PROSITE entry PS51349

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51349
Entry name [info]	FMN_HYDROXY_ACID_DH_2
Accession [info]	PS51349
Entry type [info]	MATRIX
Date [info]	01-DEC-2007 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00482
Associated ProRule [info]	PRU00683

Name and characterization of the entry

Description [info]

FMN-dependent alpha-hydroxy acid dehydrogenase domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=383;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=378;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3386879; R2=0.0065414; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=2425; N_SCORE=18.2; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=637; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-19; D=-80; I=-80; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='P';  M= -26, -60, -14,   7, -23, -54, -45, -45, -34, -48,  10, -43,  25,   2,  17,   4, -22,  -8, -63, -48;
/M: SY='P';  M= -14, -55,  11, -19, -49,  -7, -43, -12,  -9, -10,  21, -10,  22, -38,  -5, -15,   2, -39, -61, -47;
/M: SY='P';  M= -29, -55, -20, -43, -40, -52,  21, -16, -26,  27,  -3,  -9,  42, -42, -48,  -3, -38, -21, -60, -41;
/M: SY='M';  M=   4, -39,   1,  10, -36, -18, -28, -13, -26, -15,  66,  16, -13,   8, -16,  24,  19,  -9, -50, -32;
/M: SY='R';  M= -16, -45,   8,   1, -37, -23,   2,   9,  19,  -5, -27,  14,   1,  -3,  29,  17, -25,  -4,  22, -32;
/M: SY='P';  M= -21,  13, -49, -43,  14, -49, -40,  42, -42,  24,  31, -45,  50, -41, -45, -39, -29,  14, -38,  16;
/M: SY='V';  M= -19, -40, -40,  -5,  -9, -45,  -1,  21, -37,  16,  33, -36,  10, -34, -40,   4,  18,  40, -46,  -4;
/M: SY='N';  M=   9,  47,  13, -27, -45,  -7, -24, -44, -25, -47, -39,  72, -40, -24, -32,  36,  14, -38, -59, -41;
/M: SY='V';  M= -14, -39, -47, -42,   6, -48, -42,  26, -41,  35,   9, -42,  12, -40, -43, -15,  15,  38, -43,  -2;
/M: SY='A';  M=  40, -40,  39,  17,  -8, -19,   1, -40, -24, -32, -35,  13,  -3, -24,   4, -11,  14, -33, -48, -10;
/M: SY='D';  M= -23, -49,  88,  41, -54, -18, -25, -29, -22, -49, -47, -11, -34, -19, -17, -13, -14, -45, -63, -40;
/M: SY='Y';  M= -11, -43, -51, -46,  49, -49,  -2,  11, -43,  39,  26, -46, -51, -40, -41, -40, -34,  -7,  50,  53;
/M: SY='E';  M= -19, -51,  -5,  69, -50, -44,   6, -52,   6, -45, -37, -25, -33,  25,  59, -27, -32, -46, -48, -37;
/M: SY='A';  M=  34, -42,   5,  17, -43, -33, -28, -43,  29, -42, -34,  -5, -36,  28,  28,  -9,   9, -36,  31, -10;
/M: SY='H';  M=  27, -41, -38, -15, -31, -40,  42,   0, -22,  19,  26, -33, -42, -10,  41, -28, -11,   6, -48, -28;
/M: SY='A';  M=  80, -32, -38, -30, -41, -20, -37, -33, -31, -36, -30, -33, -37, -29, -19, -12, -22, -12, -43,  -6;
/M: SY='R';  M= -31, -48, -26,   5, -48, -40,  10, -48,  51, -44, -33, -21, -37,  47,  62,   1,  -3, -44, -46, -32;
/M: SY='R';  M= -11, -49, -10,   3, -45, -40, -23, -49,  41, -44, -33, -23, -39,  42,  71,  -6, -30, -44, -43,  -7;
/M: SY='R';  M=  -9, -46, -33, -24, -36, -43, -26, -17,  29, -18,   0,   3, -42,  11,  70, -28, -15,  10, -44,   0;
/M: SY='L';  M= -34,   3, -53, -44, -15, -54, -38,  31, -44,  58,  54, -47, -49,  -5, -42, -43, -31,  12, -43, -24;
/M: SY='P';  M=  -8, -50, -14, -12, -52,  -7, -36, -43, -30, -50, -40,  -5,  96, -30, -40,  24,   1, -43, -50, -47;
/M: SY='K';  M=   0, -48, -13,  -6, -45, -38,  25, -46,  53, -45, -35, -24,  50, -17,  41, -13, -11, -42, -45,  -8;
/M: SY='F';  M=  -5, -40, -36, -17,  48,  14, -34, -13,   8, -26,  30, -11, -13, -10, -17,  23,   2,   2, -36, -20;
/M: SY='V';  M=  33, -37, -41, -18,   7,   7, -41,   4, -38,   7,  -3, -35, -42, -35, -41,  13, -14,  39, -45, -30;
/M: SY='W';  M= -43, -51, -56, -48,  66, -49, -36, -24, -42,   1, -24, -51, -52, -43, -27, -44, -41, -16, 121,  61;
/M: SY='D';  M=  36, -42,  64,  16, -46,   0,  29, -46, -27, -45, -39, -16, -35, -23, -33,  10,  -6, -38, -54,  -9;
/M: SY='Y';  M= -48, -98, -80, -85,  61, -89, -20, -53, -71, -46, -41, -79,-103, -62, -66, -12, -65, -62,   0, 222;
/M: SY='Y';  M= -25,   9, -51, -48,   3, -53, -34,  49, -44,  33,  -8, -46, -50, -41, -44, -40, -30,  26, -28,  59;
/M: SY='D';  M=  32,   1,  51,  24, -40, -32,  -2,  -9, -23, -38, -35, -21, -37, -22,  10,  12, -10, -22, -49,   5;
/M: SY='G';  M=   3, -40, -29, -35, -48,  65, -34, -51, -31, -51, -42,   2, -36, -27, -15,  54, -21, -43, -47, -42;
/M: SY='G';  M=  25, -43, -33, -17, -51,  80, -39, -53, -36, -51, -42, -22, -37, -33, -43,   2, -32, -45, -44, -46;
/M: SY='A';  M=  70, -31, -34, -29, -44, -21, -37, -35, -31, -38, -32, -26, -35, -27, -36,  29,  28, -23, -48, -39;
/M: SY='D';  M= -13, -48,  44,  38, -20,  43, -26, -49, -26, -46, -40,   5, -36,  -2, -33, -10, -31, -46,  30,  30;
/M: SY='D';  M=  -4, -46,  80, -10, -49,  -8, -25, -46,   1, -20, -40,   3, -37,  14,  -1,   3, -11, -43, -59, -38;
/M: SY='E';  M= -27, -48,  -9,  79, -51,  17, -26, -50,  -6, -31, -39, -24, -29,  28, -23,  -6,  -6, -44, -48, -41;
/M: SY='W';  M=   0, -46, -38, -10,  11, -43,  21,  11, -10,  -2, -22, -14, -44,  12,  37, -21, -31,  15,  67,  10;
/M: SY='T';  M=  -7, -32, -27, -31, -40,   5, -36, -32, -28, -36, -32,  -2, -30, -30, -36,  23,  85, -24, -55, -37;
/M: SY='L';  M=   0, -42, -44, -34, -18, -46,  -2,  -4,   8,  49,  23, -40, -46,  18, -19, -35, -31,   7,  23,  19;
/M: SY='R';  M=  22, -45, -17, -21, -42, -36,  39, -27,  19, -40, -31,   3, -40,  21,  64,  -4, -12, -37, -46,  -6;
/M: SY='R';  M=  17, -46,  32,  41,  -3, -36,  19, -45, -14, -41, -36,  11, -37, -16,  45, -13, -29, -40, -43,  13;
/M: SY='N';  M= -32, -38,  -6, -27, -45, -21,  18, -23, -19, -50, -37, 105, -43, -20, -27, -15, -17, -45, -65, -39;
/M: SY='R';  M= -31,  -3, -33, -14, -32, -31,  17,  25, -17,  -2, -21,  13, -42,  13,  51, -10,  10,  10, -48, -13;
/M: SY='Q';  M=  27, -41,  25,  31, -47, -30, -26, -42, -18, -30, -35,  25, -35,  39,   7,  18,  11, -36, -51, -38;
/M: SY='A';  M=  62, -35,  26, -26, -43, -10, -37,  -7, -32, -35, -31, -25, -37, -28, -37,  25, -20,   2, -50, -39;
/M: SY='F';  M= -43, -43, -54, -50,  86, -52, -31, -15, -46,  30, -14, -48, -55, -48, -43, -43, -36, -22,  25,  56;
/M: SY='D';  M=  -1, -45,  57,   7, -50,   1,  19, -50,   5, -48, -40,  17, -37,  17,  23,  26, -24, -45, -55, -36;
/M: SY='R';  M=   1, -48,   8,  21, -48, -18,  41, -50,  20, -45, -35,   0, -38,  27,  61,  -4, -30, -44, -49, -32;
/M: SY='W';  M= -37, -49, -53, -46,  15, -53, -45,  58,  -5,  10, -14, -46, -47, -39, -21, -42, -34,  10,  97,  30;
/M: SY='R';  M=   0, -45, -33,   8,   0,  22,   2, -19,  -9,  19, -23, -30, -42,   8,  48, -20, -33, -31, -40,  -7;
/M: SY='F';  M= -39, -42, -55, -50,  66, -55, -41,  37, -48,  48,  -7, -49, -20, -47, -47, -45, -33,  -9, -28,  -9;
/M: SY='R';  M= -19, -46, -35, -28, -34, -45,  37,  13,  14, -27,  17,   4, -43, -20,  67, -31, -30,  20, -47,  -8;
/M: SY='P';  M= -20, -58, -34, -21, -56, -37, -35, -44, -28, -51, -38, -37, 106,  40, -37, -15, -28, -47, -48, -48;
/M: SY='R';  M= -16, -49, -31, -21, -45, -41,  41, -51,  25, -44, -33, -23, -42, -12,  86,   8, -30, -44, -48, -30;
/M: SY='M';  M=  10, -39, -47, -41, -24, -44, -39,  36, -36, -12,  54, -39, -13, -35,  -6, -10,  -4,  48, -45,   8;
/M: SY='L';  M= -22,  15, -54, -47,  33, -53, -38,  -5, -47,  67,  15, -51, -53, -42, -45, -44, -32,  -3, -37, -18;
/M: SY='R';  M=  -8, -44, -35, -28, -35, -23,   1,  18,  21, -13,  13,   0, -41,   7,  50, -28,   2,  21, -48, -31;
/M: SY='D';  M=  -6, -47,  73, -16, -54,  49, -29, -54, -15, -53, -47,  22,   5, -28, -36, -22, -29, -50, -57, -43;
/M: SY='V';  M=   2,  57, -17,  -4, -28, -47, -44,  13, -39,  -2,  36, -41, -13, -38, -43, -33, -24,  58, -54, -34;
/M: SY='S';  M=  13,   8, -14,  23, -18, -21,   3, -36, -11, -39, -34, -22,  -7,  14,  -2,  45,  25,  -8, -50, -34;
/I:         I=-22; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='N';  M= -18, -46,  28,  27, -49, -11, -24, -45,  31, -33, -37,  40,  10,  29,  12,  -2, -10, -33, -51, -38;
/M: SY='R';  M=  -8,  35, -40, -32, -37, -28, -36,   8,  -7, -11, -25, -35,  41, -27,  57, -31, -15,  25, -49, -36;
/I:         I=-22; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='D';  M= -17, -45,  84,  10, -52, -31,   1, -51, -10, -50, -46,  12, -35, -21, -12,  28,  -4, -46, -64, -38;
/M: SY='L';  M= -12, -38, -44, -39, -19, -48, -38,  18, -39,  54,  26, -38, -24, -11, -41, -30,  42, -11, -45, -27;
/M: SY='S';  M=  -9, -40,  -8,  24, -47,   5, -28, -46,  -5, -47, -39,  -2,  -2,  -2,  20,  61,   7, -39, -50, -38;
/M: SY='T';  M= -15,  32, -35, -35, -33, -42, -42,  16, -31, -25, -24, -25,  -9, -35, -17, -15,  77,  23, -56, -35;
/M: SY='T';  M=  -5, -39,  -5,  44, -44, -37, -30, -37,   6, -39, -34, -20, -30,  15,   2,  12,  60, -18, -52, -37;
/M: SY='F';  M= -34, -40, -54, -47,  53, -54, -42,  36, -45,  37,  22, -47, -50, -16, -44, -42, -30,  35, -34, -14;
/M: SY='F';  M= -39, -42, -13, -41,  60, -51,   0,  -2, -43,  52,  26, -44, -51,   0, -41, -42, -34, -17,  27,  -9;
/M: SY='G';  M= -20, -46,   1, -41, -53,  88, -38, -60, -37, -56, -45,   4, -38, -35, -45, -19, -36, -54, -45, -47;
/M: SY='Q';  M= -22, -47,  -1,  24,   2, -41,  32, -21,  12, -15,   0,   5, -39,  43,  38, -15, -12, -15, -44,  -4;
/M: SY='R';  M= -31, -45,  -1,  30, -43, -40,  17, -40,  37, -41, -34,  15,   4, -15,  42, -15,  25, -12, -49, -15;
/M: SY='W';  M= -34, -43, -45, -40,   3, -48,   3,  28, -38,  43, -10,  -9, -15,  -4, -18,  -9, -14,   7,  48,  20;
/M: SY='S';  M=  23, -39,  -3, -24, -47, -14, -33, -41,  14, -45, -37,  -9,  49, -24, -28,  52,  20, -35, -50, -40;
/M: SY='M';  M=  27, -36, -39, -12,  -7, -37,  -3, -15, -34,  13,  66, -33, -39, -30, -36,   8,  23,  14, -45,  -9;
/M: SY='P';  M= -36,   9, -37, -26, -55, -38, -40, -44, -33, -53, -40, -43, 115, -37, -46, -33, -29, -48, -50, -53;
/M: SY='F';  M= -33, -41, -55, -50,  50, -55, -46,  47, -47,  27,  12, -48, -49, -47, -47, -42, -28,  45, -36, -15;
/M: SY='M';  M=   2,  35, -49, -46,  29,  -8, -33,  27, -42,  16,  48, -42, -47, -39, -42, -35, -30,  12, -30,  45;
/M: SY='I';  M= -33, -43, -52, -47,  20, -55, -46,  60, -45,  30,  11, -46,  -6, -17, -46, -40, -11,  30, -41, -22;
/M: SY='A';  M=  62,  33, -34, -31, -45,   7, -36, -40, -32, -41, -35, -25, -37, -27, -36,  47, -18, -28, -48, -41;
/M: SY='P';  M=  -6, -59, -37, -25, -55, -36, -40, -43, -33, -53, -39, -42, 113, -36, -45, -31, -28, -46, -49, -52;
/M: SY='T';  M=  13,  14, -39, -38, -30, -41, -44,  26, -36,  -9,   2, -30, -38, -37, -41,  -8,  58,  38, -53, -33;
/M: SY='G';  M=  55, -39, -36, -38, -49,  68, -40, -47, -36, -46, -38, -25, -37, -33, -42, -15, -30, -36, -44, -44;
/M: SY='M';  M=  17,   5, -47, -41,   7, -18,   1, -10, -37,  32,  64, -41, -46, -34, -12, -33, -29,  22, -40,  11;
/M: SY='H';  M=  25,   0, -30, -26, -38,  -2,  63,  -7, -28,   4, -24,  16, -39,  40, -30,   8,   5, -29, -51, -28;
/M: SY='G';  M=  17, -11, -28,  11, -50,  56, -33, -51,  24, -48, -39, -23, -37,  -3,  28,  -6, -31, -43, -45, -41;
/M: SY='M';  M= -22, -39, -53, -45, -16, -51, -36,  19, -43,  55,  76, -46, -47, -37, -42, -41, -13,  12, -43, -23;
/I:         I=-21; MD=-65;
/M: SY='A';  M=  42,  25, -18, -37,   5,  15, -36, -10, -37, -11,  18, -35, -44,  -6, -40, -25, -30,   1,  34,  28; D=-21;
/I:         I=-21; MD=-65;
/M: SY='H';  M=  26, -47, -10, -28, -36, -34,  92, -48, -26, -42, -32,  20, -42, -24,  11, -15, -33, -45,  89, -17; D=-21;
/I:         I=-21; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='P';  M=   9, -52, -10,  -3, -50, -37, -33, -41, -20, -33, -35, -33,  86,  18,  35, -14, -28, -28, -48, -43;
/M: SY='D';  M= -19, -48,  58,  41, -51,  12, -25, -50,  11, -33, -41,  -1, -35,  18,  19,  -3, -28, -46, -53, -39;
/I:         I=-22; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='G';  M=  32, -42, -35, -41, -51,  81, -40, -53, -38, -51, -41, -22, -37, -35, -44, -17, -34, -44, -44, -46;
/M: SY='E';  M= -31, -51,  47,  88, -54, -43, -23, -55, -13, -48, -45, -21, -27,  -7, -23, -26, -30, -48, -54, -43;
/M: SY='V';  M=  -1, -11, -46, -40, -23, -27, -42,  24,   6,  24,   0, -41, -45, -36, -11, -34,  -9,  48,  19,  -4;
/M: SY='A';  M=  54, -38,   1, -25, -12,   4,  36, -22, -12, -38, -31,  10, -37,  26, -30,   2,  -9, -30, -47, -32;
/M: SY='T';  M=  11, -36, -41, -39,  -2, -40, -41,  22, -37,  22,   6, -33, -41, -35, -41,  18,  37,  30, -47, -28;
/M: SY='A';  M=  79, -31, -38, -31, -42, -21, -40, -29, -33, -22, -28, -33, -37, -30, -37, -12,  -8,   0, -46, -40;
/M: SY='R';  M=   2, -48, -28,   3, -43, -40, -24, -45,  35, -28, -32,  -1, -40,  22,  76, -26, -31, -32, -44, -11;
/M: SY='A';  M=  72, -34, -37, -32, -45,  27,   6, -34, -34, -37, -31, -30, -37, -30, -38, -14, -24,  -4, -46, -40;
/M: SY='A';  M=  69,  65, -39, -33, -42, -24, -39, -34, -34, -18,  -4, -32, -39, -32, -39,   7,  -7, -23, -49, -40;
/M: SY='A';  M=  48, -39, -17,  16, -43,  -5, -30, -39,  13, -40, -33,  -6, -35,  18,   9,  10,   1, -23, -44,  -3;
/M: SY='Q';  M=  30, -43, -22,  30, -48, -33, -26, -45,  34, -43, -34,  10, -35,  35,  34,  -2,  -5, -37, -47, -37;
/I:         I=-22; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='F';  M=  25,   5, -34,   8,  34, -38, -34, -26,  11,  14, -23, -31, -40, -28,   2,  -7,  24, -14, -38,  -2;
/M: SY='G';  M= -22, -46,  23, -33, -53,  79, -34, -58, -18, -55, -44,  25, -38,  -9, -25, -19, -34, -53, -48, -45;
/M: SY='I';  M=  16, -39, -45, -42, -26, -44, -46,  57, -37,  -1, -14, -37, -41, -37, -13,   0,  18,  36, -48, -31;
/M: SY='P';  M=   0,  20, -42, -35, -38,  -2, -42,  16, -38,  -2,  15, -41,  84, -38, -45, -32, -28,   6, -48, -41;
/M: SY='Y';  M= -37, -45, -44, -37,  67, -47, -22,  -8, -34,  -7,  50, -38, -48,  36, -33, -19, -33, -25, -14,  70;
/M: SY='T';  M= -14,  42, -41, -41, -30,  11, -42,  33, -37, -12,  36, -30, -39, -37, -42,  -2,  46,  24, -51, -33;
/M: SY='L';  M= -34, -41, -50, -43,   5, -53, -40,  37, -43,  53,  31, -44,  -8, -13, -43, -38,  10,   8, -42, -24;
/M: SY='S';  M= -21, -67, -51, -53, -88, -38, -57, -87, -53, -94, -81, -28, -67, -36, -62, 182, -10, -72,-105, -72;
/M: SY='T';  M= -20, -33, -26, -28, -38, -32,  16, -32, -27, -21, -30,  -3, -32,  -6, -33,  44,  78, -26, -56, -33;
/M: SY='Y';  M=   5, -42, -41, -36,  25, -42, -29, -14, -34,  14,  34,   9, -46,  28, -34, -31, -29,  26,  45,  46;
/M: SY='A';  M=  64, -33, -33, -30, -46,  16, -36, -39, -31, -41, -35, -25, -35, -26, -36,  45,  -5, -28, -47, -40;
/M: SY='S';  M=  -2,   0,  -9, -31, -38, -29, -33,   1, -29, -33, -30,  31, -37, -27, -35,  56,  33,  20, -55, -36;
/M: SY='C';  M= -18,  84, -16, -14, -11, -40, -33, -27,  10, -13,  54, -29, -43,  -7,  -6,  12,  14,  -4, -48,  -2;
/M: SY='P';  M= -21, -41,   4, -25, -44, -29, -33, -39, -29, -27, -36, -22,  66, -26, -36,  58,  37, -35, -53, -40;
/M: SY='P';  M= -33, -43, -49, -43,   8, -51, -43,  41, -42,  32,  36, -45,  44, -41, -45, -38,   1,  26, -44, -26;
/M: SY='E';  M= -22, -51,  12,  88, -54, -44, -24, -53,   2, -46, -42, -25,   5,  18, -20, -26, -30, -46, -50, -42;
/M: SY='E';  M= -18, -48,  62,  68, -53, -39, -24, -50, -17, -46, -42, -17, -30,  22, -25, -22,  18, -44, -56, -40;
/M: SY='V';  M= -27,  -4, -52, -48, -21, -55, -53,  57, -45,  11,  -9, -46, -47, -45, -48, -24, -12,  62, -51, -29;
/M: SY='A';  M=  59,  26, -39, -32, -40, -13, -39,  -2, -29, -30, -27, -32, -39,   2,   6,  -2,  -6,  20, -48, -38;
/M: SY='A';  M=  53, -39, -11,  11, -46, -28, -32, -28,  21, -40, -33,  -9,  19,  -5,  12,   7, -23, -20, -47, -39;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='A';  M=  63, -37,  -7,  -9, -46, -11,  46, -38, -26, -38, -30, -26, -37,  31,  -6, -15, -10, -18, -49, -34;
/I:         I=-15; MD=-47;
/M: SY='A';  M=  26,  23, -38, -37, -13,  -9,  -4,  15, -13,   0,  11,   5, -42, -32,  -4,   6,   3,  13, -49, -33; D=-15;
/I:         I=-15; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='P';  M= -36, -75, -28, -31, -79,  30, -61, -76, -58, -79, -68, -14,  49, -57, -67, -28, -55, -74, -74, -73; D=-15;
/I:         I=-15; DM=-47;
/M: SY='D';  M= -25, -49,  55,  19, -56,  21, -32, -55,   5, -54, -48,   9, -39,  -8, -32,   9,  10, -49, -61, -45; D=-15;
/I:         I=-15; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='Q';  M=  10, -46,  10, -25, -52,  25, -33, -45,  -9, -46, -38,   6, -12,  48,   0,  -3,  21, -25, -53, -42; D=-15;
/I:         I=-15; DM=-47;
/M: SY='P';  M= -17, -50,  11,   2, -26, -40,   1,   2,  -1, -14, -29, -10,  76,  11,  -8, -29,  -8,  -3, -49, -37;
/M: SY='F';  M=  -1, -44, -42, -34,  42,  -8,  23,  -2,   2,  19,  19, -34, -45,   5,  33, -33, -33, -13,  25, -16;
/M: SY='W';  M= -42, -58, -63, -50,  51,  -4, -53, -34, -42, -29,  19, -54, -49, -43, -44, -46, -48, -43, 148,  16;
/M: SY='F';  M= -43, -44, -54, -48,  94, -50, -32, -21, -44,  -8,   4, -46, -54, -11, -41, -42, -38, -26,  62,  50;
/M: SY='Q';  M= -58,-109, -48,  -7,-119, -74, -34, -91, -18, -81, -54, -39, -72, 227, -19, -36, -63, -95, -83, -61;
/M: SY='L';  M= -35, -39, -54, -47,   8, -55, -39,  13, -47,  69,  31, -51, -52, -41, -44, -46, -32,  11, -40, -21;
/M: SY='Y';  M= -82,-104, -80, -87,  23, -95, -13, -53, -70, -46, -39, -84,-106, -61, -64, -72, -71, -63,   7, 235;
/M: SY='W';  M= -17,  -1, -52, -44, -18, -49, -44,   9, -42,  16,  29, -48,   8, -41, -43, -38, -13,  51,  86,  20;
/M: SY='W';  M= -30, -45, -36, -31, -27, -38,  -8, -13, -22,  12,  33,  11,  49,  21, -34,  17,  -6,  -6,  56,  21;
/M: SY='K';  M=  -7,   2, -25,  12, -48,  10,  -2, -29,  62, -46, -36,  -5,  20, -16,  11,   2, -14, -41, -46, -38;
/I:         I=-24; MD=-77;
/M: SY='D';  M= -34, -48,  90,   2, -55, -16, -24, -54, -12, -54, -50,  29, -10, -24, -32,  -1,  -9, -50, -68, -41; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='R';  M= -37, -53,  29,  -7, -43, -43,   6, -47,  -4, -36, -35,  -8,  21, -16,  81, -31, -34, -30,  50, -31;
/I:         I=-24; MD=-77;
/M: SY='D';  M=   1, -47,  46,  28, -52,  38,   1, -52,  14, -50, -42,  -1, -36,   5, -10, -11,  -9, -46, -53, -41; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='F';  M= -21, -42, -18,  -3,  53, -51, -38,  28,  -8,  30, -13, -41, -47, -36,   8, -38, -31,  16, -34, -15;
/M: SY='M';  M=  22, -36, -30, -32, -35, -32, -30,   1, -26, -24,  54,  38, -38,  -5,   3,   7,  35,   9, -51, -33;
/M: SY='R';  M=  20, -45,  24,  38, -47, -37, -26, -45,  37, -29, -35,  -4, -35,   1,  43, -23, -12, -39, -48, -37;
/M: SY='D';  M=  -8, -44,  49,  27, -23, -17, -23, -46,   7, -44,  -6,  29, -35,  39, -23,  32, -22, -42, -52, -35;
/M: SY='M';  M=  -3, -40, -51, -43,  18, -49, -37,  24, -37,  43,  57, -45, -48, -36,   7, -39, -30,  20, -41, -21;
/M: SY='V';  M= -17, -39, -54, -47,   3, -54, -45,  34, -46,  46,  20, -49, -49, -43, -46, -41, -27,  50, -45, -25;
/M: SY='R';  M=  33, -45,   1,  42, -48, -35,   3, -45,  13, -30, -33, -25, -35,  41,  42, -22, -29, -38, -47, -36;
/M: SY='R';  M= -33, -50, -28,   3, -46, -42,  23, -51,  16, -45, -34,  -7, -41,  23,  86,   2, -31, -46, -47, -31;
/M: SY='A';  M=  68, -33, -41, -34, -37, -26, -42,  11, -35, -26,   1, -35, -39, -32, -39,   0, -21,  26, -47, -37;
/M: SY='E';  M=   1, -46, -16,  55, -44, -39, -26, -39,  34, -19, -33,  22, -34,   9,  28, -18, -27, -13,   4, -36;
/M: SY='A';  M=  49, -40,  -8,  21, -47, -28,  22, -43,  26, -42, -34,  -9, -35,  12,  15,  11, -24, -34, -48, -36;
/M: SY='A';  M=  55,  39, -40, -33, -34, -31,  -4,  -5, -33,  17,   0, -33, -41,   0, -18,  -3,  -2,  -9, -47, -34;
/M: SY='G';  M= -21, -47,  13, -37, -53,  84, -37, -59,  -9, -55, -45,  -2, -38, -33, -22, -20, -36, -53, -46, -46;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='C';  M=  18,  77, -47, -44,  50, -41, -35,   5, -41, -13,   1, -39, -49, -41, -42,  -2, -28,   4, -29,  44;
/M: SY='K';  M=  -8, -42,  15,   1, -46, -35,  10, -42,  59, -43, -35,  -2, -34,   2,  16,  19,  20, -22, -49, -34;
/M: SY='A';  M=  51, -34, -34, -34,   8,  25, -39, -33, -33, -35, -31, -25, -35, -32, -38,   1,  50, -17, -45, -33;
/M: SY='L';  M= -35, -41, -55, -49,   1, -57, -45,  54, -48,  57,  -2, -50, -50, -43, -47, -45, -30,  18, -42, -23;
/M: SY='V';  M=   4,  23, -52, -46,  29, -49, -48,  25, -44,   2,  23, -45, -48, -45, -45, -35, -25,  63, -45, -23;
/M: SY='L';  M= -20, -39, -54, -48,  34, -54, -43,  29, -47,  53,  -5, -50, -51, -44, -46, -42, -30,  34, -38, -19;
/M: SY='T';  M= -44, -62, -53, -60, -75, -75, -73, -57, -53, -67, -59,  -1, -58, -63, -70, -11, 193, -42,-116, -71;
/M: SY='V';  M=   7,   6, -49, -43, -23, -48, -47,  12, -42,  28, -11, -43, -46, -42, -44, -31,  13,  62, -52, -31;
/M: SY='D';  M= -38, -51, 105,  -1, -58, -34, -23, -56, -25, -54, -53,  -5, -37, -24, -33, -25, -27, -53, -73, -40;
/M: SY='T';  M=  36, -35, -39, -35, -30, -34, -39, -17, -34,   4,  36, -31, -38, -33, -38,   4,  48,  19,  48, -30;
/M: SY='P';  M=   7, -50, -18, -26, -44, -35, -37, -24, -31, -28,  -3, -34,  90,  11, -39,  -1,  15, -36,  46, -39;
/M: SY='V';  M=   5, -38, -47, -41,  17, -44, -41,  11, -36,  -9,  39, -39, -44, -37,  -3,   2,  -1,  54,  33,  -5;
/M: SY='P';  M=   2, -10, -10, -34,   9,   5, -35, -24, -37,  32,   3,   0,  55, -34, -41,  10, -27, -27, -43, -31;
/M: SY='G';  M= -19, -46, -33, -42, -51,  86,   0, -58, -38, -54, -44, -20,  -7, -34, -44,  12, -34, -52, -45, -45;
/M: SY='W';  M=  14, -46,  -6, -27, -30, -16, -26, -23,  21, -41, -34,  51, -42,  -5,  29, -24, -29, -39,  86,  29;
/M: SY='R';  M= -74,-106, -66, -42, -91, -94, -44,-105,  13, -89, -67, -52, -90, -19, 203, -62, -71, -92, -91, -64;
/M: SY='E';  M= -33, -51,  19,  68, -34, -44,  31, -44, -18, -19, -34, -27,  34, -14,   0, -29, -17, -42, -40,  35;
/I:         I=-22; MD=-71;
/M: SY='R';  M=  -4, -51,  -3,  -3, -42, -29,  14, -28,   8, -42, -34, -28, -44,   1,  72,  -9, -33, -19,  22,  -5; D=-22;
/I:         I=-22; MI=-71; MD=-71; IM=-71; DM=-71;
/M: SY='D';  M= -20, -51,  92,   9, -59, -35, -25, -56, -25, -55, -51,  21, -39,  13, -33, -26, -29, -53, -70, -42; D=-22;
/I:         I=-22; DM=-71;
/M: SY='W';  M=   8, -42, -39,   2, -26, -44, -36,  21, -10,  27,  30, -37, -42,  -4,  20, -30,  11,   3,  48, -27;
/M: SY='R';  M= -34, -50,  -2,  -6, -46,  -8,  49, -52,  29, -45, -34,  -7, -40, -13,  78, -14, -14, -46, -49, -30;
/M: SY='N';  M= -16, -37, -20, -30, -34,  -9, -22, -16, -26,   6,  -2,  73, -41,  -6, -31,  36,   5, -32, -50,  -2;
/I:         I=-24; MD=-77;
/M: SY='G';  M=   0, -47, -28, -12, -51,  52, -31, -50,  19, -38, -38,  22,   8,  25,  17,  -9, -31, -46, -47, -42; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='F';  M= -36, -40, -44, -43,  71, -25,   3, -16, -21,  24,  45,  12, -48, -39, -38, -13, -13,  -8,  18,  -7;
/I:         I=-3; MD=-8;
/M: SY='S';  M= -14,   4,  -3,  -5,   2,  -3,  -4,   1,  -9,   0,   1,   0, -40,  -9, -34,  29,  17,  17, -49, -30; D=-3;
/I:         I=-3; MD=-8;
/M: SY='F';  M= -14, -52, -49, -27,  16,  10, -46,  -5, -25,   6, -30, -20, -54,   6, -46,  -7, -38,  12, -48,  -8; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='P';  M= -19, -77, -54, -26, -75, -34, -58, -65, -52, -73, -61, -26,  85, -54, -63, -50, -49, -67, -70, -72; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -28, -60, -13,  -4, -19, -51, -46, -35, -25, -21, -10, -47,  77, -40,  -6, -30, -37,   5, -57, -47; D=-3;
/I:         I=-3; DM=-8;
/M: SY='R';  M= -42, -57, -18, -33,  24, -19,  -3, -49,  12, -46, -40,  -5,  23,  18,  33, -12, -39, -49, -41,  24; D=-3;
/I:         I=-3; DM=-8;
/M: SY='M';  M=   1, -53, -54, -47,   1, -54,   6, -28,  -6,  18,  23, -49,   7, -43, -21, -28, -40,  -2, -50,   6; D=-3;
/I:         I=-3; DM=-8;
/M: SY='T';  M=  25, -46, -40, -24, -47, -13, -42, -18, -17, -14, -35, -11,  -3, -11,   7,   6,  26, -19, -57, -44; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M=  -7, -52, -48, -45,   5,   7, -47,   5, -29,   4,   5, -19,  37, -43, -27, -20,   0, -18,  21, -36; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='R';  M=  -7, -55, -47, -36, -20, -27, -40, -41,  24, -18,  19, -39, -52,   4,  45, -21, -40, -11, -54, -41; D=-3;
/I:         I=-3; DM=-8;
/M: SY='N';  M= -40,  23,   0,  -8, -52,   2, -39, -45, -32, -20, -42,  36, -51,  -2,  12, -32,  17, -18, -65, -49; D=-3;
/I:         I=-3; DM=-8;
/M: SY='L';  M= -52, -60, -33, -63, -37, -72, -60,  24, -63,  27,   9, -62, -66, -59, -64, -57,  -5,   1, -64, -27; D=-3;
/I:         I=-3; DM=-8;
/M: SY='L';  M=  21, -50, -59, -52, -37, -53, -53,   1, -52,  30,  -2, -54, -58, -19, -54, -25, -19,   3, -59, -43; D=-3;
/I:         I=-3; DM=-8;
/M: SY='Q';  M= -45, -61,  30,  -9, -67, -29, -33, -62,  14, -61, -50,  33, -50,  56, -11, -34, -27, -61, -65, -50; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='Y';  M=  13, -48,  -4,  -2, -31,   7, -35, -16, -39, -21,  15,   0, -48, -35, -43,  -2, -33,   9, -43,  39; D=-3;
/I:         I=-3; DM=-8;
/M: SY='M';  M=   3,  22, -50, -27,  19, -27, -42, -21, -45,  25,  35, -44, -51, -42, -46, -17,  10,  -1,  22,   4; D=-3;
/I:         I=-3; DM=-8;
/M: SY='T';  M=  -2,   6, -35,   3, -43, -22, -39, -27, -30,  -3, -16, -29, -42, -15,   8,  32,  41, -32, -56, -41; D=-3;
/I:         I=-3; DM=-8;
/M: SY='H';  M= -14,   8,  29, -25, -55, -10,  61, -58,  31, -53, -43, -25, -18,  -6,  12, -14, -21, -53, -63, -38; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -49, -72, -52, -40, -66, -54, -54, -39, -28, -50, -50, -55,  92, -17, -55, -30, -43, -31, -64, -63; D=-3;
/I:         I=-3; DM=-8;
/M: SY='R';  M=   4, -56, -10, -42, -54, -27, -18, -39, -37, -33, -43, -19,   3, -16,  19,  -9,  -4,  12, -67, -50; D=-3;
/I:         I=-3; DM=-8;
/M: SY='W';  M= -64, -79, -87, -70,  32, -66, -79, -52, -63, -23, -52, -80, -71, -65, -65, -70, -70, -62, 133, -16; D=-3;
/I:         I=-3; DM=-8;
/M: SY='A';  M=  25,   6, -60, -53, -57, -29, -57, -48, -49,  -6, -45, -53, -62, -17,  -4, -15, -17, -28, -69, -57; D=-3;
/I:         I=-3; DM=-8;
/M: SY='W';  M= -26, -77, -71, -37, -44, -68, -63, -55, -28,  -3, -49, -69, -71, -19,   0, -62, -64, -60,  97,  -3; D=-3;
/I:         I=-3; DM=-8;
/M: SY='D';  M= -35, -70,  27,  -2, -71,  -2, -49, -44, -21, -49, -60,   5, -61, -14,   5, -32, -51, -64, -76, -61; D=-3;
/I:         I=-3; DM=-8;
/M: SY='F';  M= -34, -62, -76, -71,  42, -73, -63, -10, -67, -15,  16, -69, -73, -69, -67, -62, -52,  24, -53,  -7; D=-3;
/I:         I=-3; DM=-8;
/M: SY='G';  M=  -4, -67, -69, -66, -56,   8, -18, -24, -35,   4,  -8, -61, -70, -61, -65, -55, -57, -19, -72, -59; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='G';  M= -29, -68, -58, -61, -12,  43, -61, -73, -37, -70, -64, -47, -63, -12, -62,  -3, -24, -68, -66, -59; D=-3;
/I:         I=-3; DM=-8;
/M: SY='M';  M= -35, -67, -59, -52, -60,  -9, -22, -31,   4, -34,  35, -50, -19, -45,  13,  -4, -50, -53, -69, -55; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -17, -77, -61, -54, -66, -62, -60, -28, -55, -44, -57, -22,  69, -58, -29, -55, -53, -59, -69, -23; D=-3;
/I:         I=-3; DM=-8;
/M: SY='H';  M= -39, -74, -47,   4, -71, -36,  47, -74, -19, -68, -57, -47,  16,   2,  25, -34, -55, -71, -74, -53; D=-3;
/I:         I=-3; DM=-8;
/M: SY='D';  M= -55, -73,  20,  -4, -66,   2, -53, -67, -51, -64,  12, -46, -63,  -3, -39, -28, -14, -66, -72, -11; D=-3;
/I:         I=-3; DM=-8;
/M: SY='L';  M= -29, -64, -35, -57,   0, -36, -56, -42, -33,  15,  15, -58, -24, -53,   2, -31, -28, -45, -63, -46; D=-3;
/I:         I=-3; DM=-8;
/M: SY='G';  M=  -3, -62, -54, -28, -61,  37, -57, -56, -28, -20, -51, -47,  -2, -50, -26, -26, -27, -33, -65, -60; D=-3;
/I:         I=-3; DM=-8;
/M: SY='N';  M= -18, -61,   8, -22, -65, -27, -45, -27, -27, -63, -56,  48,  -8, -44, -51,  -1, -40, -34, -77, -60; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M=   1, -54, -10, -45,  -1, -53, -47,  10, -27,  -5,   4, -48,  22, -45, -16, -27, -38,  12, -50,   8; D=-3;
/I:         I=-3; DM=-8;
/M: SY='D';  M= -29, -55,  34,  30, -59, -10, -38, -49, -19, -53, -49,   6, -46,   5, -19,  11, -18,  -7, -66, -50; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -29, -59,  -7, -40, -55,  11,  -1, -47,  -5, -19,  -8,   2,  35, -12, -28,  -8, -27, -22, -63, -50; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='Y';  M= -15, -64, -24, -45, -16, -31,  50, -55, -25, -51, -44, -21, -22,  -6, -20, -26, -25, -55, -42,  56; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M=   0, -52, -18, -12, -22, -26, -43,  -9,  -3,   2, -33, -15,  39, -36,   9, -34,  10, -22, -55, -43; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M=  -8, -55,  14,   8, -57,  30, -39, -54,  -3, -53,  -7, -30,  42,  -1,  -1,  -7, -19, -50, -56, -49; D=-3;
/I:         I=-3; DM=-8;
/M: SY='G';  M= -19, -50,   4,   9, -51,  40, -35, -50,  24, -22, -40,  13, -16,  -8,   9, -27,  -4, -47, -53, -44; D=-3;
/I:         I=-3; DM=-8;
/M: SY='K';  M=   3, -46,   0,  11,   8,  -5, -36, -21,  18,  -6, -34,  -9, -17, -27,   1,  12,   2, -35, -48, -35; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='G';  M= -32, -71, -24,  -8, -67,  -1, -61, -25, -28, -31, -56, -53, -21, -51,  -5, -24, -14, -41, -75, -64; D=-3;
/I:         I=-3; DM=-8;
/M: SY='G';  M= -37, -69,  -2, -55, -75,  33, -57, -75, -56, -76, -67,  11,   4, -55, -64, -14, -10, -70, -77, -69; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -22, -69, -69, -60, -17, -67, -62, -43, -59,  13,  -7, -66,  35, -59, -20, -27, -53, -30, -68, -54; D=-3;
/I:         I=-3; DM=-8;
/M: SY='Q';  M=   2, -50,  13,   4, -47,  10, -38, -42,  -3,   7, -35, -18, -13,  21, -14,   2, -15, -41, -55, -43; D=-3;
/I:         I=-3; DM=-8;
/M: SY='G';  M=  17, -45,  17, -29,  -1,  34, -36, -41, -10, -28,  -9, -26,  21,   7, -16,  19, -28, -24, -47, -37; D=-3;
/I:         I=-3; DM=-8;
/M: SY='V';  M=   0, -42, -42, -38,   0, -15, -38,  11, -19,   0, -22, -35, -10,   3, -38,  14,  17,  30, -42,  23; D=-3;
/I:         I=-3; DM=-8;
/M: SY='M';  M=  20, -41, -37,  -9, -36,   2, -37,   6, -31,  -4,  30, -31, -21,  15,  -6,  14,  12,  15, -49, -35; D=-3;
/I:         I=-3; DM=-8;
/M: SY='A';  M=  37, -41,  18,   4, -45,   0, -33, -40,  -8, -29, -35, -24, -17,   9,  13,  15,  16, -24, -49, -20; D=-3;
/I:         I=-3; DM=-8;
/M: SY='W';  M=   3, -47, -44, -22,  50, -43,  24, -28, -37, -12, -27, -39, -17,   4, -38, -18,   1, -13,  91,  46; D=-3;
/I:         I=-3; DM=-8;
/M: SY='M';  M=  -6, -42, -48, -20,  -8, -26, -42,  14, -40,  28,  47, -44,  -9,  -4, -42, -36, -10,  34,  46, -26; D=-3;
/I:         I=-3; DM=-8;
/M: SY='Y';  M=  18, -43,  16,   8,  11,  22,   4, -21, -32, -27, -13,  -3, -40, -29, -37,  16,  -6, -15, -40,  26; D=-3;
/I:         I=-3; DM=-8;
/M: SY='W';  M=  16, -45, -18,  12, -33,   2, -34, -24,   8, -15, -33, -16, -40, -24,   9,  22,  -8, -23,  73,  14; D=-3;
/I:         I=-3; DM=-8;
/M: SY='Q';  M= -19, -44, -32, -27,  24,   7,   4, -32, -26,   3,  13,  22, -22,  53, -10,  12,   0, -34, -39,   6; D=-3;
/I:         I=-3; DM=-8;
/M: SY='F';  M=  -4, -40, -43, -40,  53,  -8, -37,  17, -38,  14,  30, -34,  -8, -10, -40,  21,   7,  -8, -34, -16;
/M: SY='D';  M=  -9, -46,  74,  -1, -46,  -6, -25, -46,  10, -47, -42,   2, -37, -21,  24,   1,   2, -29, -54,  -3;
/M: SY='P';  M=  22, -46, -11, -23, -47, -32,  22, -39, -26, -26, -33,   2,  75,  31, -13,  -2,  15, -37, -50, -39;
/M: SY='S';  M=  24,   5,   2, -27, -38, -25, -30, -37, -29, -17, -34,  13,   7, -24, -34,  61,  17, -31, -49,  -3;
/M: SY='L';  M= -35, -43, -51, -44,  31, -52, -42,  38, -45,  48,  -8, -48,  36, -43, -46, -29, -30,  13, -38, -21;
/M: SY='T';  M= -23,  38,  18, -26, -43,  -9, -30, -39, -24, -41, -36,  31, -35, -14,  -3,  33,  64, -32, -58, -38;
/M: SY='W';  M= -43, -68, -66, -46, -13, -42, -67, -43, -40, -42, -43, -60,  16, -40, -45, -20, -51, -56, 163,   0;
/M: SY='D';  M=  -2, -47,  47,  42, -51, -36,  21, -49,  40, -46, -38,   9, -33,  28,  -2, -16, -11, -44, -52, -36;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='D';  M= -23, -48,  92,  -7, -41, -35,   2, -49, -11, -47, -45,  -9, -37, -24, -31, -11,   7, -46, -54,  26;
/M: SY='I';  M= -15, -41, -53, -48,   2, -54, -45,  52, -46,  43,  -5, -48, -49, -43, -47, -41, -28,  38, -41,   3;
/M: SY='E';  M=  38, -44,  -3,  49, -50, -33, -29, -45,  16, -44, -36,  -9,  24,   4,  21,  -7, -26, -37, -48, -40;
/M: SY='W';  M= -10, -58, -52, -22,   7, -42, -46, -39,  -1, -22, -35, -47, -46,  -9,  10, -40, -26, -45, 145,  25;
/M: SY='L';  M= -35, -41, -55, -49,  12, -57, -43,  46, -48,  60,  -2, -51, -51, -43, -47, -45, -31,  19, -40, -22;
/M: SY='R';  M=   0, -50, -31, -17, -48, -41,   4, -49,  25, -43, -32, -24, -41,  46,  83, -26, -33, -43, -45, -32;
/M: SY='S';  M= -14, -42,  42,  38, -48, -31, -25, -46,  16, -45, -10,  14, -33, -16,   1,  44,   9, -40, -54, -38;
/M: SY='Q';  M= -15, -47, -41, -32,  18, -24,  29,  33, -14,  15,  21, -34, -44,  39,  23, -33, -33, -18,  25,   8;
/M: SY='W';  M= -17, -45, -42, -38, -24, -38, -49, -35, -33, -37, -36, -32, -37, -35, -39,   4,  66, -34, 133, -14;
/M: SY='D';  M= -17, -47,  52,   0, -51,  15,   3, -51,  28, -49, -41,   3,   5,   9,  24,  20, -25, -46, -53, -38;
/M: SY='G';  M= -28, -42, -40, -20, -27,  48,  16, -20, -21,  43,  32, -32, -44, -33, -20, -13, -33, -13, -44, -30;
/M: SY='P';  M= -18, -57, -33,  -9, -54, -38, -35, -45,   3, -52, -39, -14, 104, -29,  12, -31, -29, -47, -48, -48;
/M: SY='I';  M= -33, -41, -55, -49,  30, -55, -44,  55, -46,  31,  46, -47, -48, -43, -46, -42, -29,  35, -40, -19;
/M: SY='I';  M=  -4, -40, -52, -47, -18, -52, -45,  52, -45,  29,  26, -47, -47, -42, -45, -38, -26,  47, -43,   5;
/M: SY='L';  M= -21, -40, -54, -48, -16, -55, -46,  45, -47,  53,  -3, -50, -50, -43, -47, -42, -28,  41, -45, -26;
/M: SY='K';  M= -65, -93, -49, -22, -97, -79, -56, -98, 186, -96, -71, -35, -65, -18,  13, -53, -54, -89, -84, -70;
/M: SY='G';  M= -19, -46, -34, -46, -53,  92, -41, -61, -39, -56, -45, -20, -38, -37, -47, -19, -38, -54, -43, -48;
/M: SY='I';  M= -30, -43, -54, -49, -20, -56, -52,  66, -46,  21,  -7, -48,  -4, -45, -49, -41, -26,  51, -48, -28;
/M: SY='Q';  M= -33,  29, -41, -13,  -5, -48, -31,  -8, -31,  49,  26, -38, -46,  63, -31, -34, -31,   0, -42, -25;
/M: SY='H';  M= -31,  33,  29,  -5, -40, -19,  71, -46, -18, -42, -34,  -1, -39, -20,  41,   8,  31, -41, -55,  -3;
/M: SY='P';  M=  12, -46, -35, -28, -43, -14,  15, -31,   2, -40, -32, -32,  83, -31, -35, -12,  19,   6, -48, -14;
/M: SY='E';  M= -18, -50,  60,  73, -55, -24, -23, -53, -15, -48, -43, -18, -30,  32, -24, -24, -29, -48, -54, -41;
/M: SY='D';  M= -36, -50, 100,  14, -56, -18, -24, -51, -25, -51, -50,  -7, -36, -24, -33, -26, -27, -26, -70, -40;
/M: SY='A';  M=  76,   7, -39, -32, -42, -23, -41, -27, -34, -33, -28, -33, -37, -31, -38, -13,  -2,  13, -48, -40;
/M: SY='R';  M=  -9, -47,   2,  32, -33, -44, -27,  10,  27,  -7,  34, -29, -38, -16,  50, -31, -30, -27, -42,   7;
/M: SY='R';  M= -15, -46,   2,  -2, -31, -46, -29,  13,   4,  26,   9, -10, -13,  -5,  59, -33, -31, -24, -46, -31;
/M: SY='A';  M=  78,  25, -39, -32, -42, -22, -40, -31, -34, -14, -28, -34, -38, -31, -38, -13, -23, -10, -46, -40;
/M: SY='V';  M=   8, -40, -44, -35, -25, -45, -39,  35,  -5,  18,   0, -38, -44,  23, -16,  -8, -25,  43, -45,  -6;
/M: SY='D';  M=   8, -46,  54,  24, -48, -19, -26, -43,  32, -21, -36,   1, -36,  30,  12, -15, -27, -27, -51, -37;
/M: SY='H';  M=  21,   5, -32,   8,  16, -22,  76,  -9, -31,   3,   2, -28, -41, -27, -14, -12, -10,  -2, -45,   0;
/I:         I=-22; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='G';  M= -20, -47, -30, -19, -53,  85, -36, -58, -33, -54, -43,   7, -38,  22, -40, -19, -36, -53, -44, -45;
/M: SY='A';  M=  56, -34, -44, -37, -29, -33, -43,  -2, -38,   0, -19, -40, -42, -36, -41, -22, -22,  51, -46,   0;
/M: SY='D';  M=  -3, -47,  85,  -7, -53, -32, -25, -50,  -1, -50, -45,   1,  -3,  12,  -4,  11,  -9, -46, -61, -39;
/M: SY='G';  M=  40, -41, -35, -40, -50,  78, -40, -51, -37, -49, -40, -23, -37, -34, -44, -16, -32, -41, -44, -46;
/M: SY='I';  M= -30, -44, -55, -52, -20, -58, -55,  77, -47,   2,  -7, -47, -45, -46, -50, -41, -26,  50, -47, -28;
/M: SY='W';  M= -29, -44, -53, -47, -17, -50, -49,  45, -43,  -7, -15, -47, -47, -42, -45,  -8, -27,  56,  91,  24;
/M: SY='V';  M= -16,  26, -53, -46, -21, -53, -50,   6, -45,  32,  -9, -48, -50, -45, -46, -38, -24,  72, -53, -30;
/M: SY='S';  M= -11, -33, -25, -27, -43, -20, -29, -42, -27, -46, -39, -14, -33, -19, -31,  88,  19, -34, -53, -36;
/M: SY='N';  M= -14, -36,  -7, -27, -46, -21, -15, -44, -19, -51, -38, 102, -41, -21, -27, -13,  17, -44, -64, -41;
/M: SY='H';  M= -78,-102, -46, -46, -75, -82, 266,-112, -56, -76, -47, -25, -79, -34, -44, -57, -75,-111,-146, -13;
/M: SY='G';  M=   1, -45, -34, -45, -52,  89, -41, -59, -39, -54, -44, -21, -38, -36, -46, -18, -37, -51, -44, -47;
/M: SY='G';  M=   7, -45, -34, -44, -52,  88, -41, -58, -39, -54, -44, -21, -38, -36, -46, -18, -36, -50, -44, -47;
/M: SY='R';  M= -73,-104, -62, -43, -91, -90, -42,-104,  11, -90, -68,  15, -90, -20, 198, -60, -68, -92, -93, -65;
/M: SY='Q';  M=  -2, -50, -22,   3, -56, -34, -18, -44, -12, -41, -29,  21, -36, 104, -13, -17, -15, -44, -44, -32;
/M: SY='L';  M= -11, -38, -53, -46,  25, -52, -40,  -2, -47,  67,  -2, -51, -52, -42, -44, -43, -31,  19, -39, -20;
/M: SY='D';  M= -37, -50, 100,  10, -57, -33, -22, -55, -23, -54, -52,  22, -37, -23, -32, -24, -26, -52, -72, -40;
/M: SY='G';  M=  -2,  -2, -30,  -9, -19,  69,   0, -48, -34, -46, -38,  -3, -37, -31, -40,   5,  19, -42, -42,   7;
/M: SY='A';  M=  37, -35, -37, -22, -36,  14,  -3,  -6, -34, -16, -25, -29, -38, -33, -39,   8,  33,  36, -51, -35;
/M: SY='P';  M= -33, -50, -42, -32, -34, -44,  -3,  11, -34,  20,  -7, -42,  87, -35,  -8, -14, -28,   5, -48, -37;
/M: SY='A';  M=  52, -35, -32, -29, -46,   1, -36, -39, -30, -42, -35, -25,  35, -27, -36,  48,  14, -30, -49, -41;
/M: SY='P';  M=  39, -36, -31, -28, -45, -13, -36, -37, -30, -42, -35, -24,  50, -28, -37,  43,  42, -30, -50, -40;
/M: SY='I';  M=  19, -40, -52, -46,  13, -48, -45,  58, -44,  28,  22, -45, -45, -41, -46, -36, -28,  23, -41, -24;
/M: SY='D';  M=  -6, -48,  73,  37, -51, -36,  36, -51,  -3, -47, -21, -14, -35, -17,  21,   3, -27, -46, -59, -35;
/M: SY='A';  M=  49,  41, -42, -37, -34, -33, -42,   6, -36, -22,  32, -34, -40, -35, -40,  -3,  17,  35, -51, -35;
/M: SY='L';  M= -18, -38, -54, -46, -11, -54, -38,  -3, -47,  76,  10, -52, -53, -40, -44, -45, -32, -10, -41, -23;
/M: SY='P';  M=   3, -51, -34,   3, -44, -38, -36, -33, -28,   3, -29, -38,  91,   1,  -1, -15, -18, -24, -47, -43;
/M: SY='E';  M=  33, -44,   8,  63, -50,  10,   3, -48, -19, -45, -38, -25, -15,   0,   1,   1, -27, -39, -49, -40;
/M: SY='I';  M= -29, -42, -52, -49, -21, -56, -54,  74, -45,  -6,  -9, -44, -44, -44, -49, -23,   0,  51, -48, -28;
/M: SY='V';  M=  38, -39, -41, -33, -34, -37,   6,   6, -23, -23,  16, -34, -42, -28,  42, -12, -25,  43, -50, -32;
/M: SY='E';  M=  18, -47,  38,  46, -52, -35, -27, -48,  32, -46, -39, -21,  26,  27,  -6, -10, -27, -42, -50, -40;
/M: SY='A';  M=  63, -37, -33,  -1, -16, -27,   0,  -8,  -4, -33, -28,  -8, -38,  -4,  -2, -17, -25,  -6, -41,   6;
/I:         I=-18; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='V';  M=   6,   6, -46, -41, -26, -45, -47,   8, -40,  10,   7, -40, -11, -41, -43, -14,  23,  63, -54, -32;
/I:         I=-19; MD=-61;
/M: SY='G';  M=   3, -49,  37, -14,  19,  37, -33, -49,  22, -46, -41,   2, -42,  -6, -11, -27, -34, -46, -44,  -7; D=-19;
/I:         I=-19; MD=-61;
/M: SY='G';  M=  -8, -54,  35,   6, -58,  45,  15, -60, -16, -55, -46, -24, -43,  26,   0, -11, -37, -54, -56, -44; D=-19;
/I:         I=-19; MI=-61; MD=-61; IM=-61; DM=-61;
/M: SY='R';  M= -21, -51,  44,   5, -51, -12, -27, -48,  35, -47, -38, -20,   6,  27,  53, -27, -31, -27, -51, -38; D=-19;
/I:         I=-19; DM=-61;
/M: SY='I';  M=   0, -41, -51, -45,  -4, -51, -45,  42, -27,  41,  11, -46, -12, -41, -44, -38, -12,  29, -45, -27; D=-19;
/I:         I=-19; DM=-61;
/M: SY='P';  M= -15, -51,  23,  50, -52, -38, -30, -46,  -2, -48, -40, -27,  75,   5, -29, -11,  13, -43, -51, -44;
/M: SY='V';  M= -27, -39, -54, -49, -20, -56, -53,  51, -46,  18,  -8, -48, -48, -46, -48, -39, -24,  68, -51, -29;
/M: SY='L';  M= -37, -43, -54, -48,  34, -55, -39,  36, -46,  52,  -6, -50, -51, -43, -45, -44, -33,  12,  46,  28;
/M: SY='F';  M=  14, -38, -51, -45,  54, -46, -39,  16, -43,  28,  26, -45, -48, -43, -43, -36, -29,  33, -32,  10;
/M: SY='D';  M= -38, -51, 105,  -1, -58, -34, -23, -56, -25, -54, -53,  -5, -37, -24, -33, -25, -27, -53, -73, -40;
/M: SY='G';  M= -15, -40, -30, -35, -48,  66, -34, -51, -33, -51, -43, -17, -36, -27, -38,  63, -19, -44, -48, -41;
/M: SY='G';  M= -19, -46, -34, -46, -53,  92, -41, -61, -39, -56, -45, -20, -38, -37, -47, -19, -38, -54, -43, -48;
/M: SY='I';  M= -30, -43, -55, -51,   7, -58, -55,  74, -47,  -5,  -8, -47, -46, -47, -50, -41, -26,  53, -45, -25;
/M: SY='R';  M= -36, -53, -31,   5, -44, -46, -23, -49,  10, -42,   5, -27, -43,   4,  94, -31, -35, -44,  20, -31;
/M: SY='R';  M= -27, -44, -30, -26, -40,   2, -26, -45,   1, -43, -34,  -2, -39, -17,  73,  25,  31, -39,  -5,  -1;
/M: SY='G';  M= -19, -47, -13, -44, -53,  91, -40, -60, -39, -56, -45, -19, -38, -37, -46, -19, -38, -54, -44, -47;
/M: SY='S';  M=  23, -35, -30, -28, -36, -30, -32, -27, -28,  11, -25,  10, -37,  26, -32,  42,  39,  -9, -50, -34;
/M: SY='D';  M= -38, -51, 101,  -2, -56, -35,  40, -56, -25, -53, -50,  -5, -37, -23, -32, -26, -28, -53, -73, -36;
/M: SY='V';  M=  -7, -38, -53, -47, -23, -53, -54,  44, -45,   0, -11, -47, -47, -46, -47, -36, -22,  74, -53, -30;
/M: SY='V';  M= -18, -38, -54, -47,  43, -53, -45,   9, -46,  42,  -8, -49, -51, -46, -45, -40, -27,  55, -39, -18;
/M: SY='K';  M= -33, -47, -26, -13, -47, -41, -27, -46,  85, -46, -34, -19, -35, -10,  42, -28, -28, -25, -43, -35;
/M: SY='A';  M=  76, -32, -39, -32, -37, -22, -36, -29, -33, -16,  35, -34, -37, -29, -37, -14, -23, -20, -42,  -7;
/M: SY='L';  M= -37, -40, -53, -45, -11, -55, -37,  12, -21,  72,  14, -51, -52, -39, -41, -46, -32,  -9, -39,  -2;
/M: SY='A';  M=  77,  57, -39, -32, -45, -21, -40, -36, -34, -37, -32, -32, -38, -31, -38,  -2, -22, -24, -48, -42;
/M: SY='L';  M= -34,   4, -51, -44, -13, -51, -36,  -5, -44,  71,  29, -48, -51, -20, -42,  -7, -30, -12, -42, -24;
/M: SY='G';  M= -19, -46, -34, -46, -53,  92, -41, -61, -39, -56, -45, -20, -38, -37, -47, -19, -38, -54, -43, -48;
/M: SY='A';  M=  82, -31, -38, -30, -44, -20, -40, -32, -33, -35, -30, -33, -36, -29, -37, -11, -22,  -7, -46, -41;
/M: SY='D';  M= -12, -43,  60,  -3, -48, -34, -26, -46,  35, -46, -40,  12, -35, -19,  26,  12,  28, -41, -55, -37;
/M: SY='A';  M=  61,  23, -40, -36,  15,  27, -39, -18, -37,  -8,  -1, -32, -40, -34, -40,  -8, -26, -24, -41, -32;
/M: SY='V';  M= -22, -36, -51, -46, -25, -25, -54,  22, -44, -10, -13, -45, -47, -46, -46, -34,   0,  81, -56, -32;
/M: SY='M';  M=  -4,  -5, -44, -43,  29,  46, -36, -21, -40,  33,  47, -34, -44,  -9, -42, -30, -19, -25, -38, -24;
/M: SY='L';  M= -31, -40, -53, -48,   0, -54, -45,  44, -46,  48,  18, -48, -49, -42, -46, -24, -27,  42, -44, -24;
/M: SY='G';  M= -19, -46, -34, -46, -53,  92, -41, -61, -39, -56, -45, -20, -38, -37, -47, -19, -38, -54, -43, -48;
/M: SY='R';  M= -37, -53, -33, -21, -46, -47, -22, -52,  16, -45, -34, -26, -45, -10, 100, -31, -35, -46, -45, -32;
/M: SY='P';  M=  44, -46, -37, -28, -50, -15, -40, -38, -33, -45, -36, -38,  93, -33, -42, -15, -26, -20, -48, -47;
/M: SY='Y';  M=  11, -43, -46, -43,  56, -43,  -2,   6, -39, -18,  17, -41, -12, -39, -39, -32,  -4,   5,  56,  64;
/M: SY='L';  M=   7, -39, -49, -43, -18, -49,  22,  21, -43,  54,  17, -45, -48, -38, -42, -38, -29,  29, -46, -25;
/M: SY='W';  M= -43, -54, -47, -45,  38, -47,   5, -29, -38, -25, -24, -46, -52, -35, -36, -40, -40, -36, 108, 100;
/M: SY='G';  M=  36, -41, -35, -40, -50,  78, -40, -52, -37, -50, -41, -23, -37, -34, -43,  -5, -32, -42, -44, -45;
/I:         I=-24; MD=-77;
/M: SY='L';  M= -22, -40, -51, -46, -14, -53, -38,  -5, -46,  71,  14,  -6, -54, -40, -45, -44, -33,  -3, -44, -26; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='A';  M=  69, -34, -33, -31, -46,  27, -36, -39, -32, -41, -34,   8, -36, -28, -37,  16, -22, -28, -47, -42;
/M: SY='A';  M=  59,  37, -41, -35, -15, -29, -39,  -9, -36,  15,  12, -16, -41, -33, -39,  -9,  -5,   0, -46, -34;
/M: SY='G';  M=  28, -42, -20, -16, -11,  52, -31, -40,  -6, -14, -31,  -6, -40,  -2,  -9, -21, -14, -36, -35,  33;
/M: SY='G';  M= -19, -46, -34, -46, -53,  92, -41, -61, -39, -56, -45, -20, -38, -37, -47, -19, -38, -54, -43, -48;
/M: SY='E';  M=  18, -45,  -3,  60, -48, -27, -27, -38,  -5, -40, -34, -26,  -7,  40,  10,   4, -26,  -1, -49, -39;
/M: SY='Q';  M=  26, -43,  15,  28, -45, -35,  -7, -15,  25, -18, -30,  -7, -35,  41,  13, -10,   0, -32, -48, -35;
/M: SY='G';  M= -19, -46, -34, -46, -53,  92, -41, -61, -39, -56, -45, -20, -38, -37, -47, -19, -38, -54, -43, -48;
/M: SY='V';  M=  15, -36, -49, -43, -27, -46, -51,  18, -42, -13, -15, -44,  -7, -43, -44, -30,  -1,  75, -55, -33;
/M: SY='E';  M=  24, -43,   4,  34, -42, -18,   5, -39,  21, -27, -33, -24, -35,  11,  28,   7,  -5, -17, -45,  -3;
/M: SY='H';  M= -19, -47,   4,  26, -46, -37,  75, -50,  26, -44, -33,  24, -36,  26,  34,  -2, -11, -46, -54, -27;
/M: SY='V';  M=  32, -35, -48, -41, -26, -41, -47,  -1, -40,  12,  11, -42, -44, -40, -42, -28,   0,  62,  30, -30;
/M: SY='L';  M= -12, -41, -52, -46,  20, -53,   5,  41, -46,  54,  -4, -47, -50, -41, -45, -42, -31,  11, -38,   1;
/M: SY='D';  M= -22, -50,  61,  50, -53, -38, -22, -52, -12, -47, -41,  10, -34,  39,  36, -24, -15, -47, -55, -38;
/M: SY='I';  M= -32, -43, -43, -39, -22, -48, -38,  57, -13,  34,  29,   4, -44,  16, -37,  -8, -27,   5, -44, -27;
/M: SY='L';  M= -37, -40, -55, -48,  30, -56, -40,  23, -48,  67,   8, -51, -53, -43, -45, -46, -32,   4, -37, -18;
/M: SY='R';  M=  -8, -42, -10, -14, -33, -39, -28,  -6,  34,   7,  -3,  20, -39, -21,  36, -12,  26, -11, -45,  -2;
/M: SY='D';  M=  36,  14,  44,   9, -49, -15,  10, -46,  29, -44, -37,   0, -36,  15,   4,  -8, -26, -38, -52, -37;
/M: SY='E';  M= -30, -51,  42,  86, -54,  -9, -24, -55, -14, -48, -44, -22, -27,  -8, -24, -26, -30, -48, -53, -43;
/M: SY='M';  M= -10, -40, -50, -46,  43, -49, -38,  44, -42,  27,  62, -41, -44, -40, -43, -35,  16,  -7, -36, -16;
/M: SY='D';  M=   2, -47,  58,  34, -45, -39,  35, -23,  16, -17, -34, -18, -36, -18,  23, -26, -14, -22, -55, -34;
/M: SY='M';  M= -16, -40, -37, -15, -28, -43, -34,  17,  -9,  21,  34, -10, -40,  -5,  23,   9,  29,  12, -48, -30;
/M: SY='T';  M=  40,  41,   6, -30, -41, -13, -35,  -6, -30, -35, -31,  26, -37, -30, -37,   8,  45,  -8, -54, -39;
/M: SY='M';  M= -15, -39, -53, -43, -20, -45, -26,  -5, -37,  23, 118, -41, -42, -29, -35, -40, -30, -12, -43, -20;
/M: SY='A';  M=  42, -39, -34, -30, -43,  31,   1, -18, -23, -35,  15,  -7, -38,  15,  27, -18,  12, -13, -47, -36;
/M: SY='L';  M= -34, -41, -46, -40,  14, -12,   0,   1, -40,  62,  -5, -11, -50,  18, -39, -39, -32,   2, -40, -22;
/M: SY='C';  M=   3,  52,  -2, -37, -26, -24, -38,  11, -38,  39,   7, -32, -43, -35, -41,  11,  30, -16, -49, -32;
/M: SY='G';  M= -19, -46, -34, -45, -53,  91, -41, -60, -39, -56, -45, -20, -38, -37, -47, -11, -37, -53, -44, -47;
/M: SY='C';  M=  21,  88, -42, -39, -30, -40,  23,  -7, -35, -18, -24, -18, -47, -37,  -6, -13,  -4,  36, -51,   9;
/M: SY='R';  M=   5, -44, -27,   1, -47, -15, -27, -44,  17, -43, -34,   6,  17,  29,  56,  -8,  31, -38, -48, -36;
/M: SY='S';  M= -16, -38,  31, -21, -44, -29,  20, -42,   0, -44, -37,  29, -34, -21,   7,  48,  48, -35, -57, -35;
/M: SY='I';  M= -17, -41, -52, -47, -19, -55, -48,  56, -44,  36,  -6, -47, -47, -42, -23, -39, -14,  45, -47, -27;
/M: SY='A';  M=  40, -41,   4,  26, -48, -24,   5, -44,  33, -43, -35,  11, -35,   8,  16,   6, -11, -36, -48, -37;
/M: SY='D';  M=  -8, -48,  62,  52, -52, -19,   6, -49,  -3, -47, -41,  14, -33,  33, -24,  -6, -27, -31, -56, -38;
/M: SY='L';  M= -22, -41, -54, -48, -15, -56, -45,  54, -47,  55,  -2, -50, -49, -43, -47, -43, -29,  25, -44, -25;
/M: SY='D';  M= -25,   7,  39, -21, -47,  11, -29, -45,  17, -47, -40,  23,  11, -23,   6,  31,  33, -40, -55, -39;
/M: SY='P';  M=   4, -49,  -6,  -9, -45, -16,   2, -20,   3, -28,  -4, -30,  68,  -4,  42, -21,  -2, -22, -48, -38;
/M: SY='D';  M= -16, -44,  62,  17,   5, -32, -25, -45, -20, -44, -40,  13, -10,  19,   9,  31,   5, -42, -52, -32;
/M: SY='H';  M=   1, -13,  13, -33,   6, -16,  41,  16, -17,  25,   5,  11, -44, -31, -17, -11, -13, -10, -42,  15;
/M: SY='L';  M= -33, -41, -21, -17, -18, -53, -41,  40, -40,  50,  -6, -16, -48, -38, -13, -40, -28,  34, -46, -27;
/M: SY='R';  M=   2,   2,  22, -11, -18, -40,   1, -12, -21,  -6, -28,  12,  -6,  16,  37, -15, -19,  11,  21, -32;
/M: SY='T';  M= -15, -46,   2,  10,  -3, -24,  27,   2,  10, -12, -31,   4,   3, -17,   1, -17,  33, -31, -52, -32;
/M: SY='R';  M=  -2,   1, -23,   2, -48, -43, -37, -39,  -2, -23, -18,   6,  32, -29,  32,   1,  -2,  -6, -57, -44;
/M: SY='W';  M=  -8, -54,  22, -14, -47, -28,  19, -27, -15, -29, -40,   0,   8, -31,  31, -19,  -5, -14,  45, -38;
/M: SY='Y';  M= -35, -60,  -8, -45, -42, -11, -47,  -9, -20,  -6, -36, -46,  -8,  -8,   9, -44,  -9,   5, -55,  12;
/I:         E1=0; IE=-255; DE=-255;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	163 in 163 different sequences
Number of true positive hits	163 in 163 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	FMN hydroxy acid dehydrogenase
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

163 sequences

CYB2_TALSN  (B8MKR3), CYB2_WICAO  (P09437), CYB2_YEAST  (P00175),

CYBL_RHOGR  (P32953), FUB9_FUSO4  (A0A0D2YG00), FUB9_GIBF5  (S0DRI9), 
FUB9_GIBM7  (W7NCP1), GLO1_ARATH  (Q9LRR9), GLO1_ORYSI  (B8AKX6), 
GLO1_ORYSJ  (Q10CE4), GLO2_ARATH  (Q9LRS0), GLO2_ORYSI  (Q01KC2), 
GLO2_ORYSJ  (Q7XPR4), GLO3_ORYSI  (B8AUI3), GLO3_ORYSJ  (Q7FAS1), 
GLO5_ARATH  (O49506), GLO5_ORYSI  (B8B7C5), GLO5_ORYSJ  (Q6YT73), 
GOX1_MAIZE  (A0A3L6E0R4), GOX_SPIOL   (P05414), HAOX1_ARATH (Q9LJH5), 
HAOX1_HUMAN (Q9UJM8), HAOX1_MOUSE (Q9WU19), HAOX1_RAT   (B0BNF9), 
HAOX2_ARATH (Q24JJ8), HAOX2_BOVIN (Q3ZBW2), HAOX2_HUMAN (Q9NYQ3), 
HAOX2_MOUSE (Q9NYQ2), HAOX2_RAT   (Q07523), HAOX_DICDI  (Q54E41), 
HAOX_ORYSI  (B8B8K5), HAOX_ORYSJ  (Q8H3I4), HMO_AMYOR   (O52792), 
LLDD_ACIAD  (Q6FFS1), LLDD_ACIB3  (B7H2H0), LLDD_ACIB5  (B7IBS4), 
LLDD_ACIBC  (B2I061), LLDD_ACIBS  (B0VND0), LLDD_ACIBT  (A3M0X0), 
LLDD_ACIBY  (B0V6L1), LLDD_ACTP2  (A3N3E5), LLDD_ACTP7  (B3GZA5), 
LLDD_ACTPJ  (B0BTC7), LLDD_ALCFA  (Q6WB83), LLDD_ALLAM  (B9K115), 
LLDD_AZOC5  (A8HTC9), LLDD_BARHE  (Q6G4R2), LLDD_BARQU  (Q6G0J2), 
LLDD_BART1  (A9IN89), LLDD_CAUSK  (B0T7X2), LLDD_CAUVC  (Q9A943), 
LLDD_CAUVN  (B8H3Q5), LLDD_CHRSD  (Q1R0J2), LLDD_CITK8  (A8ARJ1), 
LLDD_CROS8  (A7MNF6), LLDD_ECO24  (A7ZTF9), LLDD_ECO27  (B7ULG1), 
LLDD_ECO45  (B7MFG9), LLDD_ECO55  (B7L725), LLDD_ECO57  (Q8XDF7), 
LLDD_ECO5E  (B5YWA7), LLDD_ECO7I  (B7NPB4), LLDD_ECO81  (B7N251), 
LLDD_ECO8A  (B7M492), LLDD_ECOBW  (C4ZXJ7), LLDD_ECODH  (B1X8M0), 
LLDD_ECOHS  (A8A670), LLDD_ECOK1  (A1AHE2), LLDD_ECOL5  (Q0TBK1), 
LLDD_ECOL6  (Q8FCB1), LLDD_ECOLC  (B1IZI5), LLDD_ECOLI  (P33232), 
LLDD_ECOLU  (B7NER0), LLDD_ECOSE  (B6I3I4), LLDD_ECOSM  (B1LK44), 
LLDD_ECOUT  (Q1R4Z0), LLDD_ECTM1  (A4XYG7), LLDD_ENT38  (A4W540), 
LLDD_ESCF3  (B7LTL2), LLDD_HAEDU  (Q7VPI9), LLDD_HAEI8  (Q4QJK8), 
LLDD_HAEIE  (A5UBE3), LLDD_HAEIG  (A5UFG9), LLDD_HAEIN  (P46454), 
LLDD_KLEP3  (B5XMV0), LLDD_KLEP7  (A6TFK0), LLDD_MYCTO  (P9WND4), 
LLDD_MYCTU  (P9WND5), LLDD_PECAS  (Q6DAY3), LLDD_PSEA7  (A6VCM8), 
LLDD_PSEA8  (B7V1I3), LLDD_PSEAB  (Q02FQ1), LLDD_PSEAE  (Q9HV37), 
LLDD_PSEE4  (Q1IF69), LLDD_PSEFS  (C3K053), LLDD_PSEP1  (A5W9B2), 
LLDD_PSEPG  (B0KIT4), LLDD_PSEPK  (Q88DT3), LLDD_PSEPW  (B1J244), 
LLDD_PSEU2  (Q4ZY06), LLDD_SALA4  (B5EXA8), LLDD_SALAR  (A9MLC3), 
LLDD_SALCH  (Q57ID8), LLDD_SALDC  (B5FLH2), LLDD_SALEP  (B5R5C7), 
LLDD_SALG2  (B5RGI4), LLDD_SALHS  (B4T986), LLDD_SALNS  (B4SXA4), 
LLDD_SALPA  (Q5PLQ7), LLDD_SALPB  (A9MVJ5), LLDD_SALPC  (C0Q1T7), 
LLDD_SALPK  (B5BHX7), LLDD_SALSV  (B4TZU7), LLDD_SALTI  (Q8Z2E5), 
LLDD_SALTY  (Q8ZL61), LLDD_SERP5  (A8GIL1), LLDD_SHIB3  (B2U5C2), 
LLDD_SHIBS  (Q31V17), LLDD_SHIDS  (Q329P9), LLDD_SHIF8  (Q0SYD1), 
LLDD_SHIFL  (Q83PP7), LLDD_SHISS  (Q3YVX0), LLDD_STRM5  (B4SMK1), 
LLDD_STRMK  (B2FIJ0), LLDD_VIBCH  (Q9KKW6), LLDD_VIBCM  (C3LWP7), 
LLDD_VIBPA  (Q87G18), LLDD_XANAC  (Q8PR33), LLDD_XANC8  (Q4V0H2), 
LLDD_XANCB  (B0RLM2), LLDD_XANCP  (Q8PE75), LLDD_XANE5  (Q3BZH2), 
LLDD_XANOM  (Q2P9K0), LLDD_XANOP  (B2SUY3), LLDD_XANOR  (Q5H6Z4), 
LLDD_XANP2  (A7IMB0), LLDD_YERP3  (A7FJF0), LLDD_YERPA  (Q1C9P0), 
LLDD_YERPB  (B2JZQ1), LLDD_YERPE  (Q8ZFV8), LLDD_YERPG  (A9R623), 
LLDD_YERPN  (Q1CGZ1), LLDD_YERPP  (A4TKI4), LLDD_YERPS  (Q66C32), 
LLDD_YERPY  (B1JPU0), LMO_MYCSM   (P21795), LOX_AERVM   (Q44467), 
LOX_ALIDK   (F4G5A4), LOX_CHLRE   (F8WQN2), LOX_LACJE   (A0A5N1I561), 
LOX_LACRM   (C2K1F0), LOX_LENH9   (C0XIJ3), LOX_LYSSC   (B1HZY7), 
LOX_NOSS1   (Q8Z0C8), LOX_ROSS0   (B7RR92), LOX_STRIN   (O33655), 
MDLB_PSEPU  (P20932), MFTD_MYCS2  (A0QSB9), MFTD_MYCTO  (P9WND6), 
MFTD_MYCTU  (P9WND7), MFTD_MYCUA  (A0PM50), QULF_PENCI  (P0DUR7), 
YKN3_SCHPO  (Q9HDX2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

102 PDB

1AL7; 1AL8; 1FCB; 1GOX; 1GYL; 1HUV; 1KBI; 1KBJ; 1LCO; 1LDC; 1LTD; 1P4C;
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