94, -22, -70, 115; D=-15;
/I:         I=-15; MD=-37;
/M: SY='S';  M= -28,-103, -20,   1, -24, -98,  20, -17, -87,   0,   5,  20,-103,  31,   6,  47, -84,  20,-103,  34; D=-15;
/I:         I=-15; MD=-37;
/M: SY='P';  M= -24,   7,  31, -28,  -4,-101, -94, -36,   5,  -2,  16, -45,  51,   9, -17,  -3,  28, -45,  48,  -9; D=-15;
/I:         I=-15; MD=-37;
/M: SY='L';  M= -97,-102,-114,-108,  26,-117,-102,  44,-105,  73,  -8,-109,-112,-103, -16,-104, -16, -10,-101, -82; D=-15;
/I:         I=-15; MD=-37;
/M: SY='R';  M= -17,  33, -93,   7,  19,-101,  -8, -93,  13,   4,   2, -27,-101, -33,  41,  29,  36, -54,-104, -12; D=-15;
/I:         I=-15; MD=-37;
/M: SY='C';  M= -30, 154,-111,-110,-103,-107,-111,-109, -33,-101,-100, -98,-121,-113,-111, -94, -92, -97,-131,-113; D=-15;
/I:         I=-15; MD=-37;
/M: SY='C';  M=  26,  32, -20, -20,-103, -34, -17,  -5,  19, -48, -93,  14,-101,  22,  16,  25,  21, -39,-111, -23; D=-15;
/I:         I=-15; MD=-37;
/M: SY='G';  M=   3,-109, -92, -41,-113,  46,  32,-109,  -3,-110,-101,  29,-103,  44,   8,  17, -11, -29,-115,-102; D=-15;
/I:         I=-15; MI=-37; MD=-37; IM=-37; DM=-37;
/M: SY='C';  M= -93, 153,-109,-110,-103,-107,-109,-110,-103,-101,-101,  -8,-122,-112, -16, -95, -92, -98,-131,-112; D=-15;
/I:         I=-15; DM=-37;
/M: SY='N';  M=   5,-105,  -9, -28,-110,  28,  43,-110,  28,-109, -98,  56, -99,  49, -13,  32, -85,-106,-113, -97; D=-15;
/I:         I=-15; DM=-37;
/M: SY='S';  M=  29, -99, -44, -22,-102, -22, -12, -96,  -9, -29,  18,  30, -98,  -6,  14,  51,  36, -32,-112, -97; D=-15;
/I:         I=-15; DM=-37;
/M: SY='V';  M=   4,  -7,  -4,  38, -94, -22,   5,  -4, -94,   1, -85, -96,  40, -92,-100, -47,  -8,  49,-111, -13; D=-15;
/I:         I=-15; DM=-37;
/M: SY='V';  M= -42,-102,-114,-109, -80,-114,-108,  59,-107,  48,  14,-108,-109,-104,-108, -21, -88,  60,-109, -89; D=-15;
/I:         I=-15; DM=-37;
/M: SY='G';  M= -25,-108, -14,-104,-114, 103,-102,-121,-100,-117,-107, -82,-100, -98,-108, -81, -99,-114,-106,-109; D=-15;
/I:         I=-15; DM=-37;
/M: SY='R';  M= -95,   7, -96, -84,  37,-106, -88, -23,  58, -24, -17, -88,-103, -77,  90, -37, -92, -47, -99, -84;
/M: SY='M';  M= -27,  -8, -97, -88, -12,-103, -15,  11,  53, -44,  64, -38,  -4,  33,   4, -25, -20,  27,  20,  -6;
/M: SY='Y';  M= -42,-109,-100,-102,   7,-106, -72, -84, -96,  -2,  15,  -9,  -6, -92, -94, -96, -94, -89, -65, 128;
/M: SY='H';  M= -52,  32, -11, -91, -15, -52,  40,  40,  17, -24, -81, -38,-103,  11,  28,  -8,  -3,  24,-102,  32;
/M: SY='T';  M=  10,  42,  -3,  -4,-103,   4, -18, -99, -88,-100,  -7, -80,  -7, -86, -30,  61,  69, -92,-114, -98;
/M: SY='T';  M=  -6, -94, -11, -35, -95, -98, -98, -83, -90, -10, -86, -82, -28, -92, -97, -13, 104,  11,-116, -95;
/M: SY='P';  M=  -1,-106, -29, -25,  -8, -24,  13, -47, -91,-102, -95,  17,  94, -90, -98,  26,  22, -23,-108, -25;
/M: SY='P';  M=  -7,-107, -31,  40, -97,-100, -90,  -2,   8, -12, -88,   5,  57,   7,  39, -13, -87,   0,-105,   6;
/I:         I=-26; MD=-67;
/M: SY='H';  M=  26,-105,  38,  31,-105, -94,  78,-105, -19, -36, -94, -18,  -2,  33, -11,  32, -86,-101,-113, -32; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='L';  M= -37,-101,-112,-105,  38,-113, -97,  13, -43,  71,  42,-107,-111, -99, -15,-102, -30, -27, -96,   6; D=-26;
/I:         I=-26; DM=-67;
/M: SY='D';  M=  37,-103,  89, -12,-108, -92, -89, -99, -87, -35, -99,  32, -15, -14, -94, -22, -13, -13,-120,-100; D=-26;
/I:         I=-26; DM=-67;
/M: SY='H';  M=   8,-107,  16,  20,  -3,  -7,  74, -50,   9,  -4, -21, -24,  21,  -2, -89,  -5, -91, -98,  41,   8; D=-26;
/I:         I=-26; DM=-67;
/M: SY='L';  M=  -8,  -4,-110,-104,   2,-111, -98,  42, -19,  57,  28,-104,-108, -98, -15, -98, -14,  -5, -98,  28; D=-26;
/I:         I=-26; DM=-67;
/M: SY='R';  M= -94,  -1, -94, -83,-102,-105, -86, -40,  10, -10,  -1, -87,-104,  28, 100,   3, -14, -98,-107, -93; D=-26;
/I:         I=-26; DM=-67;
/M: SY='D';  M= -34, -11,  66,  19, -42,  57, -89,-107, -89, -49,  33,  39, -99, -87, -97,   7, -88,-104,-114,-100; D=-26;
/I:         I=-26; DM=-67;
/M: SY='M';  M=   7, -19, -97, -26, -30, -49,  10, -30,  35,  39,  62,  -2,-102,  -8, -34, -19,   3, -49,-103,   1; D=-26;
/I:         I=-26; DM=-67;
/M: SY='Y';  M=-101,-106,-106,-105,  89,-110,   1,  -2,-100, -28, -20,-101,-111, -10, -98, -97, -14, -84, -69, 102;
/M: SY='C';  M= -17,  93, -99, -98,   1, -99,-101, -82, -96,   7, -85, -89,-102, -97,-101,  37,  69,  23,-113, -93;
/M: SY='L';  M= -96,-100,-110, -18,  69,-113, -99,  14,-105,  71, -67,-108,-111,-102,-104, -22, -91,  -4, -93, -73;
/M: SY='D';  M= -18,-104,  65,  16,  31, -96,  30, -49, -14, -97, -95,  16, -99, -37, -46,  24,  13, -97,  32,  47;
/M: SY='H';  M= -26, -19, -30,   0, -92,-104,  51,  30,  40,  -7,  12, -89,-100, -25, -21,  -6,  12,  43,-111, -89;
/M: SY='D';  M=  -3,-102,  67,  11, -34, -91, -85, -47,  14,-104, -98,  53, -96,  28, -85,  34,  17, -43,-115, -96;
/M: SY='C';  M=  24,  49,  11, -33,-102, -48, -10, -99,  34,  -8, -30,  23, -99,  14,  19,  44, -19, -95,-111, -96;
/M: SY='I';  M= -35,  23,-110,-106, -80, -23,-105,  68, -21,  41, -11,-104,-107,-101,-103, -45, -88,  44,-105, -16;
/M: SY='Q';  M= -30,  -1, -22, -15,   9, -98,  24, -11,   5,   9, -85,  11,  17,  38, -16,  27,  17, -27,-101,  21;
/M: SY='C';  M= -51,  80, -37, -14, -94, -43, -95, -39, -91,  -6, -13, -32,-101, -89, -23,  67,  34,  19,-112, -13;
/M: SY='Y';  M= -49,-110, -98, -98, -56,-106,  21, -87, -19,  -9, -79, -98,-110,   2, -37, -35, -94, -91, -65, 129;
/M: SY='Q';  M= -16,-104,   5,   2, -95,-100,  -9, -24, -47, -14,  52, -87, -29,  80,  -8,  -1,  11,  22,  16,  -4;
/M: SY='L';  M= -26, -99,-107,-100, -28,-110, -97,  -9,   6,  73,  -2,-103,-108, -96, -32, -97,  12,  18,-100,  10;
/I:         E1=0; IE=-380; DE=-380;

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Post-processing [info]

COMPETES_HIT_WITH

PS51788; PS51789; PS51790; PS51792

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	10 in 10 different sequences
Number of true positive hits	10 in 10 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Mis18
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

10 sequences

MIS18_SCHPO (Q9P802), MS18A_BOVIN (A5D7N9), MS18A_HUMAN (Q9NYP9),

MS18A_MOUSE (Q9CZJ6), MS18A_OTOGA (B5SNH4), MS18A_PANTR (Q68UT5), 
MS18A_PLEMO (B1MT51), MS18A_RAT   (B2RZC4), MS18B_HUMAN (O43482), 
MS18B_MOUSE (A2AQ14)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

4 PDB

5HJ0; 5J6P; 7SFY; 7SFZ