PROSITE entry PS51626

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51626
Entry name [info]	SAM_MT_TRM1
Accession [info]	PS51626
Entry type [info]	MATRIX
Date [info]	01-NOV-2011 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51555
Associated ProRule [info]	PRU00958

Name and characterization of the entry

Description [info]

Trm1 methyltransferase domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=381;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=376;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5641465; R2=0.0073400; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=59129.0000000; R2=0.0000000; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=1286; H_SCORE=59129; N_SCORE=12.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=537; H_SCORE=59129; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-34; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='T';  M=   5, -88,   8,   9, -87, -45, -37,   1,  18, -77,  45, -23,  -6,   5,  11,  12,  45,  10, -98, -82;
/M: SY='E';  M= -17, -51, -49,  34,  -5, -50,   5,  29, -17,  19, -66, -81, -88, -40, -11, -14,  20,  30,   9,   6;
/M: SY='I';  M= -41, -25, -94, -59,  -5, -73,  27,  74, -89,   3, -59, -44, -23, -29, -60, -46, -15,  45, -89,  18;
/M: SY='R';  M= -43,  -6, -73,  22, -90, -87, -12, -11,  40, -84, -78, -17, -29,  39,  48,  11,  43,  -7, -96, -40;
/M: SY='E';  M= -62, -99,  -4, 111,-101, -75, -71,-102, -39, -94, -90, -73, -37,  -8, -69, -56, -78, -94, -98, -91;
/M: SY='G';  M= -36, -93, -80, -47, -97,  98, -85,-104, -50,-100, -22, -23, -86, -81, -23,  -9, -82, -98, -91, -30;
/M: SY='K';  M=  -4, -90, -51,  -6, -86, -22, -77, -59,  58,  15,  -1, -33, -85,  27,  34,  27,   4, -61, -93, -81;
/M: SY='A';  M=  74, -81, -60, -81, -85, -48, -88,  -7, -80, -55, -16, -40, -48, -80, -34, -16,  38,  37, -97, -84;
/M: SY='K';  M= -32, -92, -51,  38, -66, -57,  -5, -27,  56, -26, -77, -30, -31,  11,  34, -14,  39, -16, -94, -19;
/M: SY='I';  M= -82, -21,-100, -96,  48,-102, -31,  82, -43,  23, -23, -92, -36, -92, -94, -45, -31,  17, -85, -66;
/M: SY='L';  M= -42, -16, -42,  -1,   8, -52, -80,  26,  16,  42, -62, -36, -27, -11, -20, -27, -23,   5, -27,  41;
/M: SY='V';  M=   7, -88, -64, -88,  45, -67, -89,  41, -29,   2, -10, -34, -37,  -1, -50, -28, -15,  55, -87, -21;
/I:         I=-13; MD=-33;
/M: SY='P';  M= -58,-115, -16, -16,-110, -71,  -3, -78, -11, -80, -97, -71, 104, -40, -94, -36, -55,-104,-108, -52; D=-13;
/I:         I=-13; MD=-33;
/M: SY='D';  M= -23, -45,  43,  33,-112, -98, -15,-108,   9, -67, -34,  19,  -1,  12, -12, -29, -69, -76,-116,-101; D=-13;
/I:         I=-13; MD=-33;
/M: SY='Q';  M= -42,-113,   0, -30, -24, -32, -44, -24, -38, -33,  -6, -10,  12,  24, -33,  -6, -23, -51,-110,  -5; D=-13;
/I:         I=-13; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='K';  M= -25,-117, -31,  -9, -54, -20,  -3, -50,  17, -85,-105,   2, -18, -41,  -6, -34, -26, -46,-118, -25; D=-13;
/I:         I=-13; DM=-33;
/M: SY='N';  M= -42, -58, -52, -17,  -5, -11, -57, -37,  10, -15, -94,  20, -47, -48, -29, -96, -24, -22,-108,   7; D=-13;
/I:         I=-13; DM=-33;
/M: SY='E';  M= -47,-115,  15,  41,-113, -51, -99, -26, -28, -62,-101, -93,  21,  -1, -52, -16, -23, -12,-119,-107; D=-13;
/I:         I=-13; DM=-33;
/M: SY='P';  M= -45,-113, -26, -38, -14, -23,-100, -21, -57, -46, -97, -32,  71,  -7,-103,   6, -23, -45,-111, -49; D=-13;
/I:         I=-13; DM=-33;
/M: SY='A';  M=  25,-101, -16,  -9, -50,   2, -91, -69,  16, -80, -95,  -6,  -8,   3, -50,  22, -16, -43,-106, -33; D=-13;
/I:         I=-13; DM=-33;
/M: SY='W';  M= -21,-103,  -5,  20, -46, -20,  27, -43,  28, -82, -40,  14, -38, -38,   4,  -9,  -9, -52,  90, -81; D=-13;
/I:         I=-13; DM=-33;
/M: SY='N';  M=  24, -89,  11,  23, -38,  29, -35, -85, -25, -27,  19,  49, -47,  32, -40,   1,  -3, -30, -97, -84;
/M: SY='P';  M= -16, -96,  12,  42, -97,  -3, -29, -94,   1, -96, -87,   7,  81,   8, -59,  18,  -4, -91, -19, -38;
/M: SY='V';  M=  40, -83, -94, -89, -58, -12, -95,  -1, -88, -52,  -1, -87, -91, -88, -91, -41,   2,  84,-100, -81;
/M: SY='F';  M= -93, -89,-105,-100, 125,-100, -84, -67, -95, -58, -68, -94,-103, -43, -93, -91, -85, -72, -58, -14;
/M: SY='Y';  M= -89, -22, -91, -93,  44, -97, -19, -11, -86, -23, -66, -90,-101, -82, -83, -85, -83, -74, -50, 127;
/M: SY='N';  M= -80, -87, -56, -73, -94, -71, -62, -55, -34, -99, -86, 122, -91, -66,  35, -64, -66, -94,-110, -88;
/M: SY='P';  M= -20,-102, -82, -58, -99, -54, -27, -91,   0, -60, -85, -37, 115, -77,  17,  -3, -53, -92, -96, -94;
/M: SY='V';  M=  30, -89,   3,   8, -26, -88, -13,  20,  12, -25, -70, -79, -40,  -7,  27, -27, -47,  46, -94, -24;
/M: SY='M';  M=   1, -91, -81, -41, -87, -30, -71, -75, -69, -47, 101, -73, -85,  98, -70,  28, -47, -77, -92, -76;
/M: SY='E';  M=  17, -92, -72,  54, -90, -88, -46, -21,  22, -36, -76, -48, -84,  46,  44, -25, -41,  26, -95, -83;
/M: SY='F';  M= -43, -34, -52, -56,  82, -61, -56,  11, -61,  17,   8, -14,   1, -12, -39, -84, -13,  24, -77,   1;
/M: SY='N';  M=  -7,   7, -45, -39, -94, -16, -65, -91, -68, -97, -86, 115, -89, -14, -76,   8, -28, -45,-109, -89;
/M: SY='R';  M= -85,-101, -81, -69, -93, -95, -70,-100, -26, -93, -81, -74, -93, -57, 120, -79, -83, -94, -93, -80;
/M: SY='D';  M= -84, -98, 119, -28,-105, -82, -71,-102, -45,-101, -99, -53, -84, -26, -80, -40, -23, -99,-118, -88;
/M: SY='L';  M= -66,  -2,-100, -94, -14,-102, -89,  50, -91,  70,  34, -95, -97, -88, -30, -64, -23,   8, -90, -72;
/M: SY='S';  M=   5, -82, -14, -76, -90,   8, -81, -46, -76, -89, -84, -65, -81, -72, -82,  87,  58, -38,-100, -85;
/M: SY='V';  M= -55,   8, -99, -94, -16,-100, -98,  51, -61,  -5, -12, -92, -94, -92, -93, -32, -11,  83, -98, -76;
/M: SY='L';  M=  41,  24, -91, -19, -47, -88, -52,   0, -86,  62,  -3, -88, -93, -21, -88,  -3, -30,  -5, -93, -77;
/M: SY='A';  M=  56,  15, -91, -87, -11, -44, -90,  11, -86,   0,  18, -43, -90, -84, -89,  -5, -22,  54, -94, -44;
/M: SY='I';  M=  31, -88, -96, -91, -31, -51, -91,  66, -54,  40, -58, -90, -92, -87, -91, -50, -15,  19, -21,   2;
/M: SY='R';  M=  14, -90, -41, -21, -49, -60, -75, -36,  52, -55, -80,  25, -85,  22,  55,  25,   3, -43,  -2, -46;
/M: SY='A';  M=  59,  -5, -61, -14, -84, -60,   5,  -8, -28, -14, -46, -17, -86,  28, -80, -12,  31,  22, -13, -46;
/M: SY='Y';  M= -26, -38, -94, -59,  74, -95,  32, -51, -86,  22,  23, -44, -98, -37, -39, -85, -57, -28,  59,  81;
/M: SY='A';  M=  35, -22, -16, -50,  15,  15, -25,  15,   3, -21, -75,   4, -55,  21,  13,  28, -73, -37, -90, -39;
/M: SY='E';  M= -27, -93,  -5,  53, -55, -60, -75, -14,  28, -35, -23,   3,  19,  16,  36,  31, -38, -49, -96, -84;
/M: SY='E';  M= -46, -93,   8,  39, -19, -24,  15,  -6,  35,  -3, -25,  15, -28,  19,  25,  -1,  -7, -66, -33, -44;
/I:         I=-3; MD=-9;
/M: SY='R';  M= -51, -54,-109, -67, -53, -21, -22, -80, -35, -27, -36, -56, -80, -21,  42, -32, -22, -23, -11,   5; D=-3;
/I:         I=-3; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='P';  M= -28,-123,   5, -39, -50, -47,-108, -52, -15, -37,-105, -60,   7,  -3,  -4,-103, -22, -28, -24, -27; D=-3;
/I:         I=-3; DM=-9;
/M: SY='C';  M= -37,  20, -24, -14, -33,  -9, -28, -42,   3, -34, -43,  -9,  15, -57, -17,  -3, -13, -45, -40, -70; D=-3;
/I:         I=-3; DM=-9;
/M: SY='Q';  M= -33,-102,  -4,  -3,  -3,  -3,   1, -29,   8,   4, -83,  -5, -12,  30,  14, -11, -17, -89,-100, -37; D=-3;
/I:         I=-3; DM=-9;
/M: SY='P';  M= -21, -46,  11,  16, -52,  28, -14,-100,  22, -47, -91,  -6,  32, -19,  16, -23, -56, -98, -24,   5; D=-3;
/I:         I=-3; DM=-9;
/M: SY='P';  M= -46,-101, -10,   7, -58,  38,   5, -60,   9, -53, -90,   3,  48,  12,  -9,  15, -61, -66,-101, -59; D=-3;
/I:         I=-3; DM=-9;
/M: SY='F';  M= -21, -95,-100, -39,  47, -42, -93,  43, -44,  43, -18, -55,  11, -92, -44, -66, -56, -15, -88, -34; D=-3;
/I:         I=-3; DM=-9;
/M: SY='R';  M= -29, -37, -24,  -1,  -9, -86, -17,  -9,   9, -34, -76,  31, -86, -22,  55,   6,  49,   5, -96, -37;
/M: SY='I';  M=  -8,  44, -99, -95,  19, -54, -93,  65, -92,  -3, -36, -92, -95, -92, -94, -84, -37,  56,  -1,  26;
/M: SY='L';  M= -13,  35,-100, -94,  -5, -69, -89,  21, -94,  79, -51, -96, -48, -89, -93, -89, -52,  -5, -90, -72;
/M: SY='D';  M= -82, -98, 101,  70,-102, -86, -71, -49, -67, -97, -95, -60, -41, -22, -76, -73, -26, -95,-110, -89;
/M: SY='A';  M=  78, -11, -86, -80, -91,  20, -88, -58, -52, -24, -78, -80,  55, -80, -87, -37, -26, -24, -94, -90;
/M: SY='M';  M= -62, -87, -99, -92,  36, -99,  -8, -23, -46,  73,  87, -54, -97, -85, -88, -90, -36, -60, -85, -65;
/M: SY='S';  M=  58,  21, -79, -55, -91,  11, -28, -60, -78, -59, -83, -69, -83, -41, -83,  76,   6, -78, -97, -86;
/M: SY='A';  M=  82, -83, -83, -82, -94,  59, -86, -89, -82, -90, -83, -45, -84, -79, -87, -19, -26, -78, -92, -49;
/M: SY='T';  M= -51,  65, -77, -49, -86, -79, -84, -30, -77, -51, -80, -67, -82, -76, -84,  70,  85, -39,-104, -84;
/M: SY='G';  M= -45, -28, -82, -55,-100, 104, -88,-107, -86,-103, -92, -68, -36, -84, -61, -67, -85,-101, -92, -95;
/M: SY='V';  M=  -8, -87,-100, -94, -66,-100, -94,  55, -49,  54, -21, -95, -96, -90, -93, -87, -75,  58, -94, -75;
/M: SY='R';  M= -84,-100, -80, -38, -92, -61, -70, -98, -23, -61, -18, -33, -52, -58, 116, -78, -82, -92, -93, -80;
/M: SY='G';  M=  45, -86, -80, -82, -95,  69, -28, -93, -81, -94, -86, -69, -46, -76, -86,  62, -25, -60, -95, -89;
/M: SY='I';  M= -44,  -4,-100, -96, -43,-103, -93,  79, -93,  53,  -4, -39, -95, -45, -52, -89, -77,  17, -92, -74;
/M: SY='R';  M= -84,-101, -80, -48, -93, -94, -70, -99, -24, -60, -81, -74, -93, -21, 118, -79, -83, -93, -93, -80;
/M: SY='Y';  M= -32, -96, -92, -61,  28, -62, -67,  11, -47, -26, -66, -91, -98, -83, -84, -85, -82,  -1,  68, 117;
/M: SY='A';  M=  75,  -5, -87, -81, -44, -17, -84, -36, -32,  18, -71, -81, -88, -30, -84,  10, -37, -12,  -9,  18;
/M: SY='K';  M= -33, -90, -79, -49, -80, -66,   2, -38,  65,  35, -68,  24, -88,   7,  16, -42,  -7,  13, -94, -46;
/M: SY='E';  M= -77, -98, -51, 111, -98, -92, -14,-100, -60, -93, -89, -43, -74,   9, -69, -30, -77, -68, -96, -31;
/M: SY='I';  M=  28, -18, -50, -87, -74, -17, -90,  49, -41,  31, -62, -27, -90, -83, -89,  17,  -3,  33, -95, -79;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='P';  M= -55,-114,  11, -28,-116,  -7, -43, -62, -20,-114,-105,  -4,  65, -20, -99,  10, -11,-109, -26,-108; D=-17;
/I:         I=-17; DM=-44;
/M: SY='G';  M= -45,  -5, -10,  -8,   2,  45,  17, -30,  11, -44, -26,  28, -36, -20, -43, -14, -31, -28, -97,  -3; D=-17;
/I:         I=-17; DM=-44;
/M: SY='V';  M=  27, -38,   4, -51, -52,   4, -88,  22, -25, -21, -22,   5, -12, -82, -13, -33, -25,  53, -97, -26; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -31, -24,  39,  34, -25,   5,  -6,   2,  18, -17, -41,  -5,   2, -13,  -2,   1,  11, -21, -97, -82;
/M: SY='K';  M= -21, -15, -20,  42,  18, -52,  25, -48,  43, -61, -37,   0, -18,   2,  15,  14, -25, -26,  31,   4;
/M: SY='V';  M=  -4, -87, -97, -61, -72, -18, -98,  61, -56,  -8, -60, -90, -93, -90, -93, -81, -15,  77, -98, -79;
/M: SY='W';  M= -78, -32, -93, -91,  24, -97,  13,  48, -87, -18,  -5, -85, -91, -88, -61, -78,  55,  45,  78,  24;
/M: SY='A';  M=  66,  -8, -92, -58,   6, -35, -89,  31, -86,  22,  19, -85, -90, -83, -89, -18, -37,   8, -91, -77;
/M: SY='N';  M= -78,   4, -38, -48, -93,   0, -64, -30, -68, -85, -86, 120, -90, -70, -77, -24, -66, -53,-110, -89;
/M: SY='D';  M= -58, -98, 120,  -1, -50, -82, -71,-101, -72,-100, -99, -54, -84, -71, -81, -73, -75, -72,-117, -87;
/M: SY='I';  M=  23, -89, -94, -89,  -5, -64, -37,  63, -12,  40,  -7, -33, -92, -83, -16, -38, -35,  -4,   5, -33;
/M: SY='D';  M= -41,  -5,  78, -45, -94, -74, -35, -92, -28, -27, -88,  68, -86, -69, -78,  61, -53, -90,-109, -86;
/M: SY='P';  M=   6, -35,   5,  35, -98, -33, -81, -41,  26, -73, -85, -76,  89, -16, -21,   8, -39, -67, -97, -91;
/M: SY='D';  M=  17, -90,  52,  29, -91, -80,  -5, -30,   7, -32, -82,  33, -21,  -9,  12,  24,   3, -48,-100, -40;
/M: SY='A';  M=  86, -10, -84, -78, -37, -39, -84, -54, -55, -21, -31, -22, -85, -76, -30,  31, -36, -47, -94, -85;
/M: SY='V';  M=   8,  10, -94, -89,  -7, -68, -27,  28, -39,   2, -44, -89, -35, -24, -16, -46, -33,  69,  -2,  28;
/M: SY='E';  M=  -7, -95,  20,  72, -94, -65,  -3, -75,  20, -78, -37,  -8,  17,  15,  18, -10,   1, -89, -95, -10;
/M: SY='L';  M=  13,  19, -89, -45, -26, -59, -82,  14, -60,  50,  -1, -26, -93, -23, -29,  18,  -3,  -3,  -4,  29;
/M: SY='I';  M=  10,  17,-100, -96, -30, -62, -94,  91, -92,   5,  60, -91, -92, -88, -95, -48, -76, -29, -91, -74;
/M: SY='K';  M= -50, -28, -27,  32, -91, -89, -38, -87,  64, -20,  -3, -49, -84,  37,  56, -43,  15, -36, -32, -81;
/M: SY='R';  M= -12, -95,  -1,  29, -48, -45,  12, -64,  37, -15, -13,  -7, -86,  29,  65, -45, -33, -67, -90,  16;
/M: SY='N';  M= -35, -85, -54, -75, -93, -41, -62, -92, -67, -61, -86, 125, -90, -68, -75, -19, -64, -94,-112, -89;
/M: SY='I';  M=  23,  18, -97, -91, -13, -66, -28,  52, -71,  39, -12, -90, -94, -87, -50, -29, -59,  46, -93, -75;
/M: SY='E';  M=   4, -25,  12,  56, -93, -58,  16, -38,  50, -49, -44, -35, -82,  13,  19,  13, -22, -35, -97, -83;
/M: SY='H';  M=  -6, -91, -86, -24,  19, -48,  60,  -8, -27,  51, -40, -31, -25, -25,  16, -21, -79, -48, -84,  37;
/M: SY='N';  M= -54, -17, -35, -53, -25, -72, -65, -10, -69, -34, -81, 119, -91, -70, -77, -22, -66, -39,-106, -43;
/M: SY='G';  M=  -3,  -3,  19,   7, -50,  60, -44, -94,  29, -39, -85,  47, -11, -10, -75, -15, -76, -58, -97, -88;
/M: SY='V';  M= -32, -41, -64, -59, -33, -35, -90,  41, -50,  46, -59, -50,   3, -22, -11, -13, -41,  49, -94, -77;
/M: SY='D';  M=  -8, -27,  52,  41, -94,   7, -45, -90,  11, -73,  -2, -30,  18,   4, -18,  36, -17, -33, -99, -43;
/M: SY='D';  M=   5,   9,  52,  16, -91, -13,  33, -51,  -9, -40, -17,  27,   3, -29, -15,  15,  -3,  -8,-102, -47;
/I:         I=-4; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='K';  M= -56, -12, -93, -46, -40, -41, -45,  -5,  41, -12, -34, -19, -41,   2,  40, -23, -35, -15,-106, -92; D=-4;
/I:         I=-4; DM=-10;
/M: SY='V';  M=  -8,  10, -34, -96, -76, -66,  14,  52, -47, -17, -68, -93, -99, -93, -96, -48, -30,  57,  38,   2; D=-4;
/I:         I=-4; DM=-10;
/M: SY='E';  M= -22, -91,  -6,  49, -32, -86,  21, -15,  34, -51, -34,   8, -59,  21,  15,   9,  18,   7, -97, -80;
/M: SY='V';  M=  10, -45, -92, -58, -46, -91, -93,  36, -86, -20, -12, -88,  43, -86, -54,  -3,   4,  68, -16, -41;
/M: SY='N';  M= -29, -86, -43, -24,   3, -81,  30, -24, -52,  -9, -27,  49, -54, -16, -35,  49,  43,  -6, -15,  24;
/M: SY='N';  M= -52,  56, -47,   6, -45, -41,  63, -86,  14,  -9, -77,  63, -41,  27,  10, -12, -22, -32, -10,  -5;
/M: SY='M';  M=   0,   8,  11,  22, -38,  31,  -6, -88,  25, -42,  38,  23, -40,   4,  12,   5, -14, -63, -96, -83;
/M: SY='D';  M= -64, -96, 106,  30, -98, -47, -71, -97, -71, -43, -93,  22, -38, -69, -50, -12, -74, -68,-110, -27;
/M: SY='A';  M=  92,  20, -85, -51, -52, -41, -87, -58, -80, -25, -76, -80, -85, -41, -59, -34,  -5, -28, -94, -86;
/M: SY='N';  M= -29,  37, -50, -51, -88, -40, -29,  -3, -48, -30, -21,  96, -91, -38,  43,   9, -26, -41,-104, -85;
/M: SY='A';  M=  29,   8,   0, -21, -19, -49, -82,   0,   7, -13,   7,  -3, -39, -17,  17,  11,  10,  29, -96, -80;
/M: SY='L';  M= -25,  -1, -96, -60,  31, -98,   2,   3, -90,  69, -32, -55, -98, -87, -51, -44, -44,  13, -83,  27;
/M: SY='M';  M= -30, -87, -97, -41,  12, -76, -78, -54, -68,  56, 115, -47, -62, -26, -55, -88, -78, -32, -88, -68;
/M: SY='H';  M=  15, -41, -47, -28,  -5, -86,  78,  -8, -39,  -7,  -8,  15, -49,   7,   8,  -9, -33, -77, -79,  74;
/M: SY='E';  M= -32, -35,  18,  53, -50, -36,   7, -71,  -6, -36, -25,  24, -33,  49,   8,  37,  -8, -88, -10, -82;
/M: SY='H';  M= -27,  35, -12,  -8,  -8, -61,  69,  -5, -21,  15,  17,  29, -63,   6,  35, -16, -19, -36, -96, -29;
/I:         I=-17; MD=-42;
/M: SY='R';  M= -16, -39, -18, -12,  -9, -48,  20, -31,  29, -41, -33, -78,  26,   1,  34,  20,  -4, -37,  10,  17; D=-17;
/I:         I=-17; MD=-42;
/M: SY='R';  M= -10,  -2, -41, -16,  14,  16,  -6, -94,  15, -19, -30, -18, -23,  -1,  21, -12, -19, -63, -15, -30; D=-17;
/I:         I=-17; MD=-42;
/M: SY='R';  M= -32,-116, -35,   2, -45, -50, -36, -39,   6, -79, -22, -22,  11,  -3,  18, -47, -18, -52,-113, -13; D=-17;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='E';  M= -34,-120,   4,  28,-113, -18, -60, -12,   0, -62,-105, -31, -74, -14, -30, -47, -48, -58,-119, -23; D=-17;
/I:         I=-17; DM=-42;
/M: SY='R';  M= -25, -54, -53, -15,  15, -22, -52, -47,  35, -17,  -5, -54,  -8,  21,  52, -38, -59, -64, -90,  19; D=-17;
/I:         I=-17; DM=-42;
/M: SY='F';  M= -64,  10,-101, -97,  98, -68, -81, -33, -93, -29, -19, -94, -40, -44, -91, -89, -83,  13,  14,  70; D=-17;
/I:         I=-17; DM=-42;
/M: SY='D';  M= -61, -97, 110, -13, -52, -38,  41,-101, -72, -98, -95,   2, -54,  -9, -79, -26, -45, -98, -25, -83;
/M: SY='V';  M= -23, -51, -98, -94,  46, -99, -22,  39, -56,   2,   9, -93, -96, -90, -90, -62, -75,  65,  -3,  51;
/M: SY='I';  M= -58, -89,-102, -98, -69,-104,-103,  86, -94, -42, -56, -94, -94, -94, -97, -87, -52,  75, -97, -76;
/M: SY='D';  M= -85, -99, 121, -49,-104, -82,  22,-104, -73,-101, -99, -53, -85, -71, -80, -73, -75,-101,-121, -86;
/M: SY='L';  M= -82, -89,-102, -96, -38,-105, -93,  62, -95,  71, -50, -98, -98, -91, -95, -92, -77,  31, -91, -72;
/M: SY='D';  M= -85, -98, 122, -26,-105, -82, -71,-101, -72,-101,-100, -53, -84, -72, -81, -73, -75, -56,-120, -88;
/M: SY='P';  M= -15, -34, -83, -38,-102, -83, -86, -91, -80,-100, -87, -87, 124, -82, -91,   2, -74, -94, -97, -99;
/M: SY='Y';  M= -91, -94, -95, -95,  96, -98, -22, -70, -89, -64, -68, -91,-102, -90, -86, -87, -84, -75, -51, 110;
/M: SY='G';  M= -66, -94, -82, -93,-100, 105, -88,-108, -87,-103, -93, -67, -86, -84, -94, -26, -84,-101, -91, -95;
/M: SY='S';  M= -21,   5, -75, -76, -89, -49,  -7, -85, -75, -66, -83, -64, -45, -71, -56,  91,  66, -55,-102, -83;
/I:         I=-45; MD=-115;
/M: SY='P';  M=  49,   3, -27, -75, -40, -56, -87, -62, -81, -93, -84, -44, 105, -81, -90,  -2, -73, -40, -97, -93; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='A';  M=  65, -35, -85, -81, -49, -50, -87,  20, -81, -50,  -2, -34, -86, -45, -86,  46,   9,  25, -96, -83;
/M: SY='P';  M=  -5, -52,  -8,   5, -97, -47, -83, -22, -40, -92,  -6,  -5, 109, -14, -69, -36, -34, -38, -98, -94;
/M: SY='F';  M= -91, -91, -98, -96, 111, -98,  19, -45, -91, -34, -67, -55,-101, -65, -89, -88, -40, -52, -58,  70;
/M: SY='L';  M= -63, -88,-102, -96,  -6,-103, -91,  58, -94,  70,  14, -97, -97, -90, -94, -91, -37,  20, -90, -71;
/M: SY='D';  M= -60, -97, 106,  11, -65, -55, -71, -99, -70, -62, -94,  -6, -14,   5, -10,  -3, -47, -96,-110, -46;
/M: SY='S';  M=  58,  20, -28, -77, -57,  10, -82, -88, -78, -70, -84, -44, -13, -14, -83,  71,   2, -79, -13, -86;
/M: SY='A';  M=  94,  10, -86, -79, -53, -38, -88, -56, -81, -82, -78, -79, -85, -78, -86,  -4, -38,  -4, -94, -87;
/M: SY='V';  M= -24,  -5, -99, -94,  36, -98, -92,  42, -92,  47,  12, -55, -96, -90, -93, -16, -75,  52, -12, -68;
/M: SY='Q';  M= -15, -95, -48, -43, -59, -69, -13, -89,  28, -18, -31,   1, -87,  90,  56,   4, -35, -88,  29, -51;
/M: SY='C';  M=  64,  75, -82, -80, -89, -28, -84, -82, -80, -44, -80,  -3,  -5, -78, -45,  48,   2, -21, -98, -42;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='V';  M=  17, -12, -71, -90, -73, -49, -94,  40, -64,  24, -30, -89, -65, -88, -91, -16,   3,  67, -98, -79;
/M: SY='K';  M=   2, -25, -40, -19, -93,  -3, -40, -65,  62, -70, -34, -16, -14, -48,  60,  17,  -2, -31, -95, -84;
/I:         I=-15; MD=-37;
/M: SY='D';  M= -42, -95,  64,  -3, -29, -85,  55, -26,  28, -41, -83,  39,  -4, -68,  35, -20, -49, -45,-103, -48; D=-15;
/I:         I=-15; MD=-37;
/M: SY='G';  M= -78, -99,  32, -15,-102,  77, -38,-105,  -9, -46, -93,  26, -43, -46,   2, -74, -85,-102,-101, -95; D=-15;
/I:         I=-15; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='G';  M= -15, -96, -86, -95, -55,  95, -92,-106, -90,-104, -95, -73, -90, -52, -97, -20, -24, -69, -96, -97; D=-15;
/I:         I=-15; DM=-37;
/M: SY='L';  M= -65, -32,-101, -94, -15,-101, -26,  38, -93,  70,  50, -96, -98, -87, -92, -63, -79,   7, -13,  22;
/M: SY='L';  M= -64, -87,-102, -95, -38,-103, -90,  35, -95,  78,  19, -99, -99, -89, -93, -92, -78,  29, -91, -72;
/M: SY='C';  M=  23, 108, -89, -39, -11,  18, -83, -82, -85, -11,  21, -81, -95, -84, -44,  15, -51, -50, -88,  47;
/M: SY='V';  M= -18,   6,-101, -95,  -1,-100, -97,  50, -93,  22,   9, -95, -96, -92, -94, -86, -73,  77, -95, -74;
/M: SY='T';  M= -18, -79, -75, -78, -85, -84, -85, -76, -75, -81, -16, -65, -77, -43, -83,  -8, 115, -69,-104, -83;
/M: SY='C';  M=  71,  94, -61, -55, -21, -53, -85, -87, -81, -86, -82, -43, -89, -78, -43,  50, -68, -77, -97, -46;
/M: SY='T';  M= -69, -79, -75, -78, -46, -68, -85, -76, -75, -81, -77, -64, -77, -79, -83, -24, 118, -68,-105, -82;
/M: SY='D';  M= -85, -99, 123, -34,-106, -82, -71,-104, -72,-102,-101, -53, -84, -71, -81, -73, -75,-100,-121, -88;
/M: SY='M';  M=  -7, -85, -86, -56, -77,  20, -83, -16, -41,  23,  80, -77, -63, -41, -55,   7,  61, -20,  -4, -78;
/M: SY='A';  M=  72, -32, -82, -76, -49,  14, -81, -88, -72, -62, -81, -75,  15,   4,  32,  35, -71, -79, -92, -38;
/M: SY='V';  M=  24, -35, -88, -84, -82, -64, -55,   4, -84, -71, -70, -49,  51, -84, -89,  21,  27,  69,-101, -84;
/M: SY='L';  M= -57, -26,-101, -93,  -1, -66, -86, -54, -94,  85,   7, -98, -28, -88, -92, -56, -51, -38,  54, -35;
/M: SY='C';  M=  37, 107, -83, -20, -51, -14, -84, -86, -81, -66, -12,   5, -91, -50, -49,  24,  28, -48,   0,   5;
/M: SY='G';  M= -42,  33, -82, -91, -99,  99, -88,-105, -53,-101, -91, -68, -86, -83, -92,  -1, -28, -97, -93, -94;
/M: SY='N';  M=   7, -88, -71, -51, -48, -22,  54, -25,  21, -67, -48,  64,  -5,  -5,   8,  40,   3, -40, -99, -35;
/I:         I=-29; MD=-75;
/M: SY='H';  M=   0,  -8,   8, -52,   0,  13,  68, -89, -20, -64, -24,  43, -92, -12, -27,   3, -45, -52, -85,  63; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='P';  M= -15,  -7, -81, -36, -37, -29,  -3, -61,  -3, -27, -80, -39,  97,   5,  20,  -4, -10, -39, -94, -25;
/M: SY='E';  M= -21, -35,  25,  71, -54, -40,   2, -26,  22, -56, -83,  14, -24,   4,  23, -50,  -6, -68, -95, -10;
/M: SY='K';  M=  22, -86, -78, -48, -88, -38, -31, -75,  63, -39, -77,   1, -15, -70, -16,  27,  32,  28, -97, -83;
/M: SY='C';  M=  36, 118, -88, -87, -88,  10, -17, -45, -86, -32, -37, -77, -93, -85, -91,  25,  18, -78,   3, -89;
/M: SY='Y';  M= -40, -41, -94, -88,  61, -97, -20,  11, -22,  36,  12, -89, -97, -15,  22, -47, -80, -15,  32,  62;
/M: SY='R';  M=  27, -92, -81, -74, -51, -32, -73, -32, -41, -86, -34, -28, -89, -34,  90,  30, -26, -43, -89,  23;
/M: SY='K';  M= -29, -94, -77, -68, -86, -87,  34, -59,  69,   4, -75,   0, -87,  -2,  67,   3, -54, -85, -18, -20;
/M: SY='Y';  M= -88, -99, -88, -90, -19, -65, -56, -74, -82, -43, -28, -89,-100, -30, -52, -83, -83, -79, -46, 136;
/M: SY='G';  M= -31, -36,   5, -84, -17,  85, -83, -96, -49, -51,   7,  20, -87, -21, -59,   2, -80, -93,  49, -46;
/M: SY='A';  M=  48, -14, -83, -83, -23,  45, -37, -77, -42, -35, -78, -74, -36, -78, -47,  47,  -6,  22, -94, -42;
/M: SY='M';  M=  -9, -90, -38, -22,  18, -62, -26,   0, -14,  -8,  47,   3, -91, -15,  21,  -2,  -3,  27,  31,  43;
/M: SY='P';  M=  18,  25, -85, -80, -39, -24, -86,  20, -80, -33, -76, -10,  87, -81,  -7,  13, -27,   3, -95, -45;
/M: SY='R';  M= -42, -13, -89, -17,   4, -61, -19,  27, -15,  40,   2, -54, -24,  -9,  43, -43, -11,   9,   9,  -9;
/M: SY='K';  M= -17, -39, -32, -47, -93, -65,  22, -92,  75, -65, -17,  26,   6, -62,  54,  14, -47, -54, -96, -82;
/M: SY='T';  M=   7, -86, -28, -81, -54,  36,  35, -27, -55, -15,  36,  16, -13, -41, -63,  22,  51,  -8, -98, -81;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='P';  M= -27, -97,  26,  52, -31, -54, -39, -92,  21, -80,  -6,  -8,  71,  -9, -11,  18, -48, -63, -31, -87; D=-17;
/I:         I=-17; DM=-42;
/M: SY='Y';  M=  19,  27, -60, -88,  68, -20,  38, -28, -86, -32, -72, -84, -54, -41, -86,   0, -79, -37,  27,  82;
/M: SY='C';  M= -14,  84, -83, -30,   4, -15,  38, -20, -17, -40,  26, -11, -30, -35, -36,  42, -28, -16, -89,  39;
/M: SY='H';  M= -31, -95, -72, -56, -55, -63, 116, -94,  24, -47, -24,  40, -22,  18,  30, -29, -41, -73,  19, -67;
/M: SY='E';  M= -78, -98,  -4, 113, -27, -93, -71,-101, -60, -93, -90, -74, -74, -38, -70, -74, -78, -94, -96, -53;
/M: SY='M';  M= -16, -88, -88, -56,   7, -29, -25,  19, -82,  20,  81,   9, -90,  36, -83, -11,  -3,  26,   4, -51;
/M: SY='G';  M=  66, -86, -83, -85, -94,  75, -87, -91, -83, -92, -85, -54, -31, -80, -89,  -7, -76, -35, -92, -37;
/M: SY='L';  M=  -9, -87,-100, -94, -63,-100, -91,  49, -94,  73, -51, -96, -39, -89, -93, -88, -34,  21, -91, -74;
/M: SY='R';  M= -85,-101, -81, -69, -93, -95, -70,-100, -41, -92, -48, -74, -93, -57, 120, -79, -83, -93, -93, -80;
/M: SY='I';  M= -10, -89, -97, -93, -68, -43, -57,  69, -91,  42,  29, -55, -93, -27, -92, -57, -18,  38, -93, -75;
/M: SY='L';  M= -29, -88,-100, -92, -34,-101, -89,  36, -49,  75,  -3, -96, -98, -19, -90, -90, -78,  25, -90, -41;
/M: SY='L';  M= -27, -88,-101, -95, -37,-102, -89,  48, -94,  76,   9, -97, -98, -89, -93, -90, -52,   8, -89, -23;
/M: SY='H';  M=  29, -90, -78, -80, -82,  60,  71, -93, -29, -59, -81,  -5, -87, -21, -36,  29, -52, -88, -87,  46;
/M: SY='Y';  M=  36,  35, -80, -31,  15, -25,   8, -79,   1, -22, -13,  -6, -88, -57, -79,  47,  11, -31, -84,  48;
/M: SY='I';  M=   1, -30, -98, -94, -41, -98, -94,  73, -92,  32,  15, -91, -93, -89, -94, -40, -10,  43, -93, -32;
/M: SY='A';  M=  61, -44, -18,  12, -84, -51, -83,   8, -38, -31,  -1, -20, -86,  12, -34,  11, -24,  21,  24, -46;
/M: SY='R';  M= -25, -93, -35, -25, -48, -61, -73, -48, -10, -22,   8, -11, -88,  36,  85,  21,  23, -83, -94, -46;
/M: SY='H';  M=  27,   2, -52,  33, -47, -84,  59,  -8, -29, -64,  -1,  -5, -85,  26,  10,  10,  24,   4, -97, -28;
/M: SY='A';  M=  94, -11, -86, -58,  -4, -29, -87, -80, -82, -12, -76, -81, -86, -78, -86, -28, -71, -70, -91, -84;
/M: SY='A';  M=  75, -40, -18, -78, -53,  -4, -82, -44, -78, -43, -80,  31, -85, -40, -47,  32, -17, -39,  34, -84;
/M: SY='R';  M=  -8,  -2, -44, -48, -90, -87, -75, -57,  55, -34,   6, -72, -36,  17,  76,  15, -20, -18, -94, -81;
/M: SY='Y';  M= -86, -16, -85, -58,  -5, -94,  59, -40, -47,  28,  -8,   2, -97,   0,  15, -82, -81, -58, -66, 103;
/M: SY='D';  M= -76, -95,  69,  20,-101,  58, -46,-102,  26, -99, -91,  26, -84,  12, -16, -36, -60, -98,-100, -89;
/M: SY='R';  M= -49,  18, -85, -75,  10, -94, -77,  -2,  54,  13, -32, -78, -91, -37,  72, -63, -45, -14, -86,  15;
/M: SY='Y';  M=  39, -15, -50, -54,  -6,  43,  32, -64, -79, -83, -36, -21, -42, -77, -18,  20, -14, -20, -80,  65;
/M: SY='I';  M=  -6, -90,-101, -96, -15,-101, -96,  88, -93,  11,  36, -92, -92, -90, -95, -86, -27,  33, -92, -73;
/M: SY='E';  M= -77, -93, -32,  65, -87, -93,  -8, -12,  29, -55, -76, -75, -83,  34,  32, -54,  15,  33, -95, -16;
/M: SY='P';  M= -83,-106, -86, -75, -97, -87, -88, -63, -81, -65, -84, -91, 126, -85, -93, -82, -76,   0, -96, -33;
/M: SY='L';  M= -42, -17, -99, -64, -38,-101, -34,  29, -70,  76,  13, -95, -98, -14, -90, -53, -78,  21, -91, -72;
/M: SY='F';  M= -42, -88, -46, -94,  67,-100, -86,  33, -93,  61,  28, -94, -98, -91, -92, -51, -61, -11, -78,  -1;
/M: SY='S';  M=  26,  54, -78, -78, -90, -42, -81, -57, -78, -89, -84, -67, -35, -72, -82,  94,  -7, -29, -99, -46;
/M: SY='Y';  M= -24,  19, -92, -40,  45, -96,  58,   1, -88,  39, -25, -88, -97, -84, -86, -85, -63,   6,   4,  77;
/M: SY='S';  M=   9, -87, -82, -80,  40, -47,  25, -54, -79, -39, -77, -32, -88,  -2, -81,  76, -35, -32,  54,  46;
/M: SY='I';  M=   1, -23,  20, -22, -78, -65,  38,  47, -17, -40,   6, -49, -87,  -1, -12,  15,  18,  20, -12,   4;
/I:         I=-45; MD=-115;
/M: SY='D';  M= -26, -95,  90,  22, -97,  22, -74, -98, -17, -75, -16,   1, -41, -23,  -1,  -5, -43, -94,-104, -21; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='H';  M= -87, -28, -50, -52,  82, -58, 116, -82, -80, -73, -71, -74, -50,   6, -28, -53, -84, -50, -79,  35;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='Y';  M= -63,  -1, -88, -90,  31, -42,  22, -36, -84, -36, -68, -86, -39, -81, -82, -81,  -1, -77, -53, 123;
/M: SY='Y';  M=   0,   3, -49, -91,  35, -38, -83,  24, -48, -13, -13, -89, -24, -88, -89, -47, -57,  61, -78,  66;
/M: SY='R';  M= -83,-100, -39, -68, -93, -93, -71, -95,  -4, -58, -80, -74, -44,  -4, 114, -48, -82, -41, -94, -80;
/M: SY='V';  M= -21,   3, -53, -92,   4, -56, -96,  34, -91,  15, -29, -90, -94, -91, -93, -42,  11,  78, -97, -75;
/M: SY='F';  M= -43,  31, -96, -93,  91, -39,  31,   9, -55, -31,  33, -87, -98, -89, -30, -53, -82, -42, -18,  65;
/M: SY='V';  M=  -9, -86, -99, -93,  29, -32, -94,  11, -90,  19,   5, -93, -96, -91, -31, -84, -73,  81, -92, -40;
/M: SY='R';  M= -33, -96, -49,   4, -60, -53, -10,  -8,   5, -10,   9, -40, -89,  35,  89, -41, -32, -41, -93, -44;
/M: SY='V';  M= -41, -85, -98, -93, -33,-100, -97,  36, -32,  10,   1, -92, -94, -91, -91, -83,  -3,  87, -99, -76;
/M: SY='H';  M= -46, -93, -18,  28,  17, -66,  41, -35,  21,   3, -72, -77, -88, -21,  39, -32,  12,  12,  12,  36;
/M: SY='R';  M= -23, -93,   0, -37, -89, -20,  21, -71,  47, -64, -28,  -7, -27,  -8,  69,   1,  23, -38, -94,  -9;
/M: SY='G';  M= -37, -90,  -8, -18, -94,  61,  -6, -64,   0, -48, -86, -16, -43, -12,  12,  58,  -1, -89, -96, -86;
/M: SY='P';  M=  47, -25,  -7, -50, -53, -25, -27, -54,   1, -51, -27, -15,  72,  16,  -3,  -9, -14, -11, -96, -87;
/M: SY='Q';  M=  21, -90, -24,  12, -48,   2,   2, -21,  20, -32, -78,  11, -32,  29,  28,  23,  -6, -18, -12, -55;
/M: SY='K';  M=  17, -93,  -2,  41, -91,  -5, -22, -50,  43, -24, -21, -35,  -7,  29,  27,   0, -26, -84, -93, -25;
/I:         I=-23; MD=-58;
/M: SY='A';  M=  58,  49, -29, -56, -84, -63,  -8, -49, -32, -30, -74, -42, -89, -80, -85,  24,  12,  47,-100, -45; D=-23;
/I:         I=-23; MD=-58;
/M: SY='K';  M= -80, -94,  60,  23, -91,  -1,  -8, -60,  66, -37, -31,  26, -84, -15, -46, -58, -39, -20, -97,  -7; D=-23;
/I:         I=-23; MD=-58;
/M: SY='E';  M=  -2, -28,  38,  42,  -5, -51,   4, -23,  36, -10, -45,  12, -86,   0,  27, -53, -40, -61, -93, -11; D=-23;
/I:         I=-23; MD=-58;
/M: SY='S';  M=  14, -22, -27, -35, -81, -12, -81, -13, -54,  26,  37,   9, -88,   5, -48,  44,  23,  -4, -97, -81; D=-23;
/I:         I=-23; MD=-58;
/M: SY='A';  M=  37,  16, -31, -51,  -3, -13, -46,  15, -33,  33,  11, -84, -30, -42, -23, -13, -12, -10, -89,  14; D=-23;
/I:         I=-23; MD=-58;
/M: SY='S';  M=  -7,  17,  12,  22, -33,  10, -44, -40,  11, -19, -82,  33, -86,  18, -14,  45, -19, -70, -14, -84; D=-23;
/I:         I=-23; MD=-58;
/M: SY='K';  M= -81, -28,  -3,  17, -32, -30,  18, -96,  67, -71, -42,  40, -36,  23,   9,   0, -49, -72, -12, -35; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='L';  M= -68,  -1, -88, -59, -15, -94,  13,  35, -65,  50,   9,   3, -46,   7, -51, -11,  35, -23, -90,  10; D=-23;
/I:         I=-23; DM=-58;
/M: SY='G';  M=   5, -91, -84, -87, -54,  83,  -7, -56, -61, -34,  40, -72, -41, -21, -55,  16, -78, -26, -93, -86;
/M: SY='Y';  M= -38,  12, -89, -89,  29, -48, -15,   0, -65,  -1,  31,   1, -96, -59, -18, -66,   0, -23,  28, 100;
/M: SY='V';  M= -32,  57, -98, -73, -18, -34, -93,  45, -90,  16,   6, -91, -25, -21, -51, -59, -58,  65, -95, -13;
/M: SY='Y';  M= -26,  16, -87, -31,  39, -12,  60, -41, -21,   5, -15, -36, -94, -22, -20, -58, -22, -19,  63,  76;
/M: SY='H';  M= -82, -20, -16,  -3,  -2, -57,  94, -50, -33, -54,  -8,  15, -42,  51, -21, -21, -28, -21, -83,  68;
/M: SY='C';  M= -79, 146, -37, -64, -86, -55, -35, -61, -39, -72, -85, -49,-104, -51, -30, -30, -45, -53,-109,  -5;
/M: SY='P';  M= -38, -93,  24,  -8, -18,  16,   6, -82, -27, -60, -35,  26,  58,  10,  -4,  12,  10,  10, -98, -52;
/I:         I=-42; MD=-106;
/M: SY='N';  M= -41, -17, -11,  23, -92,  40, -18, -58,   0, -52, -85,  43, -85,  18,  10,  33,   1, -54,   6, -33; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='C';  M= -78, 133, -56, -37, -48,  -1, -34, -27, -89, -27, -81, -81,-100, -39, -61, -16,   3, -43,-101,  21; D=-42;
/I:         I=-42; DM=-106;
/M: SY='G';  M= -13,  30,   0,   1, -39,  49,  16, -36, -21,   6,   1, -56,  12,  33, -27,   4, -36, -83, -92, -10;
/M: SY='S';  M=  -9, -23, -33,  23, -22,   2,  32, -55, -28, -30, -38,  19, -86,   3, -32,  45,   8, -14,  22,  44;
/I:         I=-3; MD=-8;
/M: SY='F';  M= -12,-112,-110,-104,  58,-110,  -2, -38, -68, -93, -94,-102,-114, -41,  29,  -8, -41, -44,  35,  10; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='K';  M=-105, -21, -65,   8, -49, -65, -24, -87,  35, -75, -21, -52, -74, -49, -12, -11, -15, -66,-120, -23; D=-3;
/I:         I=-3; DM=-8;
/M: SY='F';  M= -59, -48, -41,   5,  29, -18,  16, -51,  -9, -35, -91, -32, -46,  -6,  21, -92,  -1, -70, -20,  22; D=-3;
/I:         I=-3; DM=-8;
/M: SY='Y';  M=  -9,-104, -35,  -6, -44,   7,   7, -46, -16, -37, -31,   8, -17,  -3, -25,  -6, -15, -13,-102,  22; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M=  -3, -45, -49, -32,  12, -44, -30, -16,  -3,  -7, -27, -31,  28,  -8,  -3, -11, -23,   5,   6,  -7; D=-3;
/I:         I=-3; DM=-8;
/M: SY='A';  M=  23,   1, -29, -15, -61,  10, -33, -42, -24, -12, -26, -39,   3, -33, -14,  20,   7, -37,-103, -30; D=-3;
/I:         I=-3; DM=-8;
/M: SY='W';  M= -20, -35, -26, -17, -47,  12, -30, -33, -20,  -9, -21,   2,  17,  27,   5,  11, -28, -46,  33, -49; D=-3;
/I:         I=-3; DM=-8;
/M: SY='G';  M=   1, -98,  -2,   0, -40,  26, -18, -15, -26,  11, -12, -24,   4,  -7,  14, -15, -44, -27,-101, -88; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -36,  -5, -11,  -7, -39,   1, -52, -50, -28,  -3, -29, -20,  64,  -5, -17,   4, -25, -18, -98,   1; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -41,-100, -24,  29, -12, -19,  -5, -24, -16, -16, -10,  -1,  53,   2, -64,   8,  -9, -25,  20, -45; D=-3;
/I:         I=-3; DM=-8;
/M: SY='C';  M=   3,  41, -24, -19,  -5,  -9, -49,   6, -41, -17, -14, -23,  30, -27, -12,   2, -13,  22,-101, -85; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -20, -97,  22,  -3, -47,  23, -83, -67,   3, -67, -44,  17,  43,  -9, -34,  30, -13, -37,-102, -43; D=-3;
/I:         I=-3; DM=-8;
/M: SY='C';  M=  -4,  30,  -3,  16, -37,   4,  19, -16,  -4, -27, -16,  -6,   1,  -2,   5,  15, -15, -38,-101, -49; D=-3;
/I:         I=-3; DM=-8;
/M: SY='H';  M= -42, -34, -27,  13, -15, -28,  33, -33,  31, -15, -80,  -7, -15,  -1,   9,   9,  31, -34, -98, -13; D=-3;
/I:         I=-3; DM=-8;
/M: SY='C';  M= -24, 140, -20, -94, -66, -35, -29, -95, -68, -71,  -6, -84, -40, -30, -61, -32, -51, -66,-115, -97; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -30,  33, -19,  41, -97, -26,  -7, -22, -24, -64, -86, -24,  72,  -8,   4,   6,  -1, -33,-102, -92; D=-3;
/I:         I=-3; DM=-8;
/M: SY='H';  M= -46, -97, -25,  43, -19, -52,  80, -22, -22, -34, -17,  23,  -3, -16,  -7, -28, -54,  13, -98,  15; D=-3;
/I:         I=-3; DM=-8;
/M: SY='C';  M= -31, 137, -22, -36, -94, -52, -95, -74, -37, -73, -21, -32, -10, -47, -23, -81, -18, -66,-115, -99; D=-3;
/I:         I=-3; DM=-8;
/M: SY='G';  M= -26, -21,  -9, -24, -96,  79, -10, -64,  -3, -74, -89,   0, -33,  -9, -17,   5, -46, -52, -95, -25; D=-3;
/I:         I=-3; DM=-8;
/M: SY='S';  M=   3, -39,  -6,   2, -24,  35,   6, -90,   6, -49, -53,  24, -18,   7, -36,  45, -25, -41,   7, -13; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='K';  M= -52, -28, -16,  16, -54, -19,  27, -91,  46, -91, -83,  25,  22,  10,  42,  23,   3, -29, -97, -53;
/M: SY='M';  M= -28, -41, -10, -28,  32, -69,  33,  -2, -51,  36,  56, -29,  19, -81, -54, -37,   2, -25,  48,  26;
/M: SY='H';  M=  -9, -91, -12, -35, -52, -29,  75,   3,  16, -49, -13,  19, -87,  18,  22, -23,  25,  19, -98, -14;
/M: SY='I';  M= -31, -14, -54,  -7,  -8, -97, -87,  50, -87,  36,  36, -54, -27, -52, -58, -29, -15,  40, -89,  14;
/M: SY='G';  M=  29,  10, -82, -55, -59,  46, -82,  -5, -81,  -8, -17,   5, -87, -78, -40,  41,  12, -25, -24,  16;
/M: SY='G';  M= -51, -94, -82, -93, -99, 104, -88, -75, -55, -73, -91, -68, -86, -84, -93, -39, -84, -61, -91, -94;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='P';  M= -49,-107, -84, -49,-100, -86, -87, -88, -62, -41, -85, -90, 127, -47, -92, -81, -76, -54, -96, -98;
/M: SY='M';  M= -29, -48,-101, -94,   0, -59, -86,  49, -92,  57,  79, -94, -95, -87, -91, -88, -49,  15, -88, -16;
/M: SY='W';  M= -92,-114, -75, -95, -54, -92, -96, -87, -87, -85, -85,-106, -97, -55, -44, -96,-100, -99, 171,  69;
/M: SY='I';  M=   0, -41, -87, -86, -73, -16, -85,  45, -31,  40, -33,  -2, -59, -81, -54,  34,  21,  -1, -93, -26;
/M: SY='G';  M=  -5,  28,   6,  -9, -99,  91, -43,-101, -40, -99, -90, -69, -36, -19, -89, -55, -82, -53, -94, -93;
/M: SY='P';  M= -18,-100,   8,  14,-100, -56, -80, -94,  29, -99, -88,  20, 103, -72, -24,  -4, -74, -93, -98, -93;
/M: SY='L';  M= -60, -88, -99, -93, -16,-102, -88,  50, -48,  74,  10, -64, -96, -55, -91, -89,  -5, -10, -89, -40;
/M: SY='H';  M= -59, -46, -76, -74,   3,   9, 123, -91, -26, -66, -75,   2, -88,  30, -73, -16, -25, -27,  55,  -3;
/M: SY='D';  M= -61, -43,  96,  15,-100, -59,  -6, -99, -48,-100, -93,  74, -85,  -8, -76,  -6, -71, -97,-113, -87;
/M: SY='P';  M=   0, -93, -62,  10, -40, -47, -22, -20,  35, -13, -12,  -1,  48, -11,  30,  -5, -30,   5, -90,  16;
/M: SY='E';  M=  10, -92,  56,  65, -94, -22, -48, -36,   4, -48, -85,   1, -54, -12, -34,   6,   2, -37,-100, -60;
/M: SY='F';  M= -47, -90,-102, -97, 107, -98, -37,   7, -92, -15, -67, -93, -65, -98, -56, -66, -24,  -8,  58,  21;
/M: SY='V';  M=  -6,  20, -60, -92, -39, -99, -93,  43, -64,  50, -36, -93, -96, -56, -43, -84, -23,  59, -95, -76;
/M: SY='Q';  M=  -2, -92,  36,  29, -58, -31,  -8, -48,  35, -56,  -5,  17, -83,  50,   6,  10,  15, -73, -97, -46;
/M: SY='K';  M=  -4, -91, -13,  29, -28, -21, -45, -59,  49, -60, -34,  18, -84,   2,  45,  28, -16, -29, -94, -49;
/M: SY='M';  M=  -3,  27, -60, -90, -49, -93, -83,  21, -65,  25, 105, -41, -92, -83, -87, -46, -17,  36, -94, -41;
/M: SY='L';  M= -20, -15, -58, -22, -10, -67, -42,  29,  -3,  63,  22, -55, -41,  -3, -13, -14, -77, -40, -89, -23;
/I:         I=-7; MD=-17;
/M: SY='D';  M= -15,-118,  25,  -8,-121, -40,-101, -74, -27, -77,-111,  -8,-111, -22,  16,   7, -25,-113,-127,-112; D=-7;
/I:         I=-7; MI=0; MD=-17; IM=0; DM=-17;
/M: SY='E';  M= -53,-111, -15,  29,-105, -19, -48, -29,   2, -26, -95, -17, -50,  -5, -37, -20, -20,   2,-116, -51; D=-7;
/I:         I=-7; DM=-17;
/M: SY='E';  M= -11,-107,  -3,  35, -30, -30, -91, -66,  11, -31, -37, -10, -99,  15, -45, -12, -23, -50,  22, -17; D=-7;
/I:         I=-7; DM=-17;
/M: SY='E';  M=   2, -45, -13,  17, -66, -31, -50, -25,  -9, -10, -25,   4, -17,   5, -38,  -5, -35,  -8,  -7, -20; D=-7;
/I:         I=-7; DM=-17;
/M: SY='E';  M=   8, -26,  17,  34, -66, -41, -29,  -9,   7, -37,  24,  13, -15, -13, -10,  -3, -23, -62,  -5, -17; D=-7;
/I:         I=-7; DM=-17;
/M: SY='Q';  M=  14, -98,  16,  17, -18, -39, -38,  -9,  14, -11, -23, -22,  22,  24, -10, -12, -37, -42,  11, -32; D=-7;
/I:         I=-7; DM=-17;
/M: SY='N';  M=  13,  17,  17,  11, -47,  17, -21, -68,  12, -24, -17,  19, -15, -31,   1,   0, -19, -16,-101, -60; D=-7;
/I:         I=-7; DM=-17;
/M: SY='R';  M= -20,  -9, -33,   4, -17, -23, -15,  -1,   7, -24,  12,  16,   8,  16,  26, -14,  -1, -24,  20,  11; D=-7;
/I:         I=-7; DM=-17;
/M: SY='Y';  M= -22, -95, -11,  20,  30, -52, -35,  17, -81,  24, -30, -53,  17,  -6,  -3, -31, -14, -27, -21,  37; D=-7;
/I:         I=-7; DM=-17;
/M: SY='W';  M=  -2, -95, -38,   1, -48,  31, -51, -68,   8, -24, -83,  27,  28,  15, -31,  -7,  12, -89,  72,   3; D=-7;
/I:         I=-7; DM=-17;
/M: SY='T';  M=  -2, -35, -18,  -1, -12,  -7, -19, -28,  -1, -13,   8,  -6, -30, -43, -23,  -2,  69, -16, -96, -18; D=-7;
/I:         I=-7; DM=-17;
/M: SY='W';  M=  10, -36, -24,   1,  -9, -10,  26, -88,  22, -34, -81,  22, -27,  18,   4,  20, -14, -54,  74,  15; D=-7;
/I:         I=-7; DM=-17;
/M: SY='K';  M=  -5, -93,  14,  35, -68, -14, -28, -43,  45, -38, -28, -15,  16,  -2,  10,  13,   3, -28, -98, -86; D=-7;
/I:         I=-7; DM=-17;
/M: SY='R';  M=  -5, -95,  25,  28, -95, -55, -33, -66,  39, -91, -19,  -2, -63,  22,  76, -23, -23, -62, -96, -83;
/M: SY='I';  M=  13,  -8, -70, -88, -73, -27, -54,  58, -51,  20,  31, -84, -20, -83, -24,   6,  15,  23, -94, -44;
/M: SY='R';  M=  -9,  -5, -31,  24, -40, -62, -15,   4,  20,   8, -17, -24, -48, -15,  30,  15,  13,   9,  22, -53;
/M: SY='K';  M= -13, -93,  -9,  16, -95,  51, -50, -31,  63, -80, -85, -48, -58, -36,  28,  -1, -15, -89, -94, -86;
/M: SY='M';  M= -43, -89, -42, -67,  -5, -98, -32,  37, -28,  57,  70, -35, -95, -84, -32, -87, -50,  17, -88,   0;
/M: SY='L';  M= -39,   3, -99, -53,  12,-101, -88,  18, -38,  76,  -1, -96, -98, -87, -44, -90, -59,  14, -88, -70;
/M: SY='T';  M= -24, -90,   7,  31, -93,  -6, -24, -51,  29, -49, -82,  28, -18,  13,  22,  26,  45, -85, -99, -85;
/I:         I=-20; MD=-51;
/M: SY='T';  M=  11,  -3, -66, -50, -32, -50, -39,  -6,   2,  15,  38, -30, -39, -27,  21, -11,  49,  10, -94, -10; D=-20;
/I:         I=-20; MD=-51;
/M: SY='M';  M=   9,  59, -34, -90, -11, -94, -88,  45, -40,  32,  63, -49, -94, -31, -55, -51, -61,  19,   1, -44; D=-20;
/I:         I=-20; MD=-51;
/M: SY='K';  M=  10, -91, -16,  10, -56, -31,  -6,   9,  34,  16, -10,   2, -17,  16,  -5,  14, -10, -61, -93, -11; D=-20;
/I:         I=-20; MD=-51;
/M: SY='E';  M=  14, -18,  23,  75, -95, -46, -12, -91,  -6, -29,   3,   6, -11,  38, -26, -40, -29, -87, -99, -86; D=-20;
/I:         I=-20; MD=-51;
/M: SY='E';  M= -55, -99,   5, 108,-101, -92, -16,-100, -61, -94, -90, -49,  -5, -33, -71, -50, -62, -62,-100, -90; D=-20;
/I:         I=-20; MD=-51;
/M: SY='L';  M=  26, -23, -58, -58, -35, -51, -84,  -4, -32,  50, -32,   7, -17, -19, -85,  29, -19,   6, -93, -30; D=-20;
/I:         I=-20; MD=-51;
/M: SY='P';  M= -66, -96,  57,  30, -60,  -1, -30, -42,  -8, -32, -85,   8,  59, -11,  -6,  17, -10, -63,-100, -57; D=-20;
/I:         I=-20; MD=-51;
/M: SY='D';  M= -14, -37,  41, -18,   2,  -6, -84,  33, -23,  10,  19, -12,   9, -81, -45, -55,  21,   7, -94, -28; D=-20;
/I:         I=-20; MD=-51;
/M: SY='P';  M=  -3,  -9,  -1, -20, -57, -40, -19, -21, -42, -51, -14,  15,  81,  -3, -15,   8, -41,  17, -99, -44; D=-20;
/I:         I=-20; MD=-51;
/M: SY='P';  M= -39,-109, -40, -44, -73, -44,  10, -69, -12, -14, -91,   5,  81, -30, -68, -10, -29, -29,-110, -65; D=-20;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='F';  M= -61, -92, -92, -57,  67,  -1,  -1, -24, -58,  36,  -2, -55,  40, -87, -88, -50,  -2, -56,   7,  54;
/M: SY='Y';  M= -38,   4, -91, -91,  81, -36,  40, -72, -87, -31, -30, -49, -36, -86, -85, -34, -50, -33, -19,  98;
/M: SY='Y';  M= -86, -33, -91, -65,  53, -96,  21,   3, -85, -39, -67, -88, -53, -14, -83, -56, -36, -10,  28, 113;
/M: SY='D';  M= -32, -30,  47, -12, -54, -45,  28, -39, -27, -61,  -7,  27, -27, -45,  40,  28,  32, -14, -14,   7;
/M: SY='L';  M= -52, -90, -91, -87, -23, -96,  -9,  34, -87,  57,  -5,   4,  29,   0, -88, -57,   5,  15, -89,   7;
/M: SY='H';  M=  -5, -93,  64, -21, -91, -25,  81, -28, -28, -73, -82, -25,  38, -38, -55,  24,  10, -38,-104, -21;
/M: SY='E';  M= -24, -22,  19,  45, -33, -51,  32, -36,  43, -37, -35,  -8, -83,   9,  20,  22,  -8, -34, -96, -33;
/M: SY='I';  M= -41, -90, -99, -50, -10,-102, -90,  63, -89,  58,  40, -94, -56, -86,  -9, -89, -61,  15, -11, -71;
/M: SY='C';  M=  56,  89, -83, -58, -12,  10,   7, -87, -82, -86, -49, -17, -89, -79, -86,  42, -12, -59,  18, -17;
/M: SY='S';  M= -13,  -8, -50, -38, -57,  14,  -1, -47,  36, -77, -29, -27, -85,   1,  48,  65, -26, -61, -96, -82;
/M: SY='R';  M= -10, -12, -33, -40,  22, -44, -81,  10,  23,  -1, -71,  -3, -90, -14,  44, -27,  22,  20,  19, -19;
/M: SY='L';  M=  -1,  -3, -59, -89,   9,  11,   5,   6, -26,  59, -10, -88, -95, -50, -54, -53, -48,   6,  25,  -1;
/M: SY='K';  M= -55, -95, -34, -42, -94,  22,  71, -97,  79, -72, -35, -17, -84, -34,  43, -13, -77, -72, -95, -78;
/M: SY='C';  M=  -7,  82, -89, -56, -28, -17, -14,  23,   5,  10,  36, -81, -92, -43,  -5, -10,  18,  18, -97, -79;
/M: SY='N';  M= -29,  -8,  23,  -1, -93, -21, -40, -71,  -5, -92, -53,  65,   0,   5,  -6,  44,  40, -38,-103, -86;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='P';  M=  -3,  30, -83, -40, -81, -84, -40,  11, -80, -25,  55,  -2,  56, -28, -86,  38,  33,   9, -96, -11;
/M: SY='P';  M= -83, -20, -86, -76, -22, -51, -38,   4, -34, -42,   4, -51, 117, -48, -66, -60, -55, -45, -95, -90;
/M: SY='P';  M= -27, -95, -22, -27, -96, -67, -79, -70,  53, -96, -85, -30,  84, -35,   8,  45,  -1, -89, -22, -88;
/M: SY='M';  M= -40, -92, -41, -23, -11, -78, -45,  36, -25,  40,  67, -86,  22, -13,  35, -66, -28, -20, -90, -27;
/M: SY='D';  M=  -5, -40,  61,  22, -91, -54, -75, -13,  24, -20, -80,  35, -27,  16, -13,   9, -15, -17,-101, -59;
/M: SY='K';  M= -20, -25,  33,  10, -37, -65,  -4, -11,  42,  -6,  12,  -2, -85,  29,  13,   4,  20, -33, -97, -80;
/M: SY='F';  M= -53, -88,-102, -96,  56,-102, -91,  48, -92,  44,  21, -95, -62, -92, -43, -89, -53,  46,  -2, -40;
/M: SY='I';  M= -16, -53, -91, -52, -48, -44,  -8,  52,  -3,  22,  44, -85, -92, -18,  44, -66, -46,  28, -92, -25;
/M: SY='S';  M=  -1,   2,  22,  53, -67,  10, -34, -74, -32, -77, -86,  13, -82,  -2,   6,  56, -34, -65,   4, -50;
/M: SY='A';  M=  72,  22, -16,  -3, -46,   0, -82, -25, -26, -55, -79, -29, -55, -39,  -2,   4, -25, -42, -91,   5;
/M: SY='L';  M= -70, -88,-101, -95, -18, -75, -87,  32, -95,  84,   1, -66, -99, -89, -93, -93, -80, -20, -88, -31;
/I:         I=-31; MD=-79;
/M: SY='R';  M= -20, -24, -80,  10, -85, -30, -18,  -6,  11,  19,  -5, -22, -90,  33,  68, -19, -37, -25, -95, -81; D=-31;
/I:         I=-31; MD=-79;
/M: SY='N';  M= -22, -92,   1,  34, -70, -25,  50, -97,  21, -71, -86,  66, -86,  13,   3,  30, -27, -93,-103, -84; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='A';  M=  51, -90, -49,   1, -85, -28, -12, -77,  -2,  32,  27, -20, -89,  40,  -4, -36, -43, -75, -95, -82; D=-31;
/I:         I=-31; DM=-79;
/M: SY='G';  M= -69, -96, -59, -93,-100, 102, -88, -82, -36,-104, -93, -31, -88, -85, -63, -69, -87,-102, -92, -36; D=-31;
/I:         I=-31; DM=-79;
/M: SY='Y';  M= -89, -97, -92, -92,  66, -72,  38, -39, -60, -69, -69, -89,-101, -84, -37, -86, -84, -24,  -3, 116; D=-31;
/I:         I=-31; DM=-79;
/M: SY='R';  M=  -6, -18,  -4,   4, -35, -53, -13, -59,  35, -50, -32,   7, -35,  42,  62, -20,   0, -16, -93,  -6;
/M: SY='A';  M=  70,   1, -67, -84, -52, -45, -92,  18, -85, -48, -69, -83, -88, -83, -89,  -4,  -8,  56, -97, -83;
/M: SY='S';  M=  -6,  33, -76, -25, -56, -35, -79, -82, -52, -70, -83, -27, -84, -38, -81,  90,  27,  -3,  -3, -11;
/M: SY='R';  M= -34, -44, -81, -73, -55,   7,  19, -45, -20, -10, -20, -19,   6,  16,  90, -18, -80, -56, -91,  -8;
/M: SY='T';  M= -25, -35, -77, -78,   8, -79, -82, -78, -77, -82, -40, -67, -34, -54, -83,  70,  88, -18, -23, -52;
/M: SY='H';  M= -71, -97, -73, -73, -82, -31, 145, -33, -76, -83, -29, -63, -88, -19, -53, -37, -57, -53,-110,   5;
/M: SY='F';  M=  -2,  70, -94, -90,  71, -58, -32,  17, -23, -12,  -3, -85, -96, -88, -14, -38,   5,   2, -77,  39;
/M: SY='D';  M=  -3,  22,  57,  14, -92, -40,   5, -57,  14, -73, -26,  42, -85,  11, -11,  40, -26, -64,-100, -14;
/M: SY='P';  M=   7, -98, -40, -22, -96,   2,  -7, -87,  -6, -59, -84, -31, 105, -40, -41, -12, -29, -29, -96, -48;
/M: SY='N';  M= -34, -91,  10, -11, -87,  14, -29, -29,  -1,  -2,   4,  50, -42,  43,  15, -23,  29, -24, -97, -32;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='G';  M=  45, -11, -81, -83, -93,  68, -85, -23, -82, -58, -39, -70, -85, -17, -87,  47,  -4, -62, -94, -88;
/M: SY='I';  M= -82, -90,-102, -98,  60, -75, -93,  72, -95,  23,  -4, -95, -96, -94, -95, -90, -77,  44, -82,  -8;
/M: SY='K';  M= -44, -95, -75, -62, -95, -88, -75, -95, 102, -68, -82, -68, -83, -58,  58, -75, -76, -62, -91, -82;
/M: SY='T';  M= -45, -79, -75, -78, -85, -85, -85, -52, -51, -80, -77, -65, -77, -79, -64,  -9, 116, -41,-105, -83;
/M: SY='D';  M= -81, -92,  98, -29, -49, -59, -68, -97, -70, -99, -93,  83, -86, -70, -78, -23,   3, -95,-115, -87;
/M: SY='A';  M=  97,  20, -52, -78, -92, -52, -86, -62, -44, -53, -37, -79, -85, -54, -59, -33, -70, -70, -94, -88;
/M: SY='P';  M= -57,-100,  16, -33,-100, -33, -82, -92, -27, -99, -88,   2, 110, -45, -42,  27, -11, -93, -99, -95;
/M: SY='W';  M= -39, -32, -48, -62,   4, -66,  -9,  24, -82,  25,  44,  16,  23, -57,  -6,   0, -77,  -3,  90,  24;
/M: SY='D';  M=  12, -90,  46,  39, -91, -16,   1, -58,  -2, -37,  -2,  13,   0,   1, -76,  42, -28, -38,   0, -45;
/M: SY='E';  M=  -7, -90,  18,  54,  14, -92,  -7, -12, -50, -21, -72, -79, -42,  20, -28, -30, -13,  54, -95, -54;
/M: SY='I';  M= -61,  45,-100, -61,   0,-103, -96,  80, -94,  34, -39, -67, -96, -56, -96, -89, -76,  38, -92, -73;
/M: SY='W';  M= -56, -96, -90,  -7,  25, -64,  28,  18,  28,   1,  26, -52, -91, -78,  -4, -84,  -5, -16, 120,   0;
/M: SY='D';  M=  -7, -95,  79,  55, -72, -33,   3, -96,  -2, -78, -89, -35, -52,   5,   9,   2, -33, -58, -32, -55;
/M: SY='I';  M=  11,  20, -96, -62, -43, -96, -94,  73, -48,   9,   6, -58, -65, -88, -92, -60,  -3,  46, -94, -40;
/M: SY='M';  M=   9,  22, -98, -92,  23, -94, -84,  42, -52,  35,  93, -90, -93, -84, -88, -39, -50,  -5, -87, -13;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	68 in 68 different sequences
Number of true positive hits	68 in 68 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Trm1 methyltransferase
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

68 sequences

TRM1L_BOVIN (A5D7S3), TRM1L_HUMAN (Q7Z2T5), TRM1L_MACFA (Q4R6C7),

TRM1L_MOUSE (A2RSY6), TRM1L_PONAB (Q5R5T0), TRM1L_RAT   (Q496Z9), 
TRM1_AERPE  (Q9YDY7), TRM1_AQUAE  (O67010), TRM1_ARATH  (Q9LFU5), 
TRM1_ARCFU  (O29443), TRM1_CAEEL  (Q23270), TRM1_DROME  (Q9VK89), 
TRM1_ENCCU  (Q8SR99), TRM1_HALLT  (B9LSI7), TRM1_HALMA  (Q5UYV8), 
TRM1_HALS3  (B0R713), TRM1_HALSA  (P57705), TRM1_HALWD  (Q18EA0), 
TRM1_HUMAN  (Q9NXH9), TRM1_META3  (A6UUN6), TRM1_METAC  (Q8TGX6), 
TRM1_METB6  (A7I9E9), TRM1_METBF  (Q466T6), TRM1_METBU  (Q12Y46), 
TRM1_METHJ  (Q2FN43), TRM1_METJA  (Q58356), TRM1_METKA  (Q8TYY7), 
TRM1_METLZ  (A2SRK9), TRM1_METM5  (A4FZY5), TRM1_METM6  (A9A871), 
TRM1_METM7  (A6VIL5), TRM1_METMA  (Q8PU28), TRM1_METMI  (P0CW64), 
TRM1_METMJ  (A3CW75), TRM1_METMP  (P0CW65), TRM1_METPE  (B8GF12), 
TRM1_METS3  (A5UM08), TRM1_METS5  (A4YHH9), TRM1_METST  (Q2NI56), 
TRM1_METTH  (O27258), TRM1_MOUSE  (Q3TX08), TRM1_NATPD  (Q3IUJ2), 
TRM1_PYRAB  (Q9V1P3), TRM1_PYRAE  (Q8ZWT5), TRM1_PYRAR  (A4WMB7), 
TRM1_PYRCJ  (A3MTQ5), TRM1_PYRFU  (P81554), TRM1_PYRHO  (O59493), 
TRM1_PYRIL  (A1RV26), TRM1_PYRNV  (B1YCV9), TRM1_PYRWO  (P20300), 
TRM1_SACS2  (Q97ZH0), TRM1_SCHPO  (Q9P804), TRM1_SULAC  (Q4J947), 
TRM1_SULIA  (C3N5E1), TRM1_SULIK  (C4KH07), TRM1_SULIL  (C3MPR5), 
TRM1_SULIM  (C3MYQ9), TRM1_SULIN  (C3NHQ8), TRM1_SULIY  (C3NDZ5), 
TRM1_SULTO  (Q971V9), TRM1_THEAC  (P57706), TRM1_THEGJ  (C5A6N2), 
TRM1_THEKO  (Q5JIB3), TRM1_THEON  (B6YUU9), TRM1_THEVO  (Q97AR2), 
TRM1_YEAST  (P15565), TRM2_ARATH  (Q9SRU7)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

6 PDB

2DUL; 2EJT; 2EJU; 2YTZ; 3AXS; 3AXT