PROSITE entry PS51359

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PURL: https://purl.expasy.org/prosite/signature/PS51359

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General information about the entry

Entry name [info]	COX5B_2
Accession [info]	PS51359
Entry type [info]	MATRIX
Date [info]	01-JAN-2008 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00663
Associated ProRule [info]	PRU00692

Name and characterization of the entry

Description [info]

Cytochrome c oxidase subunit Vb, zinc binding domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=100;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=95;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8524109; R2=0.0047637; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=15732.1523438; R2=8.5646677; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1816; H_SCORE=31286; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=976; H_SCORE=24091; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-16; D=-80; I=-80; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='A';  M=  36, -44, -42, -37, -44, -12, -41, -38, -35, -43, -38, -35,  13, -35, -11,  15,  -5, -10, -50,  -2;
/M: SY='H';  M=  12,  37, -25, -18, -35, -29,  51, -33,  29,   1, -22,   5, -35,  29,   3,  18, -20, -30, -45, -25;
/M: SY='P';  M=   4, -38,  15,  13, -26,  -6, -24, -27,   3, -16, -26, -21,  33, -20, -26,  19,   8,  -2, -34,  33;
/M: SY='G';  M=  -2, -36, -28, -27, -39,  50, -30, -32,  24, -34,  24, -17, -32, -21, -22,  36, -18,  -4, -42, -33;
/M: SY='T';  M=   1, -34, -22,  18, -33,  -7, -26, -22, -19, -10,  34,   4, -30,  19,  -2,   9,  44,   1, -46, -29;
/M: SY='M';  M= -25, -35,   5, -34,  18, -43, -34,  28, -35,  25,  47, -32, -40, -33, -37,  -1,   4,  33, -40, -18;
/M: SY='P';  M=  -1, -44,  -4, -25,  31, -33, -34,  -1, -30, -31, -28, -31,  86, -32, -38,   2,  -2, -27, -36, -25;
/M: SY='T';  M=   0, -34,  18,  -1, -36, -29,  32,   1, -22, -31, -26,  25,  18, -22, -29,  10,  54, -22, -52, -29;
/M: SY='D';  M= -29, -43,  74,  -7, -40, -32, -24, -35,   6,   2, -31, -11,  36, -21, -26,   3,  -1, -35, -54, -33;
/M: SY='P';  M= -13, -38,   6,  -4, -19, -41, -29,   4, -31,  37,  30, -32,  39, -28, -35, -28,  15,   0, -39,   5;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='E';  M=   0, -40,  25,  57, -36, -32, -17, -36, -14, -33,  23,  27, -28,  21, -21, -17,   8, -33, -42,  10;
/M: SY='Q';  M= -24, -43, -18,  24, -40, -34,  38, -11, -12,  -8, -21, -17, -31,  81, -14,   8,   6, -31, -42, -24;
/M: SY='A';  M=  60, -30, -26,   7, -36, -22, -32,   5, -25, -27, -23,  14, -32, -23, -31, -10,   9,   5, -44, -34;
/M: SY='T';  M=   4, -28, -27, -28,  20, -32, -33, -19, -26, -24, -23, -17, -29, -29, -32,  14,  76,   5, -43, -23;
/M: SY='G';  M= -21, -40,  20, -31,   7,  67, -28, -40, -30, -11, -32,  36, -36, -29, -36, -17, -27, -40, -40, -31;
/M: SY='L';  M= -27, -37, -34,  10, -16, -43, -33,  21, -33,  51,  -4, -36,  14, -28, -36,   1,   7,  -9, -40, -24;
/M: SY='E';  M=   2, -41,  37,  59, -44, -33, -22, -33,  10, -36, -32, -17, -27,  21, -18,   5, -21,   3, -48, -34;
/M: SY='R';  M=  -1, -40, -21, -18, -38, -31,  31, -39,  31, -16, -26,  35, -37, -10,  64,  -3, -23, -36, -45, -27;
/I:         I=-21; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='H';  M= -27, -40, -25,  19,  15, -37,  42, -26,   0,  19, -17, -24, -37, -16,  31,  19, -23, -27, -31,  29;
/M: SY='E';  M= -24, -44,  -1,  82, -44, -38,  33, -42, -10, -38, -34, -20, -23,  -2, -18,   4, -23, -15, -47, -33;
/M: SY='M';  M= -31, -39, -48, -40,  -9, -47, -30,  27, -38,  49,  61, -44,  13, -32, -38, -39, -28,  -6,  41,  16;
/M: SY='L';  M= -28, -35, -38, -35, -10, -42, -27,  -3, -34,  58,  -1,  10, -45,   1, -34,  -2, -23,   9, -35,  14;
/M: SY='G';  M=  44, -33, -32, -32,  11,  49, -33, -33, -31,  -9, -27, -22, -34, -28, -36,  18, -21, -26, -36, -29;
/M: SY='K';  M=  20, -36, -30,  -3, -27, -35, -30,  -1,  52,  24, -14, -26, -34, -18, -11, -24, -22,   5, -39, -28;
/M: SY='M';  M= -11, -39, -39, -29,  15, -42, -25,  11,   6,  18,  53, -32, -40,   5,  35, -30, -26,  10, -32,  16;
/M: SY='E';  M=   5, -38,   4,  37,   7, -31, -23, -31,   4, -32, -28,   4, -31,  30,  13,  21,   0,  -3, -41, -26;
/M: SY='G';  M= -16, -39, -26, -37, -36,  76, -28, -47, -31, -45, -36,  18, -34, -29, -37,   1,   5, -42, -35,  16;
/I:         I=-19; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='I';  M= -28, -43,  -1,  26, -21, -45, -26,  38, -19,   7, -13, -29, -36,  32,  19, -29, -25,  11, -35,  20;
/M: SY='D';  M= -29, -43,  81,  19, -49, -30, -18, -46,  10, -45, -41,  26, -31,  14, -20, -17,   7, -43, -59, -34;
/M: SY='P';  M= -11, -43, -39, -31, -23, -41, -34,  21, -28,  -1, -16, -38,  69, -32,   6, -30, -23,  33, -37,  19;
/M: SY='F';  M= -37, -40, -43,   0,  83, -47, -28, -15, -37,  18, -14, -41, -47, -39, -37, -38, -32, -20,  60,  41;
/M: SY='D';  M= -28, -41,  69,  30, -48,   3, -17, -48,  10, -48, -41,  54, -31, -14, -21, -17, -20, -45, -57, -37;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='M';  M=  -2, -33, -44, -38,  36, -39, -30,   9, -35,  32,  68, -35, -40, -31, -35,   1,  -4,  10, -33, -13;
/I:         I=-21; MD=-65;
/M: SY='R';  M= -30, -46,  23,  -3, -47,  13, -29, -47,  18, -24, -38,  14, -39, -21,  29,  10,  -6, -43, -52, -39; D=-21;
/I:         I=-21; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='P';  M= -32, -49, -22,  10, -39, -36, -24, -43,  35, -45, -34,  21,  68, -17,  24, -26, -26, -43, -39,  14; D=-21;
/I:         I=-21; DM=-65;
/M: SY='V';  M=  -7, -36, -44, -38,  17, -44, -41,  28, -38,  25,  -8, -40,  33, -38, -41, -31,  -1,  45, -40, -21;
/I:         I=-19; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='D';  M= -37, -51,  38, -22, -37, -47, -33,  15, -28,  12, -22, -29,   2,  34,   5, -34, -32,  -8, -52, -34; D=-19;
/I:         I=-19; DM=-61;
/M: SY='T';  M=  11, -35, -30, -24,   4, -34,  12,  20,  29, -22, -20, -21, -33, -21,  10,   9,  32,   7, -41, -23;
/M: SY='S';  M=  -1, -38, -24,   1, -42,  35, -27, -37,   0, -40, -33, -18,  17, -17,  30,  42, -17, -10, -43, -35;
/M: SY='P';  M=   2, -39, -25, -26, -41,  33, -27, -36, -15, -40, -31,  23,  40, -21,  37,   0,  20, -15, -45, -36;
/M: SY='F';  M= -10, -36, -31, -27,  61, -32, -26, -25,  25,  -1, -22,  13,   1, -25,  -1,  24, -20, -26, -26,  -8;
/M: SY='G';  M= -15, -41, -26, -39, -48,  86, -33, -55, -33, -51, -40,  17, -34, -31, -40, -14, -31, -49, -40, -43;
/M: SY='T';  M= -17, -28, -23, -25, -34, -32, -31, -26, -19, -30, -26, -12, -25, -24,   6,  16,  86, -18, -52, -30;
/M: SY='M';  M= -28, -40, -32,   5, -26, -42, -28,  10,  33,  17,  46, -30,  19, -18,  24, -30, -24,  11, -41, -26;
/M: SY='D';  M= -28, -43,  56,  53, -47, -33, -19, -47,  40, -44, -38,  18, -27,  -8, -11, -19,  -3, -42, -50, -35;
/M: SY='D';  M=  -1,  44,  61, -13, -44, -22, -18, -43, -20, -45, -39,  61, -35, -19, -27,  24, -15, -39, -60, -36;
/M: SY='P';  M= -31, -57, -32, -20, -51, -33, -35, -39, -28, -49, -36, -38, 113, -32, -41, -29, -24, -44, -44, -49;
/M: SY='N';  M=  -1,  29, -28, -35, -21, -35, -30,  39, -30,  -4, -14,  44, -39, -30, -35, -21,  20,  25, -43,  11;
/M: SY='I';  M= -26, -37, -42, -11, -15, -47, -38,  41, -36,  36,  19, -40, -41,   0, -37, -14, -23,  34,  38, -21;
/M: SY='V';  M= -19, -33, -49, -43, -18, -50, -51,  40, -41,  -3,  -6, -43, -43, -42, -42, -32, -17,  75, -50, -26;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='P';  M= -28, -46, -21,  20, -46, -34, -29, -38,  17, -43, -33,  -3,  87, -20,  -2, -21,  24, -38, -45, -40;
/M: SY='S';  M=   7, -29, -22, -22, -39, -16, -25, -37, -22, -40, -34, -10, -28, -15, -27,  79,  24, -28, -48, -31;
/M: SY='C';  M=  22,  44,   1,  -6,  15, -11, -28,  18, -30,  -8, -18, -29, -39,  14, -32, -23, -24,   6, -29,  39;
/M: SY='F';  M= -26, -37,  23, -27,  49,  14,  32,  -4, -30, -23, -24, -19, -36, -30, -33,   6,  33, -24, -29,  24;
/M: SY='D';  M= -28, -43,  66, -11, -45,  17,  33, -38, -23, -42, -36,  33,  38, -23, -31, -20, -23,  -7, -57, -33;
/M: SY='E';  M=  24, -38, -20,  34,  20, -30,  24, -36,   3, -32, -27, -22, -33, -14,  29,  16, -22, -30, -31,  22;
/M: SY='R';  M= -31, -49, -27, -14, -43, -41, -17, -47,  10, -40, -28, -21, -39,  36,  92, -24, -30, -42, -40, -27;
/M: SY='Y';  M= -31, -42, -43, -42,  -1, -48,  14,  49, -37,  16,  31, -38, -43, -32, -36, -35, -26,  15, -18,  69;
/M: SY='V';  M=   6, -32, -47, -41, -19, -45, -48,  27, -39,   4,  -7, -42, -43, -40, -41, -29, -17,  73, -50, -27;
/M: SY='G';  M=   6,  38, -31, -40, -46,  82, -37, -52, -35, -48, -39, -17, -35, -33, -42, -15, -31, -44, -41, -43;
/M: SY='C';  M= -52, 280, -92, -93, -73, -84, -92, -87, -84, -68, -68, -65,-114,-100, -97, -58, -53, -62,-133, -94;
/M: SY='T';  M= -23, -35, -28,   5, -27, -39, -34,  33, -24,  -1, -16, -23,  17, -26,  -1,  -1,  57,   3, -46, -29;
/M: SY='C';  M= -36, 189, -69, -86, -88, 144, -79,-103, -74, -89, -76, -41, -80, -75, -89, -38, -62, -84, -93, -89;
/M: SY='E';  M= -23, -39, -20,  35,  25,  34, -26, -31,   0,   5, -24,   3, -33,   7, -25,   6,  -4, -31, -35, -23;
/I:         I=-19; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='P';  M= -28, -47,  50,  44, -49,  -5, -25, -44, -19, -45, -39, -18,  69, -17, -29, -21,   8, -42, -50, -40;
/M: SY='G';  M=  18, -40,  43,   8, -33,  43,  37, -44, -25, -40, -33, -14, -33, -21, -30,  -2, -25, -38, -38,  27;
/I:         I=-22; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='D';  M= -43, -62,  39,  37, -67,  10, -38, -68, -34, -65, -59,  12, -46, -30, -43, -36, -42, -63, -70, -56; D=-22;
/I:         I=-22; DM=-71;
/M: SY='E';  M=  27, -36, -13,  46, -44,  -4, -22, -41, -14, -40, -33,   7, -28,  17,   9,  37, -16, -33, -44, -35;
/M: SY='H';  M= -29, -41,  13, -19, -32, -35, 111, -39, -24,  -9, -19, -10, -34, -16, -22,  -1,  21, -38, -62,  -9;
/M: SY='N';  M=  -7, -36,  34,  26, -41, -28, -23, -31,   3, -37, -32,  38,  16, -17, -24,   9,  32,  -2, -52, -35;
/I:         I=-24; MD=-77;
/M: SY='I';  M=  -7, -41, -50, -44, -22, -50, -50,  52, -43,   9,  -9, -45,  16, -42, -46, -36, -24,  47, -47, -29; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='I';  M= -27, -38, -32, -28, -18, -40,  23,  29,   1,  27,  15,  11, -39,  20, -26,  -8,  -2,   8, -37,  13;
/M: SY='W';  M= -40, -56, -64, -46,  48, -41, -56, -29, -39,  -8, -29, -56, -46, -40, -41, -45, -46, -40, 152,   9;
/M: SY='F';  M= -34, -36, -47, -41,  64, -46,  31,   5, -39,  37,  60, -38, -45, -36, -36, -38, -29, -11, -24,  -1;
/M: SY='W';  M= -29, -44,   2,   5, -21, -38,  11, -31,  -5, -14,  16, -27, -34, -23,   9, -23,  38, -32, 119, -11;
/M: SY='L';  M= -10,  39, -47, -40, -14, -46, -38,  18, -40,  49,  20, -43,  -6, -37, -41, -35, -24,  34, -42, -24;
/M: SY='H';  M=   0, -40, -18,  25, -34, -10,  75, -42,   7, -36, -27, -16, -31, -12,  36,  -2,  18, -36, -45,   6;
/M: SY='K';  M= -26, -44, -13,  51, -43, -39, -21, -36,  53, -37, -29, -19, -28,  29,  30, -22, -24,  -4, -41, -32;
/M: SY='G';  M= -22, -43,  52,  11, -49,  59, -26, -52,  17, -49, -41,   7, -31, -20, -24, -17, -27, -47, -47, -38;
/M: SY='Q';  M= -26, -43,  15,  36,   8, -35, -21, -40,  36, -37, -30, -17,  11,  43,  19,  -3,   2, -37, -39, -26;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='P';  M=  -9, -44, -38, -27, -30, -38, -36,   1, -32,  21, -16, -39,  85,  -4, -38, -30, -24,  13, -43, -34;
/M: SY='Q';  M=   5, -40, -22,  13, -32, -10,  30, -31,  20, -32, -25, -19, -33,  40,  28,  -4,   8,  -3, -36,  20;
/M: SY='R';  M= -30, -47, -30, -18, -37, -43, -21,   0,   5, -31, -23, -24, -40,  22,  87, -26, -29,  -3, -41, -27;
/M: SY='C';  M= -52, 280, -92, -93, -73, -84, -92, -87, -84, -68, -68, -65,-114,-100, -97, -58, -53, -62,-133, -94;
/I:         I=-24; MD=-77;
/M: SY='W';  M= -42, -62, -13, -42, -44,  -4, -49, -42, -46, -13,  23, -47,  59, -44, -52, -18, -41, -47,  67, -40; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='E';  M= -24, -42,  20,  61, -33, -11,  19, -32, -15, -31,  15,   4, -28,  17, -21,  -2, -23,  -6, -40,  17;
/M: SY='C';  M= -52, 280, -92, -93, -73, -84, -92, -87, -84, -68, -68, -65,-114,-100, -97, -58, -53, -62,-133, -94;
/M: SY='G';  M= -15, -41,  11, -34, -48,  82, -33, -54, -32, -50, -41, -13, -33, -29, -40,   8, -29, -48, -41, -41;
/M: SY='H';  M=  -8, -40, -19, -13, -34, -29,  67, -38, -15, -34, -24,  21, -33,  66, -16,  18,  17, -36, -40,  21;
/M: SY='W';  M= -26, -41, -44, -38, -14, -44,  44,  17, -36, -14, -15, -38, -42, -34, -36, -32,  -7,  53, 100,  23;
/M: SY='F';  M= -38, -40, -46, -44,  84, -46, -19, -15, -38, -10, -15, -40, -50, -41, -36, -36, -31,  -6,  -1,  77;
/M: SY='K';  M=  -6, -41, -24, -11, -39, -35, -23,  -3,  70, -30,  25, -17, -30,  34,  16, -22, -23, -28, -38, -28;
/M: SY='L';  M=   3, -35, -44, -37, -12, -43,  31,  16, -38,  56,  46, -39, -43, -31, -36, -34, -27,  -6, -39, -18;
/M: SY='V';  M= -24, -38,  -1,  17, -27, -41,   9,   6,  37, -20, -18,  -2, -35, -20, -16, -26, -20,  48, -43,   4;
/M: SY='Y';  M= -31, -45,  12,  11,   6, -38,  35, -29, -15, -29, -24,  11,  21, -18,  34, -26, -26,  -5, -23,  62;
/M: SY='V';  M= -26, -36, -42, -34,  16, -47,  15,  27,  15,  26,  17, -35, -41, -31, -28, -33, -22,  45, -40, -18;
/M: SY='G';  M=  -5, -43, -26,   5, -42,  52, -29, -40, -21, -12, -30, -22,  42,   8,  15,   7, -26, -38, -41, -37;
/M: SY='P';  M= -11, -44,  23,   4, -31, -32, -24, -29, -24,  -4, -26,   1,  72,  10, -31,   5, -21, -15, -39,  17;
/M: SY='P';  M=   4, -40,   1,  28, -30,   0, -26, -22, -22, -14, -24, -25,  37,  25, -28,   6, -21,  17, -38,  16;
/M: SY='G';  M= -35, -50,  11,   9,   7,  29,  16, -45, -36, -13, -37,  13, -45, -32, -41, -11, -36, -45, -46,   3;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	14 in 14 different sequences
Number of true positive hits	14 in 14 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

14 sequences

COX4_NEUCR  (P06809), COX4_SCHPO  (P79010), COX4_YEAST  (P04037),

COX5B_BOVIN (P00428), COX5B_HUMAN (P10606), COX5B_MOUSE (P19536), 
COX5B_PIG   (Q5S3G4), COX5B_PONAB (Q5REG2), COX5B_RAT   (P12075), 
COX5B_VULVU (Q710D6), COX5_DICDI  (P29505), CX5B1_ARATH (Q9LW15), 
CX5B2_ARATH (Q9SSB8), CX5BL_ARATH (Q9SSS5)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

110 PDB

1OCC; 1OCO; 1OCR; 1OCZ; 1V54; 1V55; 2DYR; 2DYS; 2EIJ; 2EIK; 2EIL; 2EIM;
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