PROSITE entry PS51388

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51388
Entry name [info]	GED
Accession [info]	PS51388
Entry type [info]	MATRIX
Date [info]	01-JUN-2008 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51388
Associated ProRule [info]	PRU00720

Name and characterization of the entry

Description [info]

GED domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=92;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=87;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4376628; R2=0.0077610; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=14085.8056641; R2=4.3883495; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=910; H_SCORE=18079; N_SCORE=9.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=524; H_SCORE=16385; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-37; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='A';  M=  36,  30,-114,  11, -49,-118, -35,  26,  -6,  -2,  18, -33, -47,  -2,-112, -11,  10,  30,-126, -43;
/M: SY='E';  M=  -9,-124,  19,  53,  -3, -56, -35, -25, -13,  12,  16, -29, -27,  42,  12,   7, -63, -69,-124, -47;
/M: SY='E';  M=  -6,-123,  32,  58, -32, -69, -31, -28,  11,  -2,  14,   8, -53,  18, -26, -52,  10, -29,   0, -51;
/M: SY='I';  M=  -7,-119,-123, -58,-102,-126,-120,  66, -14,  19,  51, -44,-121,-114, -52, -34,  29,  29,-125, -33;
/M: SY='H';  M=   9, -36,-115, -74, -52, -74,  58,  30,  13,   2,  23, -49, -33,  26,  43, -13, -59, -28,-122,  10;
/M: SY='D';  M=  27, -40,  65,  19, -29,-111,-106, -28, -48, -23, -25,  41,-116,  12, -11,   6,   0, -70,-130, -37;
/M: SY='C';  M= -70,  64,  -3, -36,-106, -48,  46,  -5, -10,  38, -14, -18, -41, -26,  35,  -7, -30, -47,-124,  16;
/M: SY='M';  M= -15, -12,-127,-122, -42, -72,-119,  24,-120,  49,  70, -23,  11,-117,-122,-114,  -5,  43,-125,-106;
/M: SY='E';  M=  -1, -13,  36,  49,-121,-117, -32, -48,  11, -14,-111, -12,-115,  19,  40,   7,   1, -34,-128, -34;
/M: SY='S';  M=  57,-115, -42, -60,-120,   4, -29,  -1,-108, -53, -23, -33, -40, -35, -23,  63,   3, -35,-128,-116;
/M: SY='Y';  M=-119,-129,-118,-121,  11,-126, -26, -64,-113,-102, -99, -24, -54,-110, -47, -63,-113, -60, -80, 134;
/M: SY='Y';  M= -61,-124,-125,-124,  68, -45, -29, -97,-118,  12,  40, -57,-129,-116,-116, -41,-112, -26,  53, 103;
/M: SY='K';  M=  -9,-122,  20,  38,-122, -40,-104, -22,  56, -42,  -8,  49,-114,  31, -36, -27,   6, -68,-127, -35;
/M: SY='I';  M= -17, -30, -60, -41,-103, -76, -26,  73,-117, -21,   2, -43,-121,-117, -32, -52,  21,  59,-128,-108;
/M: SY='V';  M=  64,  -9,-119, -40, -45, -58,-121, -15,-114, -51, -14,-114,-119, -44,-118,  22, -57,  66,-128,-113;
/M: SY='M';  M=   6, -34,-114, -51, -22, -35,-106, -16,  10,  27,  57,  -3,-120,  17,  56,  10,-105, -35,-120, -16;
/M: SY='K';  M= -72,-124,  30, -35, -59, -11,-105,-119,  87, -50,   5,  -6, -50,  -5,  25, -54, -32, -33,-122, -18;
/M: SY='R';  M= -23, -34,-105, -15,-117,-116, -44, -21,   4, -79,-108,  37, -43,   8,  81,  -7,  40,  -9,-126, -19;
/M: SY='F';  M=-113,-119,-132,-126,  87,-131,-118,  42,-123,  31,  36,-124,-128, -43,-122, -69, -54,  34,-106, -28;
/M: SY='I';  M=  26, -30,-118, -32,-108,-119, -32,  57, -35, -34, -42, -56,-119,   0,  21,   2,   9,  42,  38,-108;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='D';  M=  -5,-121,  94, -55,-124, -48, -98, -33,-101,-125,-119,  85,-117, -14,-109, -57, -54, -70,-138, -10;
/M: SY='V';  M= -23, -34,-111, -33, -38, -36, -31,   8,-109, -20,  23,  25,-118,  31,-112,  42,  29,  51,-126, -21;
/M: SY='V';  M=  28,  43,-123,-120,-105, -76,-125,  57, -44, -26, -94, -42,-122,-117, -52, -23,   0,  66, -25,-110;
/M: SY='P';  M= -14,  29, -59,-108,  -8, -43, -20, -17, -40, -74,   7, -15,  97, -50, -20, -14,  -4,  20,-126,-115;
/M: SY='Q';  M=-110,-123, -48, -62, -57,-121,-106, -39,  70,  49,  35,-106,-118,  77, -91, -47,-107,-105,-119,-106;
/M: SY='A';  M=  61, -11,-118,-114,  17, -36,  18,  -2, -53, -37,-100,-110,-118,-112, -58,  -1,  25,  43,-121,   0;
/M: SY='I';  M= -50, -18,-129,-126, -99,-133,-129,  87,-122,  10, -86,-122,-123,-121, -53,-115,   6,  57,-126,-106;
/M: SY='M';  M= -55, -44, -18,  68, -55, -25,  -3, -35, -37, -33,  77,  28,-114,  25,   1, -36, -62,   6,-126, -45;
/M: SY='H';  M= -55,  -1, -27,-107, -10,-116,  86, -32, -99, -33, -37,  41,-121, -50,  51,  19,  -7, -35,-116,  63;
/M: SY='C';  M= -45,  81, -59,  23,  55, -44,  75, -30, -23, -11,  20, -56,-121, -20,   7, -29,  -6,-109,-120, -36;
/M: SY='M';  M=-112,-118, -68,-121, -10,-130,-113,  17,-121,  78,  78,-125,-127, -14,-119, -57,-109, -14,-118, -31;
/M: SY='V';  M= -73, -32,-129,-123,  13,-131,-123,  47, -31,  54, -30, -50,-127, -39,-120,-118,-105,  63,-121,-101;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='N';  M= -69,-123,  34, -19, -72, -71,  -8,-121,  22, -31,-112,  58,  -5,  35,  49,  30, -49, -70,-126,  -2; D=-21;
/I:         I=-21; DM=-53;
/M: SY='H';  M= -30, -30,  12,  23, -34,  14,  51,-120,  40, -21, -37,  21,  21,  12,  -1, -15,   7,-118,-126, -52;
/M: SY='L';  M=   7,  16, -23,-115,  21,-119,-116,  -1,-117,  47, -40, -55,  35,-115,-119,  19,   8,  21,-120, -20;
/M: SY='P';  M= -18,  33, -53,  29, -29,  -6,  25, -64,  31, -23,  -7, -22,  33,  25,  17,   1, -12, -49,-122,   5;
/M: SY='D';  M= -23,-122,  48,  34,-120, -30,   6,-120,  19, -24,-112,  20,-114,   9,  33,  24,  18, -78,-127,  -8;
/M: SY='Q';  M= -60,-122,   9,  16,  -9, -40, -48,  44, -26,  -3,-100,  32,  -8,  56, -66,   5,  -5,   6,-125,-108;
/M: SY='F';  M= -45,-118,-131,-124,  70,-129,-115,   6, -67,  65,  58,-125, -32,-120,-120, -69,-109, -10,-109, -27;
/M: SY='Q';  M=-104, -31,   2,  11, -46,-112,  32, -58, -53,  -1,-107,   3,  13,  70,  11,  52,  14,-113,-125, -24;
/M: SY='P';  M= -33,-125,   3,  -3, -23, -33, -34,-116,   9, -19,-110,  23,  74,  27,  30,  17, -13, -39,-126,-114;
/M: SY='E';  M=   1,-121,  13,  63,-117, -39,   4, -25, -14, -36,-107, -21,-112,  30,  -1,  -7,  24,  17,-127, -17;
/M: SY='L';  M= -19,-118, -52, -47, -14, -74,-115,  19, -45,  67,  61,-121,-124, -25, -32,-116, -18,   4,  22, -42;
/M: SY='V';  M= -11,-119,   2,  -8,  12, -34,  -2,  26, -54,   4,  -7,-115,-122, -21, -58,-110, -29,  67,-119,  26;
/M: SY='S';  M=  20,  33, -16,   7, -62,  -4,   4, -13, -22, -44, -20,  31, -25,  29,   8,  34,   3, -27,-127, -46;
/M: SY='Q';  M=   0, -32,   6,  37,-123,  -1,  11,-117,  24, -26, -45,  46,-115,  49,  29, -11,-104, -21,-128,-113;
/M: SY='M';  M= -38,-118,-128, -26,   7,-129,-113,  15, -66,  74,  79,-125,-126,-114,-119,-120,-109, -13,-116, -19;
/M: SY='Y';  M= -16,-120,  23,-106, -23,  17, -11, -51,-107, -20,  13, -10, -30,  37, -51,  30,  25, -18,-112,  68;
/M: SY='D';  M= -14,-123,  73,  -7,-121,   2,  23, -14,  24, -45,-112,   9,-115,  13, -13,   3,   1, -38,-130, -16;
/M: SY='N';  M=  17,-121,  29,  50, -31, -35,-102,-121,  16, -77,-114,  53,  -2,  15, -11,  15, -22, -68,-125,  -8;
/I:         I=-15; MD=-39;
/M: SY='E';  M= -26,-131,  49,  68,-132,  -7,  12,-131, -65, -27,-122,  -8, -30,   2, -51, -11, -16,-127,-138,-123; D=-15;
/I:         I=-15; MI=0; MD=-39; IM=0; DM=-39;
/M: SY='Q';  M=   3,-134,  -8, -22,-131, -27, -37, -33,   3,  -4, -34,  -7,-129,  69,   4, -48, -36, -35,-137,-123; D=-15;
/I:         I=-15; DM=-39;
/M: SY='L';  M= -14,  16, -62,-121,  -9,-128,-119,  41,-121,  50,  16,-123, -19,  -9,-122, -39, -66,  40,-120,  13; D=-15;
/I:         I=-15; DM=-39;
/M: SY='E';  M= -35,-125,  47,  52, -10, -52,  -9, -64,  -9, -32,  -8,  19,  -8,  22,  32, -16, -25, -28,-128, -51; D=-15;
/I:         I=-15; DM=-39;
/M: SY='R';  M=  14,-123,  16,  35, -32, -37, -31,-121,   6, -52, -36,   8,-116,  40,  52,  27, -58, -72,  18, -45; D=-15;
/I:         I=-15; DM=-39;
/M: SY='L';  M=-113, -13, -38,-124,   9,-132,-118,  55,-123,  70,  53, -44,-127,-119,-123,-121,-108,  -7,  -4, -99;
/M: SY='A';  M=  70,-113,-124,-116, -28, -54,-115, -17,-117,  55,  63,-118,-121,-112,-118,-104,-105, -22,-120,-106;
/M: SY='A';  M=  38, -33, -30,  19,-122,  20,-107,-119,  14, -76,   0,  20,-114,  34,   5,  35, -10, -57,  16, -56;
/M: SY='E';  M=-108,-129,  -8, 115,-129,-123,-101,-129, -90,-123,-120,-104, -10, -83,-100,-105,-108, -58,-127, -34;
/M: SY='D';  M= -73, -12,  76, -58,-126, -68,   2,-124,-101,-125, -16,  44,  36, -46,  -6,  62,  -2,-120,-137,-116;
/M: SY='P';  M= -14, -35,   5,  33, -56,-112, -36, -41,  12, -74,-114,  11,  90,   7, -59,  27, -62, -46,-128,-119;
/M: SY='E';  M=   9,-123,  43,  50,-118, -11,  37, -43, -20, -61,-111,  -6, -28,  22,   7,   9, -13, -25,-125,  13;
/M: SY='I';  M= -15,-118, -27, -46, -42,-124,-120,  59, -63,  -2, -93, -31, -39,   1, -14, -16,  30,  57,-127,-108;
/M: SY='A';  M=  48,-118,-112, -37,-116, -47,  20, -26,  25, -13,  -4,-106, -39,  33,  34, -16,  12,  18,-125,-111;
/I:         I=-30; MD=-77;
/M: SY='Q';  M=  35, -37,  14,  38,-124, -50,  -9, -40,   7, -57,  11, -26,-116,  48,  26, -26, -14, -15,-129,-115; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='K';  M= -42,-126, -42,  55,-123, -51, -32,  -5,  57, -44, -37, -25,-113,  53,  57, -50,-107,-115,-123,-112;
/M: SY='R';  M=-114,-130, -44, -99,-122,-124,  21, -51, -42,-120,-110,-103,-122, -29, 119,-108,-113, -50,-125,-109;
/M: SY='Q';  M=   4,-122,  36,  43,-122, -50, -37, -23,  43, -15,-109,  24,-113,  47, -16, -45,  12, -46,-128,-113;
/M: SY='E';  M=  -2, -18,  13,  43,   6, -70,  14, -67,  30,-116,  -5,  -8,-114,  39,  37,  -2,   3, -81,   6,  -2;
/M: SY='C';  M=  15,  72, -49,-119, -98,-124, -37, -16,-120,  71,  -2,-120,-127, -42,-121, -51,  -8,   0,-124, -35;
/M: SY='Q';  M=   1,   5, -55,  12,-118,  -8,-107, -11,  49, -10,-105, -14,-115,  62,  18,  -4,  -5, -20,-123, -38;
/M: SY='E';  M=  -1,-123,   8,  56,-123, -29,  -1, -31,  44, -72,-111,   9,-112,  41,  31, -16, -23, -36,-126, -48;
/M: SY='R';  M= -27,-123, -17,  31,-119,-117,-103, -63,  49, -16,  45,   6,-115,  41,  54,  -6, -11, -28,-125,-111;
/M: SY='L';  M= -38,-120,-118, -14,-100,-126, -19,  33,  24,  59, -34, -53,-123,   8,  -3, -33,-106,  23,-121, -16;
/M: SY='E';  M=   3,-123,  14,  58, -60, -69, -34, -71,  52, -54, -32, -15,-111,  43,  17, -11,   7,-116,  -8,-113;
/M: SY='R';  M=  37,   1, -39, -38, -61, -73, -25,  -5,  26,  10,  12, -27, -39, -35,  43, -12, -33,  24,-125,-110;
/M: SY='L';  M=-115,-118, -38,-122,  -8,-132,-114, -57,-124,  91, -21,-128, -17,-118,-122,-123,-110, -36,-115,  11;
/M: SY='E';  M= -38,-124, -12,  58,-124, -75, -10, -40,  52, -71,-111, -23,-112,  49,  32,  16,  -9, -23,-126,-113;
/M: SY='E';  M=  12,-123, -11,  65,-123, -29, -24, -66,  41, -25,-111, -13, -58,  45,  13, -14, -33, -58,  -9,-114;
/M: SY='A';  M=  83,  -8,-114,-112, -27,  42,-117, -61,-112, -70,-110,-105,-115,-109,-117,  21, -24, -37,-123,-116;
/M: SY='Q';  M= -23,-121,-112, -20, -26,-119, -34, -43,  20,  39,  56, -20, -46,  58,   3,  11, -31, -46,-116,  26;
/M: SY='Q';  M= -15,-122,  14,  40,  -9, -36, -18, -54,  31, -48,-110,   7,-114,  56,  30,   4,  12, -32,-124, -45;
/M: SY='I';  M=  12,   8, -38,  13,-111,-120,-115,  55,  17, -30, -43, -58, -54,  15,   9, -17,  15,  24,  -1,-110;
/M: SY='L';  M= -60,  67, -64,-125,  22,-131,-122,  48,-125,  67, -85,-125, -53,-122,-125,-120,-108,  11,  -7,-101;
/M: SY='K';  M=  15, -39,  -2,  19,-121, -15,   3,-120,  39, -60,  -5,  31, -14,   8,  39,  23, -19, -71,-125, -23;
/M: SY='E';  M=  14,-121,  17,  49, -70, -18,  -7, -59, -18, -76, -10,  -7,-112,  45,  34,  36,   3, -75,-127,-113;
/M: SY='L';  M=   0,  27,  -9,-119,  33,-126,  34,  23, -67,  35,  -9, -51,  -4,-118,-121, -45, -63,  35,-121,  -5;
/M: SY='R';  M= -24,-125,  -7, -14,-120, -15,-110, -22, -12, -56,  39,   4,  24,  36,  46,  14, -23,  11,-129, -47;
/M: SY='M';  M=  21, -36,  35,   0, -64,   7,   4, -35, -12, -58,  45,  -3,   0, -22,   5, -11,   0, -31,  -3,-115;
/M: SY='Q';  M=   9,-125,  -8, -24, -11, -17,  -2, -24,   2,  20,-105, -24, -18,  34,  24,   1, -15, -33,-126, -26;
/M: SY='H';  M=  13, -10, -30,  -4, -61, -10,  31, -74,   2, -10, -43, -23, -53,  24,  16,   8,  10, -15,-130, -12;
/M: SY='F';  M=   4,-126, -18, -28,  21,  -2, -37, -41, -39,   5, -31,   4,  -7, -15,-121,  -2,  15,   9,-128, -25;
/I:         E1=0; IE=-255; DE=-255;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	83 in 83 different sequences
Number of true positive hits	83 in 83 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	GED
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

83 sequences

DMP34_HUMAN (Q6PK57), DMP46_HUMAN (Q6ZS02), DNM1L_BOVIN (Q2KIA5),

DNM1L_CAEEL (Q8WQC9), DNM1L_DANRE (Q7SXN5), DNM1L_HUMAN (O00429), 
DNM1L_MOUSE (Q8K1M6), DNM1L_RAT   (O35303), DNM1_SCHPO  (Q09748), 
DNM1_YEAST  (P54861), DRP1A_ARATH (P42697), DRP1B_ARATH (Q84XF3), 
DRP1C_ARATH (Q8LF21), DRP1D_ARATH (Q8S3C9), DRP1E_ARATH (Q9FNX5), 
DRP2A_ARATH (Q9SE83), DRP2B_ARATH (Q9LQ55), DRP3A_ARATH (Q8S944), 
DRP3B_ARATH (Q8LFT2), DRP4C_ARATH (Q9ZP55), DYN1_BOVIN  (Q08DF4), 
DYN1_CAEEL  (P39055), DYN1_HUMAN  (Q05193), DYN1_MOUSE  (P39053), 
DYN1_RAT(P21575), DYN2_BOVIN  (A6H7I5), DYN2_HUMAN  (P50570), 
DYN2_MOUSE  (P39054), DYN2_RAT(P39052), DYN3_HUMAN  (Q9UQ16), 
DYN3_MOUSE  (Q8BZ98), DYN3_RAT(Q08877), DYNA_DICDI  (Q94464), 
DYNB_DICDI  (Q9U1M9), DYN_DROME   (P27619), MGM1_CHATD  (G0SGC7), 
MGM1_YEAST  (P32266), MSP1_SCHPO  (P87320), MX1B_MOUSE  (P09922), 
MX1_BOVIN   (P79135), MX1_CANLF   (Q9N0Y3), MX1_EUMJU   (Q4ADG8), 
MX1_HORSE   (Q28379), MX1_HUMAN   (P20591), MX1_ICTPU   (Q7T2P0), 
MX1_MACMU   (A1E2I4), MX1_MOUSE   (Q3UD61), MX1_ONCMY   (Q91192), 
MX1_OTABY   (Q4ADG7), MX1_PHOVI   (Q4ADG6), MX1_PIG (P27594), 
MX1_PONAB   (Q5R5G3), MX1_RAT (P18588), MX1_SHEEP   (P33237), 
MX2_BOVIN   (Q9BDI7), MX2_BUBBU   (A0MWD1), MX2_CANLF   (Q9N0Y2), 
MX2_HUMAN   (P20592), MX2_ICTPU   (Q4U4N4), MX2_MACMU   (A1E2I5), 
MX2_MOUSE   (Q9WVP9), MX2_ONCMY   (Q91196), MX2_PIG (A7VK00), 
MX2_RAT (P18589), MX2_SHEEP   (Q5I2P5), MX3_ONCMY   (Q91197), 
MX3_RAT (P18590), MXA_DANRE   (Q8JH68), MXB_DANRE   (Q800G8), 
MXC_DANRE   (Q6DKF0), MXE_DANRE   (Q800G5), MX_ANAPL(P33238), 
MX_CHICK(Q90597), MX_CTEID(Q6TKS7), MX_DICLA(Q2KTC2), 
MX_EPICO(Q6PW23), MX_LARCR(Q000A9), MX_SINCH(Q6TN15), 
MX_SOLSE(Q5U752), SDL5A_SOYBN (Q39828), SDLCA_SOYBN (Q39821), 
VPS1_SCHPO  (Q9URZ5), VPS1_YEAST  (P21576)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

33 PDB

3LJB; 3SNH; 3SZR; 3ZVR; 3ZYS; 4BEJ; 4UUD; 4UUK; 4WHJ; 4X0R; 5A3F; 5GTM;
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