PROSITE entry PS51562

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51562
Entry name [info]	RNA_CAP0_MT
Accession [info]	PS51562
Entry type [info]	MATRIX
Date [info]	01-NOV-2011 CREATED; 22-FEB-2023 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51562
Associated ProRule [info]	PRU00895

Name and characterization of the entry

Description [info]

mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=286;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=281;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2489257; R2=0.0087920; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1792; N_SCORE=18.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=484; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-37; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='S';  M= -59, -67, -43, -29, -42, -26, -30, -81, -30, -27,-111,  28,-114,   5,  -7,  88,  24, -57, -38, -28;
/M: SY='P';  M= -37,-123, -29,   7, -33, -75,   5, -13,  19,   3, -14, -26,  50,  21,  41,   4,  22, -33,-124, -49;
/M: SY='I';  M=   3, -14, -55, -37, -12, -36, -27,  77, -51, -11, -37, -81, -74,  -6,  12, -27,  26, -27,-120, -15;
/M: SY='Y';  M= -31,-122, -66,  -8,  32, -21, -27,  30,  29,  -7,-100, -44, -68,  -2,  -2,  17, -30,  -6,   3,  53;
/M: SY='H';  M=  -2, -28, -23, -50, -36,  19,  62, -59,  -4, -22, -19,  25,  46,   3,  -5, -15, -27, -17,-120,  36;
/M: SY='M';  M= -65,-119,-127,-118, -17,-129, -12,  15, -90,  71,  82,-121,-126,   7,   0, -82, -68, -32,-118, -23;
/M: SY='R';  M=-112,-127, -12, -57,-121, -31, -30, -85,  27, -52, -49, -15,-120, -54, 106, -36, -26, -78,-124, -47;
/M: SY='N';  M=  -1,   1,  14, -17,   8, -62,  13, -45,  18, -82,-111,  78,-118,   7,  29,   4, -30, -24,-126, -18;
/M: SY='F';  M= -50,-120,-129, -96, 107,-128,  34, -15, -83,  20, -19,-121,-130,-124,-120, -92, -91, -41, -15,  34;
/M: SY='N';  M= -82,-118, -90, -51, -35,-105,  97, -32, -99, -94, -47, 110,-119, -38, -70,  -5, -40,-121,-140,-105;
/M: SY='N';  M= -45,-115, -44, -56,-121, -55, -93, -78, -58, -43, -32, 125,-120, -59, -78, -17, -63,-121,-139, -66;
/M: SY='W';  M= -82, -52, -85, -33,  63,-123,-121, -74, -63, -18, -34, -73, -72, -37, -63, -39, -60, -55, 152,  47;
/M: SY='V';  M= -17, -52,-129,-125, -53,-129,-126,  74,-122, -24,   1, -63,-123,-121,-124, -61, -34,  76,-124,  -4;
/M: SY='K';  M=-109,-124,-103, -90,-125,-117,-106, -84, 116,-123,-112, -96,-111, -88, -73, -53, -70, -37,-120,-113;
/M: SY='S';  M=   9, -47, -73, -29, -69, -48,-107, -85,  23, -61,-113, -46,-113, -13,  14,  86,  23, -90,-125, -23;
/M: SY='V';  M= -16,  23, -38,   2, -80, -73, -19,  32, -18, -17,  41,   8, -72,  16,  -4, -21,  16,  46, -48, -35;
/M: SY='L';  M= -48,-118,-129,-122, -51, -83,-116,  34, -72,  79,  51,-124,-127, -41, -41, -76, -26, -22,-120,-102;
/M: SY='I';  M=-113, -54,-132,-129,  -2,-136,-126, 104,-124,   9, -14, -91,-123, -78, -79, -77,-107, -34,-116,   5;
/M: SY='Q';  M=  -9,-121, -10, -31, -45,  -3, -12, -18,  18, -60, -66,  54,-117,  64, -10,  24, -23, -70,-117,  47;
/M: SY='T';  M= -46, -32,  -2,  37, -45, -44,  -2, -31,  43,  -5,  -8,  10,-113,  21,   5,  -1,  44, -58,-125, -31;
/M: SY='Y';  M=  15, -13,-120,-119,  62, -65,  19,  -1,-115, -37, -20, -30,-125, -67, -82, -12, -35,   4, -96,  95;
/I:         I=-8; MD=-20;
/M: SY='C';  M=  17,  67, -89,-119, -18, -37,-121,  14, -70,  16, -29, -76, -77,-116, -73,  26,  21,  37,-128, -37; D=-8;
/I:         I=-8; MD=-20;
/M: SY='Q';  M=  -9,-127,  18, -11, -90, -49,   3, -88,  33, -90, -76,  26,  31,  39,  11,  31, -27, -56,-131, -44; D=-8;
/I:         I=-8; MD=-20;
/M: SY='K';  M= -43, -34, -25,  -8, -27, -53,   0, -53,  49, -26, -45, -20,  27,  13,  36, -24,-116, -91,-132, -36; D=-8;
/I:         I=-8; MD=-20;
/M: SY='I';  M= -33, -15, -42, -32, -29, -96, -62,   6, -38,  -8,  -1, -89, -34, -42, -56, -79,  -5,  -3,-152, -93; D=-8;
/I:         I=-8; MI=0; MD=-20; IM=0; DM=-20;
/M: SY='N';  M= -25, -23, -19, -11, -56,   0, -86, -44,  -2, -83, -63,  28, -39, -11,  -9,   9, -19, -31, -57, -43; D=-8;
/I:         I=-8; DM=-20;
/M: SY='P';  M= -28, -64,   4,   5, -62, -28,  24, -58,  14, -99, -66,  25,  47,  12,  22,  -5, -50, -70,-135, -29; D=-8;
/I:         I=-8; DM=-20;
/M: SY='G';  M= -27,  -2,  12,  -9,-120,  41,  12, -99,  24, -79, -48,  38,  25,   9,  23,  -5, -15, -89,-124,  11;
/M: SY='D';  M=  19,   8,  35, -22, -11, -16, -48,   2,  -8,  18,  15,  -9,   5,  14, -46,   8, -20, -31, -21, -35;
/M: SY='T';  M=  -3, -14, -34, -71,-112,-113, -15, -13,  17, -60, -19,   6, -67, -39,  47,  38,  48,   5,  32,   1;
/M: SY='V';  M= -36, -66,-130,-124, -75,-131, -62,  30,-122,  29, -23,-126,-126,-122, -88,-115,-102,  91, -29, -71;
/M: SY='L';  M= -69,  27,-131,-125, -11,-132, -54,  24,-124,  85,   6,-128,-130,-119, -88,-122,-109, -18,-119,-101;
/M: SY='D';  M= -37,-127, 120,  21,-134, -80,-101,-133,-101,-130,-129, -85,-113, -99, -82, -49,-105,-128,-146,-118;
/M: SY='L';  M= -85,-119, -73,-125,   1,-133,-116,  52,-123,  76,  49,-126,-128,-118, -76,-122,-109, -29,-115,   2;
/M: SY='C';  M=  62,  86, -20,-115, -47,  62,-116,-122,-114,-120,-115,-105,-119,-112, -60, -14, -67,-113,-123,   5;
/M: SY='C';  M= -25, 143,-125,-125,  -9, -52,-124, -36,-121, -84,-110,-114,-133,-125,-126,   5, -77,  12,-135, -14;
/M: SY='G';  M= -97, -46, -48,-122,-130, 108,-118,-138,-117,-134,-123, -71,-116,-115,-124, -97,-115,-131,-122,-125;
/M: SY='K';  M= -81, -59,-104, -93,-125, -81,  11,-126,  93,-123, -58,   5,-115, -26,  74,-105,-107, -69,-123,-111;
/M: SY='G';  M= -29,-123,-112,-123,-129, 106,-118,-134,-117, -89, -75, -98,-116,-114,-124, -69, -72, -86,-121,-124;
/M: SY='G';  M=  -5,-123,-110, -74,-129,  99,-115, -87,-113,-128, -23, -32, -67,  30,-119, -43,-112,-126,-122,-122;
/M: SY='D';  M= -83,-128, 126, -79, -74,-112,-101,-133,-102,-131,-131, -83,-115,-102, -72,-103,-105,-130,-149,-117;
/M: SY='L';  M= -49,-118, -76, -78,  -8, -58, -56,  42,-122,  77,  43, -61,-126, -30,-121,-119, -37, -41, -47, -73;
/M: SY='M';  M= -36,-123,  -4, -17, -14,  20,  41, -25,  -5,  12,  48,  13,  26,  19,  -4,   0, -35,-109,   4,   1;
/M: SY='K';  M=-110,-125,-103, -90,-125,-118,-105, -68, 114, -94,-112, -96,-111, -88,  10, -72,-105,-121,-119, -60;
/M: SY='W';  M=-121, -25,-137,-125,  35,-123,-120,-110,-118, -51,  22, -71,-128, -72, -75,-124,-124, -95, 162,  75;
/M: SY='Y';  M=  12,  -7,   6,  -2,  14, -79, -42,  23,  25, -11, -50, -26,-119,  16,  16,  -6, -20, -16,-114,  45;
/M: SY='H';  M= -31, -59,  10, -25, -10, -38,  60, -36,  49, -38, -20,  29,-117,  21,  13,  -2, -34, -20,-118,  39;
/I:         I=-17; MD=-44;
/M: SY='A';  M=  63,  12,-111, -76,-119,  19,   1, -59, -26, -25,  -7,  21, -79,   0, -27,  28, -31, -17,-127, -69; D=-17;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='N';  M= -50, -64, -19,   4,-125,  39,  12,-126,  47, -63,-114,  51, -12,  16,  51, -25, -67, -88,-126, -83;
/M: SY='I';  M=  -9, -65,-127,-122, -74,-128, -78,  71,-120,   9, -63, -69,  30,-119, -62,-113, -17,  61,-124, -14;
/M: SY='S';  M=   6, -54,  -2,   2, -95,  30,   4, -98,  41, -64,-113, -17,-114,  11,  25,  44,   7, -68,-125, -39;
/M: SY='H';  M= -83, -15, -34,  36,  49, -36,  78,-112,   8, -18, -23,  13,-118,  -6,  -7, -12,  -4, -50, -40,  39;
/M: SY='Y';  M= -89,-120,-126,-123,  -2,-129,-106,  -5,-119,  34,  -1,-124,-129,-116, -74, -78, -83,  60,  11,  96;
/M: SY='V';  M= -74, -21, -52, -93,  34, -88,  -7,  37, -86,   8, -27,-120,-125,-121,-122, -86,  -4,  79,-120,   4;
/M: SY='G';  M=   9,  48,-115,-122,   3,  93,-118,-123, -85, -40,   9,-102,-118,-115,-123, -99, -61, -70,-121,-117;
/M: SY='I';  M=   8,   3,-126,-122,   1,-126, -52,  64,-120,  12, -13,-119,-123, -72,-122, -91,  18,  58,-122,  -8;
/M: SY='D';  M=-115,-128, 125, -28,-135,-112,-101,-134,-102,-132,-131, -59,-114,-101, -71,-103,-105,-130,-150,-118;
/M: SY='I';  M= -38, -59,-123, -63, -48,-127,-123,  90, -22, -21, -65, -24,  32, -35, -75, -13, -41,  19,-123, -50;
/M: SY='S';  M=  65, -10,  56, -69, -85,-101, -10,-119,-106,-121,-115, -44, -66, -69,-111,  72, -56, -75,-131,-116;
/M: SY='E';  M=  20,-121,  25,  44, -55, -46, -17, -80,  19, -15, -37,   1,  14,   5,   7,  17, -13, -45,-124,  -3;
/M: SY='E';  M=   0,-120,  38,  43,-120, -29,  -6, -48, -10, -71, -48,  33, -46,   5,  -1,   4,  17,  30,-131, -80;
/M: SY='S';  M=  28,  13, -53,  -2,-122,  18,-107, -86, -78, -82, -16,  44, -69,-100, -61,  82, -93, -54,-129,-117;
/M: SY='I';  M= -93,-120,-131,-127, -95,-134, -62,  82,-124,  51,   4, -71,-125,-121,-125,-120, -81,  43,-123, -65;
/M: SY='E';  M=  12, -65,  32,  53,   1,-114,  23,  -7,  20, -66, -40,   9,-113,  23, -15,   3, -11, -43,-123,  -3;
/M: SY='Q';  M= -32, -77,  27,  64, -73, -52,   1, -19, -95, -89, -62,  45, -73,  72, -40,  18, -23, -62,-128, -44;
/M: SY='A';  M=  80,  76, -61, -56, -53, -37, -86, -70, -33, -24, -75,-110,  19, -73,  -5, -27, -54, -62,-125, -69;
/M: SY='R';  M= -14,-122, -16,  -4, -35, -79,  12,  13,  31, -19,  27, -11, -66,  28,  57, -58,   6,  -1,-122, -16;
/M: SY='D';  M= -12,-124,  61,  47, -73, -33, -19, -79,   2,-122, -76,  11, -75,  39,  46,   0, -11, -88,-129, -40;
/M: SY='R';  M= -61, -67, -68, -56, -80,  37, -48,-128, -24, -78,-113, -23,-120, -48, 106, -25, -74, -84,-123, -61;
/M: SY='Y';  M=  46, -42,-119, -68,  16, -69,   3, -23, -19, -32,-101, -76,-123,-109, -45, -40,-109, -25,  73, 101;
/I:         I=-8; MD=-21;
/M: SY='C';  M= -36,  55, -28,  41, -44, -55,   3,  -5,  17, -29,  11,  40, -78,  -4,  -9,  -7,  -9, -67,-128,   0; D=-8;
/I:         I=-8; MD=-21;
/M: SY='S';  M=   9, -53,  13,  27, -99,  -5, -53, -50,   6, -65,-118,  13, -82,  10, -19,  43,  -9, -18,-134, -82; D=-8;
/I:         I=-8; MD=-21;
/M: SY='M';  M= -54, -26, -40, -69,  -6, -78, -28, -25, -79,   8,  71, -14,-133, -21,  60, -20, -54, -83,-130, -11; D=-8;
/I:         I=-8; MD=-21;
/M: SY='Y';  M= -28, -54, -57, -65, -52, -55,  -8, -45,   3, -33, -52,  11, -72, -44,  10, -71, -45, -28,-120,  76; D=-8;
/I:         I=-8; MD=-21;
/M: SY='N';  M= -25, -29, -20, -11,-136, -17, -68, -32, -11, -10, -44,  34,-137,   8, -19,  -4, -25, -66,-147, -65; D=-8;
/I:         I=-8; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='R';  M= -56, -52, -43, -77,-145, -21, -53, -88,  39, -61,-134, -15, -57,  -4,  41, -17, -57, -68,-147, -70; D=-8;
/I:         I=-8; DM=-21;
/M: SY='R';  M= -37,-137, -34, -19, -64, -34, -40,-136,  49, -62, -67,  20, -48, -31,  50, -10, -59,-133, -61, -16; D=-8;
/I:         I=-8; DM=-21;
/M: SY='R';  M= -23,-131, -12,   0, -31,  -7, -42,-128,  36, -81, -42,   2, -22,  13,  41,   8,  -7, -65,-130, -11; D=-8;
/I:         I=-8; DM=-21;
/M: SY='R';  M= -48, -52, -23, -33,  -1, -11,  25, -74,  36, -52, -50,  31,  -6, -16,  47, -17, -10, -64, -32,   2; D=-8;
/I:         I=-8; DM=-21;
/M: SY='R';  M= -13, -51,  -5, -15, -82,  -1,  -8, -66,  29, -84,-116,  14,  43,  22,  48,   5, -25, -96, -46, -18; D=-8;
/I:         I=-8; DM=-21;
/M: SY='N';  M= -40, -32,   4, -33,  -1, -11,  14, -26,  34, -24, -32,  40,  31,  13,  13,  13, -30, -56, -65,  22;
/I:         I=-45; MD=-115;
/M: SY='P';  M= -28, -54, -35, -45,  25, -14, -29,  14,  -1,  -7,  23,  10,  35,  -9,  16,   2,   7,  -8,-120, -10; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='F';  M= -63, -15, -73, -23,  87, -47, -40, -35, -51, -38,   6,-116,  60, -70, -80, -82,  16, -44, -47,  54;
/M: SY='K';  M= -42, -45,  14,   2, -74, -47,   6, -56,  46, -84,-112,  40,  33,  20,  10,  25,  17, -47, -42, -15;
/M: SY='A';  M=  73,  14,-120,-114,  -9, -47, -39,   3,-113, -41,  60,-112, -51, -42,-116, -22, -11,  18, -48,  -6;
/M: SY='E';  M= -46, -53,  20,  50, -15, -74,  30, -19,   9,  -8,   5,  -8,-114,  12,  -6,  10,  24, -47,-121,  26;
/M: SY='F';  M= -96, -58, -81,-128, 116, -85,-114, -34,-124,   3, -66,-123,-131, -74,-122,-119, -31, -37,  -9,  21;
/M: SY='I';  M= -39,  -2, -64, -68,  31, -83,  34,  61, -49,  12,  -4, -35, -93, -35, -49, -72, -16,  43,-117,  16;
/M: SY='Q';  M=  18,  23, -42,   8,-117,-115,  51, -42,  -5, -35,-103,  30, -51,  58, -21, -61,  14,  40, -41,-110;
/M: SY='A';  M=  58,   4, -74, -74, -49,  47,  -5, -77, -20,   5,  -3, -66, -79,   4, -33, -23,  -1, -26,-123, -44;
/M: SY='D';  M= -55, -60, 115, -60, -92, -43,-101,-130, -76,-130,-127,  41,-115,-102, -78, -18, -45, -86,-146, -84;
/M: SY='C';  M=  19,  96, -77, -88,  23, -15,-118,  12, -68,  20,   1,-113,   2, -60,-120,  17, -12, -23,-123, -56;
/I:         I=-42; MD=-106;
/M: SY='F';  M= -13,  31, -78, -40,  67,  20, -47, -72, -37, -19, -27, -24,-121, -49,  -2,  28,  30, -88,   4,  21; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='S';  M=  -3, -20,  23,   2, -37,  16,  -6, -89,  33, -34, -28,  10, -52, -19,  -5,  33,  13,  -2,-127, -61; D=-42;
/I:         I=-42; DM=-106;
/M: SY='E';  M= -19, -24,  29,  44,-118, -78,  -2, -33,  -1, -13, -36,  28,  41,  -3, -21,  10,   1,   3,-129, -52;
/M: SY='S';  M= -11, -37,  23,  -6,  15, -68, -43,  23,  -9,   8, -60,  19,  14, -24,   2,  36, -28, -37, -24, -17;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='L';  M= -56, -39,  20,  12,  11, -57,-110,   7, -58,  41, -18,  29, -31, -54, -23,   5,  36, -27,-123, -43;
/M: SY='Y';  M= -14, -52, -24,  -3, -15,   0, -63,  30,   2,  30, -14, -22, -35, -47,  -6,  -2, -22,   2,  -9,  33;
/I:         I=-5; MD=-14;
/M: SY='D';  M= -41,-133,  53,  47, -64, -65, -71, -61, -14,-104,-125,   4, -48,  39, -66,  12,   3, -53,-141,-125; D=-5;
/I:         I=-5; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='V';  M= -65, -38, -57, -42, -20, -44,  -3, -25, -57, -15, -49, -21, -31, -29, -24, -20, -97,   5,-151, -31; D=-5;
/I:         I=-5; DM=-14;
/M: SY='K';  M= -57,-145, -52, -24,  13, -42,  -4, -13,  15, -38,-126, -36, -39, -84, -12, -43, -13, -22, -51,   3; D=-5;
/I:         I=-5; DM=-14;
/M: SY='R';  M= -32, -78,  -3, -21, -22, -22, -22,  -7,  -2, -12, -40,  -5, -13, -41,   6, -22, -88, -26,-142, -56; D=-5;
/I:         I=-5; DM=-14;
/M: SY='K';  M= -41, -45, -23, -19, -25, -55, -36, -15,  38, -38, -62,  27,  27,   5,  -5, -16, -34, -48,-134, -17; D=-5;
/I:         I=-5; DM=-14;
/M: SY='Y';  M= -43, -65, -16, -40,  13, -36,  -6,  -8,  -4, -15, -32, -12,  11,   0, -12,   8, -14, -22, -28,  51; D=-5;
/I:         I=-5; DM=-14;
/M: SY='G';  M= -50, -70, -50, -15,  19,  28,  -1, -21,   4,  -6,-111,  11,   1,   9, -20,  -5, -16, -11, -26, -44; D=-5;
/I:         I=-5; DM=-14;
/M: SY='D';  M= -40, -35,  35, -22, -15, -53, -30,   1,   9,  -7, -45,  13,  25, -41, -16,  12,  -9, -11, -32, -27; D=-5;
/I:         I=-5; DM=-14;
/M: SY='K';  M=  -7,  -3,  -9, -27, -16,  19, -11, -59,  39, -19, -50,   4,  33,  -2, -18,   2, -20, -62, -13, -32; D=-5;
/I:         I=-5; DM=-14;
/M: SY='N';  M= -14, -10,  18,  17, -12,  10,  -8, -91,  30, -48, -30,  30,  16,   5,   5,  26, -15, -34,-125, -32;
/M: SY='N';  M= -29,-122,  10,   9, -16,  18, -19,  12,  23, -26,  25,  28,   3,   4,  20, -28,   3, -46, -33, -32;
/M: SY='K';  M= -34,-123, -54, -13, -45,  31,-108, -23,  40,  -6,   7, -26,  24,  36,  17, -10,  16, -51, -22, -16;
/M: SY='F';  M= -18,  -5,-131,-128, 115,-127,-112, -55,-123, -38, -66,-123,-131,-129,-121,-117, -78,  -4, -35,  47;
/M: SY='D';  M=-112,-125, 113, -39,-132, -74,  28,-131,-101,-129,-125,  29,-114, -18, -84,   1, -28,-128,-146,-115;
/M: SY='V';  M=  -4, -14,-124, -76, -43, -76, -15,  60,-117,  19, -41, -17,-123,-117, -26, -44,  -7,  64,-126, -53;
/M: SY='V';  M=  -8,  36,-127,-123, -38, -54,-128,  56, -77, -76, -92,-120,-123,-121,-123, -14, -31,  84,-129, -66;
/M: SY='S';  M= -52,  22, -10,-106, -36, -73,-108, -21,-106,-118, -69,  29, -71,-101,-111,  99,   8, -25,-131,-113;
/M: SY='C';  M= -30, 133,-126,-124, -55,-122,-121,  27,-120, -38,  69, -46,-129,-121, -83,   0,-106, -52,  34, -67;
/M: SY='Q';  M=-108,-128,-103, -71,  -5, -87,  24,-115, -92, -59,  54,  17,-116, 126, -93, -50,-108,-118,-120,-104;
/M: SY='F';  M= -83,-119, -56,-126, 119, -73,-113, -96,-122,  -3,  15, -23,-131, -42, -57, -76,-113, -79, -93, -45;
/M: SY='A';  M=  82,  61, -69,-109, -47, -22,   8,-113,-110,-115, -13,-105,-116,-107, -64,  45, -47, -37,-127,-115;
/M: SY='M';  M= -47, -68,-132,-126,  47,-131,-119,  62,-123,  54,  69, -79,-126,-120,-123,-120,-108,   6,-115, -95;
/M: SY='H';  M=-115,-128,-100, -99,-117, -87, 151,-131,-103,-116,-102, -13,-117,  31, -72, -75,-114, -85,-147, -87;
/M: SY='Y';  M=-118, -48, -58, -82, -12,-125, -45, -72,-112, -50, -55, -35,-130,-108, -74, -76,-112, -83, -78, 137;
/M: SY='M';  M=  47,  52,-119, -82,  54, -22, -55, -69,-114,  -3,  64, -74, -36, -56,-116,  41, -83, -52,-115, -11;
/M: SY='F';  M= -74,  48,-133,-128, 114, -94, -56, -46,-124,   4,  12, -79,-132,-130, -81,-120, -70, -81,  52, -74;
/I:         I=-31; MD=-79;
/M: SY='E';  M= -10, -16,   1,  78,-126,  -9, -42, -80,  26, -79,-116, -36,-111,  25, -20,  20, -44, -52,-127, -27; D=-31;
/I:         I=-31; MD=-79;
/M: SY='S';  M= -66, -67,-122,-123,-138,-121,-127,-135, -25,-138, -63,-111, -76,-117,-125,  80,  49,-127,-149,-132; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='E';  M= -37,-126,   3,  81, -51,-119,  -9, -17,  17, -23, -46, -25,  20,  25, -14, -31, -40, -34,-124,  -8;
/M: SY='E';  M=  -7,-123,  43,  61, -63,-101, -75, -31,  13, -35, -19,   3, -16,  43,   6,  -4, -11, -42,-127, -51;
/M: SY='Q';  M=  -6, -38, -48, -62, -74, -91,  35, -46,  34, -86, -27, -20,-114,  54,  36,  44,  46, -26,-127, -75;
/I:         I=-42; MD=-106;
/M: SY='A';  M=  66, -30,-125, -81,  14, -82,-121,  15, -80,  29,  -3,-120,-122,-115,-120, -47,-106,  22,  59, -52; D=-42;
/I:         I=-42; MD=-106;
/M: SY='R';  M= -46, -69,  22,  36,-122,-116,  31, -63,   1, -65, -20,  33,-117, -16,  74,  13, -25, -76, -38, -41; D=-42;
/I:         I=-42; MI=-106; IM=-106; DM=-106;
/M: SY='N';  M= -21,  20, -58, -14, -52, -22, -38, -45, -20, -30,  34,  75,-117,  39,  23, -20,  43, -59,-129, -46;
/M: SY='M';  M= -26, -84, -82,-124,  87,-127,-113,   1,-121,  27,  93,-121,-126,-120,-120, -69, -27,   4, -54, -60;
/M: SY='L';  M= -32,  31, -83,-121,  29, -92,-117,  30, -25,  69,  43,-123,-127, -23,-118,-118, -63,  -6, -36, -99;
/M: SY='R';  M= -23, -54,   7,  28, -90, -57,  19, -88,  45, -69, -34,   6,-114,  28,  56,  14,   7, -77, -54,  -1;
/I:         I=-33; MD=-84;
/M: SY='N';  M= -36, -59, -45,-108, -49,-104, -37, -27, -66, -51,-114, 119,-122,-102, -54, -42,   2, -52, -34, -73; D=-33;
/I:         I=-33; MD=-84;
/M: SY='V';  M=  21,  19,-131,-125,-103,-128,-130,  51,-123,   9, -33,-125,-126,-123,-125, -92,-104,  78,-130,-110; D=-33;
/I:         I=-33; MI=-84; MD=-84; IM=-84; DM=-84;
/M: SY='S';  M=  39,  21, -25, -43, -66, -72,  -8, -87,   5, -84,-114,  19,-116, -70, -24,  72,  20, -61,-130, -38; D=-33;
/I:         I=-33; DM=-84;
/M: SY='E';  M=  -7, -16,  22,  49,-125, -25, -32,-122,  22, -63, -43,  31, -73,  16,  20,  30, -11, -48,-129, -42; D=-33;
/I:         I=-33; DM=-84;
/M: SY='C';  M=   5,  60,-113, -81, -27,-117,  48, -41, -26,  19, -17,  29,-124, -55,  19,  11, -11, -43,  -2,  51; D=-33;
/I:         I=-33; DM=-84;
/M: SY='L';  M= -78, -20,-127, -85, -92,-130,-116, -12,-122,  88,   5, -64,-127,-117,-121, -75,  21, -36,-121,-103;
/I:         I=-38; MD=-97;
/M: SY='K';  M=   9, -43, -51, -28,-124, -88,  -9,-121,  82, -58,-111,  -6, -95,   2,  57, -29, -29, -39,-125,-113; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='P';  M= -36, -33,  16,   8,-123, -77, -59, -20,  21, -51, -18,   5,  94, -83, -44, -21,  -4,   4,-129,-119;
/M: SY='G';  M= -99,-123,   2, -47,-129,  98, -26,-134, -46,-131, -49,  36,-116, -45,-118, -97, -42, -97,-125,-122;
/M: SY='G';  M= -45,   2, -77,-122, -94, 105, -86,-136,-116,-132,-122, -98,-116,-114, -89, -36, -47,-129,-122,-124;
/M: SY='Y';  M= -72, -60,-118, -80,  33,-125,  26,  11,  -3, -17,   0, -40, -26, -80,   9, -52, -21,  15, -97,  99;
/M: SY='F';  M= -48,-118,-133,-129, 116, -94,-117,  -6,-125,   4, -35, -79,-131,-131,-123,-120,-112,   4, -95, -52;
/M: SY='I';  M= -68, -30,-128, -85,  31,-131,-124,  85, -88,  21,  -4, -23,-124,-121,-124, -90, -17,  31, -20, -48;
/M: SY='G';  M=  23,  -4,-117, -83,  -4,  85,-120,  27,-118, -26, -17,-105,-118,-115,-123, -67, -82, -34,-120,-114;
/M: SY='T';  M= -78, -16,-107, -80, -68, -88,-116,  -5,-107, -52,-104, -97,-109,-110,-115,   2, 114, -21,-133,-112;
/M: SY='T';  M= -23,  73,-118, -83,   6, -94, -57,  47,-115, -14,  18,-108,-118,-116,-120, -35,  79,   0,-126, -34;
/M: SY='P';  M= -58,-125,-120, -79,  35,-121,-113,   7,-114, -38,  49, -46,  93,-115,-120, -51,  -6,  24,-113,  43;
/M: SY='D';  M=-111,  38, 106, -69,-128,-108, -54, -91,-102, -88, -70,  68,-117,-102,-110,   3,-101,-125, -16, -58;
/M: SY='G';  M=  52,  18, -25, -45,-124,  57, -15, -91, -31, -97,-115, -47,  -6, -59, -85,  52, -47, -91,  -8,-118;
/M: SY='D';  M= -41, -27,  59,  37, -59, -50,  11, -97,  28, -61,-114,  51, -56,   7,   0,   9, -20, -47,-128,   7;
/M: SY='R';  M=   6, -52, -39,  34, -20, -80, -50, -61,  32,  -3,   2, -50,-116,   6,  34,  -6,  24,  12,  15, -16;
/M: SY='I';  M=-110,-120,-132, -89, -94,-135,-126,  83,-125,  53, -18,-126,-125,-121,-126,-121,-106,  43,-123,-104;
/M: SY='W';  M= -21, -22, -40, -34,  37, -85,  -9,  13, -26,  21,  42, -19,-123, -61,   6, -17, -70,  36,  62,  19;
/M: SY='K';  M=  -9,-123,  38,  33, -90, -35, -24,-106,  42, -98, -47,  23, -58,  25,  39,  22, -23, -87,  -1, -12;
/M: SY='R';  M= -26, -76, -89, -58, -36, -65,  15,  -7,  46,  33,  21, -46,-120,  -2,  68, -30, -48, -62, -32, -36;
/I:         I=-4; MD=-10;
/M: SY='L';  M= -19, -58,-132,-126,  28,-131, -77, -10,-125,  72,  24,-128, -74, -72,-124, -60, -68,  -7, -16,  25; D=-4;
/I:         I=-4; MD=-10;
/M: SY='K';  M= -20, -62,  -1,   3, -78, -18, -29, -94,  39, -75,   7,  16,-125,  35,  32, -24, -13, -70,-135, -60; D=-4;
/I:         I=-4; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='K';  M= -24, -69, -31,   2, -50, -31, -17, -25,  37, -18, -30,  19, -15,  -3,  -5,  -8, -42, -33,-134, -14; D=-4;
/I:         I=-4; DM=-10;
/M: SY='K';  M= -27, -61, -15,   3, -59, -22,  -9, -99,  59, -58, -74,  24,  -5, -19,  41,   8,  -8, -48, -38, -65; D=-4;
/I:         I=-4; DM=-10;
/M: SY='S';  M=  -6,-121,  28,  28,-126,  -9, -32,-123,  27, -92,-115,  27,  -9,  39,  23,  40,   9, -92,-128,-115;
/M: SY='T';  M=   8, -30,   6, -18,   6,  25, -78,   0,  12, -40, -36, -19, -33, -44, -29,  25,  37,   1, -39, -17;
/M: SY='E';  M= -48,-125,  36,  62, -80,   5,  -3, -27, -22, -74, -71,   5,  38,   1, -82,   1, -67, -18,-120,  45;
/M: SY='T';  M= -29, -24, -18,   3, -42,  18, -49,  15,  -5, -16, -16,  -1, -26, -66, -30,   7,  65,  -3,  -3, -67;
/I:         I=-10; MD=-26;
/M: SY='N';  M= -53,-130,  29,   0, -63, -35,   4, -21,  14, -27, -20,  47,   8, -20, -26,  -1, -27, -33, -25,  -8; D=-10;
/I:         I=-10; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='E';  M= -37, -45, -11,  39, -46, -41, -72, -30,  20, -57, -66, -17, -58,  -3,  13,  32,  16, -18, -69, -34; D=-10;
/I:         I=-10; DM=-26;
/M: SY='F';  M= -63, -37, -12,  -3,  81, -29, -33, -33,  -5, -31, -26,  -4, -52, -57, -35, -11, -31, -30,  50,  -6; D=-10;
/I:         I=-10; DM=-26;
/M: SY='G';  M= -56,-128, -16,  29,-133,  80,-116,-136,   0,-134,-125, -19,-118, -52, -23,  12, -56, -98,-129,-126; D=-10;
/I:         I=-10; DM=-26;
/M: SY='N';  M= -69,-120,   9, -15,-126, -45, -25, -70,   6,-129,-118, 111, -71, -35, -25, -17, -13, -94,-139, -70; D=-10;
/I:         I=-10; DM=-26;
/M: SY='S';  M= -36,-124,  35,  36,-125,  -8, -67,-125,  44, -93,-118,   8,  -4, -17,   1,  44,  -3, -74,-128, -11; D=-10;
/I:         I=-10; DM=-26;
/M: SY='I';  M= -69, -10, -61, -76,   3, -74, -12,  54,   2,   8,  -9, -49, -72,  -7, -46, -39, -17,  52, -18,   4; D=-10;
/I:         I=-10; DM=-26;
/M: SY='Y';  M= -72,  28,-123,-120,  52,-126, -25,   3, -10,  -9,  10, -66, -52, -64, -73, -84, -82, -27,  68, 105;
/M: SY='S';  M= -53, -29, -84,   3,  -7, -47,  19, -35,  42, -15, -45,  10, -69,  20,   8,  55,  26, -73, -40, -30;
/M: SY='I';  M= -46, -55,-130,-126,  38, -95,-125,  74,-123, -11, -13, -70, -75,-123,-124, -85, -55,  65, -15,   4;
/M: SY='E';  M= -23, -77,   3,  58,-122, -65,  -9, -34,  31, -68,-111, -37, -53,   2,  34,  13,  45, -23, -46,-113;
/M: SY='F';  M= -70, -76, -50, -53,  93, -72,-114,  36,  34, -11,   5, -62, -34,-115, -28, -68, -61, -41, -15,  -1;
/M: SY='D';  M= -64, -70,  55,  38, -79, -34, -15,   7,  31, -25, -24,   0,  12,  -2, -19,  -3,  -4,  -5,-130,-113;
/M: SY='K';  M= -12,   3,  22,  32, -35, -36, -27, -71,  46, -78, -39,  13,  -2,  17, -12,  20, -23,-117,   5,  45;
/M: SY='D';  M= -30,-124,  64,  40, -74, -53, -51, -33,  45, -29, -32,  -8,  24, -31,  -9,  -3,   0, -63,-130,-115;
/I:         I=-6; MD=-16;
/M: SY='Y';  M= -22, -91,   2, -17,  17, -40, -11, -13, -28, -18, -50, -14,  15,  -6, -39, -19,   9, -34, -41,  55; D=-6;
/I:         I=-6; MD=-16;
/M: SY='D';  M= -40, -24,  23,  -3, -16, -43,-131, -46, -21, -62, -72, -20,  13, -46, -28, -16,  -4, -33, -16, -40; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='D';  M= -27, -77,  26,  15, -28,  10, -59, -41,  23, -49, -45,  -7,  10, -18, -38,  -6, -19, -99,-137, -54; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M= -20, -79,  47,  29, -15, -38, -47, -41,  21, -37, -66,  15,   1,  -5, -31,   3, -36, -36,-131, -15; D=-6;
/I:         I=-6; DM=-16;
/M: SY='N';  M= -27, -57,  15,   4,  18, -16, -39,  -2,   8, -14, -33,  21,  14, -24, -18,   1,  12, -37,  15, -77; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -47, -39,  -7,   2,  26, -11, -24,   8,   1, -17, -18,  10,  38, -10,   8,   6, -37, -23, -63, -26; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -41,-126, -20,   4, -20, -29, -52, -17, -20,  -6, -28,  14,  69, -32, -43,  21,  13, -19,-129, -39; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -20, -23, -19, -10, -56,  23, -54, -14, -37,  11, -33, -79,  55,   4, -48,  17,  -1, -19, -40, -26; D=-6;
/I:         I=-6; DM=-16;
/M: SY='F';  M= -58,  -8, -67, -54,  89, -84, -36, -39, -31,   0, -64, -12, -80, -73,-120, -41, -14,  -9,  42,  51; D=-6;
/I:         I=-6; DM=-16;
/M: SY='G';  M= -14, -64, -54, -70, -75,  95, -55, -75, -36,-102,-122, -66, -43,-115,-123, -30, -37, -78,-126,-125; D=-6;
/I:         I=-6; DM=-16;
/M: SY='H';  M=  16,  22, -14,-110, -27, -54,  37,  19, -27,  -1,   1,  29, -85,  34, -51, -21, -18, -14,  31,  31; D=-6;
/I:         I=-6; DM=-16;
/M: SY='K';  M=  -3, -30,   6,  24, -92, -11,-107, -56,  67, -65,   3, -66,   6,  33,  26, -19, -36, -44,-125, -69; D=-6;
/I:         I=-6; DM=-16;
/M: SY='Y';  M=-115, -54,-122, -58,   1, -90, -97,  44, -59, -14, -53,-121,-128,-113,-115, -80, -68,   0,  13, 119;
/M: SY='H';  M= -28,  -3,  38, -28, -17, -22,  69, -34, -11, -38, -14,  27, -52,   9, -12,  10,  22, -37,  26,  30;
/M: SY='F';  M= -50, -64,-127,-125, 102, -45, -49,  -4, -80, -28,   5, -12,-128,-125,-121, -53, -44,  40,-100,  14;
/M: SY='Y';  M=  -8,-120, -33, -36,  32, -83,  49, -76,   0, -43, -45,  11, -81,  16, -11,  30,  35, -42,  33,  61;
/M: SY='L';  M= -60,-119,-126, -91,  -8, -70,-115,  -3,-118,  74,  35, -52, -45,  23, -77, -57, -52,  12,  44, -26;
/M: SY='E';  M= -22,-123,  30,  54, -37, -28, -14,   9,   6, -30,  -4,  -5,   8,  28,  -2,  -8,   4, -48,-125, -33;
/M: SY='D';  M= -58, -75,  71,  40,   3,  13, -39,-123, -17, -88, -58,  31, -60, -24, -77,  35,  -7, -64,  28,-111;
/M: SY='A';  M=  48, -34, -40, -25,   9, -24, -28,  21, -51, -60,  -8,  19, -63,  -1, -51,  27,  -2,  20,-122, -19;
/I:         I=-45; MD=-115;
/M: SY='V';  M= -36,-119, -23,   8, -12, -50, -54,  27, -30, -31,  33,  22, -85, -29,-116, -33, -32,  72,-128, -68; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='D';  M= -54,-124,  76,  49,-128,  10, -50, -60,  -4, -94, -81,  52, -51,  17, -37, -25,  -2, -92,-134,-117;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='Y';  M= -46,-135,  38,  -2, -14, -17, -25, -78, -86,-102, -14,  21,   5, -59, -63,  -4, -14, -18,-127,  54; D=-21;
/I:         I=-21; DM=-53;
/M: SY='C';  M= -11, 102,-122, -32,  25, -96, -63,  12, -78, -20,  33, -39,-126,   3, -74,  -6, -25,  29,-123,  12; D=-21;
/I:         I=-21; DM=-53;
/M: SY='P';  M= -36, -59,   8,  28,-123, -80, -45, -18,  -7,-119, -43, -15,  93, -74,   3, -38,  39, -37,-128, -46;
/M: SY='E';  M=-107,-129, -57, 117,-131,-123, -22,-132, -74,-124,-120,-103,-103,   1, -98, -56,-108,-124,-128,-120;
/M: SY='Y';  M=-118,   1,-120, -67,  60,-124, -63,-104,-115, -69, -63, -45, -79, -64,-113, -34,-112, -79,  53, 125;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='L';  M=-111,-117, -90,-123,  -7,-131,-118,   2,-123,  81,   0, -64, -75, -66,-122, -50, -73,  38,-120,-101;
/M: SY='V';  M= -46, -71,-129,-124, -42,-130,-128,  32,-122, -28, -38,-124, -73,-123,-123, -85, -44,  98,-128,  -5;
/M: SY='H';  M=-113,-126,  40, -37, -18,-113,  82, -67, -38, -68,-110,  61,  69, -10, -47, -42, -19, -59,-124,  38;
/M: SY='W';  M=-117,-125, -73, -87,  86,-125, -68,   1,  -3, -23,   5, -57,  27, -39, -15, -61, -30, -28, 101,  30;
/M: SY='P';  M= -27, -74,  51,  50, -60, -61, -57, -81,  24,-125, -70,  22,  67,   6, -24,  -3, -19, -80,-130,-118;
/I:         I=-38; MD=-97;
/M: SY='Y';  M=  -9, -75, -29, -14,  30,-132, -30, -71, -38, -16, -55, -24, -72, -37, -67,   0,  10, -14, -29,  48; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='F';  M= -20, -73, -24, -78,  66,-103,-115,  12, -62,  59,  15, -72,-126, -85,-120, -59,  -4,   7,-111,  -7;
/M: SY='F';  M= -58, -20, -46,  23,  48,-127,-117,  47, -20,  20, -10, -30,-121, -81, -67,-111,  19,  38, -56, -39;
/M: SY='R';  M= -33, -66,   7,  47, -96,-116, -32, -99,  58,-123,-114,  16,-113,  33,  60,  -1, -24, -74,-126, -75;
/M: SY='L';  M=  11, -42, -17,  23, -28, -47, -51,  27,   5,  34,  20, -53,-118,  -6, -33,   3,   1,   4,-124,-108;
/M: SY='M';  M=  39,  43,-127, -93,  37,-120,-115,   8,-118,  50,  79,-120, -72,-115, -66, -59,-107, -36,-116, -48;
/I:         I=-24; MD=-60;
/M: SY='A';  M=  51,  24, -64,  -3,-140, -54, -60, -75,  10, -62,   0, -65, -90, -53, -14, -46, -89, -92,-144, -81; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='E';  M=   0, -53,  20,  66, -72, -80, -19, -61,  48, -38, -75,  -1,-111,  -1,  10,   7, -18, -56,-126, -36;
/M: SY='E';  M= -21,-125,  26,  66, -57, -75,  22,-125,  57, -72,-114,  19,-111,  27,   4, -11, -72, -96,-125, -25;
/I:         I=-38; MD=-97;
/M: SY='Y';  M= -22,  54, -92, -95,  26, -55,  44, -40, -95, -23, -13, -30,-135, -71, -77, -83,-117, -21, -60,  99; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='G';  M=-102, -66,  24, -83, -35,  86,   9,-130, -32, -84, -55,  54, -78, -14, -45, -45, -79,-127,-126, -61;
/M: SY='L';  M=-115,   0, -85, -90,  64,-131,-115, -11, -94,  74,  48, -89, -81, -78,-121, -79,-110, -22, -35, -38;
/M: SY='E';  M= -91, -64,  12,  77, -81,-120, -18, -42,  41, -63, -61, -23, -27,  -1,  23, -21,   1,  -3,-126, -30;
/M: SY='L';  M= -78,  20, -87, -51, -43,-130,-115,  11, -53,  80,  -8,-125,   3, -65, -48, -71, -81,  -6,-118,  -3;
/M: SY='V';  M= -42,-118, -16, -11,-104, -57, -19,  41, -12,   2,  19, -61,-121,  -1, -35, -33, -36,  72,-127, -42;
/M: SY='Y';  M= -49, -67,  36,  53,   3, -53,  -8, -82, -28,  -5,  12, -30, -78,   0, -19,  19, -10, -51,  21,  58;
/M: SY='T';  M= -43, -51, -20,  -4, -21, -64,  32, -17,  39, -24, -61,  18, -12,   6,  16,  21,  40, -35,   8,  10;
/M: SY='K';  M= -16, -80,  32,  28, -32, -43, -60, -38,  52, -21,  14,  -7, -31,  31,  11,   4, -15, -39,   0, -40;
/M: SY='N';  M= -70,-120,  28,  14, -89, -14, -36, -85, -41,  -4,  -4,  66,  26,-100,  16,  31,  26, -65,-131, -58;
/M: SY='F';  M= -32,  -2,-131, -94, 114, -81,-114, -73, -70,  11,   7, -80, -63, -83,-121, -59, -58, -59, -33, -25;
/M: SY='H';  M=  -3,-122,  18,  23, -59, -32,  69,  -5,  -6, -12, -29, -12,  15,  11, -25,  15,   3, -18, -28,  -8;
/M: SY='E';  M= -50, -61,  64,  74, -63, -51, -12,-127,  -3,-100, -56,  47, -73,  10, -54,   1, -15,-122,-132, -59;
/M: SY='F';  M= -24, -67, -82,-120,  81, -64, -43,  25, -26,  17,  23, -25, -86,  -1, -85, -86, -51,   7,  21,  42;
/M: SY='Y';  M= -51,-123,-123, -79,  70, -14, -29,  12, -48,   4, -38, -40, -17,-116, -50, -88, -83,  -9,  53,  89;
/M: SY='N';  M=  -3, -65,  39,  48, -41, -55,   6, -34,  12, -15, -32,  50,  -5,  -6, -26, -15, -22, -38, -58,  -2;
/M: SY='E';  M= -32,-123,  37,  50, -35, -66, -15,  10,   8, -23,  -9,  10,  -2,  12,   6,  13,  -7, -62,-124,  -1;
/M: SY='H';  M= -21, -49, -30,  36,  26, -52,  63,-116, -27, -55,   0,  57, -50,   9,   9,  -1, -54, -80, -30,  53;
/M: SY='K';  M= -26,  -2, -23, -32, -51, -27,  -8,  -9,  51, -29, -15,  -1, -38,   0,  42,  38, -12, -21,-123,  -8;
/M: SY='N';  M=  -4, -71,  23,  17, -59, -20, -13,   0,  29, -30, -45,  34,  14,   5,  23,  -4,   9, -50,-126, -32;
/M: SY='Y';  M= -38, -78,  23,   8,  26,   3,  16, -27,   9, -27, -66,  15, -12,  13,  -9,  11,  15, -46,  20,  30;
/I:         I=-5; MD=-13;
/M: SY='F';  M= -55,-130,  13, -12,  43, -25,  13, -76, -11, -27,  -4,  13,  40, -60, -10,   7, -36, -44, -12,   9; D=-5;
/I:         I=-5; MD=-13;
/M: SY='E';  M= -28,-132,  13,  38,  10, -30, -11, -56,  23, -64, -30,  -1, -13, -14, -12,   3, -12, -56, -48, -26; D=-5;
/I:         I=-5; MD=-13;
/M: SY='N';  M= -61,-135,  15,   3, -17,   4,  10,-100,  -6, -33, -15,  43, -53, -30, -43,   3, -52, -85, -37,  12; D=-5;
/I:         I=-5; MD=-13;
/M: SY='L';  M= -15, -70, -31, -20, -20,  -6, -72, -23, -14,   3, -30, -37, -66,  -8,  -1, -23, -31,  -8,-138, -20; D=-5;
/I:         I=-5; MD=-13;
/M: SY='M';  M= -20, -59, -47, -36,  -4, -50, -57,  -9, -16,  -3,  -2, -25, -32, -34, -57, -11, -68, -51,-142, -11; D=-5;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='E';  M= -15, -47, -22,   4,  -7, -68,  -1, -37, -67, -25, -41, -10, -12, -52, -11, -32, -17, -41,-147, -36; D=-5;
/I:         I=-5; DM=-13;
/M: SY='R';  M= -25,-143, -44, -28, -40, -51, -25, -32,   5,  -8,  11, -14, -47, -29,  25, -29, -35, -60, -58, -21; D=-5;
/I:         I=-5; DM=-13;
/M: SY='Q';  M= -28, -59, -11,  -1, -27, -28, -35, -46,   1, -20, -13,  11, -21,  11, -18, -28, -50, -47, -67, -46; D=-5;
/I:         I=-5; DM=-13;
/M: SY='R';  M= -78,-139, -63, -17,   7, -38, -87, -68, -12,  13,   0,  -5,-138,  -6,  16,   4, -52, -55, -36,   2; D=-5;
/I:         I=-5; DM=-13;
/M: SY='M';  M= -38,-137, -36, -34,   9, -58, -28, -25, -17,  14,  19, -31, -47,  -5, -22, -33,  -6, -32,-132,  15; D=-5;
/I:         I=-5; DM=-13;
/M: SY='M';  M= -35,-138,  -6,  -5, -17,  -6,  -8, -45,  12, -58,  29,  -1, -37,  12,  11, -16, -38, -45,-139, -74; D=-5;
/I:         I=-5; DM=-13;
/M: SY='R';  M= -21, -71, -25, -13, -87, -29, -20, -44,  22, -43,   2,   3, -47,  -6,  25, -14,   5, -18, -20, -60; D=-5;
/I:         I=-5; DM=-13;
/M: SY='M';  M= -45, -43, -34, -64,   3, -27,   4, -36, -19,  17,  54, -19, -44, -21, -12, -35, -63,  -3, -21,  -3; D=-5;
/I:         I=-5; DM=-13;
/M: SY='W';  M= -68, -61,  -4,  -4, -15, -10,  -1, -37,  17, -49, -26,  22, -34,  -9,  11, -15, -21, -23,  31, -15; D=-5;
/I:         I=-5; DM=-13;
/M: SY='R';  M= -42, -77,   6,  12, -14, -10, -11, -73,  22, -69,-120,  18, -57, -19,  24,  -5, -12,   1, -56, -30; D=-5;
/I:         I=-5; DM=-13;
/M: SY='Y';  M= -13, -56,   5, -56,   1, -13,  -2, -30, -11, -26, -20,  -1,   8, -28,   4,  15, -18, -38,-126,  33; D=-5;
/I:         I=-5; DM=-13;
/M: SY='M';  M= -40,-131,  25,  -5,  -8,  14, -15, -32, -24, -13,  45,  26, -45,   1, -10, -68, -40, -32,-131,  -4; D=-5;
/I:         I=-5; DM=-13;
/M: SY='R';  M= -30, -28, -19, -32, -48,  23,  -9, -84,  31, -32, -69, -11, -19,   5,  32,  -9, -24, -17,-131, -21; D=-5;
/I:         I=-5; DM=-13;
/M: SY='D';  M= -32, -26,  27,  -7, -43, -22,  17, -39,  12, -26, -38,  25, -19,  20, -43, -30, -13,   5, -28, -17; D=-5;
/I:         I=-5; DM=-13;
/M: SY='G';  M= -21, -60,  10,  -9, -22,  40, -74, -51, -12,   5, -17,   7,  -1,-113, -36,   3, -17, -61,-128,   1; D=-5;
/I:         I=-5; DM=-13;
/M: SY='T';  M= -34, -75, -23,  -1, -51, -40, -17,   6,  -3, -19, -14, -23,   5, -14,  -7,   1,  54,  23,-131, -57; D=-5;
/I:         I=-5; DM=-13;
/M: SY='M';  M= -54, -58, -86, -30, -51, -17, -63,  18,  -7,  53,  66,   3, -32, -37, -43, -30, -16, -12,-125,-108; D=-5;
/I:         I=-5; DM=-13;
/M: SY='S';  M= -51, -65,  15,   8, -53, -16, -45, -73, -28, -61, -13,  41, -10, -33,  -4,  71,  39, -71,-130, -73;
/M: SY='K';  M= -23,-124,  38,  40, -61, -25, -45, -32,  48, -48,   6,   7,  21,  34, -13,  -2,  -7, -94,-126, -75;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='D';  M=  13, -53,  61,  60, -42, -66, -46, -80, -16,-102, -22,  -7,  -8,   8, -15,  25, -41, -56,-127,  -3;
/M: SY='E';  M= -40, -29,  17,  87, -41,-118,   3, -55, -53, -11,  16, -53, -80,  48, -73,   7, -52, -77,-125, -25;
/M: SY='W';  M= -84,-130, -45,  12,  -4, -94, -26, -29,  40, -30,  29, -33, -81,  15,  14, -21, -83, -54, 134,  13;
/M: SY='E';  M= -34,-125,  38,  88, -88, -97, -47, -84,  14, -83,-116, -28, -24,  28, -12, -26,   7, -72, -43,-116;
/M: SY='I';  M=  47, -48, -74, -43, -11, -83, -55,  49, -69,   7,   9, -75,-121,-115,-119, -87, -21,  45,  39,   8;
/M: SY='S';  M=  43,  15, -63, -85,   6, -87,-116,  21, -44,  11, -12, -65, -85, -71, -39,  51,  14,  12,-123,-107;
/M: SY='S';  M= -47, -38,   5,  -7,  43,  28,   6, -81, -12, -92, -64,  -7, -87, -25,   7,  62,  11, -87, -46, -10;
/M: SY='L';  M= -67, -36, -96,-122,  26, -57,-114,  21, -71,  75,  31, -78, -78, -63, -36, -36, -56, -27, -55,   6;
/M: SY='Y';  M=-117, -50,-112, -61,  20,-121,   2, -92, -60, -65, -33,  44,-128,-107, -57,-110, -85,-110, -34, 128;
/M: SY='R';  M= -31,  20, -22, -56, -23, -45,   3,   5,   9,   7,  27,   4, -55,  -1,  56,   4,   6,   9,-125,-107;
/M: SY='Y';  M=  44, -18, -82, -56,  -9, -39,-111,   9, -45, -40, -58, -14,-119, -43,-115, -19,  35,  39,  19,  61;
/M: SY='F';  M= -66, -19,-128,-125, 105,-127,-111, -11, -79,  -1,  19, -41, -93, -46, -62, -40, -46, -11, -95,  46;
/M: SY='V';  M=  48,  51, -40, -26, -81, -79, -41,  32, -31, -53, -28, -26, -66,-113, -61, -17, -58,  63,-129, -77;
/M: SY='F';  M= -94, -57,-130, -63, 117, -47, -59, -57, -54,  -6,  -8,-122, -77, -74,-120, -71, -89, -52, -92,  21;
/M: SY='Q';  M= -61, -44, -56,  35,-119, -96, -31, -26,  54, -76, -50, -52, -67,  62,  55, -34,   5, -10, -55,   0;
/M: SY='K';  M= -89, -73, -34, -78, -41,-117, -55, -80, 104,-102, -26, -18, -25, -90,  28, -35, -63,-120,-119, -18;
/M: SY='R';  M= -16, -83, -31,  10, -65, -50, -23,  26,  20, -11,  27, -13,   0, -19,  35, -18,   2,  31,-125, -35;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	55 in 55 different sequences
Number of true positive hits	55 in 55 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	mRNA cap 0 methyltransferase
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

55 sequences

MCEL_CAMPM  (Q8V2R8), MCEL_CAMPS  (Q775U0), MCEL_CWPXB  (Q8QMV9),

MCEL_CWPXG  (Q80DX6), MCEL_FOWPN  (Q9J584), MCEL_MONPV  (A0A7H0DN85), 
MCEL_RFVKA  (P25950), MCEL_VACCA  (O57209), MCEL_VACCC  (P20979), 
MCEL_VACCT  (Q9JFA8), MCEL_VACCW  (P04298), MCEL_VAR67  (P0DSX5), 
MCEL_VARV   (P0DSX6), MCES1_ARATH (Q9LHQ7), MCES1_ORYSJ (Q6Z9U7), 
MCES2_ARATH (Q5HZ60), MCES2_ORYSJ (Q6K833), MCES_ASPCL  (A1CT57), 
MCES_ASPFU  (Q4WN42), MCES_ASPNC  (A2QVS9), MCES_ASPOR  (Q2UM19), 
MCES_CAEBR  (Q61E36), MCES_CAEEL  (Q9XVS1), MCES_CANAL  (Q5ADX5), 
MCES_CANGA  (Q6FML4), MCES_CRYNB  (P0CO65), MCES_CRYNJ  (P0CO64), 
MCES_DANRE  (Q1MTD3), MCES_DEBHA  (Q6BMH4), MCES_DROME  (Q9VJQ4), 
MCES_ENCCU  (Q8SR66), MCES_EREGS  (Q754U7), MCES_HUMAN  (O43148), 
MCES_KLULA  (Q6CKI0), MCES_LODEL  (A5E032), MCES_MACFA  (Q4R7K1), 
MCES_MOUSE  (Q9D0L8), MCES_NEOFI  (A1DMG9), MCES_PICGU  (A5DDJ4), 
MCES_PICST  (A3GEV2), MCES_PYRO7  (A4R8D7), MCES_RAT(Q5U2U7), 
MCES_SCHPO  (O74880), MCES_XENLA  (Q9I8S2), MCES_XENTR  (Q28FT4), 
MCES_YARLI  (Q6CC11), MCES_YEAST  (P32783), MCE_ASFB7   (P32094), 
MCE_ASFK5   (P0C995), MCE_ASFM2   (Q65216), MCE_ASFP4   (P0C993), 
MCE_ASFWA   (P0C994), MCE_MIMIV   (Q5UQX1), R1AB_WBV24  (Q008X6), 
R1A_WBV24   (Q008X5)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

26 PDB

1RI1; 1RI2; 1RI3; 1RI4; 1RI5; 1Z3C; 2HV9; 2VDW; 3BGV; 3EPP; 4CKB; 4CKC;
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