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PROSITE entry PS51569


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS51569
Entry name [info] DOT1
Accession [info] PS51569
Entry type [info] MATRIX
Date [info] 01-FEB-2011 CREATED;
01-FEB-2011 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51569
Associated ProRule [info] PRU00902

Name and characterization of the entry

Description [info] Histone-lysine N-methyltransferase DOT1 (EC 2.1.1.43) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=315;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=310;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.5815594; R2=0.0080066; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1427; N_SCORE=13.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=615; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-15; D=-100; I=-100; B1=-1000; E1=-1000; MI=-200; MD=-200; IM=-200; DM=-200;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 21 in 21 different sequences
Number of true positive hits 21 in 21 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] B_Cuche
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
21 sequences

DOT11_CAEEL (Q6AW06), DOT1L_DICDI (Q55AX2), DOT1L_DROME (Q8INR6), 
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PDB
[Detailed view]
46 PDB

1NW3; 1U2Z; 3QOW; 3QOX; 3SR4; 3SX0; 3UWP; 4EK9; 4EKG; 4EKI; 4EQZ; 4ER0;
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