PROSITE entry PS51698

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PURL: https://purl.expasy.org/prosite/signature/PS51698

Direct ScanProsite submission

General information about the entry

Entry name [info]	U_BOX
Accession [info]	PS51698
Entry type [info]	MATRIX
Date [info]	01-DEC-2013 CREATED; 26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51698
Associated ProRule [info]	PRU01034

Name and characterization of the entry

Description [info]

U-box domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=75;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=70;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5493274; R2=0.0088457; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11980.6113281; R2=1.2929937; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=673; H_SCORE=12851; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=447; H_SCORE=12559; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-105; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='D';  M= -65,-259,  43,  42,-260, -48,   8, -43,  19, -74,-248, -22,   3,  35,   7,  13,  18, -65,-265,-249;
/M: SY='P';  M=  -8, -55,-255,-248,-244,-258,-254,  55, -48,  -9,-231, -72,  56, -35,  30, -63,  -3,  31,-261,-247;
/M: SY='P';  M=-248,  -9,-253,-242,-250,-255,-250,-241, -30,  24,-239,-256, 112,-248, -34,-249,-243, -27,-257,  -3;
/M: SY='P';  M=  -8, -59,  51,  29,-257,-246, -61, -39,  -6,-251,  18, -50,  62,   8,-240,  23,  17, -51,-263, -54;
/M: SY='E';  M=  -3, -49,  25,  65,  46,-253,  36,  14, -80,-239, -12,-240,-249, -76,-242, -14,-240, -60,-244,  52;
/M: SY='F';  M=-248,-249,   8,-250, 108,-255,   0,-225,-248,  21,  52,  20,-259,-251, -79,-247,-241,-231,-229,   6;
/M: SY='C';  M=-241,  60, -30,-245,  31,-255,  10,  48,  -9,  39, -55, -33,-254, -51,  32,  -1, -43, -30,-248, -12;
/M: SY='C';  M=-239, 152,  51,-245,-251, -26,-252,-257,-249,-249,-249,-237,-263,-254,-256,-239,-238,-246,-277,-257;
/M: SY='P';  M=  27,-256,-241,-234,-258, -69,-245,-249, -57,-256,-245, -51, 116,-239,-247,  31,   6,-247,-257,-254;
/M: SY='I';  M= -50,-251,-261,-258,-224,-264,-256,  99,-255,  50,-211,-254,-253,-250,-256,-249, -34, -29,-251,-233;
/M: SY='S';  M=-224,-242, -41,-235, -55,-234,-237,-241,-235, -39,  46,-225,-241,   1,-239,  97,  66,-236,-259,-240;
/M: SY='L';  M= -49,-250, -21,-240,  11,  42, -17,-107,  28,  54, -18,   5,-251,   3, -11, -20, -91,-235,-247,  -3;
/M: SY='E';  M= -26,-253,  26,  85, -29, -44,-233,-251, -28, -54,-243,-229,-238,  66,-230,   2,  34,-247,-256,-243;
/M: SY='P';  M=-239,-250,-257,-250, -38,-259,-253,  55,-251,  51, -84,-254,  60,-250,-254,-246, -24,  55,-253,-236;
/M: SY='M';  M=-241,-249,-259,-250,  55,-253,-236, -49,-245, -67, 141,-248,  34,-240,-245,-247, -26,-224,  20,-222;
/M: SY='K';  M= -27,  -8, -57,  42,-250,-244, -13, -38,  62, -87,-240,  16, -23,  -8,  38,  23,   2, -23,-255, -28;
/M: SY='D';  M=-242,   3, 106,  36,-256,-243,  52,-257,-230,-255,-251,  31,-244,-228, -40, -55, -42, -52,-271, -26;
/M: SY='P';  M= -16,-267,-244,-233,-263,-244,-247,-251,-240,-260,-247,-250, 134,-243,-252,-239,-236,-254,-256,-260;
/M: SY='V';  M=-121,  57,-256, -87,-234,-258,  28, -74,-248,-106,  37,-249,-255, -36, -98,-241, -24, 101,-265,-238;
/M: SY='I';  M= -58,  77,-257,-254, -85,-259,-257,  79, -67, -17, -53,-248,-253,-250, -47, -55,  13,  56,-258,-238;
/M: SY='T';  M=  33,-243,-248,-245,-233,-245,-247,  13,-244,  48,-222,-241,-248,-241,-248,  40,  49,  31,-256,-238;
/M: SY='P';  M=  44,   4,-239,   2, -72,-239,-243, -25, -25,-249,-242,-239,  93,  -6, -26,  38, -34, -51,-256,-249;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='S';  M=-228,  50,  62, -32,-253,-235,-236,-251,-232,-253,-248, -36,-243,   0, -41,  88,  44,-244,-265,-245;
/M: SY='G';  M= -33,-253,-240,-250,-259, 106,-246,-266, -63,-262,-251, -25,-246,-241,  -1,-227,-244,-259,-251,-254;
/M: SY='Q';  M=-240,-253, -38, -65,  35,-250,  75,  27, -13, -45, -26,  -3,-249,  76, -77, -63,  21,   0,-244,  42;
/M: SY='T';  M= -57,-242,-242,-243,-239,-247,-248,  32,-240, -45,-229, -48,-243,-242,-246,  23,  98,  44,-262,-240;
/M: SY='Y';  M=-248, -25,-255,-255,  90,-258,-228, -11,-248,-223,   8,-251,-260,-248,-246,-247,-242, -10,-214, 115;
/M: SY='D';  M=-240,-258,  94,  92,-262, -15,-231,-263,-225,-258,-255, -34,-238,-221,-235,-233,-236,-257,-266,-250;
/M: SY='R';  M=  14,-254,-242,-230, -45, -73,-235, -64,  42,  10,-233,-235,-250,  29,  95,-236,-239, -45,-251,-238;
/M: SY='E';  M=  -3,-249, -63,  51,-248, -14, -53, -59, -21, -17, -12, -80, -37, -28,  46,  46,  32, -13,-257,-243;
/M: SY='S';  M=  41,  36, -48, -58,  -1, -14,-239, -33,-240,  11,-233,  41,-248, -58,-244,  44,  19, -27,-250,  22;
/M: SY='I';  M=-241,-253,-262,-258, -48,-266,-258, 107,-254,  11, -13,-253,-252, -16,-256,-250,-236,   4,-251,-233;
/M: SY='E';  M= -48,-253, -63,  69,-247, -48, -63,  -1,  14,   5,-233, -22,-243,  64,  -3, -27, -21,  16,-255,-242;
/M: SY='K';  M= -18, -40,-230,  45,-255,-246,-235,-248,  63,-116,-242,  13,  50,  31,  43, -34, -39, -12,-255,-246;
/M: SY='W';  M=-248,  50,-260,-250,   8,-252,  72,-241,-246,-240,-239,-253,-256, -16,-246,-249,-251,   0, 158,  58;
/M: SY='L';  M=-244,-250,-256,-250,  41,-261,-247,  64,  17,  65, -48, -22,-255,-245, -12,-249,-238, -43,-245,-227;
/I:         I=-31; MD=-79;
/M: SY='D';  M= -47,-279,  41,  -9, -80, -71, -56,-280,  -7, -88,-271,  11,-270,  23,  15,  -5, -69,-276,-286,-269; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='K';  M= -20, -37, -19,  22,-246,   3, -51, -40,  56,  20, -10,  -8, -23, -57,  31,  22, -21,-240,-254,-242;
/M: SY='G';  M=  -3,-251,  13,   6, -34,  57,  20,-253,  45,-253,-245,  18,-244, -31, -19,  11, -20, -38,  28,-242;
/M: SY='H';  M=-240,  35,  10, -28,  20, -23,  94, -81,  -3, -59,-237,  58, -13,-233, -83, -20,  25, -36,-254,  29;
/M: SY='G';  M= -45,  16, -12, -35, -19,  46,  10,  -3,  18, -38, -49,  40,  21,  -6,  17,  12, -19,-243,-255,-242;
/M: SY='T';  M=-231,-243,-233, -47, -20,-243, -33, -90,  28,-243,-238,  20,   7, -42, -74,  22, 100, -19,-260,-241;
/M: SY='C';  M=-236, 117,  66, -61,-254,-240,  15,-256, -10,-253,-249,  51,-251,-236,-241,  45, -68,-249,-272,-249;
/M: SY='P';  M=-241,-265, -39,-233,-259,-245,-246,-248,-240, -37,-245,-247, 130,-242,-251,  -6, -32,-252,-257,-257;
/I:         I=-33; MD=-84;
/M: SY='M';  M= -66, -26,-253, -46,  46,-257, -31,  32,  23, -65,  67, -27,-254, -27, -50, -52, -13,  56,-252,-231; D=-33;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='T';  M= -94,-243,  10,-237,-250,-244,-242, -96,-236,-247,-243,  50,-242,-239,-244,  -5, 110,-236,-270,-247; D=-33;
/I:         I=-33; DM=-84;
/M: SY='N';  M=-238,-256,  -7, -56,-259,  61, -13,-261,   6,-258,   3,  63,-250,  23,  56, -52,-240,-258,-259,-248; D=-33;
/I:         I=-33; DM=-84;
/M: SY='Q';  M= -26,-253,-231,  46,-251, -69,   0,-243,  34,   7, -26,-232,-243,  95, -74,  -3,  10, -47,-254,-240; D=-33;
/I:         I=-33; DM=-84;
/M: SY='P';  M=  -9,-257,-108,  13,-254,-246, -33, -48,  43,-124, -22,-238,  97, -17,   6, -17,  -9,  -4,-256,-248;
/M: SY='L';  M= -68, -17,-259,-252,   8,-260, -39, -31,-253,  91, -27,-257,  -9,-248,-252,-250, -24, -46,-248,-229;
/M: SY='T';  M= -81,-248,  37,   3,-248, -72, -27,-244,   1, -43, -58,-227,  42,   3,-237,  59,  66, -52, -11, -25;
/M: SY='H';  M= -14,-250,  15,  32, -63, -26,  74,  -2, -40,   8,  28,  22,  -5, -35, -77,  18,   9,-237,-256,  -3;
/M: SY='D';  M= -48, -49,  57,  28,  14, -39,   3,-118,  29, -27,-241, -24,-243, -15, -18,  44,  30, -61,-256,-238;
/M: SY='D';  M= -79, -28,  71,   2, -65,-118,-233, -34, -63, -23,  15,  39, -73,  41, -60,  44,  26, -42,-262,-242;
/M: SY='L';  M=-240, -36, -95, -29, -28,-259,-246,  22,-249,  79, -21, -42,-256,   0,-249, -20,-237,  22, -28, -63;
/M: SY='I';  M= -60,-248, -68, -52, -79,-256,-252,  74, -18, -39,-222,-243,  -4, -27, -43, -29,  51,  55,-257,-238;
/I:         I=-42; MD=-106;
/M: SY='P';  M= -34,-263,  -9, -44,-258,-247, -29, -42,  27, -57,-244,-243, 116,-238, -18, -60, -43, -54,-257,-253; D=-42;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='N';  M=-240,-246, -31,-237,  -7,-237,   1, -49, -18,  27,-233, 114,-252,-232,-236, -52,-228,  -3,-262,-239;
/M: SY='H';  M=-242,-253, -24, -62, -29,-249,  80, -15,  26,  26,-228,  38,  29,-233,  14, -67, -28,   0,-250,  38;
/M: SY='T';  M=  37, -28,-238,  32,  40,-243,-244, -15,-238,  -8, -65, -42, -42,-237,-244,  28,  59,   8,-251,-234;
/M: SY='L';  M=   7,-247, -24,-247,-227, -19,  44,  -4,-249,  77,  34, -50,-254,-243,-248, -30,-237, -12,-253,-233;
/M: SY='K';  M=-242,-256,-236, -77, -46, -69,  -2,-253,  87, -51,-239, -34, -26,  -5,  80, -93,-238,-250,-247,  10;
/M: SY='N';  M=   4,-248, -19,  23,-248, -54, -63,  20,-106,-107,  -2,  64,-244,  32,   5,  51,  -2, -12,-259,-243;
/M: SY='A';  M=  41,-247, -43, -21, -42, -46,-242,  -2,  -2,  26,  29,-239,-248,  27,   9,   1,   5,  20,-253,-238;
/M: SY='I';  M= -50,-254, -32,   6,-233,-258,  -7, 100,  -3,-104,-220,-245,  -3,-242,-247,  -9,-234,   9,-254,-237;
/M: SY='Q';  M=  -3,-252,  23,  -3, -43,  16,  30,-246,   7, -23,  -7,   2,   4,  66,  -2,  16, -18, -42,-255, -51;
/M: SY='E';  M=  20, -23,  14,  56,-254, -56,  -1, -75,  -2, -92,-242,  -5,  11,  18,  41,  16,  11, -54,-258,-245;
/M: SY='W';  M=-249,-264, -65, -44,  61,-252, -45,-241,-246, -44,-239,-257,  17, -43, -54, -65, -73,-249, 156,  58;
/M: SY='C';  M= -98, 108,-246,-243, -36,-100,  51, -22,   4,  29, -15,  -8,-255, -67,  21,  22, -57, -14,-260,-238;
/M: SY='D';  M=   3,  46,  47,  42, -37, -46,  13,-244,  -2,  -9,-239, -42,-245,  33,   2,   8,   5, -16,-259,-242;
/M: SY='Q';  M=   2,-252, -20,  36,-252,-244, -66, -77,  -5, -82,-241,  -3,  50,  55,  22,   8,  46, -51,-256, -23;
/M: SY='N';  M= -37,-250,-230,  -4,-247, -42,  68, -29,  10, -98,-237,  77,-248,  22,  13,  15, -57,  31, -24, -71;
/M: SY='T';  M= -35, -34,   9, -30,-249,  19,-239, -27,  26,  -6,-239,  18, -18,  23,   5,  32,  38, -73,-257, -51;
/M: SY='Y';  M= -31,-253, -30, -33,  23, -64,-242,  32, -22, -50,  13,  23,   6, -27, -15,  33, -24,   4,  34,  35;
/M: SY='K';  M=  -2,-257,  31,  19, -87,-107,-240, -39,  36,  -4,-241, -22,  28,  24, -17,  12, -54, -33,-256,   9;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	125 in 123 different sequences
Number of true positive hits	125 in 123 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	U-box
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

123 sequences

CHIP_ARATH  (Q9SRS9), CHIP_CHICK  (Q5ZHY5), CHIP_HUMAN  (Q9UNE7),

CHIP_MOUSE  (Q9WUD1), CHIP_RAT(A6HD62), LIN1_LOTJA  (C6L7U1), 
LIN2_LOTJA  (D1FP57), LIN_MEDTR   (D1FP53), LUBX_LEGPA  (Q5X159), 
LUBX_LEGPH  (Q5ZRQ0), PPIL2_ARATH (Q9FJX0), PPIL2_ASPFU (Q4WVU5), 
PPIL2_ASPOR (Q2U5W8), PPIL2_CAEEL (P52012), PPIL2_CRYNB (P0CP91), 
PPIL2_CRYNJ (P0CP90), PPIL2_EMENI (Q5AXT6), PPIL2_GIBZE (Q4IBK5), 
PPIL2_HUMAN (Q13356), PPIL2_MOUSE (Q9D787), PPIL2_MYCMD (Q4P555), 
PPIL2_NEUCR (Q7RXA6), PPIL2_RHIO9 (P0C1J1), PPIL2_SCHPO (Q09928), 
PR19A_ARATH (Q94BR4), PR19B_ARATH (O22785), PRP19_BOVIN (Q08E38), 
PRP19_CAEEL (Q10051), PRP19_CHICK (Q5ZMA2), PRP19_DICDI (Q7KWK5), 
PRP19_HUMAN (Q9UMS4), PRP19_MOUSE (Q99KP6), PRP19_ORYSJ (Q9AV81), 
PRP19_RAT   (Q9JMJ4), PRP19_SCHPO (O14011), PRP19_YEAST (P32523), 
PUB04_ORYSJ (Q6EUK7), PUB10_ARATH (Q9C9A6), PUB11_ARATH (Q8GUG9), 
PUB12_ARATH (Q9ZV31), PUB12_ORYSJ (Q5VRH9), PUB13_ARATH (Q9SNC6), 
PUB14_ARATH (Q8VZ40), PUB15_ARATH (Q681N2), PUB16_ARATH (Q9LZW3), 
PUB17_ARATH (Q9C7R6), PUB18_ARATH (Q9XIJ5), PUB19_ARATH (O80742), 
PUB1_MEDTR  (E4NKF8), PUB20_ARATH (Q9C8D1), PUB21_ARATH (Q5PNY6), 
PUB22_ARATH (Q9SVC6), PUB23_ARATH (Q84TG3), PUB24_ARATH (Q9SF15), 
PUB24_ORYSJ (Q10FT0), PUB25_ARATH (Q9LT79), PUB26_ARATH (Q9FXA4), 
PUB27_ARATH (Q9FLF4), PUB28_ARATH (Q9LXE3), PUB29_ARATH (Q9LSA6), 
PUB2_ARATH  (Q5XEZ8), PUB30_ARATH (Q058P4), PUB31_ARATH (Q9FHN9), 
PUB32_ARATH (Q94A51), PUB33_ARATH (Q8GUH1), PUB34_ARATH (Q8S8S7), 
PUB35_ARATH (Q9SW11), PUB36_ARATH (Q8GZ84), PUB37_ARATH (Q683D5), 
PUB38_ARATH (Q9FJP6), PUB39_ARATH (Q9STT1), PUB3_ARATH  (Q8GWV5), 
PUB40_ARATH (Q9FL17), PUB41_ARATH (Q0WUF6), PUB42_ARATH (Q9CAA7), 
PUB43_ARATH (Q9SFX2), PUB44_ARATH (Q9LM76), PUB45_ARATH (Q9C7G1), 
PUB46_ARATH (Q3E9F7), PUB47_ARATH (Q3E9F6), PUB48_ARATH (Q3E9F5), 
PUB4_ARATH  (O22193), PUB50_ARATH (Q9FGD7), PUB51_ARATH (Q9FKG5), 
PUB52_ARATH (Q9FKG6), PUB53_ARATH (Q9LU47), PUB54_ARATH (Q9LQ92), 
PUB55_ARATH (P0C6E7), PUB56_ARATH (Q8GXQ7), PUB57_ARATH (Q9SGT1), 
PUB57_ORYSJ (Q0DR28), PUB58_ARATH (Q9SGT2), PUB5_ARATH  (O23225), 
PUB62_ARATH (Q6DBN5), PUB63_ARATH (Q58FY4), PUB6_ARATH  (O48700), 
PUB70_ORYSJ (Q5WA76), PUB73_ORYSJ (Q6K762), PUB75_ORYSJ (Q10PI9), 
PUB7_ARATH  (Q9CAG5), PUB8_ARATH  (O81902), PUB9_ARATH  (Q9SRT0), 
RNF37_HUMAN (O94941), RNF37_MOUSE (Q925F4), SL11_ORYSI  (A2ZLU6), 
SL11_ORYSJ  (Q0IMG9), UBC4_MIMIV  (Q5UQ40), UBE4A_BOVIN (A5PKG6), 
UBE4A_HUMAN (Q14139), UBE4A_MOUSE (E9Q735), UBE4A_PONAB (Q5R9G3), 
UBE4A_RAT   (Q6P7A2), UBE4B_HUMAN (O95155), UBE4B_MOUSE (Q9ES00), 
UBE4_ARATH  (Q9LF41), UBE4_CAEEL  (Q09349), UFD2_SCHPO  (Q9HE05), 
UFD2_YEAST  (P54860), WSDU1_CHICK (Q5ZMC3), WSDU1_DANRE (A0AUS0), 
WSDU1_HUMAN (Q8N9V3), WSDU1_MOUSE (Q9D0I6), WSDU1_RAT   (Q5FVN8)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

71 PDB

1N87; 1T1H; 1WGM; 2BAY; 2C2L; 2C2V; 2KR4; 2KRE; 2QIZ; 2QJ0; 3JB9; 3L1X;
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