PROSITE entry PS51774

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51774
Entry name [info]	NAB
Accession [info]	PS51774
Entry type [info]	MATRIX
Date [info]	01-SEP-2015 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51774
Associated ProRule [info]	PRU01110

Name and characterization of the entry

Description [info]

Networked (NET) actin-binding (NAB) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=81;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=76;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6251471; R2=0.0089701; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=12085.3046875; R2=3.6689038; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1380; H_SCORE=17148; N_SCORE=15.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=432; H_SCORE=13670; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-40; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='Y';  M=-106,   8, -20, -30,  25, -60,  42, -12, -25,  -2, -20, -19,-117,   6, -10,   2, -58,-101,-106,  44;
/M: SY='S';  M=  -6,-112, -20, -37,-118, -55, -18, -58,  23,-116,-109, -92,  15, -94, -63,  66,   5, -60,-124,-110;
/M: SY='W';  M= -27,   2, -36,-105,-101,-109, -19, -52,   3, -25,  12,-106,  18,-101, -15,  33, -57, -61, 110, -33;
/M: SY='W';  M=  -4,-120,-112,  -7,  14, -24,-112,-106,-104,  -9,-103, -17, -45,  14, -41,  13,-105, -54, 115, -89;
/M: SY='W';  M=-109,-121,-125,-117,  51,-117,-116, -23,-110, -11, -19, -56, -47,-112, -24,  -8, -29, -15, 125,   1;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='D';  M=   5,-116,  51, -26,-118,  11, -43, -54,  -4,-115, -22,  18, -19, -15,   7,   7, -96, -70,-122, -37;
/M: SY='S';  M=  -3,-108, -25, -36, -43, -17,-102,-107, -40,-112,-107,  14, -41, -95, -44,  69,  17, -12,-123,-107;
/M: SY='H';  M= -47, -16,   3,  14, -41,-110, 111,-115, -53, -75, -15, -20, -32,  22, -29, -52, -27, -63,-128, -42;
/M: SY='I';  M= -32,-111, -22,-108, -20, -30, -45,  62,-104,  -1,  34,   8,-112, -24,  -9, -51, -48,  14,-113, -43;
/M: SY='S';  M= -33, -13,  30, -46, -41, -22, -21,  -9, -29, -62,   3,  -2, -30,  -1,  31,  38,   6, -56,-116, -23;
/I:         I=-20; MI=0; MD=-50; IM=0; DM=-50;
/M: SY='P';  M= -18,-114, -48, -96, -33, -59, -14, -44, -98, -24, -98, -36,  86, -20, -39,  27,  17, -17,-117,-106;
/M: SY='K';  M= -98,-113, -20,  21,  -1,-106, -30, -46,  42, -31,   8,  16, -14,  12,  13,  14, -26, -51,-110,  -1;
/M: SY='Q';  M= -58,  14, -39, -47,-113, -56,  54,-111,  31, -58,   5,  46,-106,  68,  -8,   6, -25,-110,-119, -99;
/M: SY='S';  M= -32,-107, -37,  -1,-110, -29, -99,  -6, -58,-109, -27, -35,  37, -89, -57,  82, -39,-100,  14,-104;
/M: SY='K';  M= -23, -10, -89,  44,-112, -35, -15,-110,  49, -71, -34, -36,  15,  31, -31,  19, -25, -61,-113, -23;
/M: SY='W';  M= -64,   9,-113, -23, -13, -49, -13, -56,-101, -65,-103, -34,   6,  33,-105,-102,  12, -69, 146, -25;
/M: SY='L';  M= -57,  18,-115, -43, -40, -51,-103, -40, -63,  75,  34, -46,-117, -31,-108,-108, -98, -15,-108, -41;
/M: SY='Q';  M= -11,-111,   1,  18, -42, -47, -95,-102,  22,  12, -94, -46,-104,  56,   1,  28, -42,-101,  39, -97;
/M: SY='N';  M= -38, -16,  14,  25, -47,  -1, -94,-102,   9, -42,  -7,  26,   7,  20, -24,   8,   9, -17,-114, -23;
/M: SY='N';  M=  12,-101, -87, -96,-105, -93, -93, -38, -91, -73, -98,  76, -38, -91, -37,  33,  61, -37,-120, -24;
/M: SY='L';  M= -97,-107,-105, -41, -53, -63,-102,   4,  43,  53, -25, -38, -39, -94, -23, -16,  -6,  11,-110, -94;
/M: SY='S';  M=  28,  19, -60,  28,-108, -97,  -2, -55,   7, -74, -98, -88,-100,  38, -13,  47,  18, -56,-114, -31;
/M: SY='D';  M= -97,-115,  75,  69,-111,  15, -89, -55, -38,-111, -20, -27, -99, -21, -94, -91, -96,-111,-115,  15;
/M: SY='M';  M= -39,-103, -44,-104, -36,-110, -98,  39,-102,  38,  99, -20,-107, -17,-102, -29, -35,  15,-108, -87;
/M: SY='E';  M= -94,-111,  72,  84,-113, -58, -17,-109, -42, -49,-104,  26, -95, -76, -89, -38, -90, -29,-120,-103;
/M: SY='E';  M=  -9,-107,  17,  51, -23, -38,  28, -64,  -7, -66, -15,  -8, -97,  40,  28,  -5,  24, -49,   8, -93;
/M: SY='K';  M= -93,-108,  -2, -79,-106, -53, -87,-104,  76, -19, -24,  31,-100,  26,  55,  -1, -89, -55,-109, -96;
/M: SY='M';  M= -88,   4,-111,-106,  -1,-112,-104,  38,-102, -21,  82, -29,-107, -32,-103, -97, -23,  77,-109, -49;
/M: SY='K';  M= -53,-105, -84,  23,-104, -23, -87,-101,  79, -15,  10,  20, -96,  21,  17, -30,  14, -99,-107, -96;
/M: SY='R';  M=  27, -17, -23,   9,-100, -37, -88,  -3,   8, -13,  20,   8, -99,  45,  50,  -5, -12, -90,-106, -30;
/M: SY='M';  M= -61,   7, -29, -99, -83,-107, -94,  56, -21,  15, 109, -28,-102, -12, -43, -19, -18, -15,-106, -86;
/M: SY='M';  M=  -5, -99,-107, -31, -79,-108, -96,   5, -40,  70,  73,-103,-106, -13, -41, -27, -40,  -4,-104, -86;
/M: SY='K';  M= -49,-104, -87,   4,-102, -39, -89, -28,  84, -29,  25, -42, -95,   7,  15,  -2,  20, -26,-105, -94;
/M: SY='L';  M= -93,-101,  -8, -96, -26,-108, -16,  35, -27,  64,  12, -25,-106,   8, -13,  -1,  -2, -32,-103, -28;
/M: SY='I';  M= -93,-104,-106, -20, -36, -24,-103,  82, -48,  35,  22, -43, -49,  -9, -27, -52, -39,  -2,-104, -87;
/M: SY='E';  M= -11,-106,  49,  62, -40, -26, -87, -51,  42,-104, -98,  -3, -34,   8,  15, -22,  -3, -58,-110, -97;
/I:         I=-14; MD=-35;
/M: SY='E';  M= -94,-111,  43,  70,-114, -74, -91, -21, -10,-109,-104,  28, -35,  11, -90,  22, -13, -41,-120,-105; D=-14;
/I:         I=-14; MI=0; MD=-35; IM=0; DM=-35;
/M: SY='D';  M= -29, -19,  59,  42,-116, -67, -97, -49, -26, -32,-106,  34,-107,  -9, -99, -47,   2, -20,-128,-109; D=-14;
/I:         I=-14; DM=-35;
/M: SY='G';  M=  16,-110,  23,   4, -47,  50,  11, -46, -98, -34,-103,   8, -37, -40,-104,  17, -52, -51,-117,-105; D=-14;
/I:         I=-14; DM=-35;
/M: SY='D';  M=-100,-115,  99,  35, -41, -46, -13,-116,  -1,-114,-111, -14,-100,  10, -91, -53, -93, -66,-126,-102; D=-14;
/I:         I=-14; DM=-35;
/M: SY='S';  M= -81, -99, -38,   0, -40,   4,  -7, -52,   1, -60, -97,  31, -96, -22, -46,  79,  35, -58,-113, -96;
/M: SY='F';  M= -96,-103, -18, -15,  91, -64, -95,  -6, -11,  -1,   2, -12, -35, -36, -49,  11, -20, -18, -88, -17;
/M: SY='A';  M=  68,  12,  -4,  -6,-106,  -8, -95, -33,   2, -54, -95,  17,   0, -86, -28,  23, -43, -59,-111,-101;
/M: SY='Q';  M= -29,-109,   9,  46,-111, -37, -16,-104,  54,-104, -40,   6, -40,  72,  19, -85, -45, -19,-109, -97;
/M: SY='R';  M= -18,-109,  -7,   1,-106,  -1, -88,-103,  22, -47, -24, -27, -41, -18,  89,  -3, -91, -20,-109, -96;
/I:         I=-18; MD=-45;
/M: SY='A';  M=  71,-100, -41, -95, -44,  -7,-101, -34, -47, -30, -91, -33, -35, -25,   3,   9, -46,  11,-111,-100; D=-18;
/I:         I=-18; MD=-45;
/M: SY='E';  M= -98,-116,  44,  88,-118,-107,  24,-119, -50,-114,-108,  -7,  -8, -76,  14, -28, -95,-114,-120,-105; D=-18;
/I:         I=-18; MD=-45;
/M: SY='M';  M=  -4,-109,  -5, -21, -43, -65, -25,  19, -50, -21,  95, -36,-107, -96, -44,   6, -47, -18,  74, -90; D=-18;
/I:         I=-18; MD=-45;
/M: SY='Y';  M= -31,  -4,   2,-105,  22, -16,  -7, -19, -27, -15, -91, -30,-116,-100, -44, -26, -62, -97, -86,  95; D=-18;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='Y';  M=-103,   6, -51, -15,  -7,-110,  20, -52, -98,  -7, -89, -35, -10, -95, -13,   9, -97, -98, -82, 105; D=-18;
/I:         I=-18; DM=-45;
/M: SY='Q';  M= -95,-113, -46,  34,-111,-103,  41,-108,  45, -48, -19,   5, -45,  70,  42, -12, -93, -50,-112, -96; D=-18;
/I:         I=-18; DM=-45;
/M: SY='K';  M= -45,-109, -86,  32, -29, -29, -89,-109,  71,-106, -98, -31, -97, -20,  60,  10, -27,-105,  55, -93;
/M: SY='R';  M= -95,-111, -20, -11,-105, -64, -86, -51,  49, -36, -93, -20,-102, -23,  98, -36, -93, -49,-107, -95;
/M: SY='P';  M= -18,-111, -90,  28,-106, -98,   5, -50, -28, -15, -11, -93,  94,  19, -15,  24, -40, -48,-110,-101;
/M: SY='E';  M= -92,-111,   9,  88,-108,-105,  -9,-102, -13,  -3, -93, -87, -11,  61, -23, -49, -91, -33,-110, -98;
/M: SY='L';  M= -97,-101,-113,-106, -19,-116,   1, -36,-104,  87, -63,-111,-114,-100, -13,-106, -94,   4,-101, -15;
/M: SY='I';  M= -21,-104,-109, -52, -34, -36,-104,  64, -32,  31,  19,-103,-106,  10,-101, -43, -35,  35,  24, -18;
/M: SY='S';  M=  29,-102,  14,  32,-107,   4,   8,-101, -20, -61,  -3,  23, -97,  40, -89,  45, -40, -31,  -4, -97;
/M: SY='L';  M= -40,-102,-108,-100,   0,-111,  28, -45, -21,  71,  70, -58,-109, -10,  -8,-101, -47, -24,-103, -82;
/M: SY='V';  M= -45,  30,-112,-107, -22,-114, -15,  15,-106,  44,   4,-107,-110,-104,-106, -98,  -8,  74,-111, -88;
/M: SY='E';  M= -90,-109,  -3,  82,-105,  -1,  10,-106,  17, -30, -96,   2, -93,  35, -39,  -7, -33, -57,-108,  -6;
/M: SY='D';  M= -92,-109,  81,  76,-114, -24, -86,-112,  -1,-110,-106,   8, -93, -31, -86, -12, -28, -55,-119,-102;
/M: SY='F';  M= -56,  10, -27,-106,  76,-111, -14,   5,-106,  51, -73, -43,-112,-105,-105, -24, -55,  14,   9, -15;
/M: SY='Y';  M= -97,-108, -92, -44,  32, -47,  93, -11, -93, -48, -84,  31,-107, -47, -92,  -7, -26, -94, -84,  96;
/M: SY='R';  M= -92,-107, -17, -16,-108, -61,  12, -48,  48,-105, -95,  42, -99,  34,  69,   6,  18,-102,-111, -95;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='Q';  M=  23, -15, -14,  14,-107,  17, -13, -15, -46, -75,  16,  -9, -98,  65,  -4,  41, -19, -95,-110, -97;
/M: SY='Y';  M=-103,-113,-101,-103,   1,-110,  59, -33, -97, -23, -80,-100,-113, -39, -94, -98, -98, -92, -66, 127;
/M: SY='Q';  M= -51,  50, -91,  10,-104,-105,  16, -53,   0,  -4, -89, -88,-103,  81,  62, -30, -23, -30,-110, -94;
/M: SY='S';  M=  33, -98, -94, -29, -38, -23, -94, -91, -93,   8, -89, -39, -99, -88, -97,  71,  33, -31,-105,  21;
/M: SY='L';  M= -59,-102,-115,-107, -20,-117,-101,  12,-108,  86,  12,-113,-114, -20,-106,-107, -94, -28,-103, -85;
/M: SY='A';  M=  73, -17, -99, -94, -33, -92, -11, -89, -31, -15, -87, -15,-104,  12, -95, -31, -87,  -6, -94,  67;
/M: SY='E';  M=  21,-107,  50,  66,-111, -51,   0, -43,   2,-106,-101,  -9, -24, -24,   3,   2, -12,-101,-115,-101;
/M: SY='R';  M= -46, -27, -94, -83,-103, -68,  46, -99,  27,  -5, -15, -87,-103,  56,  80, -19, -25, -21,-109, -91;
/M: SY='Y';  M=-101,  42,-102,-103,   4,-109,  33, -17, -31, -55, -83,-100,-113, -94, -95, -25, -95, -92, -69, 124;
/M: SY='D';  M= -35,  15,  95,  11,-113, -36,   7, -38, -19,-110,-106,  18, -27, -84, -92,  27, -86,-106,-125,-101;
/M: SY='H';  M= -96,-110,  13, -10,-104, -99,  96, -52, -23, -15, -89,  45,-102,  76,  17, -28, -92,-105,-115, -36;
/M: SY='L';  M=  18,  -2,-109,-102, -82, -59, -23, -13,-103,  72,   9,-104,-109,   0,-103, -25, -10, -15,-106, -89;
/M: SY='R';  M= -55,-104, -94, -27, -44, -45, -93,   6,  30,   4, -31, -45,-100,  21,  52,  19,  45, -26,-109, -94;
/M: SY='G';  M= -13,-105, -92, -20, -27,  51, -95, -50,  19, -70, -99, -13,  31, -87,  17,  39,  15,-101,-107, -42;
/M: SY='E';  M= -62,-110, -27,  82, -46, -34, -21,-101,  48, -12,  -8, -32, -10,  -4, -36, -63, -52, -29,-109, -98;
/M: SY='L';  M= -61, -30,-101, -97, -16, -60,  13,   7, -24,  41,   5,   5, -15,   1,   4,  21, -35,  26,-106,  -7;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	16 in 16 different sequences
Number of true positive hits	16 in 16 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	NAB
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

16 sequences

CIP1_ARATH  (F4JZY1), KIP1L_ARATH (Q9SX73), KIP1_PETIN  (Q94CG5),

NET1A_ARATH (Q9LUI2), NET1B_ARATH (F4JIF4), NET1C_ARATH (Q9ZQX8), 
NET1D_ARATH (F4HZB5), NET2A_ARATH (P0DMS1), NET2B_ARATH (F4I131), 
NET2C_ARATH (Q8LPQ1), NET2D_ARATH (F4IJK1), NET3A_ARATH (Q66GR8), 
NET3B_ARATH (Q4PSJ7), NET3C_ARATH (O82259), NET4A_ARATH (F4KEW8), 
NET4B_ARATH (Q84VY2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment