PROSITE entry PS51365

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51365
Entry name [info]	RENAL_DIPEPTIDASE_2
Accession [info]	PS51365
Entry type [info]	MATRIX
Date [info]	01-FEB-2008 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00678
Associated ProRule [info]	PRU10073

Name and characterization of the entry

Description [info]

Renal dipeptidase family profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=373;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=368;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1039176; R2=0.0066114; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1270; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=665; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-14; D=-80; I=-80; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='D';  M= -21, -36,  38,  13, -26, -30, -20,  17,   5,   1,  24, -14,  21,  14, -18,   5, -15, -13, -39, -23;
/M: SY='H';  M= -20, -33, -20, -18,  16, -25,  50, -25, -15,  -5, -17,  13,  47, -16,  10,  19,  10, -25, -36, -13;
/M: SY='Q';  M=   2, -33, -17,  21,  17, -28, -21,  22, -17,   2, -12,  10,  14,  23, -22,   5, -15, -10, -31, -16;
/M: SY='E';  M=   1, -38, -15,  35, -28, -33, -20,  15,  -6,  -1, -14, -22,  27,  21,  32, -19, -20, -14, -35, -25;
/M: SY='E';  M=  -1, -38,  24,  56,  14, -29, -13, -34,  -6, -28, -25, -13, -22,  50, -12, -14, -20, -31, -32, -18;
/M: SY='R';  M= -20, -39, -12,  39, -33, -35, -16,  -2,  18, -24, -18, -17, -26,  42,  44, -17, -20,   4, -36, -24;
/M: SY='A';  M=  50, -26, -20,  20,  11,  14, -26, -23, -20,  -5, -18, -21, -26, -16, -26,  -8, -16, -16, -30, -21;
/M: SY='R';  M=  12, -33, -16,  16, -32, -28, -17, -27,  29,  -6, -17, -14, -26,  36,  37, -11,  10, -23, -35, -24;
/M: SY='P';  M=  13, -36,  21,  28, -36, -27,  28, -27,  -7, -30, -23, -16,  38,  -9,  32, -15, -18,  -2, -42, -25;
/M: SY='I';  M=  -3, -31, -43, -38,  -8, -43, -38,  56, -36,  33,   5, -36, -36, -32, -37, -29, -17,  31, -34, -16;
/M: SY='C';  M= -24,  64, -36, -31,  -9, -39,  49,  -3, -31,  42,  51, -28, -39, -24, -29, -29, -22,  -8, -39, -12;
/M: SY='R';  M= -20, -38,  24,  37, -39, -29, -14, -41,  40, -37, -28,  -9, -24,   0,  48,   7, -17, -35, -38, -26;
/M: SY='E';  M=  -1, -37,  40,  52, -41, -26,  34, -40,  -6, -35, -28,  -8, -21,  37, -12,   7, -17, -35, -43, -24;
/M: SY='F';  M=  17, -24, -23, -25,  33, -21, -25,  -9, -23, -16, -16,  15, -30, -22, -27,  32,  12,  22, -31, -12;
/M: SY='P';  M= -25, -47, -27, -16, -36, -30, -30,  14,   4, -29, -21, -30,  96, -24, -27, -24, -18, -21, -37, -35;
/M: SY='V';  M= -19, -28, -43, -37,  -6, -45, -37,  36, -36,  40,   6, -39, -39, -34, -36, -31, -16,  48, -37, -16;
/M: SY='I';  M= -19, -31, -44, -40,  15, -46, -43,  58, -36,   5,   2, -36, -36, -36, -38, -29, -15,  51, -35, -13;
/M: SY='D';  M= -27, -40,  94,  10, -47, -23, -12, -45, -14, -44, -43,   6, -26, -13, -23, -15, -16, -42, -63, -30;
/M: SY='G';  M=  -7, -31, -21, -29, -38,  69, -27, -40, -24, -39, -31,  -8, -25, -22, -31,  23,  23, -32, -36, -33;
/M: SY='H';  M= -57, -80, -25, -25, -54, -60, 243, -91, -35, -55, -26,  -4, -58, -13, -22, -36, -54, -90,-125,   8;
/M: SY='N';  M= -22, -28,   1, -19, -30, -14,  -6,  13, -11, -29, -21,  87, -33, -12, -19,  -7,  -7, -21, -51, -28;
/M: SY='D';  M= -54, -80, 188,  20, -94, -47, -25, -91, -28, -87, -86,  12, -52, -27, -45, -30, -33, -84,-125, -59;
/M: SY='L';  M= -24, -27, -38, -34,  40, -41, -28,   4, -33,  49,   4, -33, -38, -32, -33, -25,  20,  10, -25,  -5;
/M: SY='P';  M= -24, -44, -30, -18, -33, -29, -24, -19, -23, -21,  55, -32,  96, -23, -31, -24, -18, -26, -37, -31;
/M: SY='W';  M= -28, -38, -43, -37,  32, -39, -20,  23, -31,  11,  43, -37, -38, -27, -30, -32, -26,  -7,  93,  58;
/M: SY='N';  M=   0, -29, -18, -18,  16, -25, -14, -11, -17,  24,  29,  45, -34,  35, -19, -15, -16, -16, -32, -14;
/M: SY='L';  M= -22, -29, -44, -37,  -4, -45, -31,  37, -36,  49,  36, -39, -39, -30, -35, -33, -19,  27, -33, -14;
/M: SY='R';  M= -27, -38, -28, -18, -13, -39, -13, -19,   4,  21,  -9, -23, -38,  -8,  71, -25, -24, -21, -25,  27;
/M: SY='D';  M= -18, -36,  45,  28, -34,  34, -21, -26,  12, -10, -25,  -9, -26, -12, -18, -16, -19,  -4, -41, -29;
/M: SY='W';  M= -21, -38, -19,  24, -24, -33, -18, -15,  13,   1,  28, -21, -28,  50,  12, -20, -21,   5,  64, -15;
/M: SY='F';  M= -26, -31, -22,   8,  53, -34, -15,  -8, -23,  16,  -8,  26, -37, -23, -26, -23, -19,   5, -13,  43;
/M: SY='R';  M= -20, -36, -15, -10, -36,   0,  31, -36,   3, -32, -21,  21, -29,  40,  56, -10,  20, -32, -39, -21;
/M: SY='W';  M= -24, -32,  -3, -20, -19, -14,  -7, -33, -11, -37, -27,  83, -34, -13, -19,  -9, -12, -37,  84,  20;
/M: SY='D';  M= -24, -35,  33,  11, -22, -34,  33, -15,  24,  22, -11, -14, -30, -11,  18, -22, -19,  -2, -40, -18;
/M: SY='L';  M= -26, -34, -41, -34,  19, -43, -32,  38, -35,  45,   4, -38,  36, -32, -36, -33, -21,   3, -28, -12;
/M: SY='Q';  M=   7, -33,  16,  -6, -29,   3, -12, -30, -10, -29, -21,  20, -26,  60, -13,  -6,  22, -27, -30,  19;
/I:         I=-13; MD=-40;
/M: SY='D';  M=  -4, -41,  62, -11, -43,   6, -23, -39, -25, -14, -35,  23, -36, -24, -32, -20, -24, -38, -57, -36; D=-13;
/I:         I=-13; MD=-40;
/M: SY='F';  M= -12, -56, -37,   1,  28, -49, -40, -48, -38, -43, -43,   5, -54,  10, -42, -38, -42, -47, -46, -29; D=-13;
/I:         I=-13; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='D';  M= -34, -53,  36,  25, -55,  -7, -25, -56, -12, -50, -43, -20, -38,  18,  29, -27, -34, -51, -54, -40; D=-13;
/I:         I=-13; DM=-40;
/M: SY='F';  M=  19, -29,  28,  10,  32, -26, -23, -12, -22,  11, -14, -18, -30, -20, -26,  10, -14,   5, -30, -12;
/M: SY='N';  M= -24, -35,  46,  12, -35, -22,  36,  -4,  24, -32, -25,  53, -27,  -8, -10, -13, -14, -28, -49, -23;
/M: SY='F';  M=  11, -29, -42, -35,  50, -36, -30,  26, -35,  40,   2, -36, -39, -33, -34, -27, -21,   1, -21,  -2;
/I:         I=-17; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='N';  M=  13, -31,  18,  11, -25,  13,  34, -33,   5, -32, -24,  34, -26, -12, -16,  -8,  12, -28, -34,  20;
/M: SY='Q';  M= -18, -35,  36,  27, -41,  22, -13, -38,  -9, -37, -28,  37, -24,  42, -15,  -8,  12, -35, -43, -29;
/M: SY='S';  M= -11, -26, -26, -27,  15,  24, -25, -13, -24,   4,  26, -15, -28, -21, -28,  31,  29,   2, -33, -16;
/M: SY='T';  M=  31, -26, -27, -22, -21, -25, -26, -13, -19,  22,  -9, -22,  22, -21,   3,  -9,  35, -10, -37, -24;
/M: SY='T';  M= -12, -30, -20, -20, -30,  10,  30,   2, -15, -26, -20, -10,  22, -15,  10,  34,  36, -18, -42, -22;
/M: SY='S';  M= -11, -28, -24, -22, -22,  25, -21, -16, -21,  20,  21, -14, -28,  18, -24,  34,  14, -16, -36, -22;
/M: SY='H';  M= -26, -40, -11,  -8, -31, -27, 109, -42, -12, -29, -15,  20, -29,  41,  -9, -14, -24, -43, -54,  -2;
/M: SY='T';  M= -13, -23, -22, -24, -22, -32, -31,  22, -21, -13, -12, -12, -22, -24, -28,  -1,  72,  14, -45, -23;
/M: SY='D';  M= -23, -37,  86,   6, -44, -20, -12, -43, -13, -43, -40,  29, -26, -12, -22,   8, -13, -40, -59, -29;
/M: SY='L';  M= -25, -31, -44, -37,  -3, -45, -29,  41, -35,  51,  48, -38, -38, -29, -34, -34, -20,   8, -31, -13;
/M: SY='P';  M=  13, -39,  13,  -7, -40, -24, -21, -24, -15, -31, -22, -19,  71,  47, -20, -14, -17,  -3, -38, -30;
/M: SY='R';  M= -25, -40, -19,  -7, -36, -34, -13, -41,  51, -35, -24, -12, -30,   1,  75, -19, -22, -35, -34, -23;
/M: SY='L';  M= -26, -28, -44, -35,   0, -44, -26,   9, -36,  64,  37, -41, -42, -28, -33, -36, -22,   1, -30, -12;
/M: SY='R';  M= -24, -41, -15,  16, -38, -33, -12, -40,  41, -35, -24, -13, -28,  28,  70, -17, -22, -35, -34, -23;
/M: SY='K';  M=  17, -33,  18,  28, -39, -22, -17, -36,  47, -35, -26,  -9, -22,  24,   0,   9, -14, -29, -36, -27;
/M: SY='G';  M=  -7, -34, -22, -31, -41,  78, -28, -47, -27, -44, -34,  -8, -27, -23, -33,  21, -20, -40, -34, -35;
/M: SY='K';  M= -19, -34, -26, -18,  17,  32, -21, -18,  32,  14,  26, -17, -30,  18, -10, -19, -22, -21, -27, -15;
/M: SY='V';  M= -18, -30, -39, -31, -11, -43, -36,  41, -31,  26,   3, -34, -37,  12, -31, -27, -15,  50, -38, -18;
/M: SY='G';  M= -11, -37,  28, -24, -43,  77, -27, -49, -26, -45, -36,  -6, -27, -24, -34,  -9, -25, -43, -36, -36;
/M: SY='G';  M=  39, -26, -30, -29, -28,  40, -34,  -6, -28, -19, -16, -22, -30, -26, -32, -10, -15,  35, -38, -29;
/M: SY='Q';  M=   5, -40, -16,   0, -46,  20, -11, -36,  -4, -32, -19, -10, -26,  87,  -5,  -7, -21, -34, -32, -23;
/M: SY='F';  M= -34, -35, -43, -40,  83, -40, -18, -11, -34,  -4, -11, -36, -44, -38, -31, -32, -27, -17,  60,  60;
/M: SY='W';  M= -34, -48, -56, -40,  49, -36, -47, -20, -33,  -1, -21, -49, -40, -35, -35, -39, -39, -31, 144,  15;
/M: SY='S';  M=  22, -23, -19, -18, -31, -11, -22, -21, -19, -29, -24,  -9, -25, -12, -23,  65,   2,   6, -41, -26;
/M: SY='C';  M=  51,  65, -33, -26, -27, -20, -34,  -8, -27, -17, -15, -26, -32, -26, -31,  -9, -12,  30, -42, -29;
/M: SY='Y';  M= -32, -36, -37, -37,  71, -39,  -7, -12, -30,  -6,  -9, -33, -44, -30, -27, -29, -26, -17,   8,  84;
/M: SY='W';  M= -18, -30, -36, -34, -13, -40, -41,  48, -30,  -3,  -5, -27, -30, -31, -35, -18,  36,  36,  62, -15;
/M: SY='P';  M= -20, -39, -15,  25, -38, -29, -21, -33,  -6, -36, -27, -18,  71, -10,  32,   4,  22, -30, -39, -32;
/M: SY='C';  M=  -2, 237,  50, -47, -67, -56, -63, -74, -57, -62, -60, -33, -82, -62, -70,  10, -32, -52,-113, -73;
/M: SY='P';  M=   5, -37,  34,  -6, -23, -24, -14, -32,  22, -32, -24, -12,  44,  20, -12,   4, -16, -30, -26,  35;
/M: SY='T';  M= -16, -30,  21,   8, -28,  20, -20, -24,   8,   6, -19,  19, -26, -14, -18,  10,  28, -22, -41, -26;
/M: SY='P';  M= -18, -37, -18, -14, -22,   7, -13, -30, -15, -31, -22,  17,  54,  39, -20,   7,  14, -30, -25,  34;
/I:         I=-13; MD=-40;
/M: SY='N';  M= -24, -37,  34,   9, -43, -25, -16, -38, -14, -41, -32,  49,  21,  23, -21, -11,  22, -36, -52, -33; D=-13;
/I:         I=-13; MD=-40;
/M: SY='Y';  M= -29, -45,  18,  36, -20, -37,  30, -39,  13, -34, -27, -18,  13,  -9,  14, -23, -25, -37, -26,  43; D=-13;
/I:         I=-13; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='D';  M= -19, -37,  51,  28, -40,   5, -17, -39,  -7, -38, -32,  -7,  22,  -9,  25,   6,   9, -34, -45, -30;
/M: SY='A';  M=  56, -23, -22, -22, -29, -13, -25,   7, -21, -20, -16,  28, -28, -19, -26,  -5, -11,   9, -38, -28;
/M: SY='V';  M= -15, -26, -43, -36,  -9, -44, -40,  19, -35,  30,   3, -39, -40, -35, -35, -28, -13,  64, -42, -19;
/M: SY='R';  M=   7, -34, -16,  13, -35, -25, -15, -35,   4, -32, -24, -12, -27,  20,  61,  20,  10, -28, -37, -24;
/M: SY='R';  M=  25, -34,  30,  -8, -35, -25, -17, -26,  -1, -28, -22, -13, -30,  22,  53, -12, -18,  -1, -39, -25;
/M: SY='T';  M=   7, -20, -17, -20, -27, -25, -27, -18, -17, -23, -19,  -7, -19, -21, -25,   5,  79, -10, -46, -25;
/M: SY='L';  M= -26, -29, -44, -36,  -1, -45, -27,  20, -36,  62,  35, -41, -41, -29, -34, -36, -22,   3, -31, -12;
/M: SY='E';  M=  14, -36,   1,  68, -42,   5, -15, -40,  -5, -34, -28, -15, -18,  27, -13, -11, -19, -32, -37, -31;
/M: SY='Q';  M= -19, -41, -17,   3, -36, -29,  -9, -24,  -3,   7, -10, -13, -28,  92,  -3, -11, -21, -28, -31, -19;
/M: SY='I';  M= -24, -35, -45, -41,  -6, -47, -37,  67, -37,  28,  37, -36, -34, -31, -38, -33, -19,  17, -32, -14;
/M: SY='D';  M= -26, -38,  88,   7, -45, -21, -10, -44, -13, -44, -40,  38, -27, -13, -21, -13, -15, -41, -61, -30;
/M: SY='V';  M=  15,  41, -39, -33, -14, -35, -38,  11, -32,  20,  -3, -34, -38, -32, -34, -22, -13,  54, -42, -22;
/M: SY='T';  M=   7, -26, -34, -31,  19, -35, -33,  30, -29,  18,  -3, -26, -31, -30, -32, -15,  34,  28, -33, -14;
/M: SY='H';  M= -26, -40, -18, -11, -18, -32,  74, -36,  38, -29, -18, -11, -30,  -4,  47, -19, -23, -35, -26,  39;
/M: SY='W';  M= -28, -45, -27, -14, -27, -36, -16, -40,  12, -33, -25, -20, -35,  -3,  83, -23, -28, -37,  84, -14;
/M: SY='M';  M= -20, -26, -38, -32,  -6, -40, -26,   7, -30,  47,  52, -31, -35, -26, -30, -24,  21,  17, -35, -14;
/M: SY='C';  M=  14,  69, -35, -35, -20,   3, -38,  43, -31,  -8,  -9, -25, -33, -31, -36, -17,   7,  16, -40, -25;
/M: SY='C';  M=  18,  40,  18,  38, -39, -24, -16, -36,  -6, -33, -26, -13, -25,  38,  17,   9, -16, -29, -40, -28;
/M: SY='R';  M=  15, -33, -16, -10, -33, -23, -13, -29,  32, -26,  26,  30, -28,  23,  44, -12, -16, -26, -36, -23;
/M: SY='Y';  M= -29, -38, -18, -25,  10, -30,  60, -23, -20, -19, -12,  28, -38, -15, -18, -20, -21, -27,  -1,  88;
/M: SY='P';  M= -24, -47, -20, -10, -45, -25, -22, -33, -16, -41, -27,  11,  96,  31, -25, -18, -17, -38, -38, -37;
/M: SY='D';  M= -17, -34,  37,  32, -39,   6, -16, -38,  34, -37, -30,  21, -22,  -5,  -7,   8,  12, -33, -42, -29;
/M: SY='D';  M= -19, -33,  55,  14, -21, -27, -16,   4, -18,  -3, -20,  -8, -27, -14, -24,  18,  14, -18, -36,  19;
/M: SY='L';  M= -26, -30, -35,   1,  41, -42, -23,   2, -30,  48,  46, -36, -38, -25, -30, -32, -22,  -4, -23,  -4;
/I:         I=-24; MD=-77;
/M: SY='T';  M=  11, -33, -24, -16, -33, -30, -25, -26,  27,  -4, -20, -17, -29,  19,  15, -11,  34, -22, -40, -27; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='Y';  M=  -3, -34, -38, -33,  41, -37, -20,  23, -31,  26,  -2, -35,  18, -29, -32, -27, -21,  -4, -11,  49;
/M: SY='V';  M=  30, -23, -30, -25, -23, -22, -32,   3, -25, -12, -12, -22, -30, -23, -29,  31,  -6,  48, -42, -24;
/M: SY='T';  M= -19, -28,  33, -13, -24, -30,  28, -19, -14,   8, -15,  -8, -25, -17,  10,  -7,  55, -16, -46, -20;
/M: SY='S';  M=  -6,  42, -17, -19, -30, -17, -23, -27, -18, -30, -25,  -6, -23, -15, -24,  56,  50, -19, -45, -26;
/M: SY='A';  M=  56, -22, -26, -21, -27, -12, -26, -18, -23,   8, -14, -20, -27, -17, -26,  27,  -9, -11, -35, -26;
/M: SY='D';  M=  37, -31,  61,  33, -41, -19, -18, -36, -14, -35, -31,  -7, -23, -10, -21,  -9, -15, -27, -45, -31;
/M: SY='D';  M= -15, -37,  46,  36, -43,  41, -17, -44, -13, -40, -33,  -6, -23,  22, -20,  10, -18, -38, -41, -31;
/M: SY='I';  M=  26, -30, -39, -34, -13, -33, -35,  53, -32,  14,  30, -31, -32, -28, -34, -21, -16,  20, -34, -19;
/M: SY='W';  M= -23, -37, -19,  22, -19, -34, -21,  19,  21,   3,  31,  13, -29, -10,  17, -23, -20, -12,  64, -16;
/M: SY='D';  M=  18, -32,  31,  20, -39, -20, -16, -36,  26, -35, -27,  -8, -24,  26,  13,  24, -12, -29, -39, -27;
/M: SY='A';  M=  47, -23, -18,   6, -34, -15, -24, -25, -16, -27, -21, -14, -22,  16, -21,  17,  36, -15, -38, -28;
/I:         I=-19; MD=-61;
/M: SY='F';  M= -35, -36, -46, -40,  71, -45, -24, -10, -30,  17,  21, -38, -46, -36,   5, -36, -29, -16, -11,  30; D=-19;
/I:         I=-19; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='A';  M=  39, -33, -23, -15, -41, -21, -21, -35,  10, -35, -26,  14, -32,  24,  33, -11, -19, -27, -40, -31; D=-19;
/I:         I=-19; DM=-61;
/M: SY='N';  M=  13,  36,  -4,  40, -42, -23, -16, -40, -13, -40, -32,  54, -30, -10, -22, -12, -17, -34, -50, -37; D=-19;
/I:         I=-19; DM=-61;
/M: SY='G';  M= -13, -37,  28, -15, -43,  66, -23, -46,  10, -42, -32,  -6, -26,  17, -20, -10, -24, -41, -36, -32;
/M: SY='K';  M= -23, -37, -18,  -5, -32, -32, -16, -32,  65,  -8, -19, -12, -27,  -1,  49, -19, -19, -29, -32, -22;
/M: SY='I';  M= -22, -33, -44, -41,  -7, -48, -41,  64, -37,  27,   6, -37, -36, -34, -39, -32, -17,  36, -35, -16;
/M: SY='A';  M=  68, -22, -28, -21, -32, -11, -30,   4, -23, -21, -17, -23, -26, -20, -28,  -2, -12,  -7, -35, -29;
/M: SY='S';  M=  -9,  41, -25, -25, -23, -21, -27,  37, -24, -15, -14, -14, -28, -18, -28,  55,  -3,  -3, -40, -23;
/M: SY='L';  M=  14, -28, -38, -30,  -9, -34, -30,   5, -32,  48,   3, -37,  18, -28, -33, -25, -18,  22, -34, -19;
/M: SY='I';  M= -23, -33, -38, -32, -10, -40, -31,  40, -31,  36,  32, -33,  37, -28, -34, -27,   9,   4, -34, -18;
/M: SY='G';  M=   9, -30, -24, -31, -34,  66, -31, -26, -26, -31, -25, -12, -27, -26, -33,  -7,  20,   2, -37, -32;
/M: SY='I';  M=   3, -29, -42, -36, -11, -40, -38,  49, -34,  15,  27, -35, -35, -32, -35, -26, -14,  47, -38, -18;
/M: SY='E';  M= -38, -81,  20, 168, -85, -70, -25, -88,  -1, -71, -64, -32, -29,  14, -21, -32, -39, -72, -79, -65;
/M: SY='G';  M=  -8, -36, -23, -35, -42,  84, -30, -50, -29, -45, -34,  -9, -27, -26, -36,  -8, -27, -43, -33, -37;
/M: SY='G';  M= -14, -33, -30, -35, -21,  66, -29, -19, -32,  29, -11, -19, -33, -28, -36, -17, -25, -21, -32, -26;
/M: SY='H';  M= -29, -40, -15, -15, -14, -31, 114, -39, -18, -25, -12,  -5, -31,  -8, -13, -19, -27, -40, -38,  43;
/M: SY='Q';  M=  -6, -30, -14,  -6, -38, -14, -13, -34,  -9, -34, -24,  -5, -24,  61, -11,  61,  -3, -29, -38, -23;
/M: SY='I';  M= -23, -33, -45, -41,  34, -47, -40,  61, -37,  17,   3, -36, -37, -37, -39, -32, -18,  33, -27,  -7;
/I:         I=-22; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='D';  M=   2, -37,  73,  29, -44,  22, -16, -43, -14, -41, -37,  -2, -24, -12, -23, -12, -18, -37, -49, -31;
/M: SY='N';  M= -11, -25,  21, -13, -34, -13, -12, -31, -13, -36, -28,  57, -25, -11, -20,  45,  31, -27, -49, -28;
/M: SY='S';  M=  -2, -25, -16, -15, -34, -11, -17, -34, -11, -36, -29,  -4, -24,  -7,  17,  72,   3, -26, -41, -25;
/M: SY='L';  M= -24, -30, -44, -38,  -3, -46, -33,  40, -37,  54,  10, -40, -40, -32, -36, -34, -20,  21, -32, -14;
/M: SY='A';  M=  43, -28, -16,  22, -38,  14, -24, -32, -17, -33, -26, -16,  28, -12, -24,  26, -11, -22, -37, -32;
/M: SY='V';  M=   7, -24, -35, -31, -14, -36, -36,  12, -29,  18,  -3, -29, -33, -30, -32, -16,  27,  54, -43, -21;
/M: SY='L';  M= -23, -28, -43, -36,  -1, -45, -30,  11, -37,  62,  11, -42, -43, -31, -34, -35, -20,  24, -33, -14;
/M: SY='R';  M= -25, -43, -21,  -7, -37, -35, -10, -41,  15, -33, -22, -14, -33,  38,  84, -18, -24, -36, -34, -21;
/M: SY='M';  M=  19, -30, -26, -12, -25, -24, -15, -13, -14,   6,  61, -18, -28,  56, -15,   8, -15, -14, -33, -18;
/M: SY='Y';  M= -29, -34, -38, -35,  48, -40, -10,  -4, -31,  30,  26, -35, -42, -27, -28, -30, -24, -10,  -1,  73;
/M: SY='Y';  M= -28, -40, -22, -20,   6, -34,  72, -25,  18, -19, -12, -17, -35, -12, -10, -22, -24, -28,  -3,  83;
/M: SY='Q';  M=  15, -35,  33,  43, -41, -23, -14, -37,  -4, -34, -27, -10, -23,  43,  16,  10, -15, -31, -39, -27;
/M: SY='L';  M= -26, -28, -44, -35,   0, -44, -26,   9, -36,  65,  33, -42, -42, -29, -33, -36, -22,   1, -30, -12;
/M: SY='G';  M=  -8, -36, -23, -35, -42,  84, -30, -50, -29, -45, -34,  -9, -27, -26, -36,  -8, -27, -43, -33, -37;
/M: SY='V';  M=   2, -27, -41, -35, -13, -39, -39,  35, -33,   3,  33, -35, -35, -32, -34, -24, -12,  61, -42, -19;
/M: SY='R';  M= -26, -41, -21,  -9, -36, -35, -12, -41,  36, -35, -23, -14, -32,   1,  84, -20, -23, -35, -34, -22;
/M: SY='Y';  M=  10, -37, -29, -30,  17, -31,   0, -17, -24, -14, -10, -30, -39, -20, -22, -20, -22, -19,   9,  97;
/M: SY='M';  M=   2, -30, -42, -35,  -9, -38, -29,  45, -32,  27,  62, -34, -34, -27, -32, -28, -17,  21, -34, -15;
/M: SY='T';  M= -11, -23, -18, -22, -29,  19, -28, -21, -18, -25, -21,  -6, -20, -22, -27,   3,  76, -14, -45, -26;
/M: SY='L';  M= -28, -29, -44, -37,  37, -45, -27,   7, -37,  62,  10, -42, -44, -32, -34, -36, -23,  -1, -24,  -5;
/M: SY='T';  M= -13, -21, -12, -19, -28, -24, -22, -20, -15, -25, -20,  33, -20, -19, -23,   4,  77, -13, -49, -26;
/M: SY='H';  M= -61, -87, -47, -41,  34, -64, 207, -74, -44, -49, -34, -26, -65, -29, -36, -49, -63, -83, 205,  17;
/M: SY='N';  M= -14, -26,  -2, -17, -35,   9,  -9, -34, -11, -39, -29,  76, -28, -11, -19,  30,  16, -32, -49, -30;
/M: SY='C';  M= -45, 237,  15, -55, -36, -69, -50, -68,  -7, -54, -51, -43, -88, -62, -58, -44, -41, -53, -70,  66;
/M: SY='H';  M= -16, -29,  35, -10, -34, -16,  58, -36, -13, -36, -27,  53, -27, -10, -18,  32,  11, -33, -53, -20;
/M: SY='N';  M= -20, -25,  -4, -20, -25, -18, -10, -20, -13,   9, -16,  76, -31, -14, -20,  -6,  30, -21, -48, -26;
/M: SY='P';  M=  17, -38, -26, -17, -34, -24, -29,  15,   5, -26, -20, -25,  79, -21, -25,   2, -14, -16, -36, -32;
/M: SY='W';  M= -33, -43, -51, -39,  52, -37, -35, -15, -33,  13, -14, -45, -41, -34, -33, -37, -34, -23, 129,  36;
/M: SY='A';  M=  65, -22, -26, -21, -36,  26, -29, -28, -23, -29, -22, -19, -26, -19, -28,  -1, -13, -15, -34, -32;
/M: SY='D';  M= -22, -36,  74,  41, -42, -27, -15, -39, -11, -37, -35,  -1, -21,  -8, -20, -11,  24, -33, -53, -29;
/M: SY='A';  M=  47, -24, -19, -20, -36,  26, -22, -31, -19, -33, -25,  20, -26, -15, -25,  35,  -8, -21, -38, -30;
/M: SY='W';  M=  63, -23, -28, -20, -29, -10, -30, -26, -22, -28, -22, -21, -26, -18, -26,  17, -11, -15,  67, -23;
/M: SY='T';  M= -15, -28,  28, -15, -25, -26, -23, -17, -20,  12, -15, -11,  27, -19, -26,  23,  46, -16, -43, -24;
/M: SY='D';  M= -15, -33,  30,  25, -29, -28, -21,  12,   9, -19, -18, -12, -26,  21, -16,  19, -11,  21, -42, -24;
/M: SY='D';  M=   0, -30,  37,  10,  13, -29, -26,  12, -21, -15, -16, -15, -28, -20, -27,   8,  12,  27, -39, -18;
/I:         I=-13; MD=-42;
/M: SY='D';  M= -29, -42,  34, -19, -24, -38, -23, -27, -21, -32, -29, -20,  19, -25,   6, -21,  24,  -6, -35,  33; D=-13;
/I:         I=-13; MD=-42;
/M: SY='G';  M= -22, -42, -21,  25, -36,  34,  29, -36, -26,   2, -25, -22, -34, -19, -31,   3, -27, -35, -45, -31; D=-13;
/I:         I=-13; MD=-42;
/M: SY='D';  M= -30, -45,  64, -11, -43,  19,  31, -43, -27, -13, -34,  -9, -36, -24, -33, -23, -28, -42, -58, -31; D=-13;
/I:         I=-13; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='G';  M=  -7, -55, -51, -55,   3,  30, -53, -58, -52, -55, -52, -39, -55, -49, -57,  -2, -42, -53, -53, -43; D=-13;
/I:         I=-13; DM=-42;
/M: SY='R';  M= -42, -54, -29,   5, -34, -48, -28, -43,   5, -13, -34,  13, -48, -23,  23, -36, -36, -44, -43,  14; D=-13;
/I:         I=-13; DM=-42;
/M: SY='P';  M= -16, -35, -24, -18, -29, -24, -25, -21, -22,   7, -18, -21,  78, -20, -30,  30,  13, -23, -38, -30;
/M: SY='Q';  M= -17, -38, -17, -11, -29,   7, -12, -34,  -6, -34, -23,  17,  40,  43,  29,  19, -15, -34, -29,  19;
/M: SY='W';  M= -16, -32,  30, -15, -22, -24, -23,   7,   7,   2, -17,  12, -30, -16, -20,  30, -11,   4,  62, -18;
/M: SY='G';  M= -14, -35, -15, -17, -39,  52,  33, -43,   8, -39, -27,  24, -28,  22,  13,  10, -19, -39, -38, -25;
/M: SY='G';  M= -10, -35, -15,   4, -41,  75, -24, -47, -22, -44, -34,  23, -26, -20, -30,  -8, -24, -42, -36, -36;
/M: SY='L';  M= -26, -29, -41, -33,  -2, -44, -26,   6, -28,  63,  10, -39, -43, -26,   8, -35, -23,  -1, -31, -13;
/M: SY='S';  M=  -6, -23, -17, -19, -27, -17, -22, -22, -18,  -4, -20,  -7, -23, -13, -23,  58,  47, -16, -42, -24;
/M: SY='P';  M=  19, -30, -18,  13, -33,   3, -26,   2, -19, -27, -22, -16,  46, -16, -26,  23,  24, -16, -39, -30;
/M: SY='W';  M= -28, -34,   9, -26,  66, -35, -22, -18, -21, -13, -17, -23, -36, -28,   9, -21,  19, -20,  72,  33;
/M: SY='G';  M=  -9, -36, -19,   3, -42,  80, -28, -49, -25, -44, -34, -10, -26, -22, -33,  -9, -27, -43, -33, -37;
/M: SY='H';  M= -23, -39, -11,  37, -29, -35,  39,   0,  25,  -2, -15, -15, -26,  27,  34, -19, -21, -22, -37, -19;
/M: SY='E';  M=   1, -36,  33,  46, -35, -28, -16,   2,  14, -28, -24,  19, -23,  -4,  18, -15, -17, -22, -41, -28;
/M: SY='C';  M=   0,  64, -39, -32, -15, -38, -34,   5, -25,  25,  -4, -33, -40, -29,   7, -24, -16,  42, -42, -22;
/M: SY='V';  M= -17, -29, -43, -38, -10, -44, -39,  46, -34,  17,  33, -37, -36, -33, -36, -29, -14,  55, -40, -17;
/M: SY='R';  M= -22, -38, -18,  13,  11,   4, -16, -30,  31,  -7, -18, -15, -29,  36,  46, -18, -22, -29, -29, -17;
/M: SY='E';  M= -20, -40,   7,  80, -38, -36, -15,  -3,  -3, -29, -27, -17, -16,   4, -13, -17, -20, -25, -39, -31;
/M: SY='M';  M= -20, -28, -43, -33,  -9, -36, -16,   8, -27,  22, 100, -31, -32, -19, -25, -30, -18,  15, -34, -10;
/M: SY='N';  M=   2, -26,   4, -16, -36,  -9,  -4, -34,  -8, -41, -28,  91, -32, -10, -16,  -3,  -6, -34, -53, -31;
/M: SY='R';  M= -27, -42, -21, -11, -34, -36,  36, -42,  15, -33, -22, -14, -34,   0,  86, -20, -25, -36, -37, -18;
/M: SY='L';  M= -25,  42, -35,   0,  -6, -44, -29,  28, -32,  52,   6, -37, -39, -27, -33, -32, -21,   2, -34, -17;
/M: SY='G';  M=  -8, -34, -23, -33, -40,  80, -30, -46, -28, -42, -33,  -9, -26, -26, -35,  -7,   6, -39, -34, -36;
/M: SY='M';  M= -20, -30, -41, -31, -12, -37, -17,  18, -20,   8,  96, -29, -31, -17,  11, -29, -18,  16, -35, -12;
/M: SY='M';  M= -23, -30, -44, -35,  -6, -40, -22,  30, -31,  41,  81, -35, -35, -24, -30, -33, -20,   4, -32, -11;
/M: SY='V';  M= -16, -30, -43, -39, -11, -46, -45,  54, -36,   5,   2, -37, -36, -36, -38, -28, -13,  59, -41, -19;
/M: SY='D';  M= -27, -40,  94,  10, -47, -23, -12, -45, -14, -44, -43,   6, -26, -13, -23, -15, -16, -42, -63, -30;
/M: SY='L';  M= -23, -29, -44, -37,  -2, -46, -32,  27, -37,  57,  10, -41, -41, -31, -35, -34, -20,  26, -33, -14;
/M: SY='S';  M=  16, -23, -16, -16, -34,  -8, -19, -32, -17, -35, -29,  -5, -23,  -9, -21,  73,   4, -24, -41, -26;
/M: SY='H';  M= -57, -80, -25, -25, -54, -60, 243, -91, -35, -55, -26,  -4, -58, -13, -22, -36, -54, -90,-125,   8;
/M: SY='V';  M=   6, -25, -37, -32, -15, -36, -35,  14, -29,   0,  43, -30, -33, -29, -31, -19,  13,  59, -44, -20;
/M: SY='S';  M=  14, -23, -16, -16, -34,  -8, -19, -32, -17, -36, -29,  -5, -23,  -8, -21,  73,   4, -24, -41, -26;
/M: SY='H';  M=   0, -36,  14,   8, -19, -31,  57, -20,  -9,  -4, -14, -15, -31,  21,  27, -17, -20,   2, -31,  28;
/M: SY='D';  M=   5, -33,  44,  16, -38,  11, -18, -36,  10, -34, -28,  -7, -24, -10,  29,  -9,  25, -28, -43, -28;
/M: SY='T';  M=   7, -22, -23, -24, -21, -29, -30,  -5, -21,   2, -11, -14, -24, -24, -28,  -2,  65,  23, -44, -23;
/M: SY='M';  M= -21, -30, -39, -28,  33, -35, -16,   3, -24,   7,  92, -28, -32,  17, -23, -27, -19,  11, -26,  -4;
/M: SY='W';  M= -25, -40, -22, -12, -19, -31,  51, -34,  29, -29, -20, -14, -29,  26,  34, -17,   6, -34,  84,  22;
/M: SY='D';  M=   2, -38,  80,   7, -46, -22, -13, -41, -11, -39, -34,   1, -26,  39, -17, -12, -17, -37, -51, -28;
/M: SY='A';  M=  49, -22, -28, -23, -26, -19, -32,  -5, -24, -16, -14, -21, -27, -23, -28,  -4,  29,  32, -40, -27;
/M: SY='L';  M= -26, -30, -44, -37,  -1, -46, -30,  31, -37,  62,  12, -42, -42, -31, -35, -36, -22,   5, -31, -13;
/I:         I=-15; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='E';  M= -22, -39,  47,  48, -42, -27, -11, -41,  20, -38, -30,  21, -23,  28,  19, -14, -18, -37, -43, -28;
/M: SY='T';  M=   5, -26, -22,  10, -20,   4, -28,  -6, -22,  16, -10, -19, -27, -21, -27, -10,  42,  20, -40, -24;
/M: SY='S';  M=   9, -22, -16, -17, -31, -14, -22, -27, -17, -31, -25,  -5, -21, -12, -22,  59,  48, -18, -43, -25;
/M: SY='R';  M= -23, -35, -17,  24, -26, -36, -17, -23,  29,  13, -14, -17, -28,  -4,  54, -18,   7, -22, -35, -22;
/M: SY='A';  M=  71, -20, -27, -19, -35,  -8, -29, -24, -22, -26, -20, -22, -26, -18, -26,   0, -11, -11, -35, -31;
/M: SY='P';  M= -26, -51, -26, -14, -45, -27, -29, -33, -22, -43, -30, -32, 108, -26, -35, -23, -18, -38, -38, -43;
/M: SY='V';  M= -14, -29, -41, -34, -14, -42, -43,  36, -33,   0,  -2, -37,  19, -35, -36, -26, -12,  64, -44, -22;
/M: SY='I';  M= -23, -35, -45, -41,  -8, -46, -35,  69, -35,  10,  58, -34, -32, -30, -37, -32, -18,  17, -33, -14;
/M: SY='F';  M=   8, -30, -41, -37,  86, -34, -23, -11, -34,  -4, -11, -33, -41, -39, -32, -25, -24, -14,  -2,  38;
/M: SY='S';  M=  -2, -23, -15, -16, -32, -11, -19, -30, -16, -34, -28,  -4, -22,  -9, -21,  71,  31, -22, -43, -25;
/M: SY='H';  M= -57, -80, -25, -25, -54, -60, 243, -91, -35, -55, -26,  -4, -58, -13, -22, -36, -54, -90,-125,   8;
/M: SY='S';  M=   0, -23, -15, -16, -33,  -8, -18, -33, -16, -37, -30,  -3, -23,  -8, -20,  77,   5, -25, -42, -25;
/M: SY='S';  M=  13, -25, -17, -19, -35,  26, -21, -34, -18, -37, -30,  -6, -24, -11, -23,  66,   0, -26, -39, -27;
/I:         I=-21; MD=-65;
/M: SY='A';  M=  56, -26, -32, -26, -34, -17, -34, -17, -27, -25, -21, -26, -32, -24, -32,  10, -13,  16, -42, -33; D=-21;
/I:         I=-21; MI=-65; MD=-65; IM=-65; DM=-65;
/M: SY='Y';  M= -32, -45, -21,  19,  17, -40,  41, -33,  -9, -26, -21, -24, -37, -12,  40, -26, -29, -33, -16,  57; D=-21;
/I:         I=-21; DM=-65;
/M: SY='A';  M=  35, -28, -18,  20, -38, -20, -27, -32, -19, -33, -28, -17, -25, -15, -26,  27,  30, -22, -44, -33; D=-21;
/I:         I=-21; DM=-65;
/M: SY='V';  M= -18, -27, -43, -37,  -7, -45, -37,  28, -36,  41,   5, -40, -40, -34, -35, -30, -15,  52, -38, -17;
/M: SY='C';  M= -42, 190, -49, -49, -53, -64,  75, -55, -30,  -7, -36,  21, -73, -42,  47, -30,  46, -45, -99, -48;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='D';  M=  21, -32,  34,  15, -40,   6, -17, -35, -13, -36, -28,  17,  22,  25, -19,  21, -12, -30, -42, -30;
/M: SY='H';  M= -23, -35,  -9, -13, -29, -23, 108, -42, -15, -31, -17,  37, -29,  -7, -13,  10, -18, -41, -59,  -3;
/M: SY='P';  M=  14, -37, -15,  26, -34, -27,  39, -29,  -8,  -6, -18, -18,  43,  35,  16, -15, -20, -27, -38, -23;
/M: SY='R';  M= -53, -82, -48, -25, -60, -74, -25, -68,  29, -14, -36, -35, -71,  -2, 173, -43, -49, -61, -69, -41;
/M: SY='N';  M= -22, -26,   6, -16, -36,  -9,  -2, -35,  -7, -43, -29,  95, -32,  -9, -16,  -3,  -6, -38, -55, -31;
/M: SY='V';  M= -14, -27, -43, -37, -10, -44, -42,  30, -35,  22,   2, -38, -39, -35, -36, -28, -12,  65, -43, -19;
/M: SY='P';  M= -21, -39, -21, -12, -38, -29, -22, -30,  -8, -34, -24, -18,  77,  23,  27, -12,  35, -28, -39, -31;
/M: SY='D';  M= -27, -40,  94,  10, -47, -23, -12, -45, -14, -44, -43,   6, -26, -13, -23, -15, -16, -42, -63, -30;
/M: SY='D';  M= -22, -39,  79,  43, -45, -25, -13, -44, -10, -41, -39,   1, -23,  -7, -19,   4, -15, -39, -54, -30;
/M: SY='V';  M= -15, -30, -30, -25, -18, -37, -30,  34, -24,  -4,  -4,  12, -34,  29, -26, -21, -12,  54, -42, -21;
/M: SY='L';  M= -26, -28, -44, -36,   0, -45, -28,   9, -37,  67,  13, -43, -43, -30, -34, -37, -22,   1, -30, -12;
/M: SY='Q';  M=  -3, -39, -12,  30, -35, -30,  36, -32,   0,  -8, -17, -14, -27,  60,  38, -14, -21, -30, -36, -19;
/M: SY='R';  M=  12, -31, -30, -22, -18,   8, -22, -13,   9,  33,  -6, -23, -34, -15,  40, -20, -21, -14, -33, -21;
/M: SY='L';  M= -21, -29, -44, -37,  -4, -45, -34,  33, -36,  50,   8, -40, -40, -32, -36, -33, -18,  38, -35, -15;
/M: SY='K';  M= -19, -35, -17,  -7, -33, -28,  33, -25,  62, -30, -21, -10,  15,  -5,   6,   6, -14,   1, -37, -21;
/M: SY='E';  M=   2, -35,  -7,  45, -39, -29, -15, -36,  41, -33, -25, -12, -21,  28,  23, -11,   9, -29, -36, -27;
/M: SY='N';  M= -21, -27,   2, -16, -35, -13,  -5, -34,  -5, -39, -27,  86, -31,  -9,  14,  -4,  17, -34, -52, -29;
/M: SY='N';  M= -16, -33,  22, -18, -40,  53, -14, -43, -12, -43, -32,  58, -30, -15,  11,  -8, -17, -40, -43, -32;
/M: SY='G';  M=  -6, -33, -22, -31, -40,  76, -27, -46, -26, -43, -33,  -8, -26, -22, -33,  26, -19, -39, -34, -34;
/M: SY='V';  M= -17, -29, -43, -38, -10, -44, -39,  45, -35,  18,  32, -37, -36, -33, -36, -29, -14,  55, -40, -17;
/M: SY='V';  M=   6, -25, -41, -35, -14, -39, -43,  28, -33,   0,  -2, -36, -36, -35, -35, -23, -10,  68, -45, -21;
/M: SY='M';  M= -18,  36, -36, -28, -18,  18, -16,  -5, -23,   2,  92, -23, -30,  17, -23, -23, -20, -10, -35, -15;
/M: SY='V';  M= -14, -28, -43, -38, -12, -45, -45,  45, -35,   3,   0, -37, -37, -36, -37, -27, -12,  65, -43, -19;
/I:         I=-15; MD=-47;
/M: SY='N';  M= -21, -29, -10, -24, -33, -23, -18, -18, -18, -30, -24,  66, -33, -21, -26,  -8,  36,  11, -56, -32; D=-15;
/I:         I=-15; MD=-47;
/M: SY='F';  M= -44, -40, -57, -52,  82, -53, -37, -16, -48,   6, -17, -47, -55, -56, -45, -44, -36, -21, -13,   9; D=-15;
/I:         I=-15; MI=-47; MD=-47; IM=-47; DM=-47;
/M: SY='Y';  M=  -3, -42, -41, -40,  20, -40, -22, -16, -36, -21, -21, -37, -47, -33, -36,  -1, -26,  12, -15,  63; D=-15;
/I:         I=-15; DM=-47;
/M: SY='P';  M= -34, -53, -30, -23, -49, -35, -30, -37, -27, -41,  18,  11,  79,  12, -35, -29, -27, -42, -49, -43; D=-15;
/I:         I=-15; DM=-47;
/M: SY='G';  M= -27, -43,  11,   5, -40,  17, -30, -25,   1, -31,  15,  15, -38, -24, -28, -25, -26,   7, -52, -37; D=-15;
/I:         I=-15; DM=-47;
/M: SY='F';  M= -36, -35, -49, -45,  84, -46, -28,  -9, -40,  -5, -13, -40, -49, -47, -38, -36, -29,   4,  -5,  38; D=-15;
/I:         I=-15; DM=-47;
/M: SY='L';  M= -27, -35, -46, -41,  -4, -49, -32,  32, -39,  39,   2, -43, -44, -35, -39, -36, -23,  26, -29,  26; D=-15;
/I:         I=-15; DM=-47;
/M: SY='S';  M= -14, -35, -25, -19, -33, -24, -24, -24, -17,  -8, -23, -18,  25,  18,   9,  45, -10,  -4, -43, -29; D=-15;
/I:         I=-15; DM=-47;
/M: SY='C';  M= -41, 191, -33,  65, -62, -68, -44, -59,  17,  -3, -39, -40, -64,  70, -32, -38, -40, -51, -85, -59;
/I:         I=-5; MD=-17;
/M: SY='P';  M= -12, -54, -47, -37,  33, -48, -44, -42,  13, -40, -39, -42,  35, -40, -32, -39, -38, -43, -39, -25; D=-5;
/I:         I=-5; MI=0; MD=-17; IM=0; DM=-17;
/M: SY='P';  M= -46, -65, -48,  -4, -55,  -8, -55, -40, -49, -21, -43, -54,  34, -47, -57, -48, -46, -13, -65, -57; D=-5;
/I:         I=-5; DM=-17;
/M: SY='N';  M=   6, -27, -19, -20, -26, -22, -22, -11, -15,  -6, -16,  29,  21, -17,   9,  23,  16,  19, -43, -26;
/M: SY='D';  M= -22, -36,  47,  14, -36,  12, -14, -32, -15, -11, -27,  47,  39, -14, -23, -13, -15, -34, -46, -31;
/M: SY='Q';  M= -18, -36, -14,  12, -33,   9, -14, -22,  16,  -5, -16,  17, -28,  57,  17, -13, -19,  -3, -35, -23;
/M: SY='A';  M=  60, -22, -22, -20, -33, -10, -25, -19, -20, -25, -20,  19, -27, -17, -25,  12,  -9,   4, -38, -29;
/M: SY='T';  M= -12, -22, -11, -19, -29, -22, -20, -22, -14, -27, -21,  39, -21, -17, -23,  16,  72, -15, -48, -26;
/M: SY='I';  M= -22, -32, -44, -40,  -6, -47, -39,  59, -37,  35,   7, -38, -37, -34, -38, -32, -17,  34, -34, -16;
/M: SY='S';  M=   7, -29,  39,  13, -38, -15, -14, -36,  11, -38, -31,  34, -24,  -7, -14,  42,  -5, -30, -45, -28;
/M: SY='D';  M= -22, -36,  69,   3, -41, -25,  36, -37, -11, -35, -28,   0, -25,  40, -16,  -9,  25, -33, -52, -22;
/M: SY='V';  M=  18, -26, -37, -32, -16, -34, -40,  33, -31,  -2,  -4, -31, -33, -31, -34, -18,   8,  57, -42, -22;
/M: SY='V';  M=  44, -24, -35, -28, -21, -24, -37,  21, -28,  -8,  -8, -29, -32, -27, -32, -13, -11,  47, -40, -24;
/M: SY='D';  M= -26, -39,  85,   8, -45, -25, -13, -44,  28, -42, -38,   3, -25, -10, -11, -15, -16, -40, -54, -29;
/M: SY='H';  M= -29, -40, -12, -13, -27, -30, 121, -45, -17, -28, -13,  -2, -29,  -6, -11, -18, -27, -45, -63,   4;
/M: SY='I';  M= -25, -33, -45, -41,  42, -47, -37,  57, -38,  27,   4, -37, -38, -36, -38, -33, -20,  22, -24,  -5;
/M: SY='D';  M= -25, -35,  68,  -5, -27, -27, -15,   6, -19,   1,  42,  25, -29, -16, -24, -19, -16, -17, -48, -22;
/M: SY='H';  M= -29, -40, -16, -17,  -8, -32, 110, -36, -19, -23, -12,  -8, -32,  -9, -14, -20, -26, -37, -27,  57;
/M: SY='I';  M=   3, -32, -42, -38, -11, -41, -39,  61, -34,   5,  31, -34, -33, -31, -37, -26, -15,  38, -36, -17;
/M: SY='R';  M= -17, -35, -26, -19, -27,  22, -25,   9,  30, -19, -16, -18, -31, -13,  42, -19, -19,  25, -36, -24;
/M: SY='E';  M= -16, -32,  34,  42, -38, -24, -14, -35,  13, -34, -28,  18, -21,  19, -11,  15,  28, -29, -44, -28;
/M: SY='V';  M= -17, -28, -40, -33, -10, -43, -34,  14, -26,  35,   2, -37, -40, -29,   7, -28, -15,  54, -40, -18;
/M: SY='I';  M=  35, -28, -34, -30, -18, -28, -36,  55, -29,  -4,  -5, -26, -28, -27, -34, -13,  15,  10, -35, -22;
/M: SY='G';  M=  -8, -36, -23, -35, -42,  84, -30, -50, -29, -45, -34,  -9, -27, -26, -36,  -8, -27, -43, -33, -37;
/M: SY='W';  M=   3, -37, -36, -30,  -5, -31, -27,  29, -28, -12, -12, -31,  25, -25, -31,   2, -18,   9,  88,  44;
/M: SY='D';  M= -25, -40,  76,  45, -45, -28, -12, -45,  -6, -40, -37,  -1, -23,  -5,  15, -16, -18, -40, -51, -30;
/M: SY='H';  M=  13, -35, -17, -16,  13, -26, 108, -36, -20, -24, -14,  -7, -30, -11, -15, -15, -24, -33, -46,   2;
/M: SY='V';  M= -16, -29, -43, -38, -10, -45, -43,  46, -35,  15,   2, -37, -37, -35, -37, -28, -13,  60, -41, -19;
/M: SY='G';  M=  18, -33, -24, -32, -41,  78, -30, -45, -28, -42, -32, -11, -27, -25, -35,  -7, -24, -36, -33, -36;
/M: SY='I';  M= -26, -35, -46, -43,  39, -48, -39,  67, -38,  18,   4, -36, -36, -37, -40, -33, -20,  16, -24,  -5;
/M: SY='G';  M=  -8, -36, -23, -35, -42,  84, -30, -50, -29, -45, -34,  -9, -27, -26, -36,  -8, -27, -43, -33, -37;
/M: SY='G';  M=  -5, -28, -19, -24, -37,  57, -24, -38, -22, -39, -31,  -6, -24, -17, -28,  48,  14, -31, -38, -30;
/M: SY='D';  M= -47, -77, 180,  16, -92, -44, -26, -88, -28, -86, -83,  10, -52, -26, -45,  15, -28, -81,-120, -58;
/M: SY='Y';  M= -33, -35, -38, -38,  76, -40, -10, -11, -31,  -5,  -9, -34, -44, -33, -28, -29, -26, -17,   7,  78;
/M: SY='D';  M= -27, -40,  94,  10, -47, -23, -12, -45, -14, -44, -43,   6, -26, -13, -23, -15, -16, -42, -63, -30;
/M: SY='G';  M=  -8, -36, -23, -35, -42,  84, -30, -50, -29, -45, -34,  -9, -27, -26, -36,  -8, -27, -43, -33, -37;
/M: SY='I';  M=  15, -28, -34, -31, -16, -31, -33,  44, -28,  -2,  30, -26, -30, -26, -32,   6,  12,  32, -38, -20;
/M: SY='P';  M= -22, -42,  42, -11, -38,  27, -24, -32, -22, -10, -27, -15,  75, -23, -32, -18, -20, -34, -41, -34;
/I:         I=-24; MD=-77;
/M: SY='R';  M= -32,  33, -32, -18,  26, -41, -23, -38,  13, -31, -27, -24, -41,  39,  45, -26, -30, -37, -33, -17; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='T';  M=   2, -27, -28, -29,  15,  35, -30, -11, -27,  11, -12, -17, -29, -27, -31,  -9,  39,   8, -33, -18;
/M: SY='P';  M= -26, -51, -26, -14, -45, -27, -29, -33, -22, -43, -30, -32, 108, -26, -35, -23, -18, -38, -38, -43;
/M: SY='Q';  M= -15, -36,  37,  36, -42, -22, -14, -38,  13, -37, -29,  -7,  16,  39, -10,  31, -11, -34, -41, -28;
/M: SY='G';  M= -11, -37,  28, -24, -43,  77, -27, -49, -26, -45, -36,  -6, -27, -24, -34,  -9, -25, -43, -36, -36;
/M: SY='L';  M= -25, -28, -44, -35,  -1, -43, -25,   8, -35,  62,  49, -40, -41, -27, -32, -35, -22,   1, -31, -12;
/M: SY='E';  M= -19, -39,   3,  68, -40,   2,  35, -44,  25, -36, -29, -12, -18,   3,  -6, -15, -20, -37, -39, -26;
/M: SY='D';  M= -27, -40,  94,  10, -47, -23, -12, -45, -14, -44, -43,   6, -26, -13, -23, -15, -16, -42, -63, -30;
/M: SY='V';  M=  -9, -25, -36, -32, -16, -35, -39,  17, -30,  -3,  -5, -30, -35, -30, -33,  15,  -7,  67, -47, -22;
/M: SY='S';  M=  -2, -23, -15, -16, -32, -11, -19, -30, -16, -34, -28,  -4, -22,  -9, -21,  71,  31, -22, -43, -25;
/M: SY='K';  M= -20,  42,  41,  -4, -38,   5, -20, -38,  53, -37, -29,  -5, -25,  -9,   0, -13,   9, -32, -41, -28;
/M: SY='Y';  M= -30, -38, -33, -34,  36, -39,  -2, -10, -28,  15,  -5, -33, -43, -23, -25, -28, -24, -16,   8,  93;
/M: SY='P';  M= -26, -51, -26, -14, -45, -27, -29, -33, -22, -43, -30, -32, 108, -26, -35, -23, -18, -38, -38, -43;
/M: SY='D';  M=  13, -31,  66,  -5, -29, -23, -18, -18, -19,   6, -19,  19, -30, -18, -25, -14, -15,   1, -48, -26;
/M: SY='L';  M= -26, -28, -44, -36,   0, -45, -28,   9, -37,  67,  13, -43, -43, -30, -34, -37, -22,   1, -30, -12;
/M: SY='I';  M= -21, -30, -39, -37,  38, -43, -36,  48, -33,  14,  -1, -30, -34, -34, -36, -23,  22,  30, -28,  -7;
/M: SY='C';  M=  38,  41,  19,  12, -27, -20, -20, -30,  19, -29, -24, -14, -26, -13, -15,  -8,   6, -21, -32,  14;
/M: SY='E';  M= -18, -38,   0,  66, -37,   4, -15, -34,  26, -28,  26, -15, -18,   2,  -7, -16, -20, -31, -37, -28;
/M: SY='L';  M= -26, -29, -44, -36,   0, -46, -29,  23, -37,  64,  12, -42, -42, -30, -35, -36, -22,   4, -30, -13;
/M: SY='L';  M=  16, -29, -27,  18, -11, -34, -25,  15, -25,  43,  29, -31, -32, -19, -28, -23, -19,  -3, -33, -18;
/M: SY='R';  M= -20, -36,  21,  39, -38, -26, -11, -41,   4, -37, -29,  32, -26,  -1,  53,  11, -15, -35, -42, -27;
/M: SY='R';  M= -23, -42, -22, -11, -37,   7, -13, -42,  13, -35, -24, -14, -33,  25,  81, -17, -25, -36, -34, -23;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='G';  M= -11, -32, -12, -27, -39,  66, -18, -43, -20, -44, -32,  52, -28, -19, -27,  10, -16, -40, -39, -34;
/I:         I=-14; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='W';  M=  13, -39, -42, -33,   1, -30, -29, -11, -28, -17, -17, -39, -37, -27, -30, -25, -26,  17, 122,  53;
/M: SY='S';  M=  -5, -23, -16, -19, -31,  11, -22, -27, -17, -31, -26,  -5, -21, -14, -23,  55,  52, -20, -43, -26;
/M: SY='D';  M= -22, -40,  56,  45, -43, -27, -10, -42,  -2, -38, -31,  21, -24,  38,  20, -13, -18, -38, -45, -28;
/M: SY='E';  M=   5, -36,  40,  56, -43, -25, -13, -39,  -6, -35, -29,  -9, -20,  39, -13,   9, -15, -33, -41, -29;
/M: SY='D';  M= -24, -41,  75,  48, -46, -27, -12, -44,  -8, -40, -36,  -1, -22,  23, -16, -14, -18, -40, -51, -30;
/M: SY='I';  M=   2, -30, -42, -36,  -7, -41, -36,  46, -35,  38,   5, -37, -37, -31, -36, -28, -17,  33, -34, -17;
/M: SY='R';  M=  26, -34, -14,  26, -38, -25, -16, -35,  32, -32, -23, -15, -25,  25,  46, -11, -18, -27, -34, -26;
/M: SY='K';  M= -18, -37, -17,  -9, -39,  37, -20, -42,  62, -39, -27,  -8, -25,  -5,  26, -14, -20, -37, -32, -27;
/M: SY='V';  M=   5, -28, -41, -35,  -9, -40, -37,  39, -34,  33,   3, -37, -37, -32, -35, -26, -15,  44, -37, -18;
/M: SY='M';  M=  20, -25, -34, -28, -12, -28, -22,  -2, -27,  35,  60, -26, -31, -21, -27,   1,  10,  -4, -34, -16;
/M: SY='G';  M=   8, -36, -28, -31,   5,  67, -30, -40, -22, -35, -29, -15, -30, -24,   6, -12, -26, -35,  62, -20;
/M: SY='R';  M= -21, -36,  17,  22, -24,  20, -20, -21,  11,  23, -13, -17, -30, -11,  27, -20, -22, -22, -36, -23;
/M: SY='N';  M= -22, -26,   6, -16, -36,  -9,  -2, -35,  -7, -43, -29,  95, -32,  -9, -16,  -3,  -6, -38, -55, -31;
/M: SY='V';  M=   6, -25, -33, -29, -13, -31, -31,   7, -29,  30,  -2, -27, -34, -26, -31,  16,   9,  40, -39, -20;
/M: SY='L';  M= -23, -29, -44, -36,  -3, -44, -28,  24, -35,  55,  47, -39, -39, -28, -33, -34, -20,  17, -32, -13;
/M: SY='R';  M= -26, -43, -23, -10, -35, -36, -11, -42,  17, -34, -23, -16, -35,   1,  90, -20, -25, -35, -35, -22;
/M: SY='V';  M= -11, -25, -42, -36, -13, -43, -45,  22, -34,   1,  -2, -38, -38, -37, -35, -25, -10,  74, -47, -21;
/M: SY='W';  M= -30, -36, -49, -38,  55, -39, -31,  -5, -34,  28,  43, -41, -40, -33, -33, -36, -29, -13, 106,   8;
/M: SY='K';  M=   1, -37,  18,  33, -39, -29, -15, -39,  48, -36, -27, -10, -24,   0,  45, -15, -18, -33, -36, -26;
/M: SY='E';  M=  27, -34,  -4,  54, -41, -24, -15, -35,  14, -32, -25, -15, -20,  45,  -8,  -9, -17, -28, -36, -28;
/M: SY='A';  M=  48, -22, -31, -25, -24, -21, -34,   1, -26, -13, -11, -25, -29, -25, -30,  -8,  13,  43, -41, -26;
/M: SY='E';  M= -20, -40,  29,  80, -43, -34, -12, -44,  -1, -36, -33, -13, -15,   6, -11, -16, -19, -36, -41, -32;
/M: SY='R';  M=  -3, -38,  16,  27, -35, -30, -13, -32,  19,  -7, -19, -13, -27,  43,  47, -15, -20, -29, -36, -23;
/M: SY='V';  M=   8, -26, -38, -34, -15, -38, -41,  34, -32,  -1,  -3, -32, -34, -33, -34, -20,   9,  61, -43, -21;
/M: SY='S';  M=  32, -26, -20, -16, -34, -13, -19, -32,  -8, -33, -25, -10, -26,  -8,  33,  53,  -4, -22, -38, -26;
/M: SY='E';  M=  14, -34,  25,  47, -35, -25, -14, -31,  -6,  -7, -22,  19, -24,  21,  13, -12, -17, -27, -40, -27;
/I:         I=-22; MD=-71;
/M: SY='Q';  M= -21, -38, -14,  27, -39,   2, -22, -24,   9, -31, -25,  19, -30,  36, -16, -16,   3,   9, -44, -31; D=-22;
/I:         I=-22; MI=-71; MD=-71; IM=-71; DM=-71;
/M: SY='M';  M= -22, -34, -27,  17, -18, -37, -24,  -9, -26,  34,  47, -29, -35, -19, -29,  14, -19, -13, -39, -22; D=-22;
/I:         I=-22; DM=-71;
/M: SY='Q';  M=  -1, -31, -18, -13, -22, -25, -15, -16,   9,  25,  -9,  29, -32,  39,  14,   7, -15, -18, -36, -21;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='T';  M=  22, -27,  28, -13, -36,  27, -23, -32,   7, -34, -27,  -7, -24, -15, -20,  23,  29, -24, -41, -29;
/M: SY='Q';  M=   5, -31, -25, -16, -24, -26, -20,  18, -13,   3,  27, -17, -28,  39,  11,  19,  15,  -8, -35, -20;
/M: SY='P';  M=  20, -32, -17,   9, -39,  27, -23, -35,   7, -37, -28, -14,  44, -13, -19,  32, -11, -29, -37, -32;
/M: SY='P';  M= -20, -44, -19,  12, -43, -24, -25, -34, -18, -42, -30, -25,  96, -18, -29,  16, -14, -36, -39, -38;
/M: SY='Y';  M= -17, -30, -19,  25,  14, -34, -22,  13, -20,   5, -10, -22, -28, -17, -25,   5,  23,  20, -26,  27;
/M: SY='E';  M=  14,  42,   2,  67, -39, -27, -16, -39,  -6, -34, -29,  15, -20,  -1, -16, -12, -17, -30, -42, -33;
/M: SY='D';  M=   3, -31,  37,  16, -23, -26, -18, -19,  20,  -3, -18, -11, -26, -12, -14,   7,   9,   2, -34,  13;
/I:         I=-10; MD=-33;
/M: SY='P';  M= -23, -38,  11, -25, -29, -34, -32,  32, -28, -18, -17,   9,  40, -28, -35,   3,   9,   9, -46, -30; D=-10;
/I:         I=-10; MD=-33;
/M: SY='W';  M=  -8, -41, -53, -46,  16, -48, -51,  40, -43,  -9, -12, -45, -44, -43, -45, -36, -26,  32,  61, -16; D=-10;
/I:         I=-10; MD=-33;
/M: SY='P';  M= -35, -61, -31,   5, -59,  -7, -37, -50, -29, -54, -42, -37,  77,  12, -39, -32, -33, -52, -51, -51; D=-10;
/I:         I=-10; MD=-33;
/M: SY='E';  M= -43, -55, -28,  38,  14, -59, -40,  -3, -34,  -6, -31, -45, -45, -29, -41, -43, -40, -31, -46, -31; D=-10;
/I:         I=-10; MD=-33;
/M: SY='Y';  M=   6, -59,   6, -40, -37, -49, -37, -54, -38, -52, -47, -42, -58, -40,   0, -39, -44, -49, -43,  30; D=-10;
/I:         I=-10; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='Q';  M=  -3, -58, -36, -18, -64, -43, -30, -53, -19, -49, -38, -31, -46,  65,   5, -27, -39, -50, -52, -41; D=-10;
/I:         I=-10; DM=-33;
/M: SY='M';  M=  -4, -48, -46, -40, -36, -46, -36, -25, -40,  11,  38,  -2, -52,  10, -41, -37, -37, -29, -54, -37; D=-10;
/I:         I=-10; DM=-33;
/M: SY='G';  M= -29, -51,  32, -30, -59,  33, -39, -62, -39, -61, -54, -21, -44, -35, -45,  16, -31, -56, -61, -50; D=-10;
/I:         I=-10; DM=-33;
/M: SY='G';  M= -31, -54,  24, -28, -61,  35, -37, -62, -35, -59, -50, -23, -44,  16, -40,   0, -36, -57, -58, -49; D=-10;
/I:         I=-10; DM=-33;
/M: SY='H';  M= -35, -51, -36, -33, -50, -44,  47, -50, -29, -49, -40, -28,  23, -30,   3,   2,  20, -46, -64, -36; D=-10;
/I:         I=-10; DM=-33;
/M: SY='C';  M=  -3, 212, -82, -71, -53, -73, -83,  25,  -3, -46, -46, -60, -87, -70, -65, -51, -47, -32, 111, -58;
/M: SY='W';  M=  -3, -39,  13,   8, -26, -33,  31, -27,  20,  -3,  28, -19, -32, -13,  17, -23, -25, -27,  61, -17;
/M: SY='E';  M= -15, -33, -10,  38, -38, -27, -21, -36,  10, -36, -30, -12, -23,  -7,  14,  31,  31, -29, -44, -30;
/M: SY='H';  M= -22, -36, -20, -20,  11,   5,  57, -31, -17,  -5, -19,  21, -34,  17,   8,  17, -19, -31, -39, -13;
/M: SY='Y';  M= -26, -36,  12,   4, -10, -37, -18, -15, -24,  14,  31, -24,  18, -21, -28, -22,  19, -18, -25,  42;
/M: SY='W';  M= -26, -45, -20,  23, -36,   6, -29, -37, -24, -13, -31,  16,  36, -21, -32,   1, -25, -39,  56, -32;
/M: SY='Y';  M= -27, -42, -35, -33, -17,  -2, -28,   8,  -3, -23, -21, -29,  18, -30, -30, -23,  18,   3, -27,  40;
/M: SY='W';  M=  -7, -47, -42, -34,  41, -39,  35, -37, -35, -30, -30, -33, -46,  11, -35,   0, -33, -38,  64,  -8;
/M: SY='K';  M= -29, -43, -26, -22,   2, -34, -29, -45,  41, -45, -38,  14, -38, -19, -11,  19, -22, -42, -44, -30;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	35 in 35 different sequences
Number of true positive hits	35 in 35 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

35 sequences

ALCJ_ASPOR  (Q2UPB0), ATAJ_ASPTN  (Q0CS61), DPEH1_SCHPO (O14124),

DPEH2_SCHPO (O59832), DPEP1_ARTBC (D4B2N2), DPEP1_ARTGP (E5R2Q7), 
DPEP1_ARTOC (C5FK77), DPEP1_BOVIN (Q3SZM7), DPEP1_COCP7 (C5PCZ0), 
DPEP1_COCPS (E9D269), DPEP1_HUMAN (P16444), DPEP1_MOUSE (P31428), 
DPEP1_PIG   (P22412), DPEP1_RABIT (P31429), DPEP1_RAT   (P31430), 
DPEP1_SHEEP (P43477), DPEP1_TRIVH (D4DEJ7), DPEP2_COCP7 (C5PCN6), 
DPEP2_COCPS (E9CV02), DPEP2_FUSV7 (C7ZIE1), DPEP2_HUMAN (Q9H4A9), 
DPEP2_MOUSE (Q8C255), DPEP2_RAT   (Q5M872), DPEP2_TALSN (B8LWT1), 
DPEP2_UNCRE (C4JQN7), DPEP3_HUMAN (Q9H4B8), DPEP3_MACFA (Q4R7M2), 
DPEP3_MOUSE (Q9DA79), DPEP3_RAT   (Q5U2X4), GLIJ_ASPFU  (Q4WMJ8), 
SIRJ_LEPMC  (Q6Q886), TCPJ_CLAP2  (M1VV65), VERJ_CLORO  (A0A1U9YI27), 
YPQQ_KLEPN  (P27509), YPQR_ACICA  (P07783)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

17 PDB

1ITQ; 1ITU; 5LWZ; 5LX0; 5LX1; 5LX4; 5LX7; 5NRT; 5NRU; 5NRX; 5NRY; 5NRZ;
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