PROSITE entry PS51363

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51363
Entry name [info]	W2
Accession [info]	PS51363
Entry type [info]	MATRIX
Date [info]	01-MAR-2008 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51363
Associated ProRule [info]	PRU00695

Name and characterization of the entry

Description [info]

W2 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=169;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=164;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3370986; R2=0.0054517; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=25306.2324219; R2=9.3313131; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1131; H_SCORE=35860; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=764; H_SCORE=32435; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-27; D=-100; I=-100; B1=-1000; E1=-1000; MI=-130; MD=-130; IM=-130; DM=-130;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-130; BD=-130;
/M: SY='D';  M= -15, -22,  56,  45, -85,  13, -67, -41,  22, -20, -74,  20,  -8,  -8, -30,  -8, -65, -20, -91, -78;
/M: SY='E';  M= -29, -83,  27,  55, -43,  -8, -65, -33,   9, -31, -19,  35, -14,   1,  -2,  27,  -4, -76, -89, -76;
/M: SY='D';  M=  -4, -13,  50,  46, -18, -31,   3, -81,   3, -48, -76,  -8,  28, -13, -21,  29, -17, -34, -90, -74;
/M: SY='D';  M= -28, -85,  49,  43, -20, -33, -65, -34,   8,   0, -69,   1,  15,  44, -64, -28,  11, -74, -85,  -1;
/M: SY='E';  M= -24, -82,   0,  52, -42, -12,  11, -24,  16, -22, -71,  21,  -6,  12, -29,  32,   1, -34, -88, -74;
/M: SY='D';  M=   5, -82,  45,  31,  15, -25,   2,  -3,   3, -28, -22, -61, -36,  37, -66,  19, -19, -14, -85, -68;
/M: SY='F';  M=   1,  11,  20,  18,  63, -46,  33, -29,  -8, -69, -22, -18,  -3, -66,  23,  -2, -14, -34,   5, -56;
/M: SY='S';  M= -33, -81, -12,  22,   6, -78,   3, -39, -18,  31, -23,   0,  -2, -15,   4,  34, -64,   5, -79,  24;
/M: SY='K';  M= -44, -84,  41,  31, -16, -37,   4, -44,  42, -14, -71,  -6,  19,   7, -20,  26, -64, -21, -13, -71;
/M: SY='E';  M=  -9, -84, -24,  71,  -2, -79, -68,   1, -27, -21,  16,  16,  28,   8, -39, -16, -35,  -7, -85, -72;
/M: SY='F';  M=  14, -78, -86, -50,  57, -85, -78,  20, -79,  35,   7, -82,  -4, -23, -51, -73, -11,  33, -73,  -7;
/M: SY='Q';  M=   3, -84, -26,   8,  -4,  17,  14,  15,   8, -37, -20,   4, -78,  49,  -2, -16, -39, -44, -75,  44;
/M: SY='E';  M=  13, -83,  23,  59, -85, -48, -12, -81,  27, -37,   4,   1, -22,  28,   8,  -2,  -2, -77, -88, -75;
/M: SY='W';  M= -34, -82, -30,  38,  -5, -48,  20, -22, -13,   2,   9, -68, -25, -62,  11,  32,  16,   2,  66, -33;
/M: SY='L';  M= -70,  -8, -88, -25,  23, -92, -80,  25, -44,  54,  17, -85, -88, -79, -81, -48, -67,  53, -79, -13;
/I:         I=-17; MD=-22;
/M: SY='E';  M=   6, -84,  14,  37, -79, -49, -71, -24,  28,  13, -67, -22, -13,  20, -34, -26,  31, -52, -88, -36; D=-17;
/I:         I=-17; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='R';  M= -38, -92,  22,  49, -93, -41, -10, -93,  33, -89, -79,  -3, -16,  39,  55, -45, -40, -88, -91, -79; D=-17;
/I:         I=-17; DM=-22;
/M: SY='L';  M=  29, -78, -79, -32,  -1, -22, -22,   2, -10,  45, -10, -36, -82, -35, -46,   1,  18, -28, -82, -25; D=-17;
/I:         I=-17; DM=-22;
/M: SY='F';  M=  12, -18, -44, -42,  33, -62, -25,  29,   7,  30,  32, -36, -84, -40,  17, -53, -34, -10, -78, -19; D=-17;
/I:         I=-17; DM=-22;
/M: SY='E';  M=  10, -11, -14,  54, -84,  -5, -67, -29,  26, -35, -72,  26, -74,  27,   4,   9, -32, -25, -88, -77; D=-17;
/I:         I=-17; DM=-22;
/M: SY='E';  M= -20, -30,  25,  66, -80, -57, -63, -43,   2, -31, -73,  26, -73,  24,  18,  10, -65, -29,  15,  -6;
/I:         I=-13; MD=-17;
/M: SY='D';  M= -40,  17,  40,  -4, -36,  12, -18,  -4,   1,  -6, -76,   6, -88,  -9, -40, -32, -76, -25,  10,  -9; D=-13;
/I:         I=-13; MD=-17;
/M: SY='K';  M= -21, -96, -51,  23, -42, -25, -84, -13,  48, -45, -19,  -6,  -8, -36, -70, -30, -25, -14, -98, -87; D=-13;
/I:         I=-13; MD=-17;
/M: SY='K';  M= -33,-102, -84,  13, -52, -35, -88,  -5,  29, -19, -25,   2, -96, -28,  -6, -58, -27, -26,-102, -41; D=-13;
/I:         I=-13; MD=-17;
/M: SY='D';  M= -90,-107,  41,  -9,-112, -25, -19,-107, -83,-109,-101,  35,  -7,  18, -48,   5, -84, -48,-119,-100; D=-13;
/I:         I=-13; MI=0; MD=-17; IM=0; DM=-17;
/M: SY='D';  M= -11, -96,  48, -20, -97,  30, -85, -89, -33, -32, -87, -72,  14,  -8, -86, -17, -10, -18,-104, -92; D=-13;
/I:         I=-13; DM=-17;
/M: SY='H';  M=  -4, -83,  -5,  14, -30, -16,  61, -18,  -6, -29,  13, -37,  23,  31, -32,  13, -65,  24, -86,  -8;
/M: SY='S';  M=  10, -17,  20,   1, -32, -18,  14, -12, -13, -17, -70,  24,  15,   2, -20,  37,  19, -53,  -1, -72;
/M: SY='P';  M=   8,  31,  30, -68, -38,  -6,   1,   4, -15, -10,  32, -12,  38,  -4, -45, -46, -18,  29, -90, -72;
/M: SY='D';  M=  15, -81,  51,  30, -83, -41, -15, -29,  -1, -39,  -8,  13, -39,   8,  18,  15,   1, -16, -91, -75;
/M: SY='N';  M=  -6, -11,  27,  36, -22, -31,  23, -10, -23, -75,  11,  57, -76,  39, -11, -34,   2, -51, -87,  -1;
/M: SY='I';  M=  21, -78, -84, -50,  -7, -84, -79,  50,  -8,  40,  17, -47, -83, -75, -77, -37, -17,  25, -80,  -2;
/M: SY='I';  M=   1, -80, -43, -35,  24, -60, -72,  43,   5,  13,  -7, -14, -82, -26, -10, -37,  13,   9, -73,  40;
/M: SY='L';  M=  -8, -81,   7,  20, -70, -52,  19, -26,  22,  44, -57,  -4, -11,  -6, -16, -46,  21, -20, -87, -70;
/M: SY='E';  M=   0, -87,  -6,  85, -78, -81, -26, -34,  15, -14, -26, -29, -71,  -7, -18, -67, -69, -60,  69, -22;
/M: SY='I';  M=  20, -15, -89, -83,  12, -85, -80,  58, -82,  46,  47, -82, -85, -78, -83, -17, -66,   4, -80, -62;
/M: SY='N';  M= -21, -81,   6,  22, -82,  -1, -10, -78,  45, -16,   1,  57, -75, -10,  11,   3,  -3, -41, -89, -75;
/M: SY='S';  M=   6, -16, -17,  25, -81,  22, -70, -77,   3, -27,   9, -29, -32, -20,   8,  48,  30, -43, -88, -76;
/M: SY='L';  M= -53, -78, -77, -49,  27, -81, -25, -30, -31,  60,  39,  35, -86, -71, -42,  20, -65, -36, -75,  18;
/M: SY='R';  M= -34, -84,   7, -27, -21, -23, -66, -11,  39, -33, -30,  24, -19,  13,  60,   0, -15,  -4, -86, -71;
/M: SY='M';  M= -23, -33, -43, -43, -26, -51,  11,  14, -35,  39,  70, -76,  -6, -11, -75, -25,  -1,  20, -79,  24;
/M: SY='A';  M=  39,  -9,   9,  25, -84, -28, -25, -38,  11, -57, -73,   0,  27, -30,   7,  32,  -5, -28, -89, -77;
/I:         I=-16; MD=-21;
/M: SY='Y';  M=  -8, -22,  11,  11, -12, -33,  31, -47, -14, -48,   0,   9, -11,  24, -28,  26,   5, -75, -75,  58; D=-16;
/I:         I=-16; MD=-21;
/M: SY='N';  M= -36, -15,  -4, -44, -95,   0,  28, -52,   4, -43, -84,  80, -90,  14, -74, -69, -32, -92,-107, -86; D=-16;
/I:         I=-16; MD=-21;
/M: SY='Y';  M=  15,-100,-106,-100,   2,-102,   5,  10, -53,  -8,  11,-100,-105, -96, -98, -91, -88,  14,   2,  23; D=-16;
/I:         I=-16; MD=-21;
/M: SY='S';  M= -26,-104,  13, -86,-109, -51, -95, -47, -40,-105, -99, -18,  23, -16, -95,  25,  23, -57,-117,-102; D=-16;
/I:         I=-16; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='D';  M= -65,-105,  42, -85,  -3,-101, -21, -49, -53,  -6,  14, -33, -42, -90, -42,  -5, -19, -91,-104,   2; D=-16;
/I:         I=-16; DM=-21;
/M: SY='H';  M= -79, -97,  17,  14, -92, -24,  64, -90,  34, -63, -82, -70,  42, -68, -39,   0, -52, -18,-100, -32; D=-16;
/I:         I=-16; DM=-21;
/M: SY='E';  M= -47,  38,  29,  57, -85,   1, -68, -81,  33, -32,  10, -27, -34,  10,  13, -35,  -5, -42, -90, -78; D=-16;
/I:         I=-16; DM=-21;
/M: SY='V';  M=   7, -79, -37, -44,  32, -24, -79,  14,  -9,  -9, -58, -74, -11, -18,  14, -45,   8,  56, -82, -64;
/M: SY='I';  M= -13,  15, -81, -78,  -6, -12, -34,  44, -40, -14,  43,  -6,   4, -72,  28, -44,  -2,  38, -85, -68;
/M: SY='R';  M=   7,  26,  -3, -37,  17, -58, -68, -38,  -6,   1,   2,  -4, -10,  11,  50,   2, -20,  -3, -80,   3;
/M: SY='A';  M=  50,  14,   2, -37,  -4, -27, -79,  30, -76,   1, -58,  -6, -81, -74, -80, -40, -39,  41, -85, -26;
/M: SY='I';  M= -29,  13, -42, -46,   8, -89,  19,  49, -81,  47,  13, -80, -55, -78, -82, -32, -18,  34, -83, -62;
/M: SY='W';  M=  20, -79, -38, -79,  40, -51, -79,   4, -42,  10,  21, -78, -27, -76, -79,   2,  -8,  37,  78,   5;
/M: SY='E';  M=  21, -12, -22,  47, -36, -27, -20, -77,  11, -21, -19, -23, -73,  40,  -5,  23,  27, -52, -87, -73;
/M: SY='A';  M=  67,  51, -41, -71, -74, -29, -75, -25, -23, -37,   4, -31, -35, -69, -75,  17,   3,   5, -84,   8;
/M: SY='I';  M= -52, -12, -92, -87,  39, -93, -81,  61, -85,  54,  27, -86, -88, -82, -85, -81, -30,  10, -76, -25;
/M: SY='F';  M= -74,  24, -14, -81,  76, -87, -75,   8, -42,  32,  51, -13, -87, -80, -49, -23,  -9,   5, -71, -50;
/I:         I=-8; MD=-10;
/M: SY='E';  M= -87,-104,  -8,  32,-100, -42,  -6, -98,  18, -48,  27, -19, -92,   8, -10,   2, -45, -97,   6, -90; D=-8;
/I:         I=-8; MD=-10;
/M: SY='H';  M=   4,-102, -99, -94,   6, -98,  23, -34, -30,  -5, -29, -91,-104, -35, -13,  15, -29, -87,-101, -12; D=-8;
/I:         I=-8; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='T';  M= -36,-109,  12, -19,-113, -24, -28,-111, -91,-112,-105,  23, -20,  -2, -98, -31,  26,-106,  10,-103; D=-8;
/I:         I=-8; DM=-10;
/M: SY='Q';  M= -24,-107,  -2,  -5,-108,  -5, -92, -48,  -1, -49, -96,  -2, -21,  12, -25, -19, -29, -60,-112,-101; D=-8;
/I:         I=-8; DM=-10;
/M: SY='E';  M= -15, -17,  21,  23, -98,  -3, -81, -12, -27, -38, -86,  20, -90,  20, -45,   4, -38, -87,-105, -91; D=-8;
/I:         I=-8; DM=-10;
/M: SY='N';  M= -13, -31,   2,  -1, -76, -87, -25,   1, -78,  -1,   6,  31, -16, -11, -83, -28,  12,  11, -94,  13; D=-8;
/I:         I=-8; DM=-10;
/M: SY='D';  M=  -8,   6,  50,  13,  16, -16, -69, -72,  25,   6, -69, -26, -16, -63,  -5,   3,  18, -33, -85, -34;
/M: SY='E';  M=  16, -22,  40,  43, -83, -16, -68, -41,  31, -35, -36,  -2, -74,  -6,   3, -15,  15,  -9, -90, -76;
/M: SY='D';  M=  11, -16,  38,   4, -38,   0, -28, -24,  -3, -13, -16,  37,  27,  21,  -8, -32, -16, -19, -89, -75;
/M: SY='M';  M=  19, -80,   5,  -8,  33, -53, -75,  34, -75,  23,  37, -74,   8,  -9, -78, -38,   4,  -3, -79, -30;
/M: SY='K';  M=   8, -79, -43,  -9, -29, -40, -29, -23,  39,  21,  18, -37,   0,   7,  -4, -64,  31,  16, -85, -70;
/M: SY='K';  M=  -5, -83,  -1,  25, -82,  -3, -12, -22,  44, -23, -70,  -4, -18,  24,  27,  10,  -8, -19, -87, -74;
/M: SY='E';  M=  10, -20,  -5,  40,  11, -43,  -3,   7,  -7,  -3, -64,  -9, -76,  35, -22,   1,   3,   3, -84, -68;
/M: SY='L';  M= -49, -12, -89, -81,  36, -90, -79,  37,  -4,  52,  36, -83, -86, -26, -39, -78, -44,  33,  -2, -58;
/M: SY='K';  M=   9, -81, -27,  39, -33,  -6, -69, -30,  53, -27,  -2, -14,   4, -57,  13,   4, -13,  -8, -84, -73;
/M: SY='K';  M=   1, -83,  -4,  25,   1, -19,   5, -83,  62, -80, -73,  14, -13,  36,   4, -10,   2, -78, -82, -33;
/M: SY='W';  M= -18, -11, -34, -71,  31, -80,  59, -23,   4, -18, -65,   1, -83, -21,  28, -21, -41, -47, 105,  55;
/M: SY='K';  M=  17,   6, -70,  -4, -76,  30, -22,  -8,  40, -54, -16, -64, -76,   0,  27,   6,  -8,  -9,   5,   2;
/M: SY='P';  M=  13,   6,  21,  11, -33, -25, -70, -22,  28, -42, -31,  13,  73, -22,  -5, -30, -24, -48, -87, -77;
/M: SY='L';  M= -47, -79, -90, -84,  30, -57, -77,  38, -83,  63, -44, -86, -89, -27, -82, -80, -69,  30, -72,  32;
/M: SY='L';  M= -75, -79, -91, -43,  57, -57, -77,  11, -84,  72,  12, -87, -90, -36, -82, -82, -71,  -3,   9, -52;
/M: SY='Q';  M=  10, -82,  -2,  34, -14, -12, -68, -26,  21,  14, -64, -33, -33,  51,   4,  -4, -16, -17, -83, -70;
/M: SY='R';  M=  -1, -82, -12,  -7, -47, -48,  11, -79,  52, -39, -70,  42, -35,   6,  61, -39,  -2, -28, -87, -72;
/M: SY='F';  M=   1, -81, -45, -79,  82, -84, -68, -31, -77,  -1, -19, -80, -88,  15, -77, -40, -70,  21,  37,  69;
/M: SY='C';  M=  25,  51, -80, -79,   2, -17, -78,  28, -41,  28, -25, -10, -82, -76, -79, -25,  25,  22, -82,  -9;
/M: SY='T';  M= -51, -81,  33, -29,  32, -43,  20, -26,  33, -72, -31,  10,  11,  17, -12, -13,  50, -19, -82, -18;
/I:         I=-10; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='S';  M= -44, -80,  43,  23, -81, -15,  10, -80,   7, -24, -73,  31, -36,   9,  -4,  45,  29, -77, -90, -22;
/M: SY='E';  M=   9, -16,   9,  41, -82, -35,  11, -49,  23, -36, -19, -26,  22,   0,  22,  15,  19, -36, -88, -74;
/M: SY='D';  M= -22, -20,  44,  21, -42, -16,  -6, -53,  40, -49, -14,   6,  -6,  13,  22,   7,  -3, -15, -89, -73;
/M: SY='D';  M=  18, -21,  42,  24, -25, -16,  28, -23,  -8,   0, -67, -22, -23, -61, -14,  23,   7, -41, -86,  -3;
/M: SY='Q';  M= -16, -89,  -8,  42, -88, -46,   6, -52, -27, -76,  19, -61,   4, 107, -55, -60, -34, -47, -83, -29;
/M: SY='M';  M= -27, -80, -17, -37, -65, -85, -35,  23,  34,  30,  54, -72, -81, -65,  31, -29, -23,  33, -85, -67;
/M: SY='D';  M=  25, -14,  61,  38, -76, -54,  24,  -4, -62, -16, -69, -30, -75,  33, -36,  -2, -31, -53, -86,  17;
/M: SY='L';  M=  24,  21, -85, -80,  42, -52, -74,  -4, -41,  57, -11, -39, -86, -38, -78, -34, -21, -10, -73,  17;
/M: SY='L';  M= -49,  14, -37, -80,  -7, -90, -77,  35, -81,  71,  22, -83, -87,  16, -80, -79, -34,  -5,  -4, -61;
/M: SY='Y';  M= -36,   5, -16,  -7, -12,  21,  44, -44,  -5,  19, -24,  13, -81,   8,  -7, -20, -14,  -7, -75,  50;
/M: SY='A';  M=  66, -17, -32,   5, -76,  12, -75,  -1,   3, -17, -66, -67, -75, -65, -41,  -9,   4, -26,  14, -28;
/M: SY='I';  M= -25, -10, -90, -85,  28, -90, -81,  62, -41,  49,  36, -83, -85, -79, -82, -42, -23,   9,  14, -58;
/M: SY='Q';  M= -18,  11, -53,  76, -37, -46, -61, -81, -27, -25, -11, -24, -71,  89, -57, -39, -24, -78, -84, -73;
/M: SY='E';  M=  11, -20,  25,  38, -34, -76,   1, -34,  12, -20, -29,  -6, -76,  31,  13,   2, -21,   6,  13,   0;
/M: SY='Y';  M= -18, -81,  -9,  -7,  65, -33,  29, -17, -25,  17,   9, -74, -85, -72, -41, -30, -69,   0, -62,  68;
/M: SY='C';  M=  -9, 117, -86, -83,  32, -65, -82,  12, -48,   8, -23, -35, -90, -22, -83, -42, -36,  11,   5, -31;
/I:         I=-14; MD=-19;
/M: SY='Y';  M=  24,  16, -19,   7,  -9,   5,  21, -65, -70,  -5, -29,   7, -38,   0, -73,  17, -17,  13, -78,  44; D=-14;
/I:         I=-14; MD=-19;
/M: SY='E';  M= -35, -18,  11,  47, -80, -49,  24, -47,  36, -12, -22,  19, -75,  -1,   4,  21, -14, -21, -89, -26; D=-14;
/I:         I=-14; MD=-19;
/M: SY='H';  M= -33, -20, -21,  -8, -40,-104,  10, -45, -17, -49,   7, -20, -54, -51, -95, -14, -14, -22,-111,  -9; D=-14;
/I:         I=-14; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='N';  M= -15,   3,  24, -41, -18,  -9,  43, -77,  20,  -9, -70,  52,   6,  -3,  20, -18, -26, -33, -89, -19; D=-14;
/I:         I=-14; DM=-19;
/M: SY='P';  M=  13, -82,  13,  13, -34, -15,  40, -14,  -1, -28, -19,  31,  45,  25, -66,  13, -10, -48, -88, -72;
/M: SY='W';  M= -15, -82,  -6,  28,  13, -76,  36, -34, -25, -25, -17,  38, -34,  -8,  37,   2,   2, -12,  42,  12;
/M: SY='P';  M=  10,   2, -11, -36,  28,  -2, -25, -24, -35,  24,   1, -11,  42, -26,   3, -10, -14, -28, -77,  10;
/M: SY='M';  M=  -9, -82,  17, -20,   4,   3, -72,  28,   9,   5,  52, -19,  18, -25,   2,  -9, -38,  -7, -83, -67;
/M: SY='P';  M= -28, -83,  15,  -4, -40,  23, -70, -76,  42, -35,   0, -30,  58, -62, -20,   9,  21, -34, -83,  -8;
/M: SY='L';  M=  -8,   3, -73,   7, -31, -81,   6,   6,  32,  35, -15, -28, -31,  -4, -17,  -3,  -7,   5,  11,   4;
/M: SY='F';  M=  -2, -77, -88, -49,  78, -58, -76,  -3, -82,  45,  13, -82, -88, -81, -81, -18, -68,  18, -66,   5;
/M: SY='P';  M=  33,  26, -76, -69,   5,  -1, -74, -39, -69,  -2,   4, -30,  65,  27, -21,  -1,   1, -11, -83, -72;
/M: SY='Q';  M=  15, -19, -39,  -5, -40, -76,  33,  -9,  36, -12,   3,   5, -78,  40,  -2,  -7, -18,   7, -79,  30;
/M: SY='I';  M=   5,  35, -90, -86,   1, -89, -85,  66, -84,  38, -47, -84, -86, -81, -85, -76, -66,  42, -81, -19;
/M: SY='L';  M= -33, -18, -92, -85,  46, -91, -78,  31, -84,  67,   9, -87, -89, -81, -83, -42, -69,   8,   5, -22;
/M: SY='H';  M= -45, -83, -16, -13,  -9, -29,  66, -71,  49, -13,  26,  13, -25,  51,   7, -26, -33,  -4, -85, -64;
/M: SY='Y';  M=  18,  22, -72,   6, -20,   6,   4, -38,   2,  19,  20,  -7, -79,  13, -69, -24,  -1,  10, -78,  33;
/M: SY='L';  M= -76, -78, -92, -85,  57, -92, -75, -13, -85,  78,  36, -88, -91, -80, -82, -45, -71, -50, -70, -23;
/M: SY='Y';  M= -78, -88, -78, -41,   6, -86,  -8, -63, -73, -43, -57, -79, -90, -69, -71, -73, -36, -38, -38, 131;
/I:         I=-30; MI=0; MD=-39; IM=0; DM=-39;
/M: SY='D';  M= -70, -85,  79,  46, -87, -51,  26, -42,  -3, -56, -77,  46, -74,  28, -31, -20, -64, -24, -97, -74;
/M: SY='N';  M=  24,   4,  -6,  34, -35, -57,  33, -71,  -3,   7,  26,  44, -76,  10, -18, -18,  11, -70, -86, -16;
/M: SY='D';  M= -71, -88, 102,  52, -91,  -3, -14, -93, -60, -89, -86, -22, -72, -21, -68, -30, -66, -89, -99, -24;
/M: SY='I';  M= -43,  10, -91, -87, -32, -93, -87,  68, -84,  24, -46, -85, -86, -83, -85, -78, -64,  67, -83,   5;
/M: SY='V';  M= -47, -78, -92, -86,   4, -94, -86,  56, -85,  51, -43, -87, -87, -83, -85, -79, -65,  61, -82, -62;
/M: SY='E';  M= -20, -16,  48,  71, -86, -11, -15, -43, -58, -34, -76, -24, -71,  12, -31,  47, -61, -78, -91, -77;
/M: SY='E';  M= -43, -88,  11, 104, -35, -25, -63, -89, -12, -54, -79, -63, -66, -15, -60, -36, -68, -83, -87, -78;
/M: SY='D';  M= -32, -86,  77,  74, -91, -74, -19, -90, -10, -87, -82,   6, -70,  15, -29,   9, -64, -85, -95, -78;
/M: SY='A';  M=  55, -75,  18,   2, -19, -11, -73, -16, -69, -53, -25, -33, -76, -37, -74,  20,  12,  27, -83,   4;
/M: SY='I';  M= -74, -83, -93, -90,  49, -95, -82,  88, -85,  16,  -4, -85, -85, -83, -86, -81, -68,  -3, -70,  26;
/M: SY='L';  M= -25, -10, -82, -32,   7, -86, -73,  19,  -1,  56,   3, -30, -10,   0, -21, -75, -44,  -4,  33,  28;
/M: SY='K';  M=  33, -81,   8,  35, -82, -32,  17, -81,  36, -49, -72,  28, -74,  21,  17,  12, -63, -45,   6, -29;
/M: SY='W';  M= -83,-107,-108, -87, -25, -82,-102, -80, -78, -77, -80,-101, -87, -79, -39, -89, -94, -94, 177,  20;
/M: SY='W';  M=  15, -86, -49, -23,   3,   1,  50, -39,  15, -72, -67, -37, -81,   1,   2, -27, -35, -75,  85,  81;
/I:         I=-4; MD=-5;
/M: SY='D';  M=  19, -83,  57,  49, -89, -32, -20, -86,  35, -85, -78,  34, -72,  12, -59,   0, -35, -54, -92, -78; D=-4;
/I:         I=-4; MD=-5;
/M: SY='D';  M=  -4, -84,  53,  19, -88,  -5,  16, -86,  48, -56, -15,  10, -74,  21, -17,  19, -38, -82, -91, -75; D=-4;
/I:         I=-4; MD=-5;
/M: SY='P';  M=  11,   6, -14,  -1, -81,  21, -76, -10,  17, -42, -16, -68,  29,  -5,  -9,   1,   1,  22, -89, -78; D=-4;
/I:         I=-4; MD=-5;
/M: SY='D';  M= -24, -90,  45,  -9, -93, -18,  13, -48,  -5, -54, -83,  15,  15, -20,   9,  42, -37, -86,-100, -82; D=-4;
/I:         I=-4; MD=-5;
/M: SY='P';  M=  -9,-100,   7, -19,-103, -11, -27,-100,  36, -64, -91, -76,  40,  -6, -21,  12, -79, -96,-102, -93; D=-4;
/I:         I=-4; MI=0; MD=-5; IM=0; DM=-5;
/M: SY='V';  M=  22, -91, -21,  19, -32, -89, -90, -74, -83, -84, -83,   9, -91, -82, -89, -18,  27,  31,-107, -89; D=-4;
/I:         I=-4; DM=-5;
/M: SY='S';  M=   5, -87,  32,  20, -41, -24, -73, -45, -26, -52,   0,   4,  -9,   8, -75,  33,  -4, -23, -93,  -5; D=-4;
/I:         I=-4; DM=-5;
/M: SY='P';  M=   4, -88,  35,  17, -91, -36, -70, -87,  17, -44, -80,  30,  54,  -4,  -7,  11, -23, -84, -94, -83; D=-4;
/I:         I=-4; DM=-5;
/M: SY='E';  M=  -9, -85,  29,  65, -88,  17, -20, -45,  34, -84, -77,  11,   1,  14, -60, -28, -36, -34, -89, -79;
/M: SY='K';  M= -45, -27, -17,  27, -34,  24, -14,  -4,  49,  -4, -25, -43, -43,  21, -60, -32,  -1,  16, -85, -72;
/M: SY='Y';  M=   2, -28,  32, -26, -32,  20,   2, -47,  22, -10,  29, -22, -78, -21,   0,  26, -34, -50, -79,  35;
/M: SY='K';  M=  30, -79,  11, -30, -46, -44, -69, -71,  50, -49, -19, -20, -75,  29,   7,  30,   0,  11, -87, -73;
/M: SY='K';  M=  35, -81,  -5,  28, -36, -74,  34, -40,  42, -59, -69, -63, -14,  22,  10,   0,  -8,   1, -87, -72;
/M: SY='F';  M= -28,  12, -44, -84,  53, -89, -78,  30, -44,  34,  30, -45, -88, -81, -81, -78, -68,  43,  12,  16;
/M: SY='R';  M= -49, -86, -74, -34,   9, -85,  19, -12,  40,  15, -62, -68, -82,  -8,  81, -71, -36, -29,  15, -63;
/M: SY='E';  M= -23, -13,  -1,  60, -89, -32, -65, -85,  51, -83, -75, -34,   1,  56, -31,   7,   0, -52, -87, -77;
/M: SY='Q';  M=   9, -79, -17, -36, -76, -50, -68, -65,  41,  11,   7,  22, -77,  45,  -7,  23,  -4,  10, -87, -72;
/M: SY='A';  M=  45,  29, -74, -73, -32, -25, -74,  -9, -71,   0,  23,  24, -79, -32, -41,  18,  36,   4,  10, -71;
/I:         I=-22; MD=-29;
/M: SY='E';  M=  27, -88, -67,  44, -89, -13, -73, -44,  39, -34, -13, -70, -79,  43,  12, -67, -49, -32, -89, -80; D=-22;
/I:         I=-22; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='P';  M= -11, -90, -70, -16, -89, -27,   7, -80,  36, -85, -75, -69,  92,  22,  11, -12, -33, -22, -87, -80;
/M: SY='F';  M= -82, -83, -97, -91, 104, -91, -79, -23, -86,   6,  10, -88, -93, -91, -84, -84, -77, -17,  85,   9;
/M: SY='V';  M= -41, -80, -45, -85,  18, -92, -87,  56, -26,  22,  -2, -84, -87, -82, -83, -42, -65,  65, -84, -63;
/M: SY='E';  M= -49, -83,  54,  55, -87, -76, -27, -81,  28, -57, -76,  11, -72,  20, -61,  -3,  42, -27, -94, -77;
/M: SY='W';  M= -52,-106,-109, -89,  -7, -82,-106, -79, -81, -78, -81,-102, -88, -81, -84, -45, -93, -50, 174, -10;
/M: SY='L';  M= -76, -17, -94, -86, -50, -95, -78, -25, -87,  90,   2, -92, -93, -80, -84, -86, -72, -49, -81, -63;
/M: SY='Q';  M=   1, -19,  -2,  52, -36, -43, -11, -87,  42, -83, -74,  -8, -74,  69,  22, -37, -30, -82, -86, -74;
/M: SY='E';  M= -66, -83,  13,  74, -88, -41, -63, -84, -57, -57, -14,  48, -71,  37, -64,  20,  26, -80, -93, -78;
/M: SY='A';  M=  81, -76,  44, -30, -87, -63, -72, -43, -68, -78, -14,  -5, -76,  21, -73, -14, -62, -67, -89, -79;
/M: SY='E';  M= -23, -90,  44,  88, -93, -81, -67, -49, -30, -59, -83, -64, -13, -21, -67,   7, -40, -84, -95, -83;
/M: SY='E';  M= -33, -10,  31,  79, -92, -24, -69, -51, -62, -88, -84,  -7, -29, -56, -70,  39, -32, -54, -96, -84;
/M: SY='E';  M= -43, -91,  41,  92, -94, -51, -67, -92, -58, -88, -85, -25, -71, -12, -67, -12, -15, -46, -96, -84;
/M: SY='E';  M= -40, -88,  54,  61, -95, -76, -70, -94, -38, -92, -87, -61, -12,   2, -71,  59, -64, -88, -99, -84;
/M: SY='E';  M= -27, -90,  52,  68, -96,  -8, -71, -96, -65, -94, -89, -21, -28, -59, -73,  43, -67, -89, -99, -86;
/M: SY='E';  M= -75, -95,  46,  67, -99, -43, -73, -55, -39, -96, -91, -13, -35, -23, -40,  37, -71, -92,-103, -89;
/M: SY='E';  M= -52, -99,  56,  74, -45, -56, -74,-102, -68, -97, -94, -34, -81, -23, -77,  -8, -78, -96,-102, -21;
/I:         E1=0; IE=-130; DE=-130;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	49 in 49 different sequences
Number of true positive hits	49 in 49 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	W2
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

49 sequences

5MP1_CHICK  (Q5ZL42), 5MP1_DANRE  (Q1LUC1), 5MP1_HUMAN  (Q9Y6E2),

5MP1_MACFA  (Q4R6R4), 5MP1_MOUSE  (Q91VK1), 5MP1_MUSMM  (Q2L4X1), 
5MP1_RAT(Q9WTT7), 5MP2A_DANRE (Q6PD83), 5MP2B_DANRE (Q803N9), 
5MP2_CHICK  (Q5ZLT7), 5MP2_HUMAN  (Q7L1Q6), 5MP2_MOUSE  (Q9CQC6), 
5MP2_PONAB  (Q5R7L4), 5MP2_RAT(Q6P7P5), 5MP2_XENLA  (Q8AVM7), 
5MP2_XENTR  (Q6P2Z0), EI2BE_CANAL (P87163), EI2BE_DICDI (Q54RF3), 
EI2BE_HUMAN (Q13144), EI2BE_MOUSE (Q8CHW4), EI2BE_RABIT (P47823), 
EI2BE_RAT   (Q64350), EI2BE_SCHPO (P56287), EI2BE_YEAST (P32501), 
IF4G1_HUMAN (Q04637), IF4G1_MOUSE (Q6NZJ6), IF4G1_RABIT (P41110), 
IF4G2_BOVIN (Q95L46), IF4G2_CHICK (O73777), IF4G2_HUMAN (P78344), 
IF4G2_MOUSE (Q62448), IF4G2_PONAB (Q5R7J9), IF4G2_RABIT (P79398), 
IF4G3_HUMAN (O43432), IF4G3_MOUSE (Q80XI3), IF5Y_ARATH  (Q9C8F1), 
IF5Z_ARATH  (Q9S825), IF5_CAEEL   (Q22918), IF5_DICDI   (Q54LA1), 
IF5_DROME   (Q9VXK6), IF5_HUMAN   (P55010), IF5_MAIZE   (P55876), 
IF5_MOUSE   (P59325), IF5_PHAVU   (P48724), IF5_PONAB   (Q5R4L0), 
IF5_RAT (Q07205), IF5_SCHPO   (Q09689), IF5_YEAST   (P38431), 
PKRA_DROME  (Q9VNE2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

49 PDB

1PAQ; 1UG3; 2FUL; 2IU1; 3D3M; 3JUI; 3L6A; 5B04; 6CAJ; 6EZO; 6FYX; 6FYY;
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