PROSITE entry PS51503

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS51503

Direct ScanProsite submission

General information about the entry

Entry name [info]	HIG1
Accession [info]	PS51503
Entry type [info]	MATRIX
Date [info]	01-AUG-2010 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51503
Associated ProRule [info]	PRU00836

Name and characterization of the entry

Description [info]

HIG1 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=92;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=87;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.2970145; R2=0.0079802; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11597.2617188; R2=7.7663736; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=966; H_SCORE=19100; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=402; H_SCORE=14719; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-23; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='P';  M= -9,-83, 24,-25,-75,-74,-10,-29,-43,-40, -3,-34, 29,  0,-16,-23,-38,-29,-14,-19;
/M: SY='R';  M=-32,-82,-36, -9,-19,-78,-67,-24,-15,-15, -6,-68,  8, -8, 10,-11,-15,-32, -6, -1;
/M: SY='P';  M=-16,-82, 20, 18,-40,-36,-66,-28,  1,-79,-73,-18, 23,-35,-63, -1,-23,-73,-85,-39;
/M: SY='S';  M=-12,-78,-11, -1,-46,-33,-64,-45,  0,-43, -6,  6,-40, 13,-61, 22,-41,-50,-83,-33;
/M: SY='M';  M=-47,-81,-28,-42,  6,  3,-66,-32,-30,  0, 11,-66,-39,  9,  5,-20,-43,-47,-72,  4;
/M: SY='D';  M=-17,-78, 15, -8,-48,-29,-26, -2,-29,-32,-24,-37,-75,-38,-11,-17,  1, -1, -5,-68;
/M: SY='E';  M=-22,-80, -5,  7,-10,-37,-68,-29,-15,-17,-26,-30,-13,-14,-10,-21, -6,-25,  3,-65;
/M: SY='W';  M=-47,-80,-23,  1,-12,-74,-24,-18,-28,-40,  7,  2, 11,-15,-27, -3,-11,-31, 23, -2;
/M: SY='Q';  M= -8,-77,  2, -7,-71,-36,-24,-19, -8,-14,  9,-41,-18, 11, -4,-16,-21,-15,-83,-67;
/M: SY='E';  M=-13,-78, 18, 30,-37,-50,-60,-27,-15,-52, 12,-34,-10, -9,-38, -5,-18,-66, -7,  3;
/M: SY='W';  M=-21,-77,-40, -8,  3, -5,-19,-30,-28,-20,  6,-21,-10,-32, -9,  9,-60,-23, 38,-36;
/M: SY='E';  M=-19,-24,  5, 33,-38,-35,-26,-51,  3,-55,-31,-13,-12, 12, 12,-25,-13,-70,-77,-17;
/M: SY='N';  M=-24,-75, 26,  2,-76,-21,-18,-51, -1,-73,-35, 32,-18, 10,-20, -4,-31,-14,-84,-34;
/M: SY='E';  M=-26,-78,-34, 44,-66,-52,-21,-38,-36,  1, 17,-63, 20, 12,-37,-43,-27,-35,-76,-10;
/M: SY='T';  M=-19,-71,-18,-36,-72,  9,-65,-45,-38,-30,-33,-15, -5,-32,-15, 27, 38,-42,-83,-69;
/M: SY='P';  M=-16,  5,-67,-24, 14,-20,-17,-16, -7,-46, 12,-62, 27,-16,-38,-39, 20,-30, -3, -1;
/M: SY='W';  M=-11,-72,-39,-13,-20,-18,-14,-20,-18,  0,-26,-60, -2,-29,-35,  8, 14,-20, 16,  1;
/M: SY='Q';  M=-57,-76,  6, 39,-74,-23, 19,-74,-30,-54,-16, -4,-17, 52,-52, 15,-23,-72,-77,-16;
/M: SY='K';  M=-11,-75,-12,-15,-45,-66,-56,-76, 64,-75,-65,-25,-21,  5, 26, -7,-36,-71,-74,-64;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='F';  M=  7,-70,-78,-53, 30,-74,-68, 22,-50, 27, 25,-72,-26,-68,-71,-29,-58, -7, -5,-20;
/M: SY='W';  M=  4,-69,-68,-61,-32,-18,-64, -6, 11, 14, 32,-36,-69, -6,-10,-11,-26, -9, 53,-54;
/M: SY='M';  M=-20,-70,  3, 17,-26,-63, 16,-58, -9,-38, 49, -6,-34,  4, 49, -8,-39,-42,-63, 28;
/M: SY='W';  M=-45,-71,-40,-39, -1,-28, 16,-63, 45,-48,-33, 18,-64,-23, 17,  9,-53,-45, 94, 24;
/M: SY='C';  M= 20, 40,-62,-40, 30,-13,-30,-20,-40, -5, 18,-55,-41,-12,-60,-12, 22, 11,-13, 13;
/M: SY='K';  M=  0,-63,-32,-46,-22,-59,-25, -9, 51,-13, 31, -1,-29,-41, 34, -1,-28, -2,-63,  0;
/M: SY='E';  M=-10,-65, 14, 66,-14,-26,-45,-32, -8,-15,  7,  8,-53, 10, 22,-10,-35,-48,-66,-35;
/M: SY='H';  M=-43,-62, 23,  9,-61,-52, 71,-43,-16,-51,-25, 65,-57, 44,-43,  0,  2,-14,-75,-18;
/M: SY='P';  M=-54,-72,-53, -7, -3,-48,-54,  5, 36,-33,-25,-53, 91,-31, 10,-51,-13,-53,-62,-23;
/M: SY='Y';  M=-35,-63,-70,-65, 47,-49,-50,  1,-63, 54, -3,-67,-38,-59,-61,-61,-53,-23, 50, 65;
/M: SY='V';  M=-18,-60,-63,-55, -2,-31,-33, 21, 27, 13,  5,-56, -3,-52, -4,-26,-27, 54,-65,-47;
/M: SY='P';  M=-18,-18,-63,-56, -2,-40,-61, 38,-58,  8,-17,-61, 82,-58,-64,-10,-36, 10,-63,-23;
/M: SY='I';  M=  5,  9,-71,-67,-21,-45,-68, 73,-65, 28,-27,-64,-65,-62,-67,-57,-47, 30,-64,-47;
/M: SY='G';  M= 30,-60,-58,-61, 11, 73,-60,-51,-58, -8,-22,-47,-60,-56,-63,-33,-51,  6,-60,-53;
/M: SY='C';  M= 23, 83,-62,-61,-17, 25,-59, 11,-58, -2, 56,-52,-62,-56,-62,-12,  2,-13,-67,-53;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='L';  M= 40,-10,-61,-58,-25, 17,-59,  1,-58, 41,-34,-54,-61,-55,-61,-12, 14,  9,-64,-50;
/M: SY='W';  M= 56, 11,-66,-58,-26,  7,-64,-38,-57,  8, -1,-59,-61,-54,-60,-20,-51,-38,117,-40;
/M: SY='T';  M= 20,-12,-57,-56,-16,-59,-61,-19,-54, -3, -6,-49,-57,-56,-59,-37, 72, 49,-71,-50;
/M: SY='A';  M= 51, 24,-59,-55,-41,  2,-61,-36,-55, -5,-43,-51, -6,-54,-59,  2, 22, 40,-69,-55;
/M: SY='G';  M= 26,-14,-56,-57,-12, 45,-57,  0,-55,-10,-45,-47,-59,-52,-59, 34, -2, 17,-61,  5;
/M: SY='M';  M= 43,  7,-64,-58,-12,-56,-59,  9,-57, -7, 66,-57,-61,-54,-59,-17,  0, 47,-66,-48;
/M: SY='L';  M= -2,-14,-67,-63,  9, 20,-58,-16,-63, 62,-27,-61,-67,-59,-63,-35,-49, 16,-58, -7;
/M: SY='I';  M= 14,-59,-64,-62, -7, 27,-60, 39,-59, 21, 10,-55,-62,-57,-62,-18,  3, 22, 10, -4;
/M: SY='S';  M= 28,-59,-56,-53, -8,  1,-50, 12,-46,  9, -3,-12,-60,-46, 26, 36,-21,-34,  6, 24;
/I:         I=-13; MD=-33;
/M: SY='G';  M=  7,-63,-60,-63, 29, 72,-59,-22,-59,-27, 32,-48,-60,-56,-63,-11,-53,-39, 54,-46; D=-13;
/I:         I=-13; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='Y';  M= 17,-62,-62,-28, 34, -8,-15,  0,-24, 16, 32,-57,-38,-52,-11,-51,-32, -6, 48, 56;
/M: SY='Y';  M= 14,-61,-38,-51, -6,-16,-47,  9, 15,-20, 27, 27,-61,-24, 20,-11,-45, 13, -6, 45;
/M: SY='M';  M=  9,-10,-53,-35,-34,-11,-12,  9,  2,-24, 46, 10,-59,-18,  4, 28,-18, 20,-62, 15;
/M: SY='M';  M=-20,-23,-34,-55, 37, 21,-49,-14,-26,-34, 61, 14,-60,-48, 22,  8, 14,-14,  6,  1;
/M: SY='R';  M=-38,-66,-18,-41,-37, 11,  9,-63, 26,-48,-24,-24,-36,  3, 78, 12,-15,-35,-64,-26;
/M: SY='N';  M=  0,-63, 32, -7,-64, 15,-43,-44,  2,-41,-54, 48,-57, 27, 47,-21, -6,-43,-69,-34;
/M: SY='G';  M= -6,-65,-37,-14,  0, 63,-54,-62, 11,-46,-55,-32, 41, 13,-20,-19,-24,-27,-61,-37;
/M: SY='N';  M=-22,-62, 38,-20,-28, -3, 10,-30,-22,-43,-22, 56,  4,  3,-34, 28,-27,-57,-60, 46;
/M: SY='M';  M=-20,-62,-33,-45,-30,-30, 11,-15, 12,  5, 57,-46, 33, 29, 24, 23, -1,-39,-65,-48;
/M: SY='T';  M= -3,-57,-11,-34,-57,-37,-48,-49, 29,-11, -2, 23,-56,  7, 15, 36, 37, -3,-14,-52;
/M: SY='M';  M=-29,-11,-31,-15, -8,  0, -4,-50, 16, -1, 44, -2,  7,  7, 38,-29, 32,-49, -3,  5;
/M: SY='S';  M= 23,-55,-47,-44,-62,  4,-49,-56,-30,-45,  7,-38,  8, 27,-49, 75, 13,-38,-67,-54;
/M: SY='Q';  M=-47,-63,-38,-34,-64,-33,-38,-21,-34,-34,-45, 72,-58, 94, -8,-28,-43, 11,-68,-52;
/M: SY='K';  M=-52,-65,-46,-35, -4,-59,  7,-60, 84,-35,-19,-17,-55,-10, 39,-46,-19,-58,-53, 29;
/M: SY='M';  M=-17,-58,-71,-64, 20,-68,-54, 21,-61, 56, 76,-65,-66,-56,-60,-59,-49, 10, 34, -3;
/M: SY='M';  M=-49,-58,-71,-63, 27,-67,-51, 29,-58,  1,114,-61,-62,-24,-57,-58,-46, 32,-58,-36;
/M: SY='Q';  M=-52,-70,-47,-33,-12,-60, 70,-65, -3,-57, -7,-39,-59, 80, 76,-44,-37,-63,-64,-41;
/M: SY='W';  M= 53,-56,-58,-54,  2,  0,-53,-45,-52, 14, 13,-20,-59,-50,-36, -5, 15,-43, 72, 27;
/M: SY='R';  M=-54,-71,-51,-38,-64,-64,-40,-70,-11,-62,-51,-44,-63, -8,111,-48,-53,-64,-63,-50;
/M: SY='V';  M=-44,-57,-71,-65,-39,-72,-66, 51,-62, -1, 61,-64,-64,-61,-63,-57,-42, 76,-69,-46;
/M: SY='Y';  M= 19,-61,-62,-59, 10,  6, 15,  8,-20, 10, 28,-56,-63,-52,-54,-49,-49, 10, 56, 70;
/M: SY='A';  M= 72,-53,-60,-54, 37, -8,-56,-30,-55, 19,-40,-54,-59,-52,-58,-25,-32,-38, -9,-21;
/M: SY='Q';  M=-47,-72,-42,-21,-77,-55,-35,-63,-27,-58,-45,-37,-54,126,-27,-36,-49,-65,-60,-48;
/M: SY='G';  M= 51,-56,-57,-58, 55, 60,-57,-55,-56,-40,-50,-47,-58,-55,-60,-12,-32,-50,-52,-42;
/M: SY='F';  M= 28, 19,-66,-61, 42,-33,-59, 32,-60, 36,  8,-59,-64,-58,-61,-18,-17, 17,-56,-39;
/M: SY='T';  M= 43,-49,-49,-49,-55,-51,-57,-42,-48,-49,-46,-40,-50,-50,-55,-27, 91, 11,-72,-54;
/M: SY='V';  M=-47,-58,-72,-67,-36,-74,-68, 60,-65, 40,-23,-67,-66,-62,-65,-59,-44, 64,-66,-45;
/M: SY='A';  M= 50,-55,-60,-58,-34, 32,-61, 28,-57,  1,-20,-52,-59,-54,-60,-11,-16, 32,-64,-52;
/M: SY='A';  M= 48, 33,-64,-58, -7,-56,-60, 19,-59, 38,-15,-59,-63,-56,-60,-18,-30, 29,-63,-47;
/M: SY='L';  M=-38,-29,-71,-65,  5,-50,-58, 38,-63, 64, 49,-66,-67,-59,-63,-60,-35, 18,-59,-40;
/M: SY='M';  M= -2,-18,-66,-62,-11,-15,-61, 32,-60, 30, 52,-59,-63,-57,-61,-29,  2, 51,-64,-45;
/M: SY='G';  M= 32,-58,-60,-60,  2, 53,-58, 11,-58, 23,-19,-51,-60,-55,-61,-12,-47, 12,-59,-21;
/M: SY='G';  M= 19,-57,-53,-56,-14, 56,-54,-11,-53,-14,-23,-42,-56,-50,-58, 36, 27,-16,-60,  3;
/M: SY='A';  M= 44,-55,-62,-58,-10, 14,-58,  6,-57, 18, 34,-54,-60,-54,-59, -7,-11, 34,-62,-28;
/M: SY='W';  M= 33,-12,-62,-59, 31, 13,-51,-22,-56,  5, 41,-40,-63,-54,-58,-15,-31,  3, 58, 50;
/M: SY='Y';  M=  3,-59,-36,-60, 47,-62,-49, 10,-57, 24, 45,-29,-65,-30,-57,-14,-16,  4, 32, 56;
/M: SY='T';  M= -1,-59,-26, 34,  5,-55, 17,-22, -1,-30, 13,-11,-54,-11, -7, 28, 35,-48, 14, 34;
/M: SY='M';  M=  7,-62,-16,-15,-53, 45,-11,-27,-24,-26, 68, -5,-58, 13, 15,-14,-31,-39,  1, 11;
/M: SY='Y';  M= 14,-63,-15,-46,  3,  3,  8,-26,  8,-23,  0,  6,-31, 37,  7,-19,-10,-14,-54, 43;
/M: SY='D';  M=-15,-68, 44, 19,-69, 19,-51,-34, 15,-44, 16,-41,-18, 27,-18, 10,-13,-61,-72,-60;
/M: SY='R';  M=  4,-71, 11, -6,-69, -1,-55,-32, 19,-50,-60, -3, -9,  8, 32, -7,-37,-29,  4,-31;
/M: SY='K';  M=-10,-76,  0,-13,-27,-22,-22,-68, 31,-31,-59,-28, -6, 19, 19,-26,-58,-50,-65, 30;
/M: SY='K';  M=-63,-77, 16, 20,-66,-20,-26,-39, 20,  3,-57,-13,-30, 18,-17,-58,-19,-43, -5,-10;
/M: SY='G';  M=-11,-78,-40,  2,-31, 21, -1,-74, 15,-53,-67,  3,-21,  6,-11,-31,-28,-40,-77,-29;
/M: SY='R';  M=-24,-80,-23,-17,-77,-37,-31,-74, 22,-49,-67,  7, 22,-15, 30,-26,-20,-37,-81,-34;
/M: SY='K';  M=-19,-78,-23, -1,-16,-13,  2,-49, 23,-40,  7,  6,-23,-32,  0, -7,-40,-70,-80,-65;
/M: SY='Q';  M= -7,-80,-35,  9,-41,-38,-63, -9,  4,-18,-61,-17,-40, 23, 16,-60,-19,-63,-78,-28;
/M: SY='W';  M=-39,-83,-10,  2,-21,-74,-65,-73,  8,-57,-68,-62, 25, 33,-23,-12, -6,-38, 34,-24;
/I:         E1=0; IE=-255; DE=-255;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	75 in 75 different sequences
Number of true positive hits	75 in 75 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	HIG1
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

75 sequences

ATL48_ARATH (Q7X843), HIG1A_HUMAN (Q9Y241), HIG1A_MOUSE (Q9JLR9),

HIG1A_PONAB (Q5NVQ1), HIG1A_RAT   (Q8VH49), HIG1B_HUMAN (Q9P298), 
HIG1B_MOUSE (Q99JY6), HIG1C_HUMAN (A8MV81), HIG1C_MOUSE (Q76I25), 
HIG2A_HUMAN (Q9BW72), HIG2A_MOUSE (Q9CQJ1), HIG2B_HUMAN (Q4VC39), 
RCF1A_TALMQ (B6QHL9), RCF1B_TALMQ (B6QHL8), RCF1_AJECG  (C0NUL6), 
RCF1_AJECH  (C6H220), RCF1_AJECN  (A6RBB3), RCF1_AJEDR  (C5GDJ2), 
RCF1_ARTOC  (C5FSQ7), RCF1_ASPCL  (A1CHC5), RCF1_ASPFC  (B0Y606), 
RCF1_ASPFN  (B8N9M0), RCF1_ASPFU  (Q4WP59), RCF1_ASPNC  (A2QI79), 
RCF1_ASPOR  (Q2UGQ3), RCF1_ASPTN  (Q0CLP4), RCF1_BLAGS  (C5JIT3), 
RCF1_BOTFB  (A6SSX6), RCF1_CANAL  (Q59N74), RCF1_CANAW  (C4YRP9), 
RCF1_CANDC  (B9WHT6), RCF1_CANGA  (Q6FSW5), RCF1_CANTT  (C5MAV2), 
RCF1_CHAGB  (Q2GMG9), RCF1_CLAL4  (C4Y631), RCF1_COCP7  (C5P447), 
RCF1_COPC7  (A8P006), RCF1_DEBHA  (Q6BIT1), RCF1_EMENI  (Q5B6J9), 
RCF1_EREGS  (Q756G1), RCF1_FUSV7  (C7YJ02), RCF1_KLULA  (Q6CWT4), 
RCF1_KOMPG  (C4QV79), RCF1_LACBS  (B0D4J7), RCF1_LACTC  (C5DLZ7), 
RCF1_LODEL  (A5E2M7), RCF1_MYCMD  (Q4PIK6), RCF1_NEOFI  (A1CXG2), 
RCF1_NEUCR  (Q7S455), RCF1_PARBD  (C1G794), RCF1_PARBP  (C0RYW2), 
RCF1_PENRW  (B6H465), RCF1_PHANO  (Q0V4P1), RCF1_PICGU  (A5DHC2), 
RCF1_PICST  (A3LVL1), RCF1_PODAN  (Q875C2), RCF1_PYRO7  (A4RI25), 
RCF1_PYRTR  (B2WBP3), RCF1_SCHJY  (B6K2Z6), RCF1_SCLS1  (A7F679), 
RCF1_TALSN  (B8MJJ2), RCF1_TRIVH  (D4DDK2), RCF1_UNCRE  (C4JHR1), 
RCF1_VANPO  (A7TFU8), RCF1_VERA1  (C9SF29), RCF1_YARLI  (Q6CBQ8), 
RCF1_YEAS1  (B3LLM2), RCF1_YEAS2  (C7GT60), RCF1_YEAS7  (A6ZM32), 
RCF1_YEAS8  (C8ZEH4), RCF1_YEAST  (Q03713), RCF1_ZYGRC  (C5DWC4), 
RCF2_SCHPO  (Q9P3B2), RCF2_YEAST  (P53721), YL87_SCHPO  (Q9UTB1)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

8 PDB

2LOM; 2LON; 5NF8; 6LUL; 6T0B; 6T15; 8C8Q; 8Q1B