PROSITE entry PS51420

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS51420

Direct ScanProsite submission

General information about the entry

Entry name [info]	RHO
Accession [info]	PS51420
Entry type [info]	MATRIX
Date [info]	01-DEC-2008 CREATED; 18-JUN-2025 DATA UPDATE; 18-JUN-2025 INFO UPDATE.
PROSITE Doc. [info]	PDOC51417
Associated ProRule [info]	PRU00754

Name and characterization of the entry

Description [info]

Small GTPase Rho domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=180;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=175;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-4.0253091; R2=0.0040597; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-11689.4511719; R2=21.1734104; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=3086; H_SCORE=53652; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=2593; H_SCORE=43213; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-16; D=-40; I=-40; I0=-16; B1=*; E1=*; MI=-210; MD=-210; IM=-210; DM=-210;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-210; BD=-210;
/M: SY='E';  M=  -5, -61,   1,  20, -58, -15,  11, -18,   5, -46, -24,  16,   6,  19,   9,  14,   3, -27, -57, -40;
/M: SY='Q';  M=   2, -66,  -8,  20, -65, -15,   6, -54,  22, -52, -28,  17,   0,  30,  17,  17,   5, -43, -61, -43;
/M: SY='P';  M= -11, -59, -11,  16, -13,  -9, -10, -43,  22, -33, -22,  20,  33,  16, -10,  11,   2, -35, -56, -39;
/M: SY='Q';  M=  -6, -66,  -9,  18, -64, -10,   4, -38,  22, -51, -28,  36,  15,  38,   0,   5,   2, -20, -61, -42;
/M: SY='N';  M=   0, -64,   8,  20, -62, -26, -10, -32,  30, -29, -27,  33,   9,  11,   3,   2,  -2,   7, -60, -42;
/M: SY='K';  M=  -9, -54, -18,  15, -11, -34,   8,  -5,  41, -23, -17,  -8, -44,  16,  15,  14,  -1,  -4, -52,  20;
/M: SY='R';  M=  -8, -62,  -6,  27, -38, -17,   6, -20,  10, -25, -25,   7, -24,  17,  27,  25,  20, -38, -58,  14;
/M: SY='I';  M= -19,  36, -65, -46, -20, -65, -31,  56, -31,  15,  22, -41, -57, -29,   6, -26, -11,  37, -32, -22;
/M:
/M: SY='C';  M= -17,  68, -84, -66, -15, -79, -48,  64, -62,  19,  20, -58, -69, -48, -61, -42, -21,  37, -44, -34;
/M: SY='V';  M= -30,   0, -81, -64,   1, -81, -52,  20, -60,   3,  11, -58, -71, -48, -62, -43, -11,  83, -50, -39;
/M: SY='V';  M= -29,  16, -83, -66, -30, -81, -52,  46, -62,  24,   0, -59, -71, -49, -63, -44,  14,  66, -49, -39;
/M: SY='V';  M= -35,  13, -91, -75, -34, -90, -63,  36, -72,  23,  -2, -69, -79, -59, -73, -54, -29,  79, -59, -48;
/M:
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M:
/M: SY='G';  M=  -8, -56,   6,   0, -55,  54, -14, -42,  -2, -44,  -7,  16, -44,   5, -16,  20, -10,  -6, -56, -14;
/M: SY='A';  M=  49, -56, -16,   8, -52,  18, -14, -39,  10, -23,  -1,  -8, -44,  29, -13,  -4,  -1, -31, -54, -39;
/M: SY='C';  M= -18,  79, -78, -61, -32, -73, -48,  35, -57, -13,  -2, -54, -66, -45, -59, -36,  10,  66, -49, -38;
/M:
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M:
/I:         I=-7; MI=0; MD=-36; IM=0; DM=-36;
/M: SY='T';  M=  -7, -37, -38, -34, -67, -36, -42, -50, -35, -58, -39, -26, -43, -27, -41,  24,  98, -35, -72, -60;
/M: SY='C';  M=  15,  72, -38, -23, -47, -43, -28, -33, -22, -38, -19, -22, -44, -14,   2,  61,  27, -24, -54, -41;
/M: SY='L';  M= -51, -57, -99, -82, -17,-103, -69,   9, -76,  75,  66, -79, -86, -59, -75, -67, -44,  12, -54, -49;
/M: SY='L';  M= -52, -56,-104, -86, -17,-106, -72,  32, -82,  74,  57, -83, -88, -62, -79, -69, -44,   8, -55, -51;
/M: SY='M';  M= -16,  19, -50, -32, -22, -60,   1,  31, -29,   5,  69,  23, -51,  17, -34, -20,  -9,  24, -32,  -4;
/I:         I=-12; MI=0; MD=-64; IM=0; DM=-64;
/M: SY='S';  M=  18,   6, -37, -20, -35, -52, -23, -19, -19, -19,  -7, -22, -47, -10,  -5,  42,  33,  37, -43, -31;
/M: SY='Y';  M= -30, -44, -58, -42,  61, -70, -17, -20, -21,  -8,  -8, -37, -61, -26,  -2, -31, -23, -17,  -9,  94;
/I:         I=-12; MI=0; MD=-64; IM=0; DM=-64;
/M: SY='T';  M=  33, -18, -29, -12, -41, -50, -20, -27,  -3, -32, -12, -16, -46,  -4, -23,  27,  62, -12, -47,   1;
/M: SY='Q';  M=  -9,  29,  -6,   3, -57, -50, -12, -28,  33, -34, -23,   3, -43,  46,  12,  29,  31, -35, -57, -40;
/I:         I=-6; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='N';  M= -29, -84,  40,  23, -84,  47, -17, -75,  -2, -71, -50,  67, -45,   3, -27, -15, -23, -62, -80, -58; D=-6;
/I:         I=-6; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='S';  M=  12,  16,  -5,  27, -33, -10, -12, -43,  18, -43, -22,  -6,  -6,  18, -13,  28,  20, -34, -56,   6;
/M: SY='F';  M= -29, -39, -70, -53,  86, -73, -25,  11, -49,   5,   2, -45, -64, -35, -50, -34,   6,  -7, -16,  49;
/I:         I=-9; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='P';  M=  -1,  -2,  -1,  -1,  -3,  -2,  -1,  -2,  -1,  -1,  -1,   0,   4,   0,  -1,   0,   1,  -2,  -3,  -2;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='E';  M=  -9, -67, -10,  51, -65, -25, -11, -54,  13, -39, -29,   8, -42,  30,   0,  16,  44, -31, -62, -44;
/M: SY='E';  M=   2, -69,  30,  36, -68, -26,  13, -34,   9, -29, -31,   8, -41,  35,  16,  11,   5, -12, -63, -44;
/M: SY='Y';  M= -54, -61, -78, -68,  37, -88, -13, -32, -63, -25, -22, -52, -78, -46, -63, -51, -47,  -8,   6, 120;
/I:         I=-3; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='V';  M=  -6, -45, -26,  12, -38, -54,   3,  12,   6, -28,  -9, -14, -46,  34,  -2,  -7,  -2,  49, -44,   2;
/M: SY='P';  M=  -9, -42, -25, -24, -75,  -8, -39, -65, -32, -68, -47, -21, 105, -23, -40,  11, -13, -46, -77, -65;
/M: SY='T';  M=  -6, -37, -38, -32, -67, -35, -40, -51, -34, -59, -39, -25, -43, -26, -41,  40,  94, -36, -72, -60;
/I:         I=-12; MI=0; MD=-64; IM=0; DM=-64;
/M: SY='V';  M=   6, -32, -56, -38,   0, -63,   9,  22, -35, -12,   3, -36, -55, -24, -39, -24,   8,  68, -35, -24;
/M: SY='F';  M= -29, -39, -18, -50,  87, -71, -19, -14, -46,   1,  -3, -42, -62, -32, -47, -32, -21,   2,  68,  32;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='E';  M= -22, -75,  59,  66, -74, -47, -13, -18,  -1, -61, -38,  -1, -43,   8, -17,   5,   6, -51, -70, -50;
/I:         I=-5; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='N';  M=  -8, -75,  17,  30, -74, -48,   4, -64,  11, -61, -38,  85, -43,   9,   1, -10,   2, -52, -70, -50;
/M: SY='Y';  M= -24, -42, -47, -30,  43, -64,  18, -19, -27, -23,  -7, -30, -56, -17,  -1, -24,  16, -16, -18,  93;
/M: SY='S';  M=  -4, -41, -31, -14, -33, -27, -19,  10, -14, -11,   7,   6, -48,  -5, -24,  42,  39,  17, -41,  -9;
/M: SY='H';  M=  28,   3, -30, -12, -17, -55,  43, -20, -12, -13,  -6,   5, -47,  -4,   3, -14,  37,  24, -42, -28;
/M: SY='D';  M=  -8,  -2,  43,  17, -63, -49, -11, -52,   4, -20, -28,  32,  -9,  28, -10,  25,  14, -16, -61, -43;
/M: SY='V';  M=  -5,  -1, -67, -33,   7, -64, -30,  39, -44,  21,  23, -41, -55, -30, -27, -25,  -4,  49, -30,  -1;
/I:         I=-10; MI=0; MD=-50; IM=0; DM=-50;
/M: SY='E';  M=   0,  -1,   0,   0,   0,  -1,   0,   0,   0,   0,   0,   0,   0,   0,   0,   0,   0,   0,  -1,   0; D=-10;
/I:         I=-10; MI=0; MD=-50; IM=0; DM=-50;
/M: SY='V';  M=   0,   0,  -1,   0,   0,  -1,   0,   0,   0,   0,   0,   0,   0,   0,   0,   0,   0,   1,   0,   0;
/I:         I=-5; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='D';  M=  -1,  -4,   3,   1,  -4,   0,  -1,  -3,   1,  -3,  -2,   3,  -2,   1,   0,   0,  -1,  -3,  -4,  -3;
/M: SY='N';  M=  -1,  -4,   2,   1,  -4,   2,  -1,  -3,   1,  -3,  -2,   2,  -2,   1,   0,   0,   0,  -3,  -3,  -2;
/I:         I=-12; MI=0; MD=-64; IM=0; DM=-64;
/M: SY='Q';  M=  -6, -67,   6,  17, -66, -48, -10, -14,  52, -53, -30,  10, -41,  53,  15,  -6,  -4, -15, -62, -43;
/I:         I=-10; MI=0; MD=-54; IM=0; DM=-54;
/M: SY='P';  M=  -9, -63,   4,  19, -60, -50,  10, -12,  15, -30, -25,  -4,  38,  30,  18,  13,   6,   3, -59, -41;
/M: SY='V';  M=  -9,  11, -69, -50,  -3, -64,  -8,  49, -45,   4,  21, -42, -56, -31, -44, -26, -10,  51, -29,  26;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='E';  M= -18, -69, -10,  49, -69, -49,  31, -35,  27, -43, -31,  34, -42,  12,  16,  27,  11, -46, -64, -45;
/M: SY='L';  M= -50, -55,-102, -85, -21,-105, -73,  39, -80,  74,  14, -82, -88, -64, -80, -69, -43,  22, -58, -52;
/M: SY='S';  M=   7, -68,   2,  16, -67,  13,  15, -56,   5, -54, -30,  24, -42,  25,  22,  39,   6, -33, -63, -44;
/I:         I=-11; MI=0; MD=-56; IM=0; DM=-56;
/M: SY='L';  M= -43,  -8, -93, -75,   5, -93, -59,  24, -71,  74,  30, -70, -79, -54, -70, -56, -35,   2, -48, -40;
/M: SY='W';  M= -31,  -4, -68, -52,  16, -73, -19, -15, -47, -16,  -4, -43, -64, -33, -48, -34, -24,   4, 145,  36;
/I:         I=-7; MI=0; MD=-36; IM=0; DM=-36;
/M: SY='D';  M= -39, -96, 104,  25, -95, -45, -25, -88, -24, -86, -68,   2, -49,  -6, -45, -23, -36, -75, -92, -69; D=-7;
/I:         I=-7; MI=0; MD=-36; IM=0; DM=-36;
/M: SY='T';  M= -12, -42, -31, -19, -51, -45, -27,  -6, -19, -41, -22,   6, -46, -12, -27,   6,  90, -24, -57, -43;
/M: SY='A';  M=  63, -47,   1,  -8,  -5,  -9, -21, -38, -12, -42, -21, -13, -44,  -3, -24,  27,  -9, -29, -56, -41;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='G';  M=  -1, -54,  17,  -7, -79,  82, -33, -68, -28, -70, -50, -12, -45, -15, -41, -10, -18, -51, -80, -64;
/M: SY='Q';  M= -18, -65,  11,   5, -19, -22, -12, -51,   3, -30, -28,  13, -43,  89, -12,  20, -11, -41, -61, -43;
/I:         I=-9; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='E';  M=  -9, -80,  42,  72, -80, -44, -15, -71,  -5, -67, -45,  20,   5,   6, -22,  -1, -19, -58, -75, -54; D=-9;
/I:         I=-9; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='E';  M=   0,  -1,   1,   1,  -1,  -1,   0,  -1,   0,  -1,   0,   0,   0,   0,   0,   0,   0,  -1,  -1,   0; D=-9;
/I:         I=-9; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='Y';  M= -59, -63, -84, -75,  69, -92,  34, -42, -70,  -7, -29, -54, -81, -48, -67, -55, -51, -42,  12, 108;
/M: SY='D';  M= -20, -75,  71,  19, -75, -48,  35, -65,  14, -61, -37,  13, -21,  11,  19,  18, -13, -52, -69, -49;
/I:         I=-12; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='R';  M= -25, -75, -14,  20, -76, -53, -11, -64,  34, -60, -37,  40, -46,  24,  69,   7, -17, -53, -66, -50; D=-12;
/I:         I=-12; DM=-61;
/M: SY='L';  M= -18, -35,  -7, -30, -16, -62, -27,  21, -29,  51,   2, -31, -53, -18, -35,  -4,   5,  21, -37, -25; D=-12;
/I:         I=-12; DM=-61;
/M: SY='R';  M= -36, -74, -35, -15, -80, -61, -15, -65,  30, -61, -41, -19,  -9,   5,  96, -26, -27, -57, -65, -55;
/M: SY='P';  M= -20, -60, -15,  -3, -64, -49, -17, -52,   1, -52, -31, -10,  88,  24,  20,  20, -15, -42, -63, -47;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='L';  M= -34, -43, -78, -61,  19, -81, -45,  28, -57,  68,  12, -56, -70, -42, -57, -16, -26,   2, -39, -27;
/M: SY='S';  M=   7,  41, -26,   7, -15, -36, -17, -14,   5, -30, -10, -14, -46,  -1, -20,  61,   6, -19, -46, -32;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='Y';  M= -68, -70, -85, -80,  42, -95,  -9, -46, -74, -35, -34, -57, -85, -53, -71, -61, -61, -48,  12, 125;
/M: SY='P';  M=  -3, -63, -10,   4, -65,  -8, -13, -53,   1, -52, -30,  22,  64,  42,  -5,  21,   7, -42, -63, -45;
/I:         I=-2; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='D';  M= -20, -76,  58,  24, -76, -19,  19, -66,  10, -62, -38,  39, -42,  46,   9,  -1, -13, -53, -70, -49; D=-2;
/I:         I=-2; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='T';  M=  27, -38, -36, -21, -45, -45, -26,  -5, -20, -34, -16, -21, -45, -12, -30,  35,  65,   2, -52, -39; D=-2;
/I:         I=-2; DM=-13;
/M: SY='D';  M= -31, -88,  89,  13, -85, -46,  39, -78, -10, -74, -52,  44, -46,   9, -28,  -8, -25, -65, -82, -59;
/M: SY='V';  M=   4,   5, -82, -65, -33, -82, -53,  47, -62,  11,  -2, -59, -72, -50, -64, -44, -13,  71, -52, -41;
/M: SY='F';  M= -38, -43, -93, -76,  63, -90, -56,  39, -71,  28,  10, -68, -77, -55, -70, -53, -30,  54, -46, -36;
/I:         I=-8; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='L';  M= -49, -54,-102, -84,  -8,-102, -68,  28, -80,  71,  59, -80, -85, -60, -78, -66, -41,  20, -53, -49;
/M: SY='I';  M= -18, -45, -93, -76, -25, -93, -62,  61, -72,  53,  32, -71, -80, -57, -72, -56, -32,  33, -54, -46;
/M: SY='C';  M=  -6, 124, -62, -50, -40, -30, -42, -13, -43,   2, -14, -39, -51, -35, -46, -14, -12,  -7, -52, -40;
/M: SY='F';  M= -70, -69, -93, -88, 105, -99,  -9, -44, -83, -31, -30, -60, -87, -57, -76, -64, -62, -47,  13,  80;
/M: SY='S';  M=  24, -58,  41,   0, -73, -42, -22, -61, -13, -62, -40,  -7, -43,  -3, -27,  74, -14, -47, -73, -55;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='V';  M= -23, -43, -94, -79, -39, -95, -70,  66, -76,   6,  -5, -73, -84, -64, -78, -59, -17,  72, -66, -55;
/M: SY='D';  M=   9, -57,  45,   8, -52, -36, -13,   5,   0, -41,   8,   5, -43,   7, -14,  34,   3,   4, -54, -38;
/M: SY='N';  M= -18, -32,   8,  11, -68, -40, -11, -57,   9, -55, -31,  67, -42,  24,  19,  45, -11, -46, -64, -45;
/M: SY='P';  M= -20, -67, -15,  10, -36, -52,  26, -54,  23, -52, -30,  -6,  67,  23,  47, -10, -13, -44, -61, -45;
/M: SY='T';  M=  12, -69,  25,  35, -68, -48, -11, -58,   3, -55, -32,  41, -20,  11, -12,  19,  41, -28, -65, -46;
/I:         I=-7; MI=0; MD=-38; IM=0; DM=-38;
/M: SY='S';  M=  -6, -38, -36, -32, -72, -34, -42, -58, -35, -65, -44, -25, -42, -27, -42,  93,  27, -41, -76, -64;
/M: SY='F';  M= -36, -44, -81, -65,  72, -81, -29,  -6, -60,  44,  17, -54, -70, -43, -58, -43, -29,  -1, -16,  57;
/M: SY='D';  M=  -5, -71,  48,  45, -71, -48,  19, -39,  11, -24, -33,  29, -42,  31, -10,   3,   0, -48, -66, -46;
/M: SY='N';  M= -14, -67,  -1,   3, -68, -47,  36, -61,  -5, -60, -39,  95, -46,   2, -18,  18, -18, -50, -68, -49;
/M: SY='V';  M=   3,  26, -86, -69, -34, -83, -56,  54, -65,   0,  -3, -62, -74, -53, -66, -46, -24,  70, -54, -43;
/I:         I=-13; MD=-67;
/M: SY='K';  M=  -1,  -3,  -1,   1,  -2,  -2,  -1,  -1,   2,   1,   0,   0,  -2,   1,   0,   1,   0,  -1,  -3,  -1; D=-13;
/I:         I=-13; MI=-67; IM=-67; DM=-67;
/M: SY='E';  M= -18, -71,  30,  39, -70, -48, -10, -31,  36, -57, -33,  30, -42,  12, -10,  10,  38, -47, -65, -24;
/M: SY='K';  M= -21, -62, -19,   5, -59, -53, -12, -46,  75, -24,  31,   3, -45,   8,   8,  -1, -13, -38, -57, -16;
/M:
/M: SY='Y';  M=  -3, -33, -45, -13,  21, -59,  -7,  20, -13,  12,  14,  17, -50,   2,  -8, -18,  -9,  18,   5,  35;
/M: SY='P';  M= -17, -58,   5,   1, -17,  -6, -14, -44,  -1, -45, -24,  -7,  73,  23, -15,   9,  24, -35, -58, -41;
/M:
/M: SY='I';  M= -25, -43, -94, -78, -38, -95, -69,  79, -75,  11,  -4, -73, -83, -63, -77, -59, -12,  56, -64, -54;
/M: SY='R';  M= -14, -67, -15,   3, -66, -52, -11, -41,  43, -12, -30,  35, -44,  28,  49,  -3,  17, -44, -61, -44;
/M: SY='H';  M= -17, -38,  19,  28, -70, -49,  74, -59,  22, -41, -32,  -2, -42,  50,  10,  11,   4, -47, -65, -45;
/I:         I=-2; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='Y';  M= -18, -10, -42, -25,  54, -58,  35,   4, -23, -18,  -1,  31, -50, -13, -30, -19,   3,  -8, -28,  55; D=-2;
/I:         I=-2; DM=-13;
/M: SY='C';  M=   1,  94, -50, -32, -22, -59, -25,   8, -29,  11,  23,   4, -51, -19, -34,  -4,   1,  -2, -32,   7; D=-2;
/I:         I=-2; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='P';  M= -14, -65,  -7,  15, -65, -37, -15, -53,  11, -52, -31,  -6,  88,  13,   4,  -3, -16, -43, -63, -47; D=-2;
/I:         I=-2; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='S';  M= -17,  -1,   7,  13, -66,  14,  28, -56,  19, -53, -30,  28, -41,  29,  10,  30,  12, -44, -63, -44; D=-2;
/I:         I=-2; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='T';  M=  21, -34, -49, -31, -26, -61, -27,  37, -29,  -8,   1, -31,  -9, -19, -35, -21,  43,  37, -37, -11;
/I:         I=-12; MI=0; MD=-64; IM=0; DM=-64;
/M: SY='P';  M= -23, -65, -14,   0, -63, -52, -14, -51,  31, -50, -29,  14,  86,   7,  10, -13, -15, -42, -60, -14;
/M: SY='I';  M= -26, -34, -77, -60, -24, -76, -44,  63, -55,  18,  39, -53, -66, -42, -56, -24, -11,  51, -42, -12;
/M: SY='I';  M= -43, -46,-101, -85, -31,-100, -72,  69, -81,  31,  32, -79, -86, -66, -81, -64, -36,  59, -62, -54;
/M: SY='L';  M= -49, -56, -93, -79, -20, -96, -67,  10, -71,  79,  13, -75, -84, -58, -71, -62, -43,  21, -55, -46;
/M: SY='V';  M= -27,  12, -75, -58, -29, -77, -47,  34, -54,   1,   1, -53, -68, -13, -56, -39, -21,  79, -47, -36;
/M: SY='G';  M=  13, -50,  -1, -10, -71,  77, -29, -58, -20, -61, -40, -14, -44, -11, -12,  -8, -14, -44, -72, -58;
/M: SY='T';  M= -17,  67, -55, -37, -27, -59, -31,  10, -34,  17,   0, -34, -53, -24, -39, -11,  68,   1, -39, -28;
/M: SY='K';  M= -36, -80, -23,  -9, -84, -60, -14, -70,  84, -64, -44, -14, -53,  65,  13, -25, -27, -61, -68, -56;
/M: SY='T';  M=  -4,  39, -46, -28, -24, -59, -24,  24, -15,  13,  19, -11, -51, -16, -32,  25,  42,   3, -34, -22;
/M:
/M: SY='L';  M= -41, -53, -70, -55, -19, -84, -47,  -1, -44,  77,  28, -54, -73,   2, -46, -47, -34, -10, -47, -37;
/I:         I=-12; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='R';  M=   0,  -1,   0,   0,  -1,  -1,   0,  -1,   0,   0,   0,   0,  -1,   0,   1,   0,   0,  -1,  -1,   0;
/M: SY='E';  M=   0,  -1,   0,   0,  -1,   0,   0,   0,   0,  -1,   0,   0,   0,   0,   0,   0,   0,  -1,  -1,   0;
/M: SY='D';  M=   0,   0,   1,   0,  -1,  -1,   0,  -1,   0,   0,   0,   0,   0,   0,   0,   0,   0,   0,  -1,   0;
/I:         I=-5; MD=-25;
/M: SY='D';  M=   0,  -1,   0,   0,  -1,   0,   0,  -1,   0,   0,   0,   0,   0,   0,   0,   0,   0,   0,  -1,   0; D=-5;
/I:         I=-5; MD=-25;
/M: SY='N';  M=   2, -10,   0,   3, -10,  -3,   3,  -8,   3,  -3,  -4,   6,  -1,   2,  -2,   3,  -1,  -3, -10,  -7; D=-5;
/I:         I=-5; MD=-25;
/M: SY='T';  M=  -6,  -8, -11,  10,  -7, -22,   6,   0,  -4,  -2,  -3,  -6, -10,   6,  -8,  -3,  16,   3, -17,   4; D=-5;
/I:         I=-5; MD=-25;
/M: SY='L';  M=   0, -17,  -6,  -4, -14, -17,  -7,   1,   5,  14,  -2,  -6, -19,   5,  -3,  -3,  -3,   3, -16, -11; D=-5;
/I:         I=-5; MD=-25;
/M: SY='N';  M=  -2, -23,   8,   8, -21, -20,  -4,  -3,   3, -17,   5,  11,  -9,   4,   4,   0,  -3,   1, -22,  -1; D=-5;
/I:         I=-5; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='E';  M=   3, -26,  -4,  13, -25, -14,  -4, -20,  12, -10, -11,   2, -10,  12,   7,  -3,   0, -16, -24, -17; D=-5;
/I:         I=-5; DM=-25;
/M: SY='L';  M=  -8, -17, -14,  -8, -12, -23,  -8,   0,  -4,  18,  -1,   2, -20,  -3,   4,  -7,  -5,  -4, -16, -10; D=-5;
/I:         I=-5; DM=-25;
/M: SY='Q';  M=  -3,  -5,   5,   2, -23, -19,  -4, -18,   7, -14,  -9,  -1, -16,  12,  11,  11,   1, -14, -23, -16; D=-5;
/I:         I=-5; DM=-25;
/M: SY='E';  M=  -2, -24,  -4,  11, -23, -19,   7,  -7,   9, -13,  -9,   3,   4,  10,   3,  -2,  -1, -14, -23,  -8; D=-5;
/I:         I=-5; DM=-25;
/M: SY='Q';  M=   0,  -8, -11,   1, -33, -14,   7, -24,  13, -11,   1,  14, -29,  24,  -7,  -1,  -5, -19, -35, -10; D=-5;
/I:         I=-5; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='K';  M= -11, -62, -10,   9, -61,  -9,   3, -51,  42, -26, -28,  17, -18,  35,  33,   0,  -1, -26, -57, -40; D=-5;
/I:         I=-5; DM=-25;
/M: SY='Q';  M=   0,  -1,   0,   0,   0,   0,   0,  -1,   0,   0,   0,   0,   0,   1,   0,   0,   0,   0,  -1,   0; D=-5;
/I:         I=-5; DM=-25;
/M: SY='E';  M=   0,  -3,   1,   2,  -3,  -1,   1,  -2,   1,  -2,  -2,   1,  -1,   1,   0,   1,   1,  -2,  -3,  -2; D=-5;
/I:         I=-5; DM=-25;
/M: SY='P';  M=   0,   0,  -1,  -1,   1,  -3,  -1,   1,  -1,   0,   1,  -1,   3,  -1,  -1,  -1,   0,   0,  -2,   0; D=-5;
/I:         I=-5; DM=-25;
/M: SY='V';  M= -32, -39, -43, -64, -32, -84, -55,  60, -62,   9,  18, -60, -73, -50, -64, -47, -25,  68, -53, -43;
/M: SY='T';  M= -18, -65,   9,  12, -64, -47, -12, -53,   9, -52, -30,  22,  29,  17, -12,  41,  50, -43, -62, -44;
/M: SY='Y';  M=   1, -51, -19,   8, -13, -51,  22, -20,   5, -35, -15,  -9,  23,  34,  -7, -10,  12, -25, -49,  64;
/M: SY='E';  M= -11, -69,  23,  58, -68, -47,  13, -33,  20, -55,  -7,  -1, -11,  33,  -9,  12,   8, -46, -63, -44;
/M: SY='Q';  M=  -2, -68,   9,  52, -68, -48,   5, -57,  18, -55,  27,  -2, -41,  63,   4,   1, -10, -46, -63, -44;
/M: SY='G';  M=  27, -36, -35, -30, -68,  75, -39, -35, -34, -60, -40, -23, -41, -25, -41,   8,  -8, -37, -72, -61;
/M: SY='Q';  M=  -6,   1,   0,  13, -31, -37,   0,   9,  14,   7,   4,  -8, -32,  22,   7,  -7,   1,   2, -34, -24;
/M: SY='E';  M=  21, -66,   6,  42, -65, -18, -10, -55,  17, -27,  -4,  24, -41,  24,  10,  11,  -9, -28, -61, -43;
/M: SY='M';  M=  -3,  -1, -62, -44, -20, -65, -32,  14, -12,  37,  71, -40, -56, -29, -43, -27, -12,  34, -33, -23;
/M: SY='A';  M=  60,  18, -27, -10, -44, -49, -19, -30,  -1, -34, -15, -15, -44,   8,  11,  17,  -9, -16, -49, -35;
/I:         I=-9; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='K';  M=  -3, -12,   0,   4, -12,  -6,  -2, -10,  11, -10,  -6,   2,  -7,   6,   4,  -2,  -2,  -8, -11,  -8;
/M: SY='Q';  M=   0, -12,   1,   9, -12,  -8,  -2, -10,   6, -10,  -6,   0,  -7,   9,   4,   1,  -2,  -8, -11,  -8;
/M: SY='I';  M=  -2,  -1,  -5,  -4,  -1,  -5,  -3,   4,  -4,   1,   2,  -4,  -4,  -3,  -4,  -3,  -2,   2,  -3,  -2;
/M: SY='G';  M=  -1,  -3,   1,   0,  -3,   2,   0,  -3,   1,  -3,  -2,   2,  -2,   0,   1,   0,  -1,  -2,  -3,  -2;
/I:         I=-5; MD=-26;
/M: SY='A';  M=   4,   0,  -2,  -2,  -1,  -1,  -2,  -1,  -2,  -2,  -1,  -1,  -2,  -1,  -2,   0,   0,  -1,  -3,  -2; D=-5;
/I:         I=-5; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='V';  M=   5,   7, -43,  -7,  17, -57, -22,  21,  13,  -4,  13, -26, -49,  -2, -30,   6,  10,  29, -33, -10; D=-5;
/I:         I=-5; DM=-26;
/M: SY='K';  M=  16,  11,  -3,   1, -51,   2,   7, -16,  24, -26,  11,   2,  -3,  14,  10,  11,   1, -18, -52, -37;
/M: SY='Y';  M= -59, -63, -79, -70,  49, -89,  29, -43, -65, -13, -29, -51, -79, -45, -63, -53, -51, -43,  11, 114;
/M: SY='L';  M= -18,   0, -68, -49,  -7, -64, -31,  32, -45,  42,  39, -42, -55, -31, -44, -18,   5,  22, -29,  29;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='E';  M= -26, -72,   2,  87, -28, -48, -16, -58,  -4, -56, -38,  -3, -46,  23, -17, -15, -20, -49, -66, -47;
/M: SY='C';  M=   4, 121, -61, -51, -52, -13, -45, -31, -48, -43, -25, -34, -43, -37, -50,  -4,  24, -10, -61, -52;
/M:
/M: SY='A';  M=  65, -36, -43, -31, -59, -37, -37, -41, -31, -49, -29, -25, -43, -22, -39,  48,  13,   7, -65, -53;
/M: SY='K';  M=   2, -42, -30, -13,   9, -55, -18, -19,  37,  32,  -6, -18, -47,  -4,  18, -15, -10,   4, -41, -29;
/I:         I=-11; MI=0; MD=-56; IM=0; DM=-56;
/M: SY='T';  M=  -5,   2,  -1,   0, -16, -53,   2, -28,  12,  -1,  16, -12, -45,  13, -18,  16,  57, -22, -47, -32;
/M: SY='Q';  M= -18, -68, -11,   6, -67, -16,  13, -56,  28, -53,   9,  46, -42,  58,  17,  18, -10, -44, -63,  -1;
/M: SY='E';  M= -12, -69,   8,  44,  -1, -49, -10, -35,  42, -40, -31,   5, -42,  44,  23,  -6, -10, -45, -63, -45;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='N';  M=  -9,  -1, -25, -15, -68,  59, -29, -56, -19, -58, -36,  61, -42, -10, -30,  24,  -9, -41, -69, -55;
/I:         I=-10; MI=0; MD=-54; IM=0; DM=-54;
/M: SY='V';  M= -43, -47,-100, -84, -32,-101, -73,  46, -81,  43,   3, -79, -87, -67, -81, -65, -37,  71, -64, -55;
/M: SY='K';  M= -18, -73,  19,  32, -74, -49,  35, -64,  44, -60, -35,  39, -42,  32,  21,   7,  -5, -51, -67, -47;
/M: SY='E';  M=   1, -75,  49,  61, -75, -48, -12, -65,   1, -42, -38,   0, -43,  37, -14,   9,   4, -52, -70, -50;
/M: SY='V';  M= -15, -43, -92, -76, -38, -94, -69,  46, -74,  13,  -4, -72, -83, -62, -76, -58, -32,  81, -65, -54;
/M:
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='D';  M= -12, -73,  50,  45, -73, -48,  23, -64,  20, -46, -35,  19, -42,  28,  15,   0,   6, -51, -67, -47;
/M: SY='E';  M=   1,   1, -15,  44, -27, -51, -12, -42,  20, -36, -22,  16, -43,  27,  -4,   4,  27,   7, -56, -39;
/M: SY='A';  M=  68, -39, -38, -22, -42, -33, -27, -22, -21, -15,   7, -23, -47, -13, -30,  14,  -9,   6, -50, -37;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='I';  M=   1,  -2,  -3,  -2,  -1,  -2,  -2,   3,  -2,   0,   0,  -2,  -3,  -1,  -2,   0,   1,   2,  -2,  -1;
/M: SY='R';  M= -17, -64,  13,  18, -62, -50,  20, -12,  28, -16,   9,  23, -42,  11,  48,  -7, -10, -15, -60, -42;
/M: SY='V';  M=  26,  31, -51, -33, -22, -60,   2,  19, -31,  -4,   5, -31, -52, -19, -35,  -4,  31,  40, -32,  -8;
/I:         I=-13; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='A';  M=  38,  34, -43, -26,  -8, -10,  11,   5, -24, -10,   2, -26, -50, -14, -31,   1,   8,  15, -34,  19;
/I:         I=-13; E1=0; MI=0; IE=0; DE=-67;

» more

Post-processing [info]

COMPETES_HIT_WITH

PS51417; PS51418; PS51419; PS51421; PS51422; PS51423; PS51424; PS52057

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	162 in 162 different sequences
Number of true positive hits	162 in 162 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.39 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo, L_Cerutti
Version [info]	7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

162 sequences

CDC42_AEDAE (Q16YG0), CDC42_ANOGA (Q17031), CDC42_BOVIN (Q2KJ93),

CDC42_CAEEL (Q05062), CDC42_CANAL (P0CY33), CDC42_CANAW (C4YDI6), 
CDC42_CANLF (P60952), CDC42_CHICK (Q90694), CDC42_COLGL (O94103), 
CDC42_DROME (P40793), CDC42_DROPS (Q29HY3), CDC42_EREGS (Q9HF56), 
CDC42_HUMAN (P60953), CDC42_MACFA (Q4R4R6), CDC42_MOUSE (P60766), 
CDC42_PIG   (Q007T2), CDC42_RAT   (Q8CFN2), CDC42_SCHPO (Q01112), 
CDC42_YEAST (P19073), CRL1_CANAW  (P33153), RAC10_ARATH (O82481), 
RAC11_ARATH (P92978), RAC13_GOSHI (Q41253), RAC1A_DICDI (P34144), 
RAC1B_DICDI (P34145), RAC1C_DICDI (P34146), RAC1_ARATH  (Q38902), 
RAC1_BETVU  (Q39435), RAC1_BOVIN  (P62998), RAC1_CAEEL  (Q03206), 
RAC1_CANLF  (P62999), RAC1_DROME  (P40792), RAC1_HUMAN  (P63000), 
RAC1_LOTJA  (O04369), RAC1_MOUSE  (P63001), RAC1_ORYSJ  (Q9SSX0), 
RAC1_RAT(Q6RUV5), RAC1_STIJA  (A0A286QZ36), RAC2_ARATH  (Q38903), 
RAC2_BOVIN  (Q9TU25), RAC2_CAEEL  (Q94124), RAC2_CAVPO  (O88931), 
RAC2_DROME  (P48554), RAC2_HUMAN  (P15153), RAC2_LOTJA  (Q40220), 
RAC2_MOUSE  (Q05144), RAC2_ORYSJ  (Q68Y52), RAC3_ARATH  (Q38912), 
RAC3_HUMAN  (P60763), RAC3_MOUSE  (P60764), RAC3_ORYSJ  (Q6Z808), 
RAC4_ARATH  (Q38919), RAC4_ORYSJ  (Q67VP4), RAC5_ARATH  (Q38937), 
RAC5_ORYSJ  (Q6EP31), RAC6_ARATH  (Q9SBJ6), RAC6_ORYSJ  (Q6ZHA3), 
RAC7_ARATH  (O82480), RAC7_ORYSJ  (Q6Z7L8), RAC8_ARATH  (Q9SU67), 
RAC9_ARATH  (Q9XGU0), RAC9_GOSHI  (Q41254), RACA_DICDI  (P34147), 
RACA_ENTH1  (Q24814), RACB_DICDI  (P34148), RACB_ENTH1  (Q24815), 
RACC_DICDI  (P34149), RACC_ENTH1  (Q24816), RACD_DICDI  (P34150), 
RACD_ENTH1  (Q24817), RACE_DICDI  (Q23862), RACF1_DICDI (O96390), 
RACF2_DICDI (Q9GPS3), RACG_DICDI  (Q9GPS0), RACG_ENTH1  (O76321), 
RACH_DICDI  (Q9GPR7), RACI_DICDI  (Q9GPR2), RACJ_DICDI  (Q9GPQ9), 
RACL_DICDI  (Q9GPQ8), RACM_DICDI  (Q54HZ7), RACN_DICDI  (Q54YY4), 
RACO_DICDI  (Q54Z85), RHBT1_HUMAN (O94844), RHBT1_MOUSE (Q9DAK3), 
RHBT2_HUMAN (Q9BYZ6), RHBT2_MOUSE (Q91V93), RHO1_CAEEL  (Q22038), 
RHO1_CANAL  (O42825), RHO1_DROME  (P48148), RHO1_ENTH1  (P31021), 
RHO1_EREGS  (Q9HF54), RHO1_KLULA  (Q8J212), RHO1_PEA(Q35638), 
RHO1_SCHPO  (Q09914), RHO1_YEAST  (P06780), RHO2_SCHPO  (Q10133), 
RHO2_YEAST  (P06781), RHO3_EREGS  (Q9HF51), RHO3_SCHCO  (Q9P8J9), 
RHO3_SCHPO  (O13928), RHO3_YEAST  (Q00245), RHO4_EREGS  (Q9P8V0), 
RHO4_SCHPO  (Q874R1), RHO4_YEAST  (Q00246), RHO5_SCHPO  (Q9HE04), 
RHO5_YEAST  (P53879), RHOAA_DANRE (Q6NUX8), RHOAB_DANRE (Q6DHM9), 
RHOAC_DANRE (Q7T2E8), RHOAD_DANRE (Q6DHE8), RHOA_BOVIN  (P61585), 
RHOA_CANLF  (P24406), RHOA_EMENI  (Q9C3Y4), RHOA_HUMAN  (P61586), 
RHOA_MOUSE  (Q9QUI0), RHOA_PONAB  (Q5REY6), RHOA_RAT(P61589), 
RHOB_BOVIN  (Q3ZBW5), RHOB_HUMAN  (P62745), RHOB_MOUSE  (P62746), 
RHOB_RAT(P62747), RHOC_BOVIN  (Q1RMJ6), RHOC_CHICK  (Q9PSX7), 
RHOC_EMENI  (Q96WY0), RHOC_HUMAN  (P08134), RHOC_MOUSE  (Q62159), 
RHOC_PONAB  (Q5RCK9), RHOD_MOUSE  (P97348), RHOF_BOVIN  (Q3SZA1), 
RHOF_HUMAN  (Q9HBH0), RHOF_MOUSE  (Q8BYP3), RHOG_CRICR  (P84097), 
RHOG_HUMAN  (P84095), RHOG_MOUSE  (P84096), RHOH_BOVIN  (Q2HJG3), 
RHOH_HUMAN  (Q15669), RHOH_MOUSE  (Q9D3G9), RHOJ_HUMAN  (Q9H4E5), 
RHOJ_MOUSE  (Q9ER71), RHOL_DROME  (Q24192), RHOQ_HUMAN  (P17081), 
RHOQ_MOUSE  (Q8R527), RHOQ_RAT(Q9JJL4), RHOU_BOVIN  (A5D7J5), 
RHOU_HUMAN  (Q7L0Q8), RHOU_MOUSE  (Q9EQT3), RHOV_BOVIN  (Q17QI8), 
RHOV_HUMAN  (Q96L33), RHOV_MOUSE  (Q8VDU1), RHOV_RAT(Q9Z1Y0), 
RHO_APLCA   (P01122), RHO_DIPOM   (P22122), RND1_BOVIN  (Q2HJ68), 
RND1_HUMAN  (Q92730), RND1_MOUSE  (Q8BLR7), RND2_HUMAN  (P52198), 
RND2_MOUSE  (Q9QYM5), RND3_HUMAN  (P61587), RND3_MOUSE  (P61588), 
RND3_PIG(O77683), RND3_PONAB  (Q5R9F4), RND3_RAT(Q6SA80)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

RHOD_HUMAN  (O00212)

PDB
[Detailed view]

278 PDB

1A2B; 1A4R; 1AJE; 1AM4; 1AN0; 1CC0; 1CEE; 1CF4; 1CXZ; 1DOA; 1DPF; 1DS6;
» more