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PROSITE entry PS51332


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PURL: https://purl.expasy.org/prosite/signature/PS51332

Direct ScanProsite submission
General information about the entry

Entry name [info] B12_BINDING
Accession [info] PS51332
Entry type [info] MATRIX
Date [info] 01-NOV-2007 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51332
Associated ProRule [info] PRU00666

Name and characterization of the entry

Description [info] B12-binding domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=132;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=127;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9990491; R2=0.0080712; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=14585.9687500; R2=8.5937500; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=1252; H_SCORE=25345; N_SCORE=12.1; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=558; H_SCORE=19381; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-22; D=-180; I=-180; B1=-400; E1=-400; MI=-155; MD=-155; IM=-155; DM=-155;
...
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Post-processing [info]

PROMOTED_BY PS51337

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 102 in 102 different sequences
Number of true positive hits 102 in 102 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 97.14 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Feature key [info] DOMAIN
Feature description [info] B12-binding
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
102 sequences

BCHE_CERS4  (Q9RFD3), BCHE_RHOCB  (P26168), BCHE_RUBGE  (Q7X2C7), 
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UniProtKB/Swiss-Prot
False negative sequences
3 sequences

CARH_THET8  (Q53W62), HPNP_RHOPT  (B3QHD1), YHGF_NEIGO  (Q51062)

		
PDB
[Detailed view]
58 PDB

1B1A; 1BE1; 1BMT; 1CB7; 1CCW; 1E1C; 1FMF; 1I9C; 1ID8; 1K7Y; 1K98; 1REQ;
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