PROSITE entry PS51512

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51512
Entry name [info]	DFDF
Accession [info]	PS51512
Entry type [info]	MATRIX
Date [info]	01-MAY-2011 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51512
Associated ProRule [info]	PRU00845

Name and characterization of the entry

Description [info]

DFDF domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=37;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4585652; R2=0.0060479; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3541.7595215; R2=1.5934267; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=999; H_SCORE=5134; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=669; H_SCORE=4608; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-35; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='N';  M=  17,-102, -29,  -3,   3,   4, -24, -34, -65, -53, -91,  41,  29,  29,  -7,  27,  17,  -6,  -3, -39;
/M: SY='Q';  M=   3, -59,   1,   8, -34,   4,  -7, -53,   4, -60, -93,  29,  29,  42,  25,   7,  23, -30,-109, -96;
/M: SY='P';  M=  12,-106,  39,  19, -76,  -9, -19, -15,   0, -78, -94, -12,  58,  -6, -11,  19, -29,   1,   4, -98;
/M: SY='K';  M=  21,-103,   5,  23, -69, -10, -21, -20,  37, -92, -20,  26,  15,  11,   3, -17,   4,   4, -47, -70;
/M: SY='P';  M=  16,-102,   6,  16, -41, -22, -56, -21,  25, -16, -61,  24,  30,   5, -20,  18,  20, -33,  -7, -95;
/M: SY='P';  M= -19,-104,  40,  -6,-101, -60,  29, -22,  28, -36, -15,   8,  46, -41, -15,  -6,  21,  24,-114, -95;
/M: SY='E';  M=  23,-101, -12,  49, -54, -11, -30,  19, -30,  -5,   1, -41,   3, -19, -73,  -2,  31,  -2,-109, -95;
/M: SY='K';  M= -45,-104,   4,  19, -54, -73, -56,   2,  55, -47, -28,  17,  -2,  42, -24, -28,   9,  28,-108, -57;
/M: SY='P';  M= -25, -40, -85,   2,  76, -52, -59, -17, -49, -11,  11,  -4,  76, -36, -99, -49, -42, -24, -92,  -9;
/M: SY='D';  M=   0,-103,  54,  34,-106, -37, -34,-101,  19, -47,  29,  17,  14,  15, -44,  16,  29, -97,-113, -97;
/M: SY='E';  M= -10,-104,  19,  61,-108,  21, -88,-102, -17,-103, -97,   7,  -8,  30,   5,   6,  26, -13,-111,-100;
/M: SY='D';  M=  -8,-110,  99,  75,-115, -97, -84,-114, -80,-110,-107, -74, -17, -76, -89, -85, -88,-108,-121,-102;
/M: SY='F';  M=-105,-103,-115,-112, 120,-112, -91, -80,-106, -72, -80,-106,-116,-113,-103,-103, -97, -85, -68,  65;
/M: SY='D';  M= -97,-109, 120, -63,-117, -93, -82,-115, -84,-114,-112,  37, -97, -84, -93, -84, -86,-112,-133,-101;
/M: SY='F';  M=-105,-102,-117,-113, 124,-113, -95, -52,-108, -43, -80,-107,-116,-116,-105,-104, -97, -84, -70,  30;
/M: SY='E';  M=  26,-106, -25,  92,-110, -97, -85, -51, -76,-101,  -8, -47, -90,  60, -83,  -7, -28, -74,-109, -99;
/M: SY='S';  M=  32,-100, -43,  22,-108,  22, -90,-105,  26,-104, -97, -48, -94,  33,   5,  54,  20, -97,-108, -98;
/M: SY='N';  M=  59, -28, -84, -54,-102, -23, -85, -95, -86, -96,  65,  83, -99, -19, -92,  34, -79, -91,-112, -97;
/M: SY='N';  M= -31, -98, -78, -92, -48, -90, -81, -86, -85,  50, -81, 108,-106, -11, -38, -59, -82, -90,-114, -93;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='A';  M=  74, -98, -50,  42,-108, -70, -91,-100,   4, -84, -33, -27, -94,  46, -47,  11, -22, -71,-107, -99;
/M: SY='K';  M= -47,-107, -43,  35,-101,-102, -87, -97,  85,  12,  25, -50, -96,  32,  20, -89, -89, -96,-104, -93;
/M: SY='F';  M= -21,-101,-116,-111, 119,-111, -98, -50,-108,  17, -77,-107,-114,-114,-105,-102, -96, -81, -75, -54;
/M: SY='N';  M=  -8,-104,  63,  56,-111, -91, -82,-109,   9,-109,-101,  75, -95,  -5, -14, -15, -17,-105,-117,-100;
/M: SY='K';  M= -50,-108, -57,  42,-110,-101, -87,-110, 104,-108, -97, -80, -92, -69,   0, -59, -88,-105,-104, -97;
/M: SY='E';  M= -32,-109,  27,  61,-103, -24, -38,  17,  16, -10, -38, -62,  19,  51, -15, -21, -47, -72,-109, -96;
/M: SY='E';  M=  13,-104,  43,  43,-103, -47, -18, -67,  20, -10,   1, -43, -96,  12,  27,   1,  22, -49,-111, -96;
/M: SY='V';  M=   7, -47, -17,  30, -68, -60, -99,  34, -17,  20, -79, -19, -34, -90, -96,  10,  -2,  45,-110, -93;
/M: SY='W';  M=  11,-104,   2,  19,  51, -97, -26, -13, -13, -35, -56, -24, -34,  22, -54,  34, -64, -12,  89, -25;
/M: SY='K';  M=  10,-104,  33,  24, -13,  18, -42, -11,  36,  -6, -27,   6, -42,  -2, -25, -27,   5, -47,-107, -94;
/M: SY='E';  M=  -8,-106,   6,  66, -68, -39,  16, -18,  39, -56, -93,  -6, -24,  27, -39,  -8,  -1, -28,-108, -25;
/M: SY='Q';  M=  10,-102, -45,  -4,  17, -80, -94,  22,  15,  26,  27, -92, -32,  37, -59,   0,  16, -12,-102, -42;
/M: SY='E';  M= -10,-104, -22,  45,-102,  32, -35,   1,   6, -38, -26,  -2, -56,  17,   9,   3,  25, -33,-108, -46;
/M: SY='K';  M=  34,-102,  -4,  42,-105, -18, -89, -73,  52, -53,  -8,  18, -61, -10, -34,  28, -52, -36,-108, -53;
/M: SY='K';  M= -21, -64,   8,  25,-103,   0,   1, -16,  46, -52, -48,  20, -36,   5, -46,  36,  18, -29,-109, -32;
/M: SY='D';  M=   5, -48,  56,  10,  -4,  25, -11, -49,   5, -33, -62,   0,   8,  10, -50,   0,   1, -34,-110, -95;
/M: SY='T';  M=  13,-103,   1,  23, -98, -18,   1, -47,  28, -29, -33,   1,   9,  17, -44,  21,  30, -30,-106,  15;
/M: SY='S';  M= -10, -40,  -8,  14, -50, -28, -26, -21,  12, -27, -89,   2,  24,  -9,   0,  28,  22,  14,-105,  22;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	28 in 28 different sequences
Number of true positive hits	28 in 28 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	DFDF
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

28 sequences

DCP5L_ARATH (Q9FH77), DCP5_ARATH  (Q9C658), EDC3_CHICK  (Q5ZLS2),

EDC3_DANRE  (Q502M5), EDC3_DROME  (Q9VVI2), EDC3_HUMAN  (Q96F86), 
EDC3_MACFA  (Q4R8V9), EDC3_MOUSE  (Q8K2D3), EDC3_PONAB  (Q5RDU9), 
EDC3_SCHPO  (O94752), EDC3_XENLA  (Q5XH48), EDC3_YEAST  (P39998), 
L14AA_XENLA (A0A8M2), L14AB_XENLA (Q8AVJ2), L14BA_XENLA (Q68FI1), 
L14BB_XENLA (Q498K9), LS14A_BOVIN (Q3MHF8), LS14A_HUMAN (Q8ND56), 
LS14A_MOUSE (Q8K2F8), LS14A_PONAB (Q5R4R4), LS14A_XENTR (Q6NVR8), 
LS14B_HUMAN (Q9BX40), LS14B_MOUSE (Q8CGC4), LS14B_XENTR (Q566L7), 
LS14H_CAEEL (Q9XW17), LSM14_PLEWA (Q9YH12), SCD6_YEAST  (P45978), 
SUM2_SCHPO  (Q9HGL3)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

7 PDB

2WAX; 2WAY; 3D3J; 4A53; 4BRU; 6F9S; 6S8S