PROSITE entry PS51344

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51344
Entry name [info]	HTH_TFE_IIE
Accession [info]	PS51344
Entry type [info]	MATRIX
Date [info]	01-DEC-2007 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51344
Associated ProRule [info]	PRU00676

Name and characterization of the entry

Description [info]

TFE/IIEalpha-type HTH domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=89;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=84;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7896526; R2=0.0077522; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=13692.6064453; R2=1.8483009; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=737; H_SCORE=15055; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=479; H_SCORE=14578; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-92; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='M';  M=  27, -14,  14, -24,  27, -91,-215,  -8, -52,  18,  44,  30, -64,-215, -94,-212, -62,   4,-223,  12;
/M: SY='N';  M= -93,-228,  35,   1,-227,-218, -48,  -6,  62, -62,-216,  63, -30,   1, -12, -17,-207, -25,-235,-219;
/M: SY='P';  M= -94,-229,  35,  26, -42,-219,-209,-227,  23,-226,  -3,  -1,  42,  19,  42,  14,  19,-224,-232,-219;
/M: SY='L';  M=  16,-220,-227, -14, -43,-229,-221, -10, -29,  74, -46,-227, -53,-217,-221, -63,-211,  13,-225,-208;
/M: SY='V';  M=   4,-221,-231,-225, -31,-231, -57,  48, -32,  32, -30,-225,-228,-222,-223,-217, -39,  64,-225,   2;
/M: SY='R';  M= -96,-230,-212, -25, -34,-225, -27, -44,  57,   2,-207, -37,-222,  48,  76, -83,-212, -54,-222, -12;
/M: SY='C';  M= -10,  45,  -7,  14,  22, -30,-210, -23,   2, -10,  38, -44,-222,  28, -32,  -2, -11, -74,-217,  43;
/M: SY='V';  M= -25,  10,-229, -53, -29,-231,-219,  27,-223,   5,  -8,-226, -30,-222,-224,-217,-207,  74,-216,  64;
/M: SY='V';  M=  40,-218,-228,-222, -42,-108,-225,  23, -70,  15,  33,-221,-225,-219,-223, -82,   7,  66,-229,-211;
/M: SY='R';  M=-216,-230,-213,  -7, -28, -60,  22,-100,   0, -20,-208,-209,-224,  -3,  95, -55, -65, -17,-219,  37;
/M: SY='K';  M=  19,-223,  16,   7,-224,  36,-212, -28,  37, -25,  28,  -8,-218, -29,  -6,  11, -22,-214,-229,-218;
/M: SY='F';  M= -86,-221,-234,-228, 102,-231,-219,  19, -44,  24,  33,-225,-231,-226, -62, -23,-213, -25,-203,-183;
/I:         I=-28; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='Y';  M= -59,-227,-224,-225,  29, -24, -17,   7,-219, -27, -16, -47,-230,-216,-218,-216, -73,  17,-192, 115;
/M: SY='D';  M=-206, -10,  74,  36,-233,  70,-212,-235,-209, -91,-226,-197, -28,-206,-217,   9, -72,-229,-234,-224;
/M: SY='D';  M= -75,-224,  66,  42,-224, -48,-209,   7,   9, -38,-215,  11, -13,-202, -66,  24,  29, -60,-235,-218;
/M: SY='E';  M= -66,-230,  35,  81,-225,-221, -21, -36,  15,-222,-217, -70,  37, -23, -12, -17, -82, -21,-228,   0;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='H';  M=  50,-222, -34,   1, -72,  34,  79,-214, -48,-215, -17, -56,-220, -32,-213, -72,-209,  12,-221,  47;
/M: SY='I';  M=  11,-221,-226, -43,   2,-228,-224,  60, -12, -13,  23,-221,-224,-216,   4, -49, -74,  58,-225,-207;
/M: SY='L';  M= -36,-223, -16,  12,-208, -84, -24,  15,  22,  40,  31, -40,  -6, -75,  17,-214,-208,  36,-227,-210;
/M: SY='V';  M= -26,-219,-232,-227, -49,-232,-231,  67,-224, -15,   5,-225,-226,-224,-226,-216, -27,  82, -17,-208;
/M: SY='L';  M=  -9,-219,-233,-226,  24, -64,-222,  40,-225,  57,  54,-227,-228,-221,-224,-219,-209,  44,-221,-202;
/M: SY='D';  M= -67,-229,  98,  48,-228, -78, -24,-230,   6, -82, -49, -11,-215, -49,   1, -35,-207,-227,-236,  -8;
/M: SY='A';  M=  68,   4,-217, -21, -45, -35,   9,   1, -32,  -2,  37, -43,-220, -74, -34, -31, -33,   0,-225, -50;
/M: SY='L';  M=-216,-220,-234,-227,  24, -85,-219,  26, -82,  83,  24,-230, -42,-221,-224,-225,-212, -30,-218,-200;
/I:         I=-15; MD=-38;
/M: SY='T';  M= -56, -15,-229, -39, -27,-234,-223,  39,-225,  35,  34,-224, -26,-222,-227,-217,  45,  11,-225,  27; D=-15;
/I:         I=-15; MI=0; MD=-38; IM=0; DM=-38;
/M: SY='R';  M= -74,-227, -77,  -4,   9, -65,-208,   2,  28, -65, -42,  -6,  39, -11,  79, -44,  -1, -58,-222, -32;
/M: SY='H';  M= -23,-226,  23,  27, -49, -12,  84,-226,  32,-104, -55,  42,-217,  -5,  24, -85, -39,-223,-225,  29;
/M: SY='Q';  M= -57,  -7,-204,  27,-227,  40,-209, -82,   1, -74,-215,  -9,  24,  57, -23,  43,  14, -56,-228,-218;
/M: SY='W';  M= -12,  72,   1,  67,-214, -71,-218, -17, -78, -42,-211, -81,  -7,-204, -26, -55,-210,  27,  99,-210;
/M: SY='V';  M= -21,-218,-229, -70, -23,-230, -18,  32,-221,  39,  60,-224,-226,-219, -76,-216, -50,  68,-224,  -9;
/M: SY='T';  M= -40,-218, -46,-204,-218,-215,   0, -69,  29, -66,-211, -40, -13,-201,  48,  42,  79, -52,-229, -34;
/M: SY='D';  M= -60,-229, 100,  82,-233,-218,-203,-231,-198, -67,-225,-193, -88,-194,-208,-205, -48,-226,-240,-220;
/M: SY='E';  M= -74,-228,  70,  96,-230,-221,-204, -56,  -1, -74,-221,-199,-209,-190, -48,-205,  -5,-222,-234,-220;
/M: SY='D';  M= -82,-229,  97,  63,-232,-217,  19,-228, -67,-226,-222, -39,-213,  26, -17, -55, -57, -37,-240,-217;
/M: SY='L';  M=-214,-220,-233,-227,-193,-235,-221,  65,-226,  77,  39,-229,-228,-220,-225,-224, -54, -31,-222,-204;
/M: SY='A';  M=  83,  18,-215, -25,-220,   4, -35, -55, -16, -30,  -9,-209,-217,-208,-214,   1, -37, -18,-226,-218;
/M: SY='E';  M= -25,-225, -20,  66, -53,-219,  23, -24,  41, -13,-209,   4,-214,  23,   5,  -8, -23,-214,-223,  13;
/M: SY='L';  M= -32,-222,  17,  34, -62,-222,-210, -19,  27,  54, -51, -32,-220,  -1,  18,   5, -72, -95,-225,-210;
/M: SY='L';  M= -66,-217,-226,-221,-197,-228,-218,   7,-220,  75,  44,-220,-224,-216,-221, -22,  51, -11,-225,-205;
/M: SY='G';  M=-205,-225, -15, -17,-229,  69, -10,-231,  57,-229, -21,  44,-216,   4,  -2, -12,-208,-227,-227,-219;
/M: SY='M';  M=-212,-220,-231,-225,  43,-232,-217,  62, -55,  35,  76,-223,-226,-219, -62,-219, -27,  25,-214,  11;
/M: SY='N';  M=-209,-224,  42,   7,-226, -82,  29,-224,  53, -44, -40,  59,  15,  39, -16,  27,-202,-223,-231,-214;
/M: SY='L';  M= -20,-222, -46, -18, -27,-221,-211,  12,  26,  32,-199, -58,  19,  28,  32,  -4,  18, -14,-223, -44;
/M: SY='N';  M= -34,-221,-196,-198,-226,-209,-201, -69,  83,-226,-215,  94, -23, -25, -10, -62,  -9,-221,-230,-217;
/M: SY='Q';  M= -64,-225,  39,  62, -59,-219, -17,  -9,  -6, -97,  19, -38,-213,  71, -18, -39,  19, -16,-227, -39;
/M: SY='V';  M= -74, -20,-230,-225,-197,-232,-225,  32,-224,  61,-185,-226,-227,-222,-224,-217,  -4,  73,-227,-206;
/M: SY='R';  M=-215,  13, -40,-202,-225, -26,  20,-232,-177,-225,-214, -43,-224,-192, 118,-209,-215,-226,-227,-212;
/M: SY='K';  M= -29,-226, -40, -21, -49,-218,   0,-224,  77, -46,-212, -74, -24,  27,  64,  12, -49,-221,-224,-212;
/M: SY='I';  M=  13,  -8,-224,-220,-201,-226, -13,  69, -36,  33,-191,-217,-223, -59, -36, -94,  34,   4,-223,   5;
/M: SY='L';  M= -71,  63,-233,-227,-194,-233,-221,  30,-226,  84, -16,-228,-232,-221,-226,-222, -52, -60,-224,-206;
/M: SY='Y';  M=  11,-223,-210, -26,  25,   9,   3, -60,-204,-211, -26,  33,-222,  23,  24, -20,  -1, -74,-205,  85;
/M: SY='K';  M= -22,-222, -16,-205,  20, -82, -30,   7,  55, -17, -55, -17,-219,  -7,  29, -18,  39, -57,-217,  28;
/M: SY='L';  M=-217,-219,-234,-226,  19,-235,-217,-182,-227,  95,  -3,-232,-233,-221,-224,-226,-213,-190,-217,-199;
/M: SY='Y';  M= -35,-227,-204,  50, -35, -71,  36,-215,  40, -51,  15, -26,-218, -32,  40, -49,-210, -30,-210,  76;
/M: SY='E';  M= -42, -32,  50,  85,-230, -12,-205,-230,  20, -73,-220,  -9,-211, -36,  17, -39, -60,-224,-231,-220;
/M: SY='D';  M=  10,-226,  79,  25,-226,-214,  48, -77,  -9, -72,  20,  37,-216,  46, -41,-203,-207, -76,-235, -54;
/M: SY='R';  M= -74,-227, -48,-202,-225,  43, -42,-227,  64, -74,  20,   3,-218, -26,  75, -37,-210,-223,-225,-215;
/M: SY='L';  M=-217,-220,-235,-228,  68,-234,-219,  36,-227,  71,  46,-229,-231,-223,-225,-225,-212, -49,-212,-192;
/M: SY='V';  M=  41, -15,-229,-223,-204,-224,-228,  58,-222,  18,-191,-223,-225,-220,-225, -65,-204,  68,-228,-210;
/M: SY='K';  M=   0,-220,   9, -13,-220,  -7,-211, -14,  41, -98,  23, -24,-216, -20,  22,  26,  37,   7,-229,-215;
/M: SY='Y';  M=-211,  44, -64, -20, -11, -77,-203, -23, -54,-207,-204, -37,-226, -46,  54,   9, -51,  31,-205,  92;
/M: SY='H';  M= -55,  13,   6, -57, -39,-221,  79, -22,  26,-216,-209, -22,-221, -38,  78, -35, -63, -15,-225,  20;
/M: SY='R';  M=-210,-224, -55, -12, -69,-220,  52, -48,  32, -44,  23, -39,-218,  19,  69,   8,  40, -43,-227, -34;
/M: SY='R';  M= -96,-226,-205,  36,-221, -42, -30,   1,  29, -80,-208,  -7,-217,  52,  65, -46,   3,  15, -28,-213;
/M: SY='R';  M= -75,-226,-211, -52, -57,-222,-207,-215,  64, -48,  -5,-205,   8,  -3,  78, -40,  17,  -8,-223, -23;
/M: SY='E';  M= -39,-226,  73,  81,-230,-216,   5,-225, -47,-225,-220,  37,-212, -32, -62, -51, -17, -20,-237,-219;
/M: SY='E';  M= -69,-224,  11,  47, -43, -72,-209, -31,  45, -33,   9,   3,  38, -50,-202,   1,  32, -28,-226, -14;
/M: SY='D';  M=  20,-223,  51,  48,-228, -20,-206, -60, -33,-224,-217,  37, -24,  24,  23, -22,  21,-218,-232,-219;
/I:         I=-13; MD=-32;
/M: SY='E';  M=  -9,-251, -11,  31,-249, -10, -21, -56,  -3, -74,-239, -35,  22, -59, -63, -84, -79, -90,-252, -60; D=-13;
/I:         I=-13; MD=-32;
/M: SY='W';  M= -64,-253,  35,-230,-248,  24,-236, -52, -47, -51,-243,  31,-247, -33,  -8,-230,-237,-248,  44,-241; D=-13;
/I:         I=-13; MD=-32;
/M: SY='Q';  M=  -4,-246, -40,-229, -40,  11,-232,-245, -46,-244,   6,  18, -15,  34, -23,  -9, -22,-242,-251,-239; D=-13;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='H';  M= -70,-247, -46,-234, -70,-248,  46,  -7, -80, -65,-226, -10,-247,  16, -23,-231,  13,  21,-253, -12; D=-13;
/I:         I=-13; DM=-32;
/M: SY='T';  M=-231,-245,-224,  -1,-247,-238, -22,-245,  19, -78, -47,  34,-239, -51,  -1,   3,  37,-240,-257,-240; D=-13;
/I:         I=-13; DM=-32;
/M: SY='H';  M=-210,-224,-213,-209, -33,-221,  63, -24,  13,-218,-212,-204, -43,-204,  54,  43,  56, -20,-229,   8; D=-13;
/I:         I=-13; DM=-32;
/M: SY='N';  M=-204, -50,-204,  -2,-218,  53,-208, -23, -27,-220, -53,  56,-217,  13, -62,  31,  35, -29,-225,  19; D=-13;
/I:         I=-13; DM=-32;
/M: SY='W';  M= -73,-231,-223,-217, -43,-222,  44,-210, -34, -41,-205,-218,-226,-208,  20, -10, -44, -20, 134,  98;
/M: SY='Y';  M=-215,  59, -46,-220,  35,-226,-202,   2,-217,  20, -38, -21,   1,-216,-217,-212,  18, -64,-197, 104;
/M: SY='Y';  M=-208,  48,-212,  11,  31,-222,  11, -20, -18, -81,-202,-209,-220,-209, -56,   5,  55,  23,-207,  82;
/M: SY='Y';  M=-215,-226,-223,-222, -51,-229,  27,  67,-218,  13,-191,-219,-226, -46,-217, -55, -17, -58,  38, 105;
/M: SY='Y';  M= -91,-222,  61,-202, -51,-215,  47,-211, -16,  16,-205,  57, -23,-204, -61, -23,  11,-213,-214,  77;
/M: SY='W';  M= -69,  13,-232,-225,   8,-223,-212, -83,-218, -57,-208,-228,-229,-216,-218, -37, -79, -57, 153,  99;
/M: SY='R';  M=  10,  37, -46, -37,-213, -54,  48, -43,  39, -76,-209,-203,  -1, -28,  69, -46,  19,-214,-220,  37;
/M: SY='Q';  M= -25,-222,-217, -25,  15,-224,  13,  46, -36,  29, -44,-213,  14,  56, -14, -35,   1,  14,-221,-203;
/M: SY='N';  M=  16, -17,  53, -10,  13,-213, -74,  -8, -27, -33,-207,  58,-218, -48, -14, -36,  23,  16,-228, -40;
/M: SY='Y';  M=-211, -22,   5, -70, -24,-225,-209,  50,-213,  13, -44, -35,  15, -25,  -7, -16, -34,  24, -15,  76;
/M: SY='D';  M= -39,-225,  93,  48, -77, -88, -12,-227,  -2, -99, -10,  47,-213, -49, -10, -33, -34,-223,-237,-216;
/M: SY='V';  M=  24,-218,   0,  10,-216, -72,  -4, -11,  31, -70,-204,  33, -71,  14, -33, -13, -11,  53,-230,-213;
/M: SY='I';  M= -54, -15,-228,-226,  -1,-230,-226,  85,-223,   7, -19,  -6,-224,-221,-225, -55, -38,  55,-224,-204;
/M: SY='K';  M= -25,  33, -15,  10,-220,-217, -51, -16,  70, -37,-210,  35,  34, -63,  41, -60, -73, -85,-225, -32;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	60 in 60 different sequences
Number of true positive hits	60 in 60 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	HTH TFE/IIEalpha-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

60 sequences

EFUD_HORCR  (A0A2Z4HPY1), T2EA_BOVIN  (A6QLI8), T2EA_DICDI  (Q557M8),

T2EA_HUMAN  (P29083), T2EA_MOUSE  (Q9D0D5), T2EA_PONAB  (Q5R8H5), 
T2EA_SCHPO  (Q9P3W1), T2EA_YEAST  (P36100), TFE_AERPE   (Q9YAD5), 
TFE_ARCFU   (O29501), TFE_CALMQ   (A8M8Z5), TFE_CENSY   (A0RYF4), 
TFE_HALMA   (Q5V3R0), TFE_HALSA   (Q9HRC7), TFE_HALWD   (Q18HD8), 
TFE_HYPBU   (A2BLW2), TFE_IGNH4   (A8ABJ9), TFE_META3   (A6UW55), 
TFE_METAC   (Q8TJB7), TFE_METAR   (Q0W8N8), TFE_METB6   (A7I7T6), 
TFE_METBF   (Q46G12), TFE_METBU   (Q12YV9), TFE_METHJ   (Q2FT22), 
TFE_METJA   (Q58187), TFE_METKA   (Q8TY11), TFE_METLZ   (A2SQM6), 
TFE_METM5   (A4G0F7), TFE_METM7   (A6VI24), TFE_METMA   (Q8PZ06), 
TFE_METMJ   (A3CVQ3), TFE_METMP   (Q6M181), TFE_METS3   (A5UKV8), 
TFE_METS5   (A4YJ15), TFE_METST   (Q2NEV4), TFE_METTH   (O27705), 
TFE_METTP   (A0B9P3), TFE_METVS   (A6UR14), TFE_NANEQ   (Q74MZ3), 
TFE_NATPD   (Q3IP08), TFE_PYRAB   (Q9UYS6), TFE_PYRAE   (Q8ZYH0), 
TFE_PYRAR   (A4WGY5), TFE_PYRCJ   (A3MY45), TFE_PYRFU   (Q8U3H5), 
TFE_PYRHO   (O58353), TFE_PYRIL   (A1RTG5), TFE_PYRNV   (B1YA16), 
TFE_SACS2   (Q980M5), TFE_STAMF   (A3DN07), TFE_SULAC   (Q4JAZ3), 
TFE_SULIA   (C3MZJ0), TFE_SULIK   (C4KIS0), TFE_SULIL   (C3MRF5), 
TFE_SULIM   (C3MY51), TFE_SULIN   (C3NFW2), TFE_SULIY   (C3N7L2), 
TFE_SULTO   (Q975T8), TFE_THEKO   (Q5JDD5), TFE_THEPD   (A1RY32)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

77 PDB

1Q1H; 5FMF; 5FYW; 5FZ5; 5GPY; 5IY6; 5IY7; 5IY8; 5IY9; 5IYA; 5IYB; 5IYC;
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