PROSITE entry PS51678

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PURL: https://purl.expasy.org/prosite/signature/PS51678

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General information about the entry

Entry name [info]	SAM_MT_PRMT
Accession [info]	PS51678
Entry type [info]	MATRIX
Date [info]	01-JUL-2013 CREATED; 01-JUL-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51555
Associated ProRule [info]	PRU01015

Name and characterization of the entry

Description [info]

SAM-dependent methyltransferase PRMT-type domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=313;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=313;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2801752; R2=0.0087699; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=3161; N_SCORE=30.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=482; N_SCORE=6.5; MODE=1; TEXT='RR';
/DEFAULT: M0=-39; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='D';  M=  13, -90,  50,  29, -15, -20,  16, -19, -21,  11, -76,  32, -86,   6, -14,   7, -73, -27, -98, -80;
/M: SY='Q';  M=  -1, -93,   4,  51, -90, -45, -75, -77,   9, -10,  14, -10, -84,  66,  20, -25, -75,  19, -96, -82;
/M: SY='D';  M=   8, -93,  39,  37, -85, -84, -75,  -6, -70, -21, -78,  17,  38,  17,  12,  16, -73,  -4, -94,  14;
/M: SY='Y';  M= -22, -97, -86, -81, -63, -88, -74, -14, -13,   0, -73, -11,  61,  -1, -17,   0, -12, -79,  81,  86;
/M: SY='F';  M=  16, -88, -18, -82,  64, -32,  60, -70, -81,  29,  13,  -1, -93,  -6,  -8, -14, -18, -26, -83, -12;
/M: SY='Q';  M= -29, -94,  26,  39, -10, -17, -73, -89,   7, -88, -82, -69, -11,  69,  32,  12,   6, -30, -91,  -2;
/M: SY='P';  M= -28,  -4, -76,  22, -23, -29,  20, -90, -73, -91,   6, -74,  80, -71,   7,  65, -69, -88, -94,  -8;
/M: SY='Y';  M= -23,  23,   8,   2,  19, -94,  55, -68, -83,  22, -66, -82, -94, -79, -83, -81, -20,  13, -72,  91;
/M: SY='C';  M=  -8, 102,   8,   2, -16,  11, -82, -87, -22, -83,  56, -72, -89, -77, -84,  57, -70, -82,-100, -85;
/M: SY='D';  M= -20, -91,  75, -14, -89,   7,  65, -87, -20, -38, -83,  -6, -84, -72, -79,  -3,  43, -20,-104, -11;
/M: SY='C';  M= -21,  83, -83, -89,  21, -25, -75,  13, -81,  -6, -72,  60, -97, -82,  -9, -78, -77, -37,  36,  71;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='D';  M= -74, -92,  67, -71, -89,  51, -79, -14, -32,  10, -80, -66, -86,  -1, -18,  33,   6, -83, -99, -85;
/M: SY='W';  M= -28, -92,  -8, -24,  -8, -21, -79,  25, -85,  42,  35, -87, -93,  17, -86, -83, -20,  -6,  64,  60;
/M: SY='H';  M=  -9, -93, -71, -72, -84, -83, 134, -96, -73, -87, -74,  20, -87, -10, -16,   7,   7, -94,-107,   4;
/M: SY='Q';  M= -80, -93, -79,  15,  11, -90,  12,   1, -73,  32,  20,  -7, -90,  75, -26,   9, -77, -73, -80,  52;
/M: SY='E';  M=  15, -89, -65,  78, -87, -87, -77, -23, -23,  -1,  18, -17, -79,  -3, -75, -68,  57, -75, -97, -84;
/I:         I=-28; MD=-70;
/M: SY='Y';  M= -99,-109,   3,-100, -77,-110, -93,   0,-101,  27, -78,  13,-112,  -8,-102,-100, -94,  10,  39,  55; D=-28;
/I:         I=-28; MD=-70;
/M: SY='S';  M=  15,-113,-105, -28,-112,-106,-108, -29, -16, -11,-101, -11,  -8,-100,-106,  18, -11, -99,-123,-111; D=-28;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='M';  M= -82, -91, -88,  11,  58, -93,  20, -65, -79, -58, 121, -84,  24,  41, -79, -84, -79, -71, -84, -62;
/M: SY='E';  M= -79,  11, -78,  61, -71, -98, -83,  23, -80,  58,  33, -88, -89, -74, -84, -14, -77,   4, -94, -78;
/M: SY='N';  M= -21,  24, -69, -70, -14, -80,  53, -91,  32, -39, -80,  79, -88,  36,  39,  -5, -17, -89, -99, -78;
/M: SY='D';  M= -82, -97, 113,  -5,-100, -83, -73, -17, -72, -94, -93, -56, -84,   7, -80, -11, -74, -25,-115, -86;
/M: SY='W';  M=   1, -93, -82, -19, -14,  -1, -79, -79,  22, -32,  18, -77,  32,  36,  12,  25, -16,  -3,  63,  19;
/M: SY='V';  M= -77, -90,  25,  18,  -3, -97, -88,  22, -22,  -6, -67, -83,   8, -80,   6, -81,  -7,  69, -98, -78;
/M: SY='R';  M= -84, -99, -78,  -9, -86, -93, -69, -97,  48, -91, -81, -73, -90, -58, 104, -78, -81, -92, -86,  32;
/M: SY='N';  M= -77, -86, -67, -80, -73,   3, -67, -83, -73, -85,   3,  91, -87, -74, -79, -63,  67, -82, -86,  70;
/M: SY='D';  M=  -7, -93,  71,  10, -94, -10, -76,  -3,  45, -38, -82,  -6, -84,  41, -68, -11, -27, -29,-100, -84;
/M: SY='Q';  M=  27, -90, -80, -69, -14, -33, -77, -81,  53, -12,   9, -73, -85,  53,  39,  -2,  15, -25, -91, -79;
/M: SY='Y';  M= -88, -98,  -7, -12,  23, -96, -59,   3, -83, -70, -68, -87, -98, -79, -81, -84, -82, -75, -51, 128;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='R';  M= -82, -96, -16, -18,  10, -29,  -2, -78,  -9,  23, -70, -77, -92,  65,  68, -78, -81, -25, -83,  41;
/M: SY='D';  M=  26, -91,  53,  23, -94, -79,  12, -91, -65, -24, -82,  49, -85,  42,  35,  14, -72, -87,-101, -83;
/M: SY='A';  M=  81, -83, -85, -12,   1, -11, -82, -74, -81, -78, -75, -81, -87, -78, -85, -14, -72,  21, -84,  43;
/M: SY='I';  M= -79, -88, -98, -95, -10,-102, -93,  58, -93,  55, -53,  -1, -97, -91, -94, -88, -75,  57, -93, -73;
/M: SY='Q';  M= -80, -94,  -6,  40,  44, -92, -74, -14,   3,   0,  29, -77, -88,  51,  25,   1, -77, -24, -82,  28;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='Q';  M=   8,-107, -90,   2,-102, -33,  27, -98,  -3,   1, -87, -87,-100,  58,  29, -85, -11, -96,-108, -93; D=-24;
/I:         I=-24; DM=-60;
/M: SY='N';  M=  25, -96, -15, -89, -94, -89,  -4, -15, -25, -14,  34,  65,-100, -86, -91, -22, -13,  -6,-112, -93; D=-24;
/I:         I=-24; DM=-60;
/M: SY='K';  M= -87,-104, -15,   3,-101, -95,  50, -98,  72, -98, -88, -77,  37,  24,  12, -82, -84, -22,  18, -86; D=-24;
/I:         I=-24; DM=-60;
/M: SY='H';  M=  14, -90,  26, -28, -27, -82,  80, -89,  31, -89, -80,  36,   2, -68,  26, -21,  30, -30,-102, -76;
/M: SY='A';  M=  49, -87,  34,   2, -24, -85,   3,  22, -23,  19, -68, -79, -89, -77, -19, -32, -73,  28, -96, -79;
/M: SY='F';  M= -76, -88, -18, -22,  57,  21, -83,   8,   6,  25, -70, -10, -89, -80, -82,  35,  22, -71, -85, -68;
/M: SY='K';  M=  28, -91, -69,  42, -96, -82, -75, -92,  60, -91, -82, -18,  -9,  51,   3,   3,  23, -85, -94, -85;
/M: SY='D';  M= -74, -93,  67,   5, -96,  45, -77, -92,   5, -41, -88,  16,  17,  -4, -78,  30, -73, -21,-101, -88;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='K';  M=  11,  10, -82, -75, -80, -84, -81, -20,  56,  10, -72, -74, -86, -72, -15,  37,  34,  12, -92,   3;
/M: SY='H';  M= -76, -90, -86, -83, -78, -31,  94,  12, -82, -32, -66, -78,  24, -81, -18, -77,  28,  67,-105, -73;
/M: SY='V';  M= -73,  16, -98, -92, -71,-101, -99,  39, -90,  -4, -59, -92, -95,  -1, -92, -83,  -7,  90,-101, -78;
/M: SY='L';  M=  -3,  49,-100, -92, -62, -97, -83, -54, -92,  77,  69, -95, -98, -86, -90, -88, -79, -21, -89,   2;
/M: SY='D';  M= -79,  15,  94, -16, -86, -90, -81, -67, -79,   3, -77, -67, -89, -79, -86, -77,  -8,  54,-110, -84;
/M: SY='V';  M= -24, -86,-101, -95, -68,-101, -99,  51, -93,  25, -56, -96, -96, -93, -95, -86, -72,  84, -98, -77;
/M: SY='G';  M= -18, -92, -82, -90, -97,  98, -87, -23, -86, -98, -89, -68, -85, -82, -92,  23, -80, -92, -92, -93;
/M: SY='C';  M=  48,  82,  52,  27, -94,  -4, -83, -90, -77, -89, -85, -70, -84, -76, -84, -65,  49, -80,-104, -90;
/M: SY='G';  M= -68, -95,  18, -88,-101, 103, -87,-108, -86,-104, -93, -66, -86, -84, -93, -67, -85,-102, -93, -95;
/M: SY='T';  M= -69,  23, -77, -76,  -3, -80, -79, -86, -67, -86, -82, -67, -83, -71,  52,  71,  75, -79, -98, -80;
/I:         I=-45; MD=-115;
/M: SY='G';  M= -76,-101, -92,-101,-103,  91, -95,-106, -95, -37,  17, -78, -95, -92,-101, -12, -91,-103,-100,-100; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='I';  M= -84, -94, -99, -92,  24,-101, -92,  73, -93,  50, -56, -95,  62, -90, -96, -90, -78, -53, -87, -72;
/M: SY='L';  M= -84, -87,-102, -94, -58,-104, -87,   3, -96,  93, -46,-101,-101, -88, -93, -95, -80, -55, -89, -71;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='S';  M=  21, -86, -78, -77, -93,  27, -81, -23, -76, -92, -85, -68,  26, -71, -13,  89, -62, -82, -97, -87;
/M: SY='M';  M= -81,  13,-100, -93, -16,-100, -85,  14, -91,  67,  90, -94, -96, -86, -90, -89, -13,  12, -91, -71;
/M: SY='M';  M=  -3, -89, -96, -87,  81, -92, -80,  -9, -21,  11,  87, -87, -94,  20, -18, -26, -79, -67,  30, -56;
/M: SY='A';  M=  82,  65, -85, -80, -89, -73, -87,   5, -18, -81, -77, -11, -87, -78, -84,  21, -69, -23, -97, -88;
/M: SY='A';  M=  78, -83, -83, -18, -86, -75,  12,   4, -22, -11, -73, -78, -86, -75, -19,  25, -69,  -3, -95, -83;
/M: SY='K';  M=  10, -94, -76, -19, -91, -86,  53,  17,  65, -84, -76, -70, -85,  42,  50, -12, -18, -80, -94, -78;
/M: SY='A';  M=  66, -85, -79,  39, -80, -80, -81, -17, -78,  19,  55, -80, -85, -72, -82,   5,  -7, -68, -92, -16;
/I:         I=-24; MD=-60;
/M: SY='G';  M= -10, -92, -84, -91, -91,  87, -85, -94, -86, -40,  36, -72, -88, -82, -92,  23, -20, -90, -91,  -1; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='A';  M=  79, -82, -82, -78, -88, -73, -83, -75, -76, -34, -76,  19, -23, -75,   5,  19,  -6,  17, -97, -86;
/M: SY='K';  M= -40, -95,  36, -13, -97, -20, -75, -98,  86, -96, -86, -66,  -9, -61,  47,   3, -75, -93, -95, -84;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='K';  M=  -6,  -2, -15, -67,  11, -84,  30, -91,  68, -87,   5, -69, -86,  24,  43,  32, -74, -87,  36, -74;
/M: SY='V';  M= -72,  11,-101, -95,   0,-102, -99,   9, -93,  -7,  11, -95, -97, -94, -94, -85, -70,  96,-100, -75;
/M: SY='Y';  M= -81, -92, -90, -90,  18, -95, -72,  37, -82,  -8, -64, -85, -94, -82,  -9, -12,  36,  10, -66,  99;
/M: SY='A';  M=  86,  24, -87, -81, -86, -73, -88,  20, -82, -14, -73, -80, -86, -79, -87,  12, -12, -65, -94, -85;
/M: SY='V';  M= -75,  68,-100, -96, -68,-101, -95,  34, -93,  18,  21, -94, -98, -93, -94, -86, -73,  80, -98,  -3;
/M: SY='E';  M= -78, -98,  37, 106, -95, -91, -70,-100, -61, -94, -90, -71, -75, -55, -71, -17, -77, -94, -96,   6;
/M: SY='K';  M=  48,  -2, -80, -73, -92,   1, -83, -82,  54, -38, -80, -14,  51, -20, -70,   3, -17,  -5, -95, -87;
/I:         I=-38; MD=-97;
/M: SY='N';  M=-100,-112, -96,-106,  37,   0,  19,-111,-102,-108,-105,  53,-115,-100,-106,  25, -94,-111,-109,  -7; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='S';  M=  -5, -90,  -3,  44, -92, -79, -73, -89,  18, -18, -82,  45,  16,  -3,  14,  51, -19, -86, -99, -86;
/M: SY='P';  M= -12, -96,   9,  31,  -5, -84, -77, -26,  17, -90, -83,  33,  78,  23,  -7, -72,  19, -86, -96, -85;
/M: SY='M';  M=  10, -87, -84, -83,  -3, -20,  22,   5, -80, -28, 111,  32, -88,   1, -81,  31, -72, -68, -93, -72;
/M: SY='A';  M=  78, -86, -86, -79, -84, -28,  13,  -1, -71, -48, -75, -80, -88, -74,  50, -67, -74,  -4,  18,  -3;
/M: SY='D';  M= -22, -94,  52,   5, -14, -88,  37,   1,  27, -81, -77,  -9, -87,  38,  30, -75, -27,  15, -93,  19;
/M: SY='C';  M=  -2,  77, -89, -83, -70, -91,  43, -12, -79,  31,  27, -82, -94,  21,   7, -22,   7,  -5, -88,  46;
/M: SY='A';  M=  69, -83, -91, -84,  21, -81, -82, -67, -84,  34,  63, -84, -89, -81, -86, -70,  19, -65, -86,   4;
/M: SY='R';  M= -31,  12, -74,  54,  -4,  -6,   8, -28, -26,  13,  -9, -78, -87, -66,  70, -78, -28, -28, -93, -78;
/M: SY='K';  M=  22, -90, -28,  32, -90, -82,   9, -85,  64,   0, -77,  16, -83,  20, -14,  19, -72, -35, -95, -82;
/M: SY='I';  M= -82, -91, -92, -92,  13, -98, -84,  74, -19,  27,  12,  29, -94, -85, -18, -86, -76,  14, -84,  31;
/M: SY='V';  M=  30, -86, -94, -88,  14, -90, -90,  44, -83, -61,  52, -86, -91, -84,   9, -12, -16,  61, -93, -74;
/M: SY='K';  M=  -8, -91,  19,  19, -19, -85,  42, -23,  53, -47, -78,  35, -85,  -1,  14, -21,   7,   1, -98, -79;
/M: SY='H';  M=  44, -89,   4, -23,   8, -29,  57, -13,  16, -47,  35, -10, -87,  16, -16,   2, -74, -24, -90,   8;
/M: SY='N';  M= -79, -87,  -4,   4, -90, -72, -62, -93, -65, -97, -86, 116, -89,  -2, -13, -19, -15, -94,-104,   6;
/M: SY='G';  M= -74,  17,  17, -75, -96,  66,  13, -96,  13, -41, -86,  50,  15,  27, -78, -20, -14, -94, -98, -88;
/M: SY='W';  M= -85, -92,-106, -95,  48, -98, -91, -58, -92,  58,  64,-100, -98, -89, -91, -94, -84,   9, 118, -57;
/M: SY='E';  M=  32, -88,  35,  49,   5, -28, -76, -90,  10, -89, -85,   3, -81,  -3, -74,  38,  24, -83, -96, -82;
/M: SY='D';  M= -31, -93,  86, -14, -97,  -4,  35, -18,   5, -95, -89,  71, -86, -69, -13, -70, -73, -92,-109, -85;
/I:         I=-29; MD=-75;
/M: SY='K';  M= -86,-100,  38, -72, -94, -94,  10,  22,  50, -86, -81,  21, -92,  20,  41, -80, -33,   6,-104, -86; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='V';  M= -76, -89,-101, -96,  -5,-104,-100,  73, -91,  -5, -57, -94, -95, -92, -21, -87, -73,  77, -95, -74;
/M: SY='T';  M= -75, -89, -67,  49, -15, -87,  29, -82,  31, -84, -79,  17, -81,  28, -15, -10,  69,  -2, -98, -80;
/M: SY='V';  M= -78, -88,-102, -96,  36,-103, -93,  48, -94,  39, -56, -96, -98, -93, -94, -89, -75,  69, -87,   5;
/M: SY='I';  M= -39,  24,-101, -97,  31,-103, -96,  84, -94,  18, -57, -94, -12, -93, -96, -89, -76,  26, -87, -13;
/M: SY='H';  M= -77, -93, -11,  45, -15, -20,  60, -93,  42, -29, -81,  15,   4, -13,  25,  35, -73, -90, -96, -78;
/I:         I=-45; MD=-115;
/M: SY='K';  M= -30,   9, -10,   6,-100,  50, -84, -99,  52, -96,  35, -73, -88, -16, -73,  30, -79, -94,-100, -92; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='D';  M= -80,  10,  61, -62, -95, -24,   9, -95,  57, -91,  29, -65, -24,   9,  58,   5, -76, -91, -99, -82;
/M: SY='M';  M=  -1, -85, -90, -85, -75, -86, -84,   8, -18,   7,  82, -82,  -7, -79, -84,  49, -68,  51, -96, -77;
/M: SY='E';  M= -76, -92,  10,  72, -92, -89,  10, -90, -61, -39, -82, -69, -79,   8,  44, -11,  65, -84,-100, -83;
/M: SY='D';  M= -77, -93,  75,  52, -18, -83,  11, -92,   6, -36, -86,  -1, -81,   8, -73,  25,  23, -89,-103, -82;
/M: SY='W';  M= -82, -92,  -7, -92, -10,-101, -96,  55, -93,  47, -58, -95, -12, -90, -94, -90, -79,  43,  95, -68;
/I:         I=-28; MD=-70;
/M: SY='T';  M= -27,-103,  11, -32,-110, -95, -92,-104,  15,-106, -98, -80,  -9,  43, -85,  37,  45, -98,-114, -99; D=-28;
/I:         I=-28; MD=-70;
/M: SY='P';  M= -26,-118,-109,-106,-112,  -1,-112,  16,  -3,-102, -99, -11,  19,  -9,-106, -27, -99,   8,-122,-111; D=-28;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='D';  M=  13, -97,  44,  35, -89, -92,  37,  16, -80,  16, -77,  31, -93, -77, -16, -81, -81, -37,-106, -86; D=-28;
/I:         I=-28; DM=-70;
/M: SY='M';  M= -10, -95, -86, -11, -12,  -5, -81,   0,   9,  20,  51, -83,  45,  51, -79, -79, -16, -35, -89,   3; D=-28;
/I:         I=-28; DM=-70;
/M: SY='P';  M=  -9, -96, -15,  16, -12,  -4,  20, -83, -11, -30, -81, -79,  93, -76, -13, -74,  22, -16, -96, -85;
/M: SY='E';  M=  11,  10,  12,  70, -89,  -5,  -1, -22, -10, -89, -84, -73,  18,  -2,  10,   0, -76, -86, -91,  24;
/M: SY='K';  M= -21, -95, -16, -63, -91, -86, -73, -92,  72, -40, -80, -69,  -9,  56,  58,   3, -17, -88, -90,  -2;
/M: SY='V';  M=  50, -86, -93, -87, -79, -86, -95,  49, -87, -66, -66, -88,  37, -86, -91, -12, -70,  64, -97, -83;
/M: SY='D';  M= -80, -93, 108, -55,-100, -79, -71, -98, -72, -99, -95,  47, -84, -71, -80,   4,  26, -94,-116, -87;
/M: SY='I';  M= -41, -90, -96, -91, -69,-101,  56,  69, -14,  33, -56, -89, -94, -86, -88, -86, -75,  53, -96, -73;
/M: SY='I';  M= -81,  18,-102, -96, -64,-103, -91,  68, -94,  59,  58, -96, -96, -89, -94, -91, -77,  19, -92, -73;
/M: SY='V';  M= -77, -88,-103, -97,  32,-103, -99,  56, -94,   9, -58, -96, -96, -95, -95, -88, -74,  78,  48, -68;
/M: SY='S';  M=  33, -82, -76, -77, -92,  27, -81, -90, -77, -92, -86, -65, -82, -71, -82,  90,  24, -81, -98, -86;
/M: SY='E';  M= -78, -99, -50, 114, -99, -94, -72, -16, -60, -91, -88, -75, -73, -52, -70, -75, -78, -89, -97, -90;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='W';  M= -84, -95,-101, -94,  44,   1, -92,  21, -91,  45, -64, -95,  10, -90, -93, -88, -19, -24, 117,  10;
/M: SY='M';  M= -80, -87, -96, -89,  40, -95, -80, -56, -87,  56,  98, -89, -12,  -5, -86, -15,   8, -21, -86, -66;
/M: SY='G';  M= -71, -93,  61,  12,-100,  78, -79,-103, -78,-100, -93,   3, -84, -75, -86,  20, -14, -97, -99, -91;
/M: SY='Y';  M=  30, -84, -78, -80, -73, -18, -75, -79, -78, -83, -78,  -3, -85, -74, -82,  63,  55, -16, -83,  68;
/M: SY='M';  M= -34,  26, -87,  37,  70,   6, -83,  34, -84,  -8,  82, -86, -90, -81, -87, -84, -80, -65, -81, -63;
/M: SY='L';  M= -80, -88, -90, -12, -67,  38, -84, -59, -89,  79,  13,  -2, -96, -84, -90, -85, -81, -66, -90, -76;
/M: SY='P';  M= -83,  17,  46, -78,   8, -93, -86,  36, -85,  33, -67, -82,  73, -85, -91, -82,  12, -24, -95, -79;
/M: SY='W';  M= -81,  24, -81, -88,  39,  43,  -6, -90, -80, -88, -85,  71, -94, -81, -24, -76, -82, -94, 124,  14;
/M: SY='E';  M= -78, -98,  19, 102,-101, -20,  14,-101, -61, -94, -89,   1, -76,  32, -70, -73, -78, -95, -99, -88;
/I:         I=-38; MD=-97;
/M: SY='N';  M= -81, -97, -79, -89, -30,  36,  19,-101, -82, -31, -93,  69, -97, -81,   1,  47, -78, -99,-109, -92; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='M';  M=  26, -89, -92, -83,  -2, -90,   9, -19, -74,  35,  96, -85, -92,  -6,  45, -81, -78, -66, -87,   2;
/M: SY='F';  M= -78, -88, -92, -89,  61, -21, -84,  33, -88,  45, -61, -84, -94,   6, -88,  45, -74, -21, -80,   0;
/M: SY='W';  M= -80,-100,  49,  35, -89,  -6, -83, -27, -75, -31, -86, -75,  77, -74, -19,   8,  -8, -89,  88, -82;
/M: SY='S';  M= -71, -89, -14,  48, -77, -81, -75, -25, -16,  -4, -78, -71, -83, -67, -77,  72,  23, -79,  34,  45;
/M: SY='C';  M= -79,  87,  16, -24, -10, -97, -84, -25, -89,  26, -65, -87, -98, -88, -90, -84, -76,  58, -86,  59;
/M: SY='L';  M= -81, -90, -87,   9, -69, -99, -82,  17, -22,  66, -57, -13, -94,  -7,  39, -86, -78,  17, -92, -76;
/M: SY='H';  M= -81, -94,  54,  10, -23, -87,  85, -26,   9, -84, -78,  -9, -86,   7, -73, -25,  29, -33,  41,  50;
/M: SY='A';  M=  77, -83, -85, -82, -86,  31, -86, -75, -81,   9, -74, -11, -87, -79, -20, -14, -72,   3, -94, -86;
/M: SY='R';  M=  21, -91, -89, -80, -76, -92,  52, -15,  -9,  39, -65, -82, -93, -73,  64, -80, -78,  24,  35, -74;
/I:         I=-24; MD=-60;
/M: SY='D';  M= -31, -96,  79,  26, -97, -86, -74, -15,  22, -40, -85,  -6, -84,  49,   8, -35,   2, -87,-103, -85; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='R';  M= -14,  24, -78, -19, -84,  -4,  36, -86,  34, -84,  40,  -8, -11,  30,  54,   9, -76, -29, -90,  27;
/M: SY='W';  M= -86, -92,-100, -92,  40, -99,  41,  -9, -88,  60,  47, -94, -98, -85, -19, -91, -83, -18,  97,  13;
/M: SY='L';  M= -31, -88, -18, -86, -65, -96,  19, -55, -23,  78,  37, -90,  -1, -83, -86, -20, -77,  -1, -92, -73;
/M: SY='K';  M=   5, -90, -71,  34, -93,   1,  15, -88,  68, -90, -82,  -9, -10, -65, -12,  10,  22, -12, -96, -84;
/M: SY='P';  M=  -8,-100,  40,  56, -98, -85,   8, -92, -34, -31, -86,  -5,  95, -70, -81, -76, -76, -92,-100, -91;
/M: SY='D';  M= -73, -90,  67,   9, -93,  49, -76, -95, -22, -95, -89,  16, -83, -72, -80,  28,  43, -90, -99,  -3;
/M: SY='G';  M=  24,  39, -85, -89, -90,  75, -90, -79, -86, -29, -80, -75, -13, -85, -92, -68,  26,  24, -96, -90;
/M: SY='I';  M= -38, -91, -86, -22,  -3, -93, -84,  56,  40,   7,  13, -18, -89,   6,  13,  -8, -17,  19, -91, -75;
/M: SY='M';  M= -29,  40, -94, -91,  -7, -93, -91,  57, -88, -36,  59, -85, -91, -86, -91,  28,   7,  55, -96, -76;
/M: SY='I';  M= -34, -91, -96, -15,  31, -98, -88,  73, -90,  13,  60, -91, -92, -86, -91, -15, -76,  14,  21,  13;
/M: SY='P';  M= -84,-109, -84, -73,-104, -86, -87, -91, -80,-102, -88, -91, 131, -84, -93, -81, -76, -97, -97,-101;
/M: SY='H';  M=   3,  51,  11, -72, -82, -80,  79, -90, -73, -87, -79, -67, -86,  40, -12,  53,  29, -85, -93,  41;
/M: SY='S';  M=  17, -89, -79, -23, -14, -81,  27, -13,  47, -81,  35, -71, -84,  -3,  23,  49,   3, -27,  37, -76;
/M: SY='A';  M=  65,  -7, -85, -85, -14,  52, -80, -82, -83, -83, -79, -77, -88, -80, -87, -20, -21, -17, -80,  63;
/M: SY='T';  M= -37, -85, -22, -33, -84, -85, -82,   7, -70, -77, -75,  -9, -84, -74,  43,  37,  76,  31,-101, -82;
/M: SY='M';  M= -75,  11, -92, -88, -70, -92, -86,  44, -87,  47,  52, -84, -92,  -5, -88,  45, -18,  22, -95, -76;
/M: SY='Y';  M= -86, -97, -85, -81,  32, -93,  68, -78,  12, -74, -70, -80, -95,   7, -11, -38, -82, -32,  32, 111;
/M: SY='A';  M=  49,  10, -94, -90, -75,  25, -90,  43, -89,  33,  30, -86, -91, -85, -91, -76, -76,  12, -93, -80;
/M: SY='Q';  M=  40,  49, -85, -77, -82, -84, -83, -11, -19,  -7,  43, -11, -89,  57, -79, -20,  17,  34, -97, -81;
/M: SY='P';  M=  38, -95, -88, -78, -90, -38, -88, -75, -83,   3, -76, -89, 106, -84, -91, -76, -75,  12, -96, -92;
/M: SY='I';  M= -30,  -2, -97, -15,  22,-100, -95,  72, -90, -26,  45, -91, -92, -89, -93, -85, -20,  60, -92, -72;
/M: SY='E';  M= -72, -90, -63,  76, -88, -38, -73, -87,   7, -84,  52,  -7, -79,  -2, -71,  47,  27, -84, -94,   3;
/M: SY='S';  M= -13,  57,  34, -77,  54, -79, -80, -79, -32,  -7, -78,   8, -90, -78, -83,  70, -67, -26, -91, -71;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='P';  M= -30, -99,   3,   5, -17, -32, -87, -83, -79, -11, -83, -82,  58,  21,   6,  21,  11,   4,-102, -89; D=-18;
/I:         I=-18; DM=-45;
/M: SY='D';  M= -85, -99,  71,  34, -94, -92, -80, -27,  25,  15, -83, -13, -89,  10, -77,  -7, -15, -87,-106, -88; D=-18;
/I:         I=-18; DM=-45;
/M: SY='L';  M= -90, -96,  -2, -24,  28,-104,  36,   4,  -9,  63,  -3, -92,-101, -86, -30, -94, -86, -69, -91, -13; D=-18;
/I:         I=-18; DM=-45;
/M: SY='W';  M= -89,-103, -18, -81,  12, -42,  57, -87,  -2, -23,   7, -83, -96,  40,  22, -85, -27, -91,  99,  66; D=-18;
/I:         I=-18; DM=-45;
/M: SY='N';  M=  12, -96, -17,  42, -99, -85, -75, -27,  40, -96, -87,  61, -88,   3,  36, -21, -77, -91,-102, -90; D=-18;
/I:         I=-18; DM=-45;
/M: SY='I';  M= -35, -93,  15,  29, -88,  20,  10,  41, -16, -81, -78,  14,  15,  24, -79,  30, -25, -26,  18, -82;
/I:         I=-10; MD=-25;
/M: SY='R';  M=   9, -95, -82, -23, -86, -86, -78, -89,   9,   0, -81,  11,  12, -71,  58,  43, -75, -86, -93,  24; D=-10;
/I:         I=-10; MD=-25;
/M: SY='S';  M=  33,  18, -93, -89, -21, -87, -91,  31, -86,  -6,  32, -84, -93, -84, -20,  43,  -7,  21, -99, -82; D=-10;
/I:         I=-10; MD=-25;
/M: SY='P';  M= -18,  17,  24, -31, -93, -13, -84, -88, -24, -22,   6,  16,  62,  30, -85,  20, -78, -30,  58, -87; D=-10;
/I:         I=-10; MD=-25;
/M: SY='F';  M= -83,  15, -23, -89,  56,  13, -85, -13, -87,  16,   9, -84, -97,  20, -20,   0,   8, -18, -84,  22; D=-10;
/I:         I=-10; MD=-25;
/M: SY='W';  M= -85,  10, -94, -93, -81,  42, -98, -97, -15, -98, -94,  37, -97, -14, -91, -26, -91, -33, 140, -70; D=-10;
/I:         I=-10; MD=-25;
/M: SY='S';  M= -79, -96,  51,   7,-102, -84,   4,-100, -73,-100, -93,  27, -19,  21,  10,  54,  26, -95,-110, -90; D=-10;
/I:         I=-10; MD=-25;
/M: SY='C';  M= -80,  72,  36, -20, -99,  -8, -85, -87, -24, -94, -89,  25,  22,  32, -86,  24, -77,  19,-110, -94; D=-10;
/I:         I=-10; MD=-25;
/M: SY='V';  M= -47,-108,-110, -21,   4,-117,-109, -73,-106,  20, -82, -15,-116, -10,-108,-102, -22,  46,-115, -94; D=-10;
/I:         I=-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='Y';  M= -34,-106, -17,  43,  28,-101,  32, -92, -87, -90, -88,  -2,-101, -82, -90, -20, -89, -33, -82,  80; D=-10;
/I:         I=-10; DM=-25;
/M: SY='G';  M= -82,-107,   8, -37,-111,  81, -97,-111, -95,-112,-103, -10,  13, -94,-103, -81, -94, -34,-107,-106; D=-10;
/I:         I=-10; DM=-25;
/M: SY='F';  M= -93,  10, -21,-101,  80,-109,-101,  13, -21, -31, -76,-100, -16,-105,-100, -97, -88,  40, -87, -66; D=-10;
/I:         I=-10; DM=-25;
/M: SY='D';  M= -91,-105,  92, -64,-106, -33,   8, -29,   0, -42, -96,  17, -94,  36, -82, -81, -84,-100,-117, -92; D=-10;
/I:         I=-10; DM=-25;
/M: SY='M';  M= -83, -90,-102, -95, -68,-101,  19, -54, -93,  65,  89, -95, -99, -87, -91, -21, -80,  24, -97, -74; D=-10;
/I:         I=-10; DM=-25;
/M: SY='S';  M= -72, -90, -77, -22, -93,  -7,  13, -91,   2, -17, -85,  14,  -5,  -5,  -7,  74,  23, -87,-102, -86; D=-10;
/I:         I=-10; DM=-25;
/M: SY='C';  M=  20,  58, -16,   6,  -4, -33,  10, -19, -76,   4, -74, -78,  31,  -5,   8,  12,  13,   0, -96, -80;
/M: SY='M';  M=  10, -86, -96, -90,  37, -93,   7,  -6, -88,  50,  84, -89, -94, -84, -88, -25, -18,   4, -85,   1;
/M: SY='D';  M= -80, -95,  58, -30, -16,  11, -77,   2,  36, -37,   8,   1,  47, -74, -23, -76, -22, -10, -91,  22;
/M: SY='P';  M= -30, -96,  48,  15,  34,  24, -80, -92,  28, -90, -86, -71,  51,  -4, -18, -32,   7, -90,  41, -77;
/M: SY='M';  M=  10, -88, -86,  14,  39, -31,   8,  22, -34,  38,  57, -84, -16, -79, -85,   2,  -8, -65, -87, -69;
/M: SY='I';  M=  43,  12, -86, -22,   9, -85,  12,  46,   1, -24, -68, -80, -88,  21, -81,   5, -17,  25, -93, -76;
/M: SY='H';  M=  21, -91,  25, -20,  11,   1,  73, -38,  -2, -81,  -5, -71, -86,  28, -76,   1,   7,   3,  41,  -5;
/M: SY='R';  M= -22, -96,  19,  18, -17, -88, -74, -27,  26, -87,  -5, -72,  32,  50,  59, -20,   7, -85, -91,  -4;
/I:         I=-10; MD=-25;
/M: SY='C';  M= -30,  70, -27,  56,  12,  19, -98, -27, -91, -96, -96, -92,-100, -88, -98, -90, -92,  -7,-108, -96; D=-10;
/I:         I=-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='Y';  M=-107,-121, -21, -24,   4, -50, -95,-109, -26,-106,-102,-102,  -1,  20, -18, -99,  11,-109, -97,  60; D=-10;
/I:         I=-10; DM=-25;
/M: SY='H';  M=  13,-104, -19, -21,   6,-100,  60,  13, -25, -31, -87, -89,-102, -90, -95,  11,   0, -86,-106,  -6; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Y';  M=  -2,-106, -93, -34, -94, -97,  21, -29, -35,-100, -93, -88,  -2,  17,  20,  32,   6, -96,-101,  40; D=-10;
/I:         I=-10; DM=-25;
/M: SY='E';  M= -88,-104, -87,  37, -99,  -2, -95, -24, -26, -21,   5, -89, -25,  33, -90, -85,  35,  15,-110, -96; D=-10;
/I:         I=-10; DM=-25;
/M: SY='P';  M=   3,-103,  -8, -85,  17, -97,   5,  -6,  -6, -38, -83, -13,  61,   4, -19, -87, -85,  20,-102, -86; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Y';  M=  10, -96, -91, -87, -79, -93,  13, -31, -25, -13,  32, -11, -98,  26, -18,  10,  -9,  22, -92,  49; D=-10;
/I:         I=-10; DM=-25;
/M: SY='V';  M= -84, -98,  38, -83, -85, -98, -90, -28, -88, -13,   9,  16,  -9,  26, -92, -25, -80,  58,  28,  -3; D=-10;
/I:         I=-10; DM=-25;
/M: SY='D';  M=  13, -95,  39, -11, -90, -21,  29, -88, -80,   4, -83,  13, -93,  11, -18,  36, -77, -28,-103,  -3; D=-10;
/I:         I=-10; DM=-25;
/M: SY='P';  M= -32, -98, -23, -22, -87, -44, -94,  24,   3,  -9, -78, -87,  54, -85, -89,  20,  -4,  25,  38, -88; D=-10;
/I:         I=-10; DM=-25;
/M: SY='V';  M=  -9,  22, -17,   2,  25, -99, -93,  -6, -90,   4, -70, -92,  16, -90, -94, -85,  -7,  59, -95,   1; D=-10;
/I:         I=-10; DM=-25;
/M: SY='D';  M= -14, -96,  49,  23, -91,  19,  11, -23,  12, -31, -84,  30,  16, -73, -17, -34, -78, -19, -99,   0; D=-10;
/I:         I=-10; DM=-25;
/M: SY='P';  M=  10, -98, -77,  32,  27,   1,  -9, -33, -23, -90, -84,  15,  69,  32, -82, -22, -79, -88, -90,   3; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Q';  M= -85,  64, -15,   5,  12, -96, -79,  -2, -34, -14, -77, -22, -95,  69,  29, -79,   7, -82, -90,  30; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Y';  M=  -7, -96,  11, -75, -82, -87,  11,  19,  19, -38, -78,   9,  35,  12,  10,  20,  -1, -79, -90,  42; D=-10;
/I:         I=-10; DM=-25;
/M: SY='L';  M= -30,  -2, -95, -20, -73, -99,   7,  15, -90,  55, -60, -93,  21,  -5, -92, -22, -78,  43, -98, -79; D=-10;
/I:         I=-10; DM=-25;
/M: SY='W';  M= -82, -91, -99, -92, -63, -95, -92,  11, -90,  64,   4, -18, -96, -86, -91,   1, -15,   5, 117, -65;
/M: SY='S';  M=  23, -85,  11,  36, -94, -30, -77, -90, -71, -91, -85, -66, -80,  27, -77,  75,  39, -82, -99, -85;
/M: SY='E';  M= -80,  22,  40,  59, -13, -88, -71, -92,  38, -88, -83, -71, -84,  18,   6,   0, -22, -89,  22,  57;
/M: SY='P';  M= -21,-100, -81, -14, -97, -20,   9, -82, -79, -92, -83, -83, 111,   7, -87,  10, -74,  11, -98, -92;
/M: SY='C';  M= -79,  64, -90, -87,  51, -22,   9,  28, -22, -31,   8,  -6, -94,  13, -30, -24,  -1,  29,  39,   9;
/M: SY='P';  M= -31, -92, -31,  35,  28, -92, -82,  19,  -2,  -7, -72, -79,  44,  23,   7, -75,  35,   6, -91, -76;
/M: SY='V';  M=  -2, -88, -93, -88,  22, -94,   8,  32, -15,  34,  10, -12,  14, -85, -87, -82, -14,  47, -89,  -9;
/M: SY='F';  M= -17, -89, -91, -81,  73, -93, -81, -68,  48,  31,  54, -83, -92, -15, -15, -82,   2, -72,  42, -59;
/I:         I=-45; MD=-115;
/M: SY='T';  M=  -2, -94, -14,  40, -94,  -2,  42, -92,   3, -30, -82, -72, -85,  28,  39, -21,  47, -87,-100, -84; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='F';  M= -81, -91,  -8, -87,  78, -32,  12,  31, -88,  11,  27, -85,  13,   4, -88,   6, -77,  11, -80, -59;
/M: SY='D';  M=  -3, -94,  94,  19,-100, -81, -73, -94,   7, -96, -91,  28,  23, -69, -76, -19, -17, -31,-109, -88;
/M: SY='F';  M= -84,  58, -93, -89,  81, -96,  55, -28, -88,  11,  27,  -9, -97,   4, -87, -84, -18,  19,  35, -56;
/M: SY='S';  M= -37, -92, -76,   9, -10, -82,  25, -84, -21, -21,  20,  -9,  34,  43,   2,  53, -17, -84,  33,  41;
/M: SY='T';  M= -75, -87, -75, -26, -84, -84,   9, -14,  36,  -9,  54,  37, -84,  23,   2,  21,  60, -75, -98, -79;
/M: SY='M';  M=  13,   7, -84, -21, -24, -88,   9,  16,  17,  20,  43,  -8,  40,  -5,  22, -22, -32, -34, -93, -78;
/M: SY='Q';  M= -29,  24, -12,  19, -90, -41, -76, -18,  30, -83,  18,  36, -12,  48,  -6,  20,   8,  11, -99, -84;
/M: SY='E';  M= -12, -91,  -5,  44,  -4, -87, -81,  30,  19, -19, -74, -11,  13, -71, -16,  29, -11,  13, -95, -80;
/M: SY='N';  M= -77, -90,   9,  24,  -5,   6,  11,   0, -72,   1, -78,  75,  -1,  -7, -18,  29, -71, -82, -98, -80;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='D';  M= -80, -96,  84,  60, -99, -83, -71,  -2, -68, -93, -89,  50,  -4,  23, -76, -22, -73, -89,-107, -88;
/M: SY='N';  M= -14,  18, -11, -80,  42,  12, -79,  -1,   2,  16, -71,  46,  -8,   7,   8, -77, -77, -10, -86,  -1;
/M: SY='S';  M= -29, -91,  36,  37,  -4, -81,   2, -25, -29, -35, -81, -69,  -9,  -3,  13,  63, -16, -83, -91,  22;
/I:         I=-28; MD=-70;
/M: SY='E';  M= -17,-111, -92,  30,  25, -24, -97,-103,   0,-102, -99, -94,-104,  19,   3,   1, -33, -23,-107, -93; D=-28;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='R';  M= -42,  22, -94, -85,  26,-100, -89,  -6,  31, -49, -86, -86,-101,  23,  42,  11, -18, -42, -96,  -2; D=-28;
/I:         I=-28; DM=-70;
/M: SY='C';  M= -79,  69, -17,  16,  -5, -14,  20, -85, -82, -17, -84, -79, -94, -81,   0,  43,  23,   2,-105, -86; D=-28;
/I:         I=-28; DM=-70;
/M: SY='K';  M=   5, -90, -11,   4, -15,  20,   9,  -5,  37, -20,  20,  14, -84,  27, -71,  37, -26, -79, -94, -80;
/M: SY='H';  M= -78, -93,   1,  28, -16, -89,  43, -25,  22,   2, -75, -74,  37,  -3,  35,  17,   7,  -7, -96, -78;
/M: SY='F';  M= -77,  22, -87, -22,  54,  14, -86,  23, -81, -17, -70,  -5, -22, -84,   5,   0,  24,  32, -86, -12;
/M: SY='K';  M= -76,  23, -13,  41, -13, -88,   7, -82,  44, -16, -78, -71, -84,  25,  28,  25,  15,   0, -95, -79;
/M: SY='F';  M= -31,  32, -95,  -3,  72, -99, -91,  24, -90,  25, -62, -92, -14, -91, -92, -85, -19,  48, -83, -63;
/M: SY='Q';  M= -76, -92, -24,  43, -15, -87,  32,  -4,   6, -34, -75,  27, -10,  53,   0,  17, -17,  20, -97, -78;
/M: SY='A';  M=  44,  -3, -19, -32,  21, -86,   7,  40, -85,  -4,  34, -16, -12, -82, -88, -31,   1,  24, -92, -74;
/M: SY='S';  M= -13,  24,  29, -72, -82, -84,  36,   4,  19, -18,  26,  -9,  -9, -15,  20,  39,   7, -77, -94,  17;
/M: SY='H';  M= -21, -92, -69,  29, -92, -13,  57, -91,  31, -88,  28,  35,  -8,  23,  38,   2,  21, -88, -98, -80;
/M: SY='S';  M= -12,  11,  15, -23, -91, -26,   4, -27, -74, -47,  18,  12,  55,  -3, -13,  61,  13, -82,-100, -85;
/M: SY='G';  M=  20,  11, -27, -22, -97,  82, -85, -98, -24, -96, -88, -68, -84, -78, -29,   9,  21, -90, -95, -91;
/M: SY='Q';  M= -30, -91,  17,   7, -14, -88, -78, -22, -18,  -6,  -9, -73,  21,  44,  32,   6,  43,  -1, -93, -15;
/M: SY='C';  M=   7,  93, -95, -91, -11, -92, -89,  24, -90,  31,  28, -88, -12, -88, -92,   7, -74,  24, -94,  -1;
/M: SY='H';  M= -83,  34,  11, -19, -89, -84, 127, -96, -73, -86,  11,  49, -87,  21, -72, -72,   6, -94,-114, -66;
/M: SY='G';  M=  55,  12, -84, -88, -94,  84, -89, -91, -85, -40, -84, -73, -86, -83, -91, -65, -79, -30, -93, -92;
/M: SY='F';  M= -28, -88,-103, -97,  87,-100, -92,  47, -94,  10,  12, -94, -98, -96, -94, -88, -78,  46, -77, -56;
/M: SY='A';  M=  62, -85, -89, -86,  11,  17, -90,  29, -85,   1, -69, -82,  -1, -84, -90, -69,  22,   7, -91, -79;
/M: SY='M';  M= -19,  11, -91, -91,  31,  47, -84,  -4, -88,  33,  56, -81, -92, -84, -90,  15, -17, -16, -86,  -2;
/M: SY='W';  M= -92,-112,-110, -96,  -1, -92, -93, -85, -88, -82, -83,-106, -98, -87, -90, -95, -98, -96, 168,  78;
/M: SY='W';  M= -34, -93,-105, -98,  97, -97, -88,   8, -92, -61,  59, -96, -98, -95, -91, -90, -85, -16, 110,  15;
/M: SY='D';  M= -30, -95, 100,  41,-100, -82,  23, -97, -19, -96, -92, -59, -82, -16, -76,  15, -73, -33,-111, -85;
/M: SY='W';  M=  -5,  13, -99, -92, -66, -94, -97,  37, -89,  13, -66, -92, -93, -88, -92, -25,  17,  48, 118,   3;
/M: SY='H';  M= -36,  13, -15,  19, -83, -39,  83, -80, -72, -37, -74,  -3, -86,  67, -74, -30,  30,  16,  36,  13;
/M: SY='F';  M= -86, -88, -19, -93,  78,-100, -83,  -7, -93,  62,  74, -94, -99, -90, -91, -92, -81, -61, -77, -56;
/I:         I=-7; MD=-17;
/M: SY='D';  M= -24,-106,  81,  -3,-111, -33, -89, -37, -86,-107,-103, -20, -27, -19, -94, -28,  27,-100,-122,-101; D=-7;
/I:         I=-7; MD=-17;
/M: SY='G';  M= -25,-112, -19,  10,-116,  29, -98,-115,  -9,-114,  -9, -11, -14, -89,   5,   6, -25,-110,-117,-109; D=-7;
/I:         I=-7; MI=0; MD=-17; IM=0; DM=-17;
/M: SY='Y';  M= -86,-103, -19,  47, -81, -94,  20, -35, -77, -93, -87, -11, -93,  31,  -9,  30, -19, -93, -87,  70; D=-7;
/I:         I=-7; DM=-17;
/M: SY='N';  M= -77, -95,   6,   9, -97,  38, -76, -92,  55, -95,  -2,  58,  54,  -8, -68, -71, -75, -32, -97, -89;
/M: SY='D';  M=  -3, -92,  46,  40, -95, -20, -77, -88,  17, -49, -84,  -3,  30,  -4,   7,  10,  32, -28,-100, -87;
/M: SY='I';  M= -76,  39, -91, -89, -11, -96,   8,  63, -85,  -4, -62, -13, -92, -19, -20, -14,  33,  49, -97, -75;
/M: SY='W';  M= -75,  11, -83,   0,  29, -15,  36, -10, -24, -12,  12,  -1, -89, -80, -83,  21,  23,  44,  59, -70;
/M: SY='L';  M= -84,  11,-102, -96,  18,-103, -87,  39, -95,  76,  14, -98, -99, -90, -93, -92, -79, -11, -85,  -3;
/M: SY='S';  M= -62, -82,  17, -73, -92, -26, -78, -90, -75, -93, -87, -61, -81, -69, -80, 100,  44, -82,-102, -84;
/M: SY='T';  M= -71,  39, -81, -83, -81, -87, -86,  37, -79, -72,  34, -70, -81, -80, -86,  21,  99, -62,-102, -81;
/M: SY='G';  M=  48, -88, -14,  19, -94,  66, -81, -91, -79, -34,   7,  16, -84, -75, -85,  15, -74, -85, -95, -89;
/M: SY='P';  M= -82,-106, -85, -74, -97, -86, -87, -86, -81, -10, -83, -90, 125, -83, -92, -13, -75, -91, -96, -97;
/M: SY='S';  M= -29, -90,  18,  20,  18,  -6, -75, -79,  -4,  22, -74,  -4, -87,  11, -19,  39,   3, -79, -85,  36;
/M: SY='W';  M=  -1, -91,  38,  40, -85, -32,  21, -88, -74, -89, -85,  22, -83, -71, -80,  24,  49, -29, 102, -75;
/I:         I=-11; MD=-28;
/M: SY='P';  M=  17, -95, -85, -31, -14, -29,  37,   4,   5, -84,   8, -79,  60, -10,   7, -17,  32, -28, -98, -83; D=-11;
/I:         I=-11; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='H';  M= -21, -94,  26, -20, -92, -89,  63, -25, -38, -44, -82, -10,  22, -80, -86,  21,  49,  15,-111, -85; D=-11;
/I:         I=-11; DM=-28;
/M: SY='P';  M= -79,   6, -17, -21, -97, -89, -88, -84, -23, -92, -86,  -9,  67,  -5, -87,  19,  66,   3,-108, -93; D=-11;
/I:         I=-11; DM=-28;
/M: SY='N';  M= -27,-118,   8,  38,-123,   9, -97,-123, -91,-122,-114,  41,  -2, -90, -16, -94, -99,-119,-125,-115; D=-11;
/I:         I=-11; DM=-28;
/M: SY='M';  M= -37,-113,-110,-110, -16,  16,   7, -96,-107, -14,  73, -15, -15,-102,-109,  -3,-100, -99,-116, -98; D=-11;
/I:         I=-11; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='D';  M= -99,-110,  44, -92,  26,-107,-100, -97, -17, -97,  40, -90, -10, -99,-101,   5,  21, -29,-114, -93; D=-11;
/I:         I=-11; DM=-28;
/M: SY='H';  M= -79,  12, -74, -75,  18, -20, 124, -94, -77, -84, -75,  16, -89,  -3, -75,  38, -76, -93, -95,  34;
/M: SY='W';  M= -90,  14,-115, -96, -59, -91,-111, -86, -89, -86, -88,-107, -97, -89, -92, -28, -98, -22, 175,  13;
/M: SY='K';  M= -39, -93, -81, -19,  40,  -8,  -2, -83,  73, -78,  62, -74, -87, -67,  28, -18, -78, -83,  35,  20;
/M: SY='Q';  M= -78,-103, -74, -55, -18, -85, -68, -92, -61, -89, -77, -71,  55, 126, -63, -69, -79, -94, -89, -79;
/M: SY='C';  M=  52,  54, -87, -85, -87,  44, -90,  37, -84, -78, -75, -78, -11, -11, -90, -68,  28,  -5, -96, -87;
/M: SY='V';  M= -19, -87, -98, -92, -12, -99, -91,  33, -87,   9,  10, -93, -96, -88,   1, -84, -73,  81, -91,  25;
/M: SY='Y';  M= -87,  34, -91, -86,  71, -96,  57, -19, -18,  10,  10, -85, -97,  27, -80, -85, -83, -75,  34,  80;
/M: SY='F';  M= -85, -92, -96, -90,  67, -97, -81, -22, -90,  43,  -2, -94,  62, -90, -91, -87, -27,   4, -74,  53;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='L';  M=  -7, -88, -94, -89,  36, -94, -84,  10, -87,  66,  28,  -3,  14, -85, -20, -24, -77, -21, -86, -69;
/M: SY='P';  M= -77, -97,  10,  16, -99,  15, -77, -96,  40, -97, -87, -21,  71,  12,  34,  19, -17, -93, -96, -89;
/M: SY='Q';  M= -78, -94,  49,  26, -96, -30, -72, -92,  58, -40, -83,  12, -82,  62, -13, -26,  27, -89, -98, -84;
/M: SY='P';  M= -80,-103, -79,   4,-100, -31, -83, -90,  17, -97, -86, -82, 113,  -1, -21, -14, -17, -42, -96, -94;
/M: SY='I';  M= -77, -90, -92, -24, -27, -32, -90,  53, -24,  21,  11, -87,  13, -84,   8, -82,  19,  50, -95, -77;
/M: SY='C';  M= -27,  65, -76,  29,   5, -87, -77, -83,   8, -36, -79, -15,  46,  14, -14,  15,  21, -27, -87,  40;
/M: SY='V';  M= -36, -87,  -8, -24,  32, -99, -92,   1, -89,  36, -60, -92, -96,  -6, -90, -85, -75,  74,  34, -70;
/M: SY='H';  M= -12,  -2, -76,  12, -86, -26,  53, -19,   5,  -7,   8,   0, -10,  20,  29,  36, -15,  -4, -98, -79;
/M: SY='E';  M=  15, -92,  -8,  53, -94, -26, -75, -86,  16, -86,  38,  17,  32,  29,  14, -20,   1, -29, -97, -86;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='G';  M= -36, -92,  31, -82,  47,  78, -82, -93, -83, -90, -87,  32,  -7, -83, -89, -69,   6, -91, -89, -77;
/M: SY='Q';  M= -76, -93,  61,  28, -97, -82, -72, -91,  10, -92, -85,  18,  -4,  63, -12,  27,  29, -31,-102, -85;
/M: SY='P';  M= -15, -91,   4,  26, -93, -83, -77, -35,  21, -88, -82,  31,  49,  22,   8,   6,  47, -16, -99, -86;
/M: SY='I';  M= -78, -89, -96, -92,  29, -97, -87,  54, -87,  42, -58, -89, -95, -86,  -9,  24, -74,  35, -84,  24;
/M: SY='S';  M= -72, -87, -71,  35, -79, -82,   8, -77,  13,   8, -75,  30, -84, -69, -74,  54,  43,  -4, -93,  23;
/I:         I=-12; MD=-29;
/M: SY='G';  M=  -7, -94, -94, -97,  12,  65, -92,  18, -93,  14, -74, -84, -95, -91, -97, -24, -83,  13, -90,   1; D=-12;
/I:         I=-12; MD=-29;
/M: SY='H';  M= -28, -98,  16,  44, -99,  -6,  52, -98,  14, -36, -87,  10, -87,  21, -17, -11,  27, -93,-106, -87; D=-12;
/I:         I=-12; MD=-29;
/M: SY='I';  M= -34,  54,-108,-103,  11,-107,-100,  56,-100,  15,  50,-100,-103, -98,-101, -94, -82,  39, -99, -79; D=-12;
/I:         I=-12; MD=-29;
/M: SY='W';  M= -31,-100, -13, -18, -90, -90,   8, -92,  -5, -23, -87,  39, -95,  31, -17,  24,  16, -42,  80,  -4; D=-12;
/I:         I=-12; MD=-29;
/M: SY='F';  M= -30,-101,-109,-102,  79,-109, -95, -22, -90,   3,   3,-100,-109, -98,  35, -96, -22,  -4, -87, -66; D=-12;
/I:         I=-12; MD=-29;
/M: SY='C';  M= -88,  54, -94, -90, -97, -97,  29,  13, -89, -23, -88,  -1,-103,  41, -21,  47, -84, -89,  36, -91; D=-12;
/I:         I=-12; MD=-29;
/M: SY='F';  M= -16,   8,-102, -96,  34,-106,  14,-103, -11, -37, -95,  -1,  -2,  14,  16, -17, -97,-103,-103,  -5; D=-12;
/I:         I=-12; MD=-29;
/M: SY='N';  M= -96,-111,  11, -97, -20, -97,   7,-118, -98,-120,-113,  57,-112, -94,-103,  52, -88,-115,-129,-105; D=-12;
/I:         I=-12; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='L';  M= -38,-119,-116,-107,-101, -19,   4, -95,  -6,  40, -87,-111,-121,  25,-104,-109,-109, -99,-120,-103; D=-12;
/I:         I=-12; DM=-29;
/M: SY='Q';  M= -90,-107, -13, -34,-104,-103, -93, -36,  39, -95, -90, -29,-101,  49,  -8,   2, -22,  30,-112, -97; D=-12;
/I:         I=-12; DM=-29;
/M: SY='S';  M=  -9,  55,  22,  -6, -17,  13, -84, -93, -78, -93, -89, -71,  -7, -77,   2,  61,  22, -40,-103, -88;
/M: SY='N';  M= -31,  12,  37, -14, -88, -40,  36, -92,  18, -22, -84,  53, -90, -11,  -4,  15,  12, -90, -99,  23;
/M: SY='H';  M= -76, -92, -78, -31, -94, -85,  73, -91, -76, -92, -85, -10,  16,   1,   2,  53,  64, -39,-109, -82;
/M: SY='D';  M= -84,  22,  53,  36, -15,  -4, -81,  -3,  46, -91, -87, -73, -89,  25, -20, -80, -82, -29, -98, -12;
/M: SY='D';  M= -39,  12,  63,  18, -89, -31,  -5, -21, -14,   0, -79, -76, -92, -80, -86,   4, -32,  37,-109, -87;
/M: SY='W';  M= -91,-103,-104,-100,  34,-100, -84,  25, -94, -13,  33, -98,-103, -91, -94,   9, -88, -76, 105,  80;
/M: SY='Y';  M= -21,  10, -87,   5, -79, -41,  10, -22, -35, -38, -84, -14, -25, -82, -19,  39, -19,  -4, -90,  62;
/M: SY='M';  M= -91,-101, -92,  40, -82,-109, -91,   7, -89,  30,  65, -97, -99, -85, -20, -93,   4,  -4,-102,  -3;
/M: SY='W';  M= -95,-115, -95,  22, -84,-100,  14, -99, -25, -41, -94, -18,-100,  32,  -7, -28, -98, -41, 136, -72;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	147 in 116 different sequences
Number of true positive hits	147 in 116 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	SAM-dependent MTase PRMT-type
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

116 sequences

ANM10_ARATH (Q9MAT5), ANM10_ORYSI (A2Y953), ANM10_ORYSJ (Q9SNQ2),

ANM11_ARATH (Q9SU94), ANM12_ARATH (O82210), ANM13_ARATH (Q84W92), 
ANM14_ARATH (A3KPF2), ANM15_ARATH (Q8GWT4), ANM16_ARATH (Q944R7), 
ANM1A_XENLA (Q8AV13), ANM1B_XENLA (Q6VRB0), ANM1_CAEEL  (Q9U2X0), 
ANM1_CHLRE  (A8IEF3), ANM1_DICDI  (Q54EF2), ANM1_HUMAN  (Q99873), 
ANM1_MOUSE  (Q9JIF0), ANM1_ORYSI  (A2Z0C0), ANM1_ORYSJ  (Q0J2C6), 
ANM1_RAT(Q63009), ANM1_SCHPO  (Q9URX7), ANM1_XENTR  (Q28F07), 
ANM1_YEAST  (P38074), ANM2_DICDI  (Q54HI0), ANM2_HUMAN  (P55345), 
ANM2_MOUSE  (Q9R144), ANM2_XENLA  (D9IVE5), ANM2_XENTR  (B3DLB3), 
ANM3_ARATH  (Q0WVD6), ANM3_HUMAN  (O60678), ANM3_MOUSE  (Q922H1), 
ANM3_ORYSI  (A2YP56), ANM3_ORYSJ  (A3BMN9), ANM3_RAT(O70467), 
ANM3_SCHPO  (O13648), ANM5_BOVIN  (A7YW45), ANM5_CAEEL  (P46580), 
ANM5_DICDI  (Q54KI3), ANM5_DROME  (Q9U6Y9), ANM5_HUMAN  (O14744), 
ANM5_MACFA  (Q4R5M3), ANM5_MOUSE  (Q8CIG8), ANM5_ORYSI  (A2X0Q3), 
ANM5_ORYSJ  (Q6YXZ7), ANM5_PONAB  (Q5R698), ANM5_XENLA  (Q6NUA1), 
ANM61_ORYSI (A2XYY8), ANM61_ORYSJ (Q7XKC0), ANM62_ORYSI (A2Z8S0), 
ANM62_ORYSJ (Q75G68), ANM6_ARATH  (Q08A71), ANM6_BOVIN  (Q5E9L5), 
ANM6_DANRE  (Q6NWG4), ANM6_HUMAN  (Q96LA8), ANM6_MOUSE  (Q6NZB1), 
ANM6_XENLA  (Q68EZ3), ANM6_XENTR  (B0JYW5), ANM7_AEDAE  (Q16NS8), 
ANM7_ANOGA  (Q7QIL2), ANM7_BOVIN  (A6QQV6), ANM7_CAEBR  (A8XFF4), 
ANM7_CAEEL  (Q9XW42), ANM7_CHICK  (Q5ZIB9), ANM7_CRILO  (Q99MI9), 
ANM7_CULQU  (B0X4N1), ANM7_DANRE  (A2AV36), ANM7_DROAN  (B3MF31), 
ANM7_DROER  (B3NP10), ANM7_DROGR  (B4JWL5), ANM7_DROME  (Q9W1V1), 
ANM7_DROMO  (B4KSL6), ANM7_DROPE  (B4GA28), ANM7_DROPS  (B5DZN7), 
ANM7_DROSE  (B4I8G2), ANM7_DROSI  (B4QI55), ANM7_DROVI  (B4LPB6), 
ANM7_DROWI  (B4MNL1), ANM7_DROYA  (B4P925), ANM7_HUMAN  (Q9NVM4), 
ANM7_MOUSE  (Q922X9), ANM7_ORYSI  (A2Y8B9), ANM7_ORYSJ  (Q5VS72), 
ANM7_RAT(Q5U4E8), ANM7_TRYB2  (Q582G4), ANM7_XENLA  (Q6PCI6), 
ANM8B_DANRE (Q5RGQ2), ANM8_HUMAN  (Q9NR22), ANM8_MOUSE  (Q6PAK3), 
ANM9_HUMAN  (Q6P2P2), ANM9_MOUSE  (Q3U3W5), ANM9_XENLA  (A0JMU5), 
CARM1_AEDAE (Q174R2), CARM1_ANOGA (Q7Q2B7), CARM1_CULQU (B0W3L6), 
CARM1_DANRE (Q6DC04), CARM1_DROAN (B3M1E1), CARM1_DROER (B3P4N5), 
CARM1_DROGR (B4JXV2), CARM1_DROME (Q9VH48), CARM1_DROMO (B4KA23), 
CARM1_DROPE (B4GZ20), CARM1_DROPS (Q29B63), CARM1_DROSE (B4HJC0), 
CARM1_DROSI (B4QVW6), CARM1_DROVI (B4LVS8), CARM1_DROWI (B4NKI9), 
CARM1_DROYA (B4PVH6), CARM1_HUMAN (Q86X55), CARM1_MOUSE (Q9WVG6), 
CARM1_ORYSI (A2YPT7), CARM1_ORYSJ (Q7XI75), CARM1_RAT   (Q4AE70), 
CARM1_SCHMA (A0A3Q0KHE7), CARM1_XENLA (Q5XK84), HSL7_YEAST  (P38274), 
SKB1_SCHPO  (P78963), SZNE_STRC2  (A0A411EW25)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

218 PDB

1F3L; 1G6Q; 1OR8; 1ORH; 1ORI; 2FYT; 2V74; 2V7E; 2Y1W; 2Y1X; 3B3F; 3B3G;
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