PROSITE entry PS51666

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General information about the entry

Entry name [info]	QLQ
Accession [info]	PS51666
Entry type [info]	MATRIX
Date [info]	01-FEB-2013 CREATED; 13-FEB-2019 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51666
Associated ProRule [info]	PRU01001

Name and characterization of the entry

Description [info]

QLQ domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=33;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4185576; R2=0.0086588; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3940.5703125; R2=1.0259246; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1049; H_SCORE=5017; N_SCORE=11.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=472; H_SCORE=4425; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-62; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M=  22, -96, -45, -80, -47,   3,  22, -11, -78, -15, -30, -23,  68,   2, -31,  33, -20, -48,  -5, -13;
/M: SY='F';  M= -99,-151, -65,-159, 114,-162, -38,   9,-156,  14,   2, -57,-163,-160, -79,-152,-145,-104,-127, -26;
/M: SY='T';  M= -80,-143,-134,-105,-149, -87,-142,-142, -45, -48, -80,  36, -44,-136,-142,  53, 101,-136,-165,-146;
/M: SY='P';  M=  29,-155, -17, -12, -20, -84, -17, -53,   8, -38, -19,   4,  78,  40, -75,  -6, -14, -53, -18,-145;
/M: SY='Q';  M=  44,-150,  15,  34,-152,-141, -52, -43, -39, -43,  12,  20, -56,  54,-137,  23,  -1, -18,-158, -47;
/M: SY='Q';  M=-139,-163, -63,-114,-167, -89, -55, -71,-120,-149, -39, -54,-146, 138,-120,-128,-141,-155,-152,-140;
/M: SY='W';  M= -49,-154,-162,-153,  -5,-157,-151,  13,-100,  59,  30,-156,-158, -40, -16,   5,-142,  -5, 114, -44;
/M: SY='Q';  M=   7,-154,  -4,  20, -16, -81,  57, -67, -21, -47,  46,  35, -55,  79, -21, -38, -15,-106,-157, -75;
/M: SY='Q';  M= -28,-154,-133,  69,-143, -91,-138, -47,-132,  41,  10,-142,-147,  75, -66,-138, -18,  -3, -58,-141;
/M: SY='L';  M=-146,-149,-164,-157,   6,-165,-148, -20,-157,  93, -25,-162,-163,-151,-155,-156,-142, -51,-148,-130;
/M: SY='R';  M=-143,-160, -59,  61, -66,-135, -16,-161,  67,-155, -82,-133,-145, -37,  81, -87,-141,-155, -24,-143;
/M: SY='H';  M=  65, -81, -63, -87,-150, -73,  73,-146,-134, -25, -31,  15,-148,  48,  -4,  -2,   4, -71,-159, -35;
/M: SY='Q';  M=-139,-164,-134,-113,-168,-147, -14,-155,-119,-150,-137,-129,-146, 139,-119,-128,-141,-157,-152,-140;
/M: SY='I';  M=  42,-149,-157,-153, -10,-153,-156,  81,-151, -36,   5, -74,-152,-149, -90, -19, -60,  36,-154, -75;
/M: SY='M';  M= -13,-149,-147, -29, -33, -47, -15, -52, -14,  52,  75, -42,-151,  41, -41, -28,  25, -37,-151, -15;
/M: SY='A';  M=  84,-144,-151,-145,-143,-113,-152,  62,-146, -85, -58,-144,-147,-142,-150,  -8, -45,  -3,-155,-144;
/M: SY='Y';  M=-151, -57,-156,-156,  85,-159,-100, -71,-150,   2,-126,-153,-163,-149,-147,-120,-144, -87,-114, 116;
/M: SY='K';  M=-142,-157,-134, -55,-157, -55,-134,-159, 100,-156,-144, -12,-145,  10,  64,-135,-138,-154,-152,-144;
/M: SY='Y';  M= -38,  59,-150,-147,  -9, -92,  50, -97, -32,  17,  60, -63,-157, -12, -20, -85, -63, -97, -65, 100;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='M';  M= -76,-148,-160,-153,  11, -99,-145,  39, -54,  77,  79, -68,-157,-146, -89,-151,-139,-115,-147,-128;
/M: SY='A';  M=  58,-144,-143, -45, -76, -38,-114, -27,  11, -49,  41, -76,-145, -30, -35,  50,  -5,  29,-156,-142;
/M: SY='R';  M=  52,-150,-137,-129,-152,-105, -37,-151,  49,-150,-141,  16, -15,   2,  73,   3, -54, -87,-152, -19;
/M: SY='N';  M= -85,-150,-126, -90,-156,  66,  -6,-159, -12,-160,-148,  96, -56,  -4,   5,   2, -91,-156,-160,-149;
/M: SY='Q';  M=  17, -84, -49,  11,-105, -55,-138, -25,  -1,  28,  37, -93, -49,  82, -71, -36, -51,  21,-153,-139;
/M: SY='P';  M= -27,-161, -64,-134, -67,  13, -72,-149, -60, -80,-145, -38, 114,   6, -30,  -8, -32, -44,-155, -58;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='V';  M=-122,-148, -76,-155, -42,-163,-157,  65,-153,  28,  -2,-155, -23,-152,-155,-147, -60,  78,-156, -73;
/M: SY='P';  M= -52,-164, -67, -53,-161,-144,-146, -94, -79, -93,-147, -90, 127,-141,-150,  16, -51,-153,-157,-158;
/M: SY='P';  M= -24,-155,   4,  23, -37, -60,   8, -59, -60, -60,  -3, -31,  76,  55, -35,  15,  11, -12,-155, -13;
/M: SY='H';  M= -24,-155,  31,  51,-151, -45,  81,-156,-101,-114, -87,  43, -33,  58, -31,  11, -34,-153,-158,  13;
/M: SY='L';  M= -72, -19,-160,-154, -51,-161,-147,  17,-153,  79,  27,-156,-159, -56,-152, -80, -32,  25, -83,  -4;
/M: SY='Q';  M=  -5,-152,-148, -52, -91, -97,-141,  22, -50,  46,  10, -99, -47,  86, -48,-114, -68,  26,-152, -46;
/M: SY='Q';  M=  -5,  -6, -12, -20,  -2, -76, -25, -11, -14,  23,  38,  10, -68,  70,  -3,   3, -40, -18,-152, -38;
/M: SY='P';  M=  46,-151, -70, -28,   6, -65, -62, -23, -30, -26, -33, -40,  72,  30, -25,   3, -36,   4,-152, -58;
/M: SY='I';  M=  12,-150,-108,-154, -68,-158,-156,  84,-152,  22,  11, -84, -36,-149,-104, -55, -37,  38,-154,-136;
/M: SY='W';  M= -52, -64, -78, -86,  42, -61, -44, -56,  12, -80,   2, -14, -18,  70,  30,  10,  15, -19,  81, -12;
/M: SY='K';  M=  -2,-153,-135, -10,-152,  33, -36, -57,  44, -45,   1,  42,  33, -12,  26,   2, -38, -43,-155, -53;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	35 in 35 different sequences
Number of true positive hits	35 in 35 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Feature key [info]	DOMAIN
Feature description [info]	QLQ
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

35 sequences

BRM_ARATH   (Q6EVK6), BRM_DROME   (P25439), GRF10_MAIZE (A5HEG9),

GRF10_ORYSJ (Q6EPP9), GRF11_ORYSJ (Q6AWX8), GRF12_ORYSJ (Q6AWX7), 
GRF1_ARATH  (O81001), GRF1_MAIZE  (A0A060D764), GRF1_ORYSI  (A2XA73), 
GRF1_ORYSJ  (Q6AWY8), GRF2_ARATH  (Q8L8A8), GRF2_ORYSJ  (Q6AWY7), 
GRF3_ARATH  (Q9SJR5), GRF3_ORYSJ  (Q6AWY6), GRF4_ARATH  (Q8L8A7), 
GRF4_ORYSJ  (Q6ZIK5), GRF5_ARATH  (Q8L8A6), GRF5_ORYSJ  (Q6AWY4), 
GRF6_ARATH  (Q9ZQ12), GRF6_ORYSJ  (Q6AWY3), GRF7_ARATH  (Q9FJB8), 
GRF7_ORYSJ  (Q6AWY2), GRF8_ARATH  (Q9SU44), GRF8_ORYSJ  (Q6AWY1), 
GRF9_ARATH  (Q8S9M3), GRF9_ORYSJ  (Q9FRG8), SMCA2_HUMAN (P51531), 
SMCA2_MOUSE (Q6DIC0), SMCA4_BOVIN (A7Z019), SMCA4_HUMAN (P51532), 
SMCA4_MOUSE (Q3TKT4), SMCA4_RAT   (Q8K1P7), SNF22_SCHPO (O94421), 
SNF2_YEAST  (P22082), SWSN4_CAEEL (G5EF53)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

10 PDB

6LTH; 6LTJ; 6UXV; 6UXW; 7C4J; 7VDT; 7VDV; 7VRB; 7VRC; 7Y8R