PROSITE entry PS51644

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51644
Entry name [info]	HTH_OST
Accession [info]	PS51644
Entry type [info]	MATRIX
Date [info]	01-MAY-2012 CREATED; 01-MAY-2012 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51644
Associated ProRule [info]	PRU00975

Name and characterization of the entry

Description [info]

OST-type HTH domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=74;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=74;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0157390; R2=0.0071836; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1098; N_SCORE=9.9; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=653; N_SCORE=6.7; MODE=1; TEXT='RR';
/DEFAULT: M0=-33; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='S';  M=   7, -38,  25,  11, -42, -49, -47,   6,  -4, -14, -17,  -6,  11,  26,  -8,  35, -12,  -1, -66, -64;
/M: SY='L';  M= -30, -33,  28, -44, -37, -89,-142,  11,  11,  39,  10,  -9,  38, -25,   3,  -9, -14,  -6, -61, -72;
/M: SY='E';  M=  -6, -75,  26,  48, -80, -66, -47, -49,  29,-104, -36,   5,  15,  16,  27,  24, -11, -30, -61, -22;
/M: SY='E';  M=  -4, -64,  37,  47, -33, -60, -25, -16,  19, -10, -35, -23, -18,  27,  16, -24,  -1, -20, -22, -35;
/M: SY='L';  M=   3,   0, -97, -80,  48,-157,-151,  26,-152,  54, -56,-154,  -2,-150,-111, -93, -46,  44, -64, -57;
/M: SY='K';  M=   8, -54, -48,   8, -55, -57, -10,  11,  47,  -7, -13,-136, -41,  21,  26,  -2,   9,  12, -37,-103;
/M: SY='R';  M=  17, -13,   6,  23, -33, -41, -20, -50,  31, -37, -35,  22,  -6,  22,  39,  16, -13, -83,-155, -42;
/M: SY='Q';  M=  -3, -56,  -6,  39, -17, -52, -18, -10,  -2,  28,  20, -13,-147,  44,  17, -96, -13, -10, -34, -25;
/M: SY='I';  M= -47, -46,-161,-155, -31,-162,-153,  67,-110,  59,  24,-155,-156,-150, -74,-148, -28,  41,-152,-133;
/M: SY='R';  M= -19,  -8, -52,   0, -57, -72,  11,  -8,  30,   5, -52, -48, -75,  27,  63, -38,  -5,  10,-151,   5;
/M: SY='E';  M=  18,-151,  27,  44, -85, -50, -44,-102,  37, -45, -35,   7, -77,  30,  14,  33, -11, -98, -69, -66;
/M: SY='L';  M=  32, -11, -95, -88, -45, -78,-150,  47,-150,  59,  -7, -66,-153, -77,-151, -23, -27,  21,-153,-136;
/M: SY='L';  M= -42, -15,-159,-109, -22,-160, -86,  41,-110,  72,   0,-155, -95,-148, -89, -47, -35,  35, -18, -55;
/M: SY='E';  M= -13, -25,  24,  32, -81, -42, -33, -11,  27, -20,  -8,   8,-103,  27,  23,  20,   6,  -9, -39,-142;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='S';  M=  20, -45,  -4,  25, -87, -38, -19, -65,  19, -32,   6,  -7, -83,  28, -11,  59,  -4, -54, -33, -27;
/M: SY='H';  M=  14,  -7,  42,   6, -15, -34,  62,-100, -15, -92, -43,  36,-147,   9,   6,  12, -30, -78, -18,  50;
/M: SY='P';  M= -27, -31,  49,  29,-157, -11,  -5,-154,  30,-125, -45,   8,  69,  -3, -24,  20, -39, -81,-159, -62;
/M: SY='N';  M= -32, -38,  55,  29,-153,  32,  -6,-120, -21, -85, -87,  55, -48,  -2, -15,  36, -37,-152,-159,  -7;
/M: SY='G';  M= -63,  14, -52, -49, -64,  86, -60,-111,  -6,-124,-147, -87,  32, -21, -14,  -6, -19, -40,  -4, -99;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='W';  M= -48, -55,-160,-153, -19,-121,-153,  47,-150,  30,  49,-154, -65, -77,-152, -41, -12,  52, 100, -10;
/M: SY='W';  M=  24, -48, -14, -43,   0, -54, -24, -69, -36,   7, -85,  18,  46, -23, -22,  27,  19, -63,  84, -23;
/M: SY='L';  M=   5,   7, -95, -86,   7, -60,   2,  16, -75,  59,  41,  -9, -24, -57, -78, -11,-136,   9,-149,  -9;
/M: SY='S';  M=  11, -85, -11, -27, -25,  11,  25, -63, -27,  15, -51, -13, -44, -49, -42,  72, -15, -58, -28, -60;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='Q';  M=  14, -37,  25,  33,-105, -31,  -2, -49,  19, -41,   5,  15, -59,  48,  24,  11, -16, -41, -78, -50;
/M: SY='L';  M= -81, -65,-117,-156,  53,-162,-151,  39,-155,  68, -83,-157,-159,-152,-154,-109, -84,  41,-144, -64;
/M: SY='P';  M= -27, -48, -46,   8,-110,  51, -35, -33,  36, -25, -41, -26,  62,  -7,  -1, -25, -37, -48, -57, -67;
/M: SY='Q';  M=  -4, -92,  17,   6, -70, -22, -61, -73,  23, -65, -65,  38,  -7,  59,   9,  40,   7, -55,-157, -62;
/M: SY='D';  M=  13, -11,  30,  27, -21,-119,  23,  -7, -29,  18,  22, -17,-148,  21,   2, -34,  -8, -23, -18,  25;
/M: SY='Y';  M= -94,-153,-155,-154,  46,-158, -21,  29,-149,  35,  40, -75,-159,-145,-147,-147,-106, -39, -62, 106;
/M: SY='K';  M= -27, -43, -99,   8, -35, -32,  26, -18,  46, -12, -11,  -4,-119,  37,  45,  12,  -7, -30,-151,  -2;
/M: SY='K';  M= -17,-153,  13,  21,-101, -84,  -7,-112,  62, -47, -25,  30,-144,  32,  50,   1, -44, -62, -15, -55;
/M: SY='K';  M= -20, -15,-139,  -2, -44,-116,  37,  -8,  44,  14,  35, -13,-147,  30,  36, -46,  11,  -9, -31, -35;
/M: SY='Y';  M= -65, -13,  21, -11,  68,-110,  29, -28, -17, -45,  -5, -22,-107,   7, -30, -19,   3, -40, -35,  78;
/M: SY='P';  M= -45,-155, -60, -63,-112,  66, -16, -87,  11,-109, -90,   6,  78, -37, -22,  17, -46, -64,-155, -69;
/I:         I=-26; MD=-67;
/M: SY='E';  M= -61, -17, -59,  34, -39, -77,  17,-112,  18, -80, -62, -51, -80,  -3,  28, -37, -37, -33,-167,  17; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='D';  M= -18, -86,  55,  10, -82, -11,  -2, -71, -13, -90,-148,  -2,  55,  28, -52,  25,  -6, -38, -17,-148; D=-26;
/I:         I=-26; DM=-67;
/M: SY='F';  M= -83,   8,-163,-157,  95,-161,-148,  16,-155,  57,  -2,-100, -81,-156,-113,-152,-142, -33,  17,-113;
/M: SY='D';  M= -67, -15,  82, -22,-156, -64,   4, -97, -17, -84, -36,  40,  63, -27,   3,   8, -85, -48,-164, -39;
/M: SY='P';  M= -20, -43, -97,  23,  11,-100,  19, -29, -65,  -1, -46, -67,  74, -25, -87,  -1, -15,  27, -19,  36;
/M: SY='R';  M=  -7, -53,  -3, -19, -99, -25,  29, -82,  37, -76, -43, -24, -98,  17,  76,  21,  -6, -46,-155, -28;
/M: SY='N';  M=  -8,-151,  41,  13, -37, -20,   6, -44,   6, -39, -87,  56, -56,  20,  -5,   6,   2, -11,  29, -15;
/I:         I=-19; MD=-49;
/M: SY='Y';  M=-150, -34,-114,-154,  53,-121,  19, -66,-150,  38, -33, -85,-163, -90, -89, -62,-144, -79, -25, 108; D=-19;
/I:         I=-19; MD=-49;
/M: SY='G';  M=-134,-160, -61, -75,-165, 100, -47,-171, -69, -93,-157, -46, -94, -42,-157, -90,-115,-123,-158,-160; D=-19;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='Y';  M= -44,  35,-158,-117,  78, -60,  32,-108, -96, -74,-135,-107,-165, -84, -80, -49, -89,  -6, -49,  94; D=-19;
/I:         I=-19; DM=-49;
/M: SY='S';  M=  -6,  15,  -8, -43, -87, -55, -74, -67,  36, -50, -28,   8,   3,  -7,  23,  40,  10, -29, -56,   7; D=-19;
/I:         I=-19; DM=-49;
/M: SY='K';  M= -70, -66,   0, -63, -83, -49, -36,-155,  70,-112,-147,  21, -34,  -9,  18,  54,  17,-116,-160, -97; D=-19;
/I:         I=-19; DM=-49;
/M: SY='L';  M= -53, -60,-162,-156,  51,-162, -92,   1,-155,  74,  37, -67, -57, -96,-108,-116, -25, -14, -52, -97; D=-19;
/I:         I=-19; DM=-49;
/M: SY='S';  M= -25,-150, -16,  27, -31, -19, -74,  -4, -13, -13,   4, -29, -60,  13, -11,  59,  25, -25, -71, -74; D=-19;
/I:         I=-19; DM=-49;
/M: SY='D';  M= -10, -53,  73,  54,-105, -68,  25,-154,   5, -84, -45,  -5, -12,  16, -18,  16,  -6, -73,-162, -71;
/M: SY='L';  M= -60,-147,-108,-153,  69,-120,-144, -15,-152,  74,  46, -58,-159, -38,-151,-113, -66, -31,-139, -25;
/M: SY='L';  M= -47, -58,-161, -91,  11,-162,-151,  52,-111,  67,  18,-156,-157,-150,-153,-149, -65,  41,-150,-130;
/M: SY='E';  M=  -4, -61,   6,  44, -41, -20, -25, -61,  40, -32, -33,  -6, -78,  38,  41,  16, -33, -52,-155,-142;
/M: SY='S';  M=  43, -11,  23,   6, -85, -58,  -7, -32,  22, -36, -47,  -7,-144, -34, -13,  54,  -4, -80,   6, -45;
/M: SY='M';  M=  -4,   5, -55, -35,  -4,-118, -18,  40, -71,  39,  67, -61, -76, -22, -40, -28,  13,  -3,  24,   0;
/I:         I=-23; MD=-58;
/M: SY='P';  M= -14, -30, -15, -21,-163, -33, -15, -91,   2, -59, -39, -32,  83,   2, -23,  21, -20, -66,-166,-157; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='D';  M= -76, -85,  82,  15, -24,  22,  34,-163, -21,-131, -90,  32, -82, -19, -31, -27, -47,-160,-167, -39; D=-23;
/I:         I=-23; DM=-58;
/M: SY='I';  M= -27,-149, -38, -34,  -7, -18, -19,  41, -27,  24, -10, -15, -53, -33, -35, -40,  20,  41, -28,  19;
/M: SY='V';  M= -29,  53, -65, -52,  59, -53,-150,  16, -73,  13, -33, -51, -66,-151, -64, -80, -52,  64,-146,   1;
/M: SY='E';  M= -34, -61,  12,  56, -68, -68,  21, -21,  19, -38, -60, -78,-143,  28,  25,  -1,  26,   9,  -9, -51;
/M: SY='I';  M= -73, -64, -92, -78,   0,-120, -70,  56,-110,  35,  22, -79, -48,-147,  -3, -88,  12,  56, -58, -66;
/M: SY='E';  M= -52, -47,   7,  48,-111, -64,  16,  -8,  34, -63, -19, -26, -70,  39,  14,  -2,   9,   9, -38,   8;
/M: SY='Q';  M= -79,   4,  22,  22, -36,   0,   3, -29,  25, -72, -48,  10, -14,  31,  30,   2,   4, -24,  24,   7;
/M: SY='P';  M= -46, -34,  31,  16, -49,   8,  -4, -18,  16, -32, -38,   0,  34,  17,  10,  14, -17, -11, -32, -20;
/I:         I=-29; MD=-75;
/M: SY='P';  M= -46, -85,   2,  27, -53,  33,  -9, -67, -21, -32, -50,  29,  42, -34,  16,  -5, -11, -71,-161, -57; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='G';  M= -22, -54,  26,   3,-113,  43,  13,-114,  21, -91,  -3,  28,  19, -10, -17,  33,  -5,-150,-158, -40;
/M: SY='G';  M= -26,-152,   5, -10, -28,  50,   2,-150,  21,-103, -20,  40, -27,  34,  -9,  14,  -5, -28,-155, -47;
/M: SY='Q';  M= -27, -84,  23,   5,-115, -20,  32,   1,   3, -44, -39,  36,  -7,  50,  11,  -8,  21,  -9, -18,-141;
/M: SY='W';  M=  -9,  28,-109, -64,   7, -78,   0,  24,   6,   9,  -6, -68, -12,-143, -14, -74, -12,  39,  74,  35;
/M: SY='Y';  M= -53, -24, -79, -36,  20,-105,  26,  27, -23,  16,  34,-145, -71,  -7,   5, -24,  -3,  28,  30,  49;
/M: SY='V';  M=  -3, -22,-107,-150, -33,-101, -49,  51, -95,  22, -41,-151, -43,  -9, -30, -36, -43,  69,-155, -35;
/M: SY='Y';  M= -33,   8, -26, -57,  16, -43,  15, -18,  16,   0,-133, -35,-103, -13,  52,  16, -15, -20, -14,  52;
/M: SY='P';  M=  15, -97,   2, -24, -61, -41,   1,  16, -32,  34, -10, -29,  44, -39,  -5, -24, -16,   4, -10, -78;
/M: SY='K';  M=   3,  -7, -40, -32, -45, -83,   0, -30,  57, -43, -48,   8,  14,  -7,  36,   5, -22,   6, -58, -24;
/M: SY='P';  M= -16, -61,  27,  22,-107,  -8, -61, -94,  27, -46, -30,  13,  31, -53,  15,  17,   0, -15, -22, -15;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	117 in 33 different sequences
Number of true positive hits	117 in 33 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	8
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	HTH OST-type
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

33 sequences

C3H18_ARATH (Q9SJ41), C3H51_ORYSJ (Q84ZT0), C3H54_ORYSJ (Q6ZK57),

LRR2_PLAF7  (C6KSS5), MARF1_BOVIN (E1BP74), MARF1_CHICK (E1BZ85), 
MARF1_HUMAN (Q9Y4F3), MARF1_MOUSE (Q8BJ34), MARF1_RAT   (Q8VIG2), 
MARF1_XENTR (B2GUN4), OSKA_DROME  (P25158), OSKA_DROVI  (Q24741), 
TDRD5_AILME (D2H3M0), TDRD5_BOVIN (E1BPH3), TDRD5_CANLF (E2QTD3), 
TDRD5_DANRE (Q1L981), TDRD5_HUMAN (Q8NAT2), TDRD5_MOUSE (Q5VCS6), 
TDRD5_RAT   (B4F7C4), TDRD5_XENLA (A1L1H3), TDRD5_XENTR (A0JM98), 
TDRD7_AILME (D2H0H6), TDRD7_BOVIN (A6QLE1), TDRD7_CANLF (E2RDV1), 
TDRD7_CHICK (E1C3S7), TDRD7_HUMAN (Q8NHU6), TDRD7_MOUSE (Q8K1H1), 
TDRD7_PONAB (Q5RAH6), TDRD7_RAT   (Q9R1R4), TDRD7_XENLA (Q6NU04), 
TDRD7_XENTR (Q5M7P8), TRD7A_DANRE (A6NAF9), TRD7B_DANRE (E7FDW8)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

11 PDB

2LH9; 2LY1; 2LY2; 3RCO; 3S93; 5A48; 5A49; 5CD7; 5CD8; 5NT7; 5YAD