PROSITE entry PS51379

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS51379

Direct ScanProsite submission

General information about the entry

Entry name [info]	4FE4S_FER_2
Accession [info]	PS51379
Entry type [info]	MATRIX
Date [info]	01-APR-2008 CREATED; 01-APR-2008 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00176
Associated ProRule [info]	PRU00711

Name and characterization of the entry

Description [info]

4Fe-4S ferredoxin-type iron-sulfur binding domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=30;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1825429; R2=0.0084008; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=693; N_SCORE=7.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=574; N_SCORE=6.0; MODE=1; TEXT='R?';
/DEFAULT: M0=-11; D=-200; I=-200; B1=-100; E1=-100; MI=0; MD=-105; IM=0; DM=-105;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-105; BD=-105; IM=-105;
/M: SY='W';  M= -6,-45, -4,  0,  5, 16, -3,-10, 11,-10, 11, -2, 11, -3,  1, -7, -3,-10, 21,  9;
/I:         MI=-105; IM=-105;
/M: SY='R';  M=  3,-35, -6,  8, -9,-10,  6, -6, 20,-14, -9, -6, 12,  6, 25,  2,  0, -1,-41,  2;
/I:         MI=-105; IM=-105;
/M: SY='P';  M=  4,-32,-23,-12,  4,-30,-10, 18,-19,  7,  8,-25, 43,-15,-18,-15, -6, 20, -4,  9;
/I:         MI=-105; IM=-105;
/M: SY='E';  M= -5,-32, -5, 14, -2,-27,  3,  4,  5, -3,  2,-11,-17,  5,  5,  2,  6, 12, -1,  7;
/I:         I=-61; MD=-32; DM=-32;
/M: SY='I';  M=-12,-23,-51,-31, 15,-39,  1, 42,-18, 18,  7,-32,-23,-23,-10,-25,-10, 38, 16,  9;
/I:         I=-53; MD=-28; DM=-28;
/M: SY='D';  M=-19,-51, 70, 13,-23,-23,  5,-19, -5,-30,-29, 48,-37, -3,-10, -1,-11,-23,-50,-17; D=-53;
/I:         I=-53; MD=-28; DM=-28;
/M: SY='P';  M=  3,-43,  2, 24,-11,-24,  5,-23,  8,-15, -7, -5, 38, 14,  4,  2,  6,-19,-13, 11;
/I:         I=-44; MD=-23; DM=-23;
/M: SY='D';  M=  0,-50, 45, 36,-35, -2,-13,-42,  1,-38,-28, 21,-27,  6,-10, 17,  1,-35,-55,-29; D=-44;
/I:         I=-44; MD=-23; DM=-23;
/M: SY='K';  M= -3,-41, -4, 10,-26,-30, -3,-18, 37, -3, -9,  3,-34,  5, 32, -4, -6,-19,-21,-20; D=-44;
/I:         I=-44; MD=-23; DM=-23;
/M: SY='C';  M=-20,145,-77,-78,-49,-62,-62,-30,-65,-37,-30,-55,-62,-57,-74,-28,-26,-27,-67,-58;
/I:         MI=-105; IM=-105;
/M: SY='I';  M=-12,-23,-16,-18,-22,-35,-29, 48, -7,  4, 15, -4,-38,-14,-19, -7, 28, 38,-35,-27;
/I:         I=-63; MD=-33; DM=-33;
/M: SY='G';  M=  5,-32, -2, -7,-19, 55,  5,-43,  2,-23,-17, 10,-41, -3,  5,  5,-15,-34,-39,-14;
/I:         I=-56; MD=-29; DM=-29;
/M: SY='C';  M=-19,144,-59,-72,-49,-60,-50,-30,-62,-36,-30,-52,-61,-55,-72,-26,-26,-26,-55,-55;
/I:         I=-56; MD=-29; DM=-29;
/M: SY='G';  M= -5,-49, -9, -9,-31, 67, -9,-51,  4,-34,-11,  2,-41, -2,  6, -8,-11,-45,-38,-22;
/I:         I=-58; MD=-30; DM=-30;
/M: SY='R';  M= 17,-25,-12, -1,-13,-28,-13,  4, 10,  9, 10, -3,-36, 10, 18,  1,  3,  0,-26,-10;
/I:         I=-61; MD=-32; DM=-32;
/M: SY='C';  M=-20,145,-77,-77,-49,-62,-62,-30,-65,-37,-30,-55,-62,-57,-74,-27,-26,-27,-67,-58;
/I:         I=-61; MD=-32; DM=-32;
/M: SY='V';  M= 15,-32,-25, 15,-14,-35,-20, 19,-13,  1, 13,-25,-36,  1,-20, 20, 25, 31,-12, -8;
/I:         MI=-105; IM=-105;
/M: SY='E';  M=  7,-45, 18, 23,-27,-22, -6,-18, 19,-19, -6,  9, -3, 14, 18,  6,  3,-12,-22,-12;
/I:         I=-63; MD=-33; DM=-33;
/M: SY='V';  M= 29,-29,-32,-11, -6,-24, -9, 15,-11, -6, -3,-11,-31,-10,-17, 24, 13, 33,-18, -7;
/I:         I=-61; MD=-32; DM=-32;
/M: SY='C';  M=-20,144,-69,-76,-49,-61,-61,-30,-65,-36,-30,-54,-62,-56,-74,-27,-26,-26,-67,-58;
/I:         MI=-105; IM=-105;
/M: SY='P';  M= -9,-58,-27,-15,-56,-35,-20,-52, -7,-47,-43,-24,110,-14,-14,-10,-20,-42,-67,-49;
/I:         I=-51; MI=-105; MD=-27; IM=-105;
/M: SY='T';  M= -4,-34,-13, -1,  7,-34,  1,-16, -7,-24, -8, -5,-19,  2,-15, 18, 20,  3,-20, 16; D=-51;
/I:         I=-51; MD=-27; DM=-27;
/M: SY='G';  M= -6,-51, 31, 19,-40, 33,  5,-48,  6,-45,-34, 30,-20, 16, -3,  4,-13,-39,-60,-21; D=-51;
/I:         I=-51; MI=-105; IM=-105; DM=-27;
/M: SY='A';  M= 48, 26,-31,-24,-26, -9,-19,  7,-20,-11, -9,-12,-26,-24,-29,  5,  0, 17, -7,-20;
/I:         MI=-105; IM=-105;
/M: SY='I';  M=-18,-24,-52,-46, 19,-50,-18, 47,-29, 27, 17,-30, -1,-37,-22,-28,-17, 21,  5,  6;
/I:         I=-61; MD=-32; DM=-32;
/M: SY='E';  M= -3,-40, 15, 22,-20,-15,  1,-18, 16,-35,-21, 10, -6, 17, 15, 14, 14,-11,-30, -4; D=-61;
/I:         I=-61; MI=-105; IM=-105; DM=-32;
/M: SY='M';  M=-11,-31,-45,-14, 16,-37,-19, 22,-13, 20, 36,-28,  3,-15,-11,-20,-12, 18, 20, 13;
/I:         MI=-105; IM=-105;
/M: SY='D';  M= -3,-36, 21, 19,-29,  0, -4, -7, 11,-24,-20, 13,  3,  4,  5,  5,  6,  3,-29,-16;
/I:         MI=-105; IM=-105;
/M: SY='D';  M= -5,-42, 29, 26,-26,  6, -2,-31, 11,-29,-24, 14, 26,  7,  6,  2, -2,-25, -2,-17;
/I:         MI=-105; IM=-105;
/M: SY='E';  M= -6,-47, 23, 24,-10, 12,  2,-16, 14,-22,-22, 10,  3,  5, 12, -2, -3,-14,-40,  1;
/I:         E1=0; MI=-105; IE=-105; DE=-105;

» more

Post-processing [info]

COMPETES_HIT_WITH

PS51085

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	3'014 in 1'480 different sequences
Number of true positive hits	2'997 in 1'467 different sequences
Number of 'unknown' hits	8 in 4 different sequences
Number of false positive hits	9 in 9 different sequences
Number of false negative sequences	40
Number of 'partial' sequences	2

Precision (true positives / (true positives + false positives))	99.70 %
Recall (true positives / (true positives + false negatives))	98.68 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	13
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	4Fe-4S ferredoxin-type
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	1467 sequences AB1E_ARATH (Q9LID6), AB2E_ARATH (Q8LPJ4), ABCE1_DROME (Q9VSS1), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	40 sequences D2HDH_PANAA (A0A0H3KZS3), D2HDH_PSEPK (Q88EH0), ETFQO_ARATH (O22854), » more
UniProtKB/Swiss-Prot 'Partial' sequences	2 sequences FERA_SULME (P81543), FERB_SULME (P81539)
UniProtKB/Swiss-Prot 'Unknown' sequences	4 sequences RPO3_ARCFU (O28002), RPO3_METAC (P0CG28), RPO3_METMA (Q8PV16), RPO3_METTH (O26144) » more
UniProtKB/Swiss-Prot False positive sequences	9 sequences CHOD_ACIBA (A0A4D6G3C8), GEOA_CASD6 (H1ZV38), M231_CONTS (Q9BPJ0), » more
PDB [Detailed view]	561 PDB 1A6L; 1AXQ; 1B0P; 1B0T; 1B0V; 1BC6; 1BD6; 1BLU; 1BQX; 1BWE; 1C4A; 1C4C; » more