PROSITE entry PS51656

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51656
Entry name [info]	4FE4S
Accession [info]	PS51656
Entry type [info]	MATRIX
Date [info]	01-AUG-2012 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51656
Associated ProRule [info]	PRU00989

Name and characterization of the entry

Description [info]

4Fe-4S domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=60;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=55;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6618776; R2=0.0096750; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=7979.3476562; R2=1.5019256; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=966; H_SCORE=9430; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=501; H_SCORE=8732; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-46; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='E';  M=  -7,-154,  16,  69, -40, -55, -32,-150,  18,-147,  27, -14,   2,  43,  24,   4, -38, -59,-155, -46;
/M: SY='K';  M= -13,-151,  11,  31, -56, -53, -17,  37,  38,  22,   0, -77, -18,  -7, -78, -30, -42,  13,-153, -25;
/M: SY='D';  M=  15,-151,  55,  18,-146, -49,-137,  -5,  25,  -5,  30,  16, -49,  -7,   3, -34, -31,  -3,   2, -74;
/M: SY='P';  M= -22,-155,  33,  57,-156, -80,-136,-150,   9, -51,-145,   9,  67,  17,  -4,  21, -31, -36,-159,-148;
/M: SY='R';  M= -20, -56, -53, -38, -37, -46, -63,  29,  21,  15, -16,  13, -17,  -3,  32,  -8,  10,  30,-155,-139;
/M: SY='I';  M=  -1,-149,-156, -55,  22,-156,-151,  63, -71,  17,  -1,-151,  11, -94,-151, -53, -30,  51, -29,   6;
/M: SY='E';  M=   2, -64,  26,  53,-145, -51, -23, -18,  18,  21,  -7,  10, -91, -11,   8, -52,  19, -45,-157, -77;
/I:         I=-26; MD=-67;
/M: SY='E';  M= -12,-155,   7,  64,-152,-102, -26,  -7,  15, -26, -37,  -3, -46,  31,  42,   7, -33, -63,-157, -88; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='I';  M= -21, -50, -53, -31, -64, -57, -64,  76, -17,  13,  54,-146,-150, -84, -34, -29, -11,  31,-153, -71;
/M: SY='Y';  M= -52, -67,   4,   0,  22,  31,  10, -51, -11,  19,  10,   8, -69, -59, -40, -67, -36, -36, -43,  76;
/M: SY='K';  M=  20, -33,  14,  24,   2, -23, -26,-153,  80,-152,-144,  10, -43, -13,  -4, -10, -93,-148,-152,-141;
/M: SY='Y';  M=   0,   9, -93,   4,  22,-152, -38,  20, -12,  35,  10, -38, -35, -29, -26, -32,   9,   2,  -1,  40;
/M: SY='L';  M= -98, -53, -15, -86, -83, -46,-144, -76, -44,  84, -29, -84,-155,-143, -93,   5,  20, -21,-152, -68;
/M: SY='P';  M= -15,-163,  -3,  24,-160, -46,-143, -97, -36, -49,-145, -46, 118, -20, -84,-137, -83,-152,-157,-155;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='G';  M= -67,-155,  22,  19,-159,  62, -47,-159,  45,-156, -16,  35,-144,  51,  10, -82,-138,-155,-155,-147;
/M: SY='T';  M=  -5,-146, -68,-147,   8, -71,-144,  33,-145,  49, -17, -95, -72, -69, -69,   1,  62, -34,-147,  23;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='N';  M=-141,  -5,  72, -61,-158, -70, -62,-156,-127,-160,-150, 114,-148,  32,-135,-125,-129,-157,-173,-148;
/M: SY='C';  M=-139, 160,-158,-158,-149,-154,-158,-156,-154,-147,-147,-145,-169,-162, -73,-141,-139,-144,-178,-159;
/M: SY='G';  M=  -9,-152, -77, -66, -83,  89, -60,-159,  13, -94, -66, -54,-145, -18,  20,   2, -24,-102,-152,-149;
/M: SY='A';  M=  65,-147, -60,  17, -49,  18, -15, -31,   6, -22, -26, -80,-144,  27, -16,  11, -39, -62,-153, -68;
/M: SY='C';  M=-139, 161,-159,-159,-149,-154,-159,-156,-154,-146,-147,-145,-169,-162,-161,-141,-139,-143,-179,-160;
/M: SY='G';  M=-127,-154, -81, -92,-160, 108,-147,-167,-145,-163,-152, -45,-146, -52, -49,-127,-145,-105,-152,-155;
/I:         I=-42; MD=-106;
/M: SY='Y';  M= -32, -19,-145,  20,  45,-155,  23, -65, -93, -52,-134,-102, -73, -15, -16,  -9, -90, -54,-125, 107; D=-42;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='P';  M=  19,-155,  25,  22, -58, -12, -11,-149,   3, -90,-144, -19,  79,  -5,  -5,   9, -91, -46,-152,  15;
/M: SY='T';  M= -65,-145,  27,-135, -82,  38,-138,-149, -91,-106,-145,  45,-142, -78, -36,  53,  78,-143,-162,-146;
/M: SY='C';  M=-139, 161,-159,-159,-149,-154,-159,-156,-154,-146,-147,-145,-169,-162,-161,-141,-139,-143,-179,-160;
/M: SY='R';  M=  14,-153, -12,  10, -36, -63,   1, -95,  17,  -2,  54, -55, -88,   1,  68, -16, -62, -92, -13,  29;
/M: SY='A';  M=  55, -60,  42,  51,-156,  -1,-138, -60, -88,-118,-144, -34,  11,  30, -84,   2,  -4, -55,-158,-148;
/M: SY='F';  M= -76, -41,-158,-152,  94,-113, -41,-123, -11,  24,  84, -69,-158,-147, -72,-148,-142,-129,-127,  59;
/M: SY='A';  M=  97,-140,-144, -90,-150, -55,-146, -84, -64, -47, -53, -69,-145,-136, -44,  -1, -23, -15,-154,-147;
/M: SY='E';  M=  19,-151, -35,  56, -87, -41, -52,   7,  35, -51,   2, -25, -72,   6,  17, -16,   4,   5,-155, -56;
/M: SY='A';  M=  86,-145,  40, -27,-154, -60, -34,-147,  34, -71, -32,-132,-144, -30, -33, -39,-132,-137,-156,-146;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='I';  M= -94, -24, -86, -49, -62,-162,-152,  71, -20,  35,  35, -74,-154,-146, -32,-147,-135,  56, -44, -38;
/M: SY='V';  M=  32, -40, -76, -97,  22, -98, -64,  27, -68,  22,  -4,-149,-153, -65, -66, -46, -36,  58,-145,  38;
/M: SY='N';  M=  12, -59,   8,  24,-152, -72,  -9,-102,  42, -29,-140,  61,-145,  44,  34, -27,  -8,-104, -49, -84;
/M: SY='G';  M= -61,-154, -35, -37,-158,  94, -13,-162,  -7,-159,-149,   5, -77,  -7,   0, -40, -39, -70,-154,-151;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='E';  M= -27, -60,  25,  64, -94, -42, -19, -43,  25,  10,   3, -10, -47,  -1,  18, -16, -64, -59,-156, -26; D=-31;
/I:         I=-31; DM=-79;
/M: SY='A';  M=  65, -37, -15,  -5, -29, -74, -60, -22,   5, -77, -19,  45, -82, -20, -35, -11,  -2,   1,-154,  -8;
/M: SY='E';  M=   2,-152,  23,  39, -65, -22,  -5, -40,  35, -55, -56,  17,  23,   5,  16,   8,  18, -59,-158,-144;
/M: SY='P';  M= -31, -68, -68, -15, -41, -26, -31,  45,  -2,  25,  13, -72,  60, -85, -11, -41, -45,  15,  10, -30;
/M: SY='N';  M= -26, -43,  51,  47, -82, -12, -31, -95,  18,-111, -71,  58,  -3, -29, -47,  12,   8, -41, -40, -34;
/M: SY='M';  M= -14, -44,  49,  -5, -39,  -8, -60,-144,  12, -21,  61,  56, -29,  22,  22, -26, -70,-107, -30, -16;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='C';  M= -89, 160,-158,-158,-149,-154,-158,-155,-154,-146,-146,-145,-169,-162,-161,-141, -71,-143,-178,-159;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='P';  M=   9, -53,-148, -76, -64,-150,  -2,  22, -15,  -5,   8, -88,  74, -28, -13, -46,   6,  45,-155, -47;
/M: SY='P';  M=  -9,-153, -22, -91,  33,-113,  42, -13, -99,  -6,  10, -33,  79, -73, -39, -11,   3,  14,-148,  20;
/M: SY='Y';  M= -51, -29, -71, -35,  -2,  41, -23, -11,  -2,  33,  29, -28, -72,-138,   7,  -7, -83, -44,   7,  57;
/M: SY='M';  M= -46,-150, -16,   0, -10,  41, -21,  -7,   7,   9,  53,  26,-147,  15, -71,   7,   0, -51,-151, -11;
/M: SY='R';  M=   0,-153,  20,  22,-150, -46, -61, -13,  33, -31, -13,  -5,   7,  21,  53, -10,   3, -31,-156, -83;
/M: SY='D';  M=   3,-154,  60,  59, -83, -49, -25, -26,  13, -27,-143,  10,  29,  13, -16, -24, -57, -89,-160,-146;
/M: SY='V';  M= -39,-149, -41,  17,-139, -29,-141,   7,  23,  23,  20,  -9,-147,   6,  19,   3,  13,  32,-155, -78;
/M: SY='V';  M=  36, -43,-145,  -6, -12,   4, -55,  18, -11,  -1,  17, -14, -71, -39, -45, -25, -40,  37, -50,  29;
/M: SY='E';  M=   9, -57,  -2,  49, -86, -68,  -8,  21,  19,  -8, -57,  -3, -32,  24, -13,   9,  -9,   0,-157,-142;
/M: SY='K';  M=  36, -19,   9,  29, -91, -36, -17, -58,  36, -45, -15,  -8, -49,  18,  23,   4,  -2, -14, -27,-143;
/M: SY='I';  M= -49, -31, -18,  14, -59, -54,-143,  42,  17,  39, -11,  18,-150, -12, -14, -51, -65,  31,-154, -63;
/M: SY='A';  M=  35, -76,   2,  -7, -67,  27,  -3, -29,  15, -14, -67,  29, -77, -16,   5,  16, -19, -35,-154, -10;
/M: SY='E';  M=  -3,-151,  16,  50, -64,  -8, -31, -38,  23, -52,-142,  43, -49,  32,  -5,  24, -14, -43,-157, -68;
/M: SY='K';  M=  26, -45, -84,  17, -48, -29,   8,  24,  28,   8, -24, -29,  -4, -27,   4, -43,   9,  -2, -41, -10;
/M: SY='L';  M=   1,-148, -86, -48, -68, -79, -29,  31, -67,  58,  50, -19, -30,   6, -40,-101, -41,  26,-152, -41;
/M: SY='Q';  M=  -9, -47, -49,  20, -31,  25, -36,   4,  32,  -3,  12,  28,  -4,  34, -36,  -8, -37, -26,-153, -77;
/M: SY='E';  M=  -3,-151,   8,  52, -65, -20, -36,  -5,  23, -12, -49,  -5,   3,  15, -12, -58,  26,   2,-156, -50;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	121 in 121 different sequences
Number of true positive hits	121 in 121 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Archaea, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	4Fe-4S
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

121 sequences

ACDG1_METMA (Q8PZ09), ACDG1_METTE (Q50539), ACDG2_METMA (Q8PV87),

ACDG2_METTE (Q9C4Z0), ACDG_ARCFU  (O29871), ACDG_METAC  (Q8TH44), 
ACDG_METJA  (Q57576), ACDG_METKA  (Q8TXF1), ACDG_METTH  (O27748), 
ACSC_MOOTH  (Q07340), MOBB_METJA  (Q58720), RNFB_ACEWD  (H6LC27), 
RNFB_AERHH  (A0KLJ3), RNFB_AERS4  (A4SNP6), RNFB_ALCBS  (Q0VP40), 
RNFB_ALIF1  (Q5E6B7), RNFB_ALIFM  (B5FCN4), RNFB_ALISL  (B6EGH6), 
RNFB_ALKEH  (Q0AAG8), RNFB_AROAE  (Q5P1B1), RNFB_AZOSB  (A1K5F2), 
RNFB_BUCA5  (B8D8R5), RNFB_BUCAI  (P57214), RNFB_BUCAP  (Q8KA20), 
RNFB_BUCAT  (B8D719), RNFB_BUCBP  (Q89AW9), RNFB_CERS1  (A3PRP4), 
RNFB_CERS4  (Q3IXC5), RNFB_CITK8  (A8AH09), RNFB_CLOLD  (D8GR71), 
RNFB_CROS8  (A7MMM3), RNFB_ECTM1  (A4XS52), RNFB_EDWI9  (C5BDE6), 
RNFB_ERWT9  (B2VEQ2), RNFB_HAEDU  (Q7VNT5), RNFB_HAEI8  (Q4QJQ7), 
RNFB_HAEIE  (A5UBJ1), RNFB_HAEIN  (P71396), RNFB_HAHCH  (Q2SKU5), 
RNFB_KLEP3  (B5XWQ0), RNFB_MAGMM  (A0L5G7), RNFB_METAC  (Q8TSX9), 
RNFB_PASMU  (Q9CNP1), RNFB_PECAS  (Q6D4W3), RNFB_PECCP  (C6DH16), 
RNFB_PSEA8  (B7UWJ3), RNFB_PSEAB  (Q02QX9), RNFB_PSEAE  (Q9HYB9), 
RNFB_PSEP7  (A6V1T8), RNFB_RHOCA  (P0CZ14), RNFB_RHOCB  (D5ARZ0), 
RNFB_SERP5  (A8GE01), RNFB_SHEAM  (A1S6N0), RNFB_SHELP  (A3QEN5), 
RNFB_SHEON  (Q8EE80), RNFB_SHEPA  (A8H537), RNFB_SHEPW  (B8CM57), 
RNFB_SHESA  (A0KX80), RNFB_SHESH  (A8FUX9), RNFB_SHESM  (Q0HIH9), 
RNFB_SHESR  (Q0HVF6), RNFB_SODGM  (Q2NSZ6), RNFB_STUS1  (A4VIV5), 
RNFB_THIDA  (Q3SHB7), RNFB_TOLAT  (C4LEP6), RNFB_VIBA3  (B7VLT8), 
RNFB_VIBC1  (A7MVC6), RNFB_VIBC3  (A5F2R3), RNFB_VIBCH  (Q9KT87), 
RNFB_VIBCM  (C3LTR4), RNFB_VIBPA  (Q87MX3), RNFB_VIBVU  (Q8D889), 
RNFB_VIBVY  (Q7MM82), RNFB_YERPA  (Q1C7K2), RNFB_YERPE  (Q8ZEC9), 
RNFB_YERPG  (A9R8U7), RNFB_YERPN  (Q1CIY8), RSXB_ECO24  (A7ZM88), 
RSXB_ECO27  (B7URW9), RSXB_ECO45  (B7M9Y2), RSXB_ECO55  (B7L5I1), 
RSXB_ECO57  (P58323), RSXB_ECO5E  (B5Z462), RSXB_ECO7I  (B7NU05), 
RSXB_ECO81  (B7MV10), RSXB_ECO8A  (B7M0I5), RSXB_ECOBW  (C4ZY91), 
RSXB_ECODH  (B1XF93), RSXB_ECOHS  (A8A0H1), RSXB_ECOK1  (A1ABH3), 
RSXB_ECOL5  (Q0THJ9), RSXB_ECOL6  (Q8FH96), RSXB_ECOLC  (B1IQC6), 
RSXB_ECOLI  (P77223), RSXB_ECOLU  (B7NB82), RSXB_ECOSE  (B6IB63), 
RSXB_ECOSM  (B1LEQ8), RSXB_ECOUT  (Q1RBG8), RSXB_ESCF3  (B7LQP2), 
RSXB_SALA4  (B5F6I9), RSXB_SALAR  (A9MRW7), RSXB_SALCH  (Q57PH9), 
RSXB_SALDC  (B5FIE6), RSXB_SALEP  (B5QV01), RSXB_SALG2  (B5RAK1), 
RSXB_SALHS  (B4THD5), RSXB_SALNS  (B4T595), RSXB_SALPA  (Q5PIC0), 
RSXB_SALPB  (A9N024), RSXB_SALPC  (C0Q507), RSXB_SALPK  (B5BKB1), 
RSXB_SALSV  (B4TV18), RSXB_SALTI  (Q8Z6R0), RSXB_SALTY  (Q8ZPM1), 
RSXB_SHIB3  (B2U2C7), RSXB_SHIBS  (Q320Y5), RSXB_SHIDS  (Q32FE5), 
RSXB_SHIFL  (Q83KY6), RSXB_SHISS  (Q3Z1Y3), Y119_METJA  (Q57583), 
Y2201_ARCFU (O28082)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

7 PDB

4DJD; 4DJE; 4DJF; 9ERI; 9ERJ; 9ERK; 9ERL