PROSITE entry PS51525

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General information about the entry

Entry name [info]	NET
Accession [info]	PS51525
Entry type [info]	MATRIX
Date [info]	01-JUL-2012 CREATED; 10-MAY-2017 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51525
Associated ProRule [info]	PRU00857

Name and characterization of the entry

Description [info]

NET domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=82;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=77;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2662618; R2=0.0056468; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11608.4716797; R2=5.0701904; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1547; H_SCORE=19452; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=750; H_SCORE=15411; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-21; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='K';  M=-10,-74, 22, 20,-74, -9,-60,-14, 37,-37,-32,  2, 21, 13, 15, 10,  8, -5,-80,-67;
/M: SY='S';  M=-18,-72,  1,  4,-73,-17,-12,-46, 29,-28,-38,-34, 29, -6, 15, 55, 11,-22,-34,-49;
/M: SY='K';  M=  5,-73,  3, 12,-71, -2,-61,-20, 30,-15, -7,  2, 13, 16, -1, 19,  7, -2, -8,-66;
/M: SY='K';  M=  8,-40,  0, 20,-49,-25,-27,-38, 32,-25,-61,  1, 28, 11, 19,  0, 15,  1,-79,-49;
/M: SY='E';  M=  5,-76, 18, 50,-40,-39,-60,-14, 26,-39,-20,-22, 35, 11,  3, -7,-27, -5,-78,-39;
/M: SY='P';  M= -5,-74, 30, 23,-75,-20,-60,-25, 32,-31,-33,  6, 36,  9, -3, 21, 12,-34,-81,-68;
/M: SY='T';  M= 16,-72, 16,  7,-18,-24,-24,-14, 19,-18,  4, 22, 28,-18, -9,-22, 31,-22,-77,-13;
/M: SY='C';  M=  6, 64,-32, 19,-68,-53,-24,-32, 28,-29, -4, 10,  2, 26,-22, 12,  9,-16,-77,  8;
/M: SY='R';  M=-18,-77,-25, 12,-72,-44,-60,-25, 41,-18,-19,-43, 41,-16, 61, -8,  2,-18,-77,-66;
/M: SY='P';  M=  6,-77,-22,  7,-39,-57, -3,-14, 17,-20,-12,-62, 78, -9,-15,-22, 10, -1,-19,-27;
/M: SY='M';  M=-63,-72,-81,-73, -3,-55,-65, 29,-70, 36, 97,-74, 30,-66,-49,-46,-59, 20, -9,  2;
/M: SY='T';  M=-50,-64,-27,-58,-70,-32,-63,-46,-28,-44,-63, 13, -6,-28,-63, 57, 88,-40,-85,-66;
/M: SY='Y';  M=  9,-74, 23,  5,  8,-72, 10, -4,-41,  8, 11,-37,  3,-10,-19,-43,  7,  2,-63, 61;
/M: SY='E';  M= -6,-77, 51, 77,-62,-28,-55,-44, -8,-44, -9, 23,-39,  1,-37,-15,-57,-48,-83,-70;
/M: SY='E';  M=-34,-80, 21, 94,-79,-73,-53,-75,-31,-52, 40,-55,-59, 45,-23,-56,-60,-72,-80,-69;
/M: SY='K';  M=-63,-77, -7,-44,-47,-71,-57,-41, 91,-54, -8,-19,-66,  6, 50,-57,-22,-71,-74,-63;
/M: SY='R';  M=-22,-19,-13,  7,-44,-71, -8, -4, 31, -5,-56,  8,-41, 30, 56,-16,-11,  4,-13,-32;
/M: SY='Q';  M=  8,-74, 10, 33,-73,-67,  2,-11, 32,-16,-59,  6,-66, 51, 15,  0, -6,-12,-79,-64;
/M: SY='L';  M=-67,-70,-84,-77, 38,-86,-71, 36,-51, 76,-32,-80,-82,-73,-75,-74,-24,-29,-67,-48;
/M: SY='S';  M= 31,-22,-37,-39,-72, 28,  5,-26,-25,-55,  3,-52,-66, 17,-18, 62,  7,-27,-78,-37;
/M: SY='E';  M=  4,-74,  4, 45,-72,-40, -8,-25, 21,-23,  1, 21,-66, 29, 24, 12,-18,-26,-11,-32;
/M: SY='D';  M= 19,-26, 48, -2,-73, -9, 16,-44, 11, -9,-12, 42,-68,  4, 21, -6,-12,-66,-83,-65;
/M: SY='I';  M=-46,-25,-83,-51,  5,-86,-76, 79,-77, 46,-11,-77,-41,-73,-78,-50,-59, 10,-71,-30;
/M: SY='N';  M= -4,-31, -6, -4,-27,  6,-54,-70, 10,-36,-15, 60,-13, 50, -5,  5, -7,-54, -5, 17;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='Q';  M=-23,-75, 12, 39,-23,-36,-25,-72, 40,-31,-16, 25,-66, 42, 26, 21,-27,-58,-76,-24;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='L';  M=-66,-70,-84,-77,-11,-85,-69, 24,-77, 80, 33,-81,-81,-71,-75,-75,-32,-10,-70,-27;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='P';  M=-28,-35, 31, -1,-79,-35,-63,-72,-26,-34,-68,  5, 93,-41,-66, 29, 15,-71,-83,-74;
/M: SY='P';  M=-11,-77, 30, 25,-79, 44,-35,-52,  2,-59,-69, -6, 59, -5,-38,-10, -2,-41,-80,-49;
/M: SY='E';  M= 12,-25, 52, 71,-28,-43,  1,-51, -1,-43,-10, -2,-43,-46,-43,-13,-27,-21,-82,-67;
/M: SY='Q';  M=-21,-77, 40,  7,-50,-59, 13,-25, 48,-24,-11,  2,-23, 55, 17,-36,-33,-37,-75,  5;
/M: SY='L';  M=-29,-28,-78,-71,-32,-79,-66, -1,-70, 68, 61,-42, 12,-11,-45,-68, -4,-10,-72,-20;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='Q';  M=  6, -9,  6, 41,-27, 24,-25,-39,-15,-30,-64, 23,-12, 41, 14, -2,-26,-33,-78,-66;
/M: SY='H';  M=-14,-47, -9, 42,-76,  5, 45,-52, 31,-72,-23,  6,-37, 35, 38,-18, -2,-50,-78,-27;
/M: SY='V';  M= 22,-68,-80,-48,-36,-78,-78, 47,-73,  9, 23,-75,-76,-71,-75,-64,-54, 73,-80,-60;
/M: SY='I';  M=-11,-31,-81,-76,-18,-56,-77, 59,-32, 30, 13,-44,-77,-71,-46,-68,-39, 53, 43,-55;
/M: SY='H';  M= -9,-77, 34, 49,-47,-21, 63,-78, -2,-64,-65, 17,-65, 59,  2,-18,-10,-75, -6,-61;
/M: SY='I';  M=-65,-75,-50,-78,  9,-86,-75, 88,-50, 21, 45,-75,-40,-38,-76,-73,-60, -3,-69, -9;
/M: SY='I';  M=-62,-73,-83,-79,-37,-87,-80, 82,-50, 27, -5,-42,-76,-73,-49,-71,-39, 47,-76,-57;
/M: SY='Q';  M=  2,-76,  4,  4,-78,-41,  5,-75, 38,-41,-63, 14,-38, 73, 39,  1, -9,-71,-20,-64;
/M: SY='E';  M=-15,-76,-11, 53,-78,-53, -1,-34, 43,-73,-65, 23,-12, 45, 16, 11,-17,-40,-79,-67;
/M: SY='H';  M= -7,-26, 22,-27,-73,-11, 49,-34, -4,-27,  1, 39,-69, 28, 42, 22, -2,-50,-83,-62;
/M: SY='C';  M= -5, 68,-16, 36,-46,-44, 18,-32,-21, -8, 33, 40,-39, -6,-44,  8,-10, -4,-83,-41;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='P';  M= 17,-87,-18,-15,-85,  4,-10,-32,-24,-36,-74,  1, 45,-26,-77,-12,-36,-19,-10,-53; D=-13;
/I:         I=-13; DM=-32;
/M: SY='P';  M=-20,-34, 10, -5,-11, -5,-28,-34,-27, 20,  7,  5, 28, 22,-51, -7,-44,-16,-81,-31; D=-13;
/I:         I=-13; DM=-32;
/M: SY='D';  M=-31, -5, 23, 15, 11, -4,-24, -2, 16, -1,-25, -4, -3,  8,-13,-14,-33, -5,-75,  3; D=-13;
/I:         I=-13; DM=-32;
/M: SY='D';  M= -8,-75, 24, 20,  2,  0,-35,-29,  2, -7,-37,  6,  3, 23,  6, -7,  2,  1,-77,-34; D=-13;
/I:         I=-13; DM=-32;
/M: SY='S';  M= -2,-44, 22, -2,-25,-21, -7,-10,-11,-35,-17, 28,  5, 13, -9, 33, 10,  9,-27,-17;
/M: SY='N';  M=  2,-25, 28, 29,-33, 21,-34,-51,-31,-50,-40, 44,-19, 13,-12, 27,  9,-38,-81,-38;
/M: SY='D';  M=-20, -7, 53, 39,-77, -6, -3,-43,-12,-41,-68, 45,  8, -5,-41, 25,-26,-32, -8,-68;
/M: SY='D';  M=-52,-26, 75, 53,-80, 32,-56,-57,-27,-60,-28,  6,-41, -2,-29,-12,-30,-54,-85,-44;
/M: SY='E';  M=-60,-79,  9, 93,-77,-39,-55,-73, -7,-44,-15,-55,-19,  7,-18,-42, -3,-19,-79,-31;
/M: SY='I';  M=-61,-20,-81,-56, -5,-55,-76, 67,-74, 29, 40,-41,-77,-37,-76,-50,-40, 51,-75,-55;
/M: SY='E';  M=-58,-77, 16, 93,-57,-73,-18,-25,-47,-39,-28,-35,-60,  4,-55,  7,-16, -8,-81,-68;
/M: SY='I';  M=-46,-71,-82,-51, 34,-84,-74, 61,-76, 53,-11,-77,-79,-73,-76,-34,-37, 27,-69,-50;
/M: SY='D';  M=-66,-79,104, 18,-82,-44,-17,-23,-35,-79,-76, 34,-38,-52,-61,-40,-56,-56,-95,-39;
/M: SY='I';  M=-63,-72,-84,-79, 35,-85,-75, 69,-76, 34, 46,-77,-77,-74,-77,-51,-36, 36,-70,-50;
/M: SY='D';  M=-62, -1, 89, 45,-80,-50, 16,-53,-17,-63,-73, 19,-65,-28,-22,  2,-23,-52,-91,-39;
/M: SY='A';  M= 38,-69, -5, 11,-42,-34, -5,-31, -4,-30,  4, -9,-66, 36,-16, 34, 23, -7,-79,-64;
/M: SY='L';  M=-43,-71,-79,-30,  9,-82,-67, 35,-72, 66, 42,-42,-79, -6,-72,-51,-61,  4,-69, -2;
/M: SY='D';  M=-15,-77, 76, -7,-82,-24,-58,-78, 18,-80,-73,-13, 53, -7,-46, 36,-14,-75,-86,-71;
/M: SY='P';  M=-26,-74, 43, -2,-39,-65,  8,-18,-18,-56,-64, 39, 60,  4,-37,  3, 36, -9,-85,-67;
/M: SY='D';  M= 12,-75, 47, 36,-73,-37, 28,-44, 26,-22,-35,-11,  0, 10,  4, -3,-23,-24,-80,-23;
/M: SY='T';  M= -4,-11,-38,-62,-37,-69,-68,  2,-21,-31, -2, -7,-65,-22,-65,-21, 90, 24,-84,-63;
/M: SY='L';  M=-47,-71,-78,-49, 42,-39, -3,  1,-11, 66, 16,-73,-79, 10,-67,-55,-46,  1,-67,-48;
/M: SY='W';  M=-36, -5,-10,-38, 24,-55,-29,-32,-16,-12,-59, -9,-75,-56, 65,-34, -5, -4,107,  4;
/M: SY='E';  M=-19,-75,-21, 49,-43,-47,-38,-68, 48,-31, 21, -4,-65, 11, 35, 10,  0,-25,-76,-32;
/M: SY='L';  M=-64,-17,-83,-53,-44,-86,-71, 29,-76, 77, 29,-81,-81,-71,-75,-75,-61, 21,-74,-55;
/M: SY='Y';  M=-28,-78, 18, 37,-24,-71, 28,-67, 24, -6,-58,  7,-69, 40, 23,-41,-41,-51,-17, 61;
/M: SY='R';  M=  4,-47, 15, 18,-22,-38,-10,-37, 41,-51,  6, 27,-68,  4, 48,-10,-20,-58, -7, -4;
/M: SY='Y';  M=-34,-75,-75,-72, 69,-53, -9,-25,-45, 16, 15,-71,-80, -3,-29,-45,-25,-40,  1, 91;
/M: SY='V';  M=-25,-18,-82,-76, -6,-54,-77, 32,-53, 19, 37,-76,-78,-73,-74,-68,-55, 78,-78,-26;
/M: SY='K';  M=  9, 14, 26,  0,  8,-39,-40, -9, 39,-27,-30,  9,-41,  1, 26,-10,  1,-12,-77,-61;
/M: SY='E';  M= -6,-73,  8, 35,-75,-14,-38,-48, 32,-55, -3, 33,-42, -1, 23, 35, -1,-40, -5,-66;
/M: SY='C';  M=  8, 60,-67,-29,  5,-25, 31,-11, 29,-31,-21,-12,-17,-58, 18,-25,-16,  5, 53, 23;
/M: SY='L';  M=-24,-71,-15,-32,  8,  0, -7,-30, 31, 43, 25,  8,-41,-12,-14, -8, -4,-20,-73,-57;
/M: SY='R';  M=-14,-20,-21, 26,-48,-10,-15,-19, 36,-60,-35, 14, 31, 28, 37, -3,-26, -9,-78,-66;
/M: SY='E';  M= 16,-37,-22, 27,-74, 12, 24,-26, 16,-53,-28, 21, 20, 23,-23,  4, 12,-15,-79,-42;
/M: SY='Q';  M=-20,-30,-13,  8,-25,  4, 26,-33, 34,-15,-18, 13, -6, 35, 19,  4,-22, -9,-76,-19;
/M: SY='K';  M=  9,-74,-19,  7,-60, 23, -3,-52, 34,-61,  2, 19, 24, 21, 11, 24,-31,-34,-78,-67;
/M: SY='K';  M=  2,-74, 11,-35,-71,  2,-37,-40, 46, -5,-27,-18,  2, 29, 27, 11,-33,  3,-78,-65;
/M: SY='K';  M=  0,-73,  1,-12,-68, -8,-59,-19, 40,-15,-28, 21,  9,  7, 20, 15, -9,  1,-76, -9;
/M: SY='P';  M= -1,-73, -1, -2,-53,-24,-32,-45, 21,-18,-14, 22, 26,  8, 26, -4, 14, 13,-76,  4;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	38 in 38 different sequences
Number of true positive hits	38 in 38 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Feature key [info]	DOMAIN
Feature description [info]	NET
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

38 sequences

BDF1_CANAL  (Q5A4W8), BDF1_SCHPO  (Q9Y7N0), BDF1_YEAST  (P35817),

BDF2_YEAST  (Q07442), BET1_CAEEL  (Q95Y80), BRD2_BOVIN  (Q32S26), 
BRD2_CANLF  (Q5TJG6), BRD2_HUMAN  (P25440), BRD2_MOUSE  (Q7JJ13), 
BRD2_RAT(Q6MGA9), BRD3_HUMAN  (Q15059), BRD3_MOUSE  (Q8K2F0), 
BRD4A_XENLA (Q08D75), BRD4B_XENLA (Q6DFF2), BRD4_DANRE  (F1R5H6), 
BRD4_HUMAN  (O60885), BRD4_MOUSE  (Q9ESU6), BRDT_DANRE  (F1QW93), 
BRDT_HUMAN  (Q58F21), BRDT_MACFA  (Q4R8Y1), BRDT_MOUSE  (Q91Y44), 
BRDT_RAT(D4A7T3), BRDT_XENTR  (F7DRV9), FSH_DROME   (P13709), 
GTE10_ARATH (Q9FGW9), GTE11_ARATH (Q93ZB7), GTE1_ARATH  (Q84XV2), 
GTE2_ARATH  (Q9LXA7), GTE3_ARATH  (Q9S7T1), GTE4_ARATH  (Q9LNC4), 
GTE5_ARATH  (Q8H1D7), GTE6_ARATH  (Q9FT54), GTE7_ARATH  (Q7Y214), 
GTE8_ARATH  (Q9LK27), GTE9_ARATH  (Q93YS6), Y0170_DICDI (Q55C84), 
Y3800_DICDI (Q54BA2), YK82_SCHPO  (Q9HGP4)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

13 PDB

2JNS; 2N3K; 2NCZ; 2ND0; 2ND1; 6BGG; 6BGH; 6BNH; 6CUI; 7JMY; 7JQ8; 7JYN; 7JYZ
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