PROSITE entry PS51332

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51332
Entry name [info]	B12_BINDING
Accession [info]	PS51332
Entry type [info]	MATRIX
Date [info]	01-NOV-2007 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51332
Associated ProRule [info]	PRU00666

Name and characterization of the entry

Description [info]

B12-binding domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=132;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=127;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9990491; R2=0.0080712; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=14585.9687500; R2=8.5937500; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=1252; H_SCORE=25345; N_SCORE=12.1; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=558; H_SCORE=19381; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-22; D=-180; I=-180; B1=-400; E1=-400; MI=-155; MD=-155; IM=-155; DM=-155;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-155; BD=-155;
/M: SY='K';  M=  -3, -56, -33, -30, -80, -15,  -2, -41,  47, -43,  45,  28,  43,  -1,  36, -28, -15, -20, -53, -60;
/M: SY='G';  M=  -6, -52, -41, -50, -41,  44, -14,  15,  14,  -9, -17, -30,  40, -44,  -4,  -2, -37,  -1, -59,   4;
/M: SY='R';  M= -27, -29, -13, -41, -61, -47,  12, -18,  54, -27, -54, -33,   6, -25,  59, -14,  29, -15, -20, -44;
/M: SY='I';  M= -12, -24, -47, -60,  24, -56, -42,  55, -68,  17,  12, -61,  -8, -52, -65,  -9, -50,  52, -36, -51;
/M: SY='V';  M= -48, -36, -42, -62, -25, -26, -69,  29, -61,  49,  30, -43, -37, -62, -36, -42, -26,  54, -24, -38;
/M: SY='M';  M= -13, -12, -67, -76,   4,   4, -68,  37, -61,  25,  38, -32, -34, -63, -66, -30,  30,  33, -81,  -3;
/M: SY='A';  M=  70, -33, -47, -46, -16,  25, -10, -31, -48, -32, -60, -52, -32, -31, -65,   3,  13, -10, -62, -52;
/M: SY='T';  M=  -5,  34, -53,  -3, -46, -50, -34, -24,  44, -20, -45, -43,  -6, -63,  -3,  -5,  67,  -8, -87, -27;
/M: SY='V';  M=  -7, -65, -29, -64, -35, -54, -32,  22, -58, -11,  28,   5,  52, -43, -43,   6, -19,  54, -63, -21;
/M: SY='G';  M=   8, -82, -19,   8,  -4,  45, -49, -60,  43,  -7, -57, -14,  21, -35, -14, -10, -59, -37, -79,  -6;
/M: SY='G';  M= -35, -53, -13, -18,  36,  56, -63, -38,  -2,   8, -37,  -6, -44,  32, -26, -12, -18, -54, -59,  -9;
/M: SY='D';  M= -41,   0,  97,   8, -21, -41, -42, -60, -50, -50, -41,  -4, -26, -53,   3, -25, -18, -54, -91,  18;
/M: SY='W';  M= -14, -40, -69, -28, -23,  46,  -9,  11, -67, -12,   5, -55, -28,   0, -46, -17, -40,  48,  58, -14;
/M: SY='H';  M= -45, -87, -42,  -9, -28, -55, 132, -48, -43, -29, -26, -43,  18, -30, -50, -40, -14, -69, -95,   6;
/I:         I=-25; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='D';  M= -24, -33,  82, -26, -67, -61, -43, -67, -56, -86, -72,  11,  73, -51, -48,  17,   3, -41, -61, -80;
/M: SY='I';  M=   8, -53, -76, -79, -22, -63, -77,  59, -48,  41, -22,  -6, -62, -60,  28, -49, -42,  11, -60, -14;
/M: SY='G';  M=  19, -65, -73, -64, -86,  92, -66, -91, -49, -81, -80, -47, -22, -72, -66, -12, -60, -76,  30, -50;
/M: SY='K';  M=  26, -51, -62, -56, -24, -76, -60,  35,  51,  35, -28, -44, -35, -12, -46, -60, -36,   5, -13, -37;
/M: SY='N';  M=  -7,  -3, -11,  10, -29, -24, -23, -36,  23,   4,  -7,  75,  -7, -44,  18, -39, -40, -36, -34, -33;
/M: SY='Y';  M= -14, -20, -66, -48, -25, -83, -59,  49, -54,  18,  22, -20, -83,  12, -39,   0, -40,  25, -54,  65;
/M: SY='V';  M= -35, -65, -92, -86, -18, -92, -84,  55, -84,  44,  36, -86, -78, -81, -84, -78, -59,  63, -84, -52;
/M: SY='A';  M=  64, -47,  11, -22, -69,  21, -34, -44,   2, -22, -24, -35, -64, -51,   9,   9, -29, -38, -84, -35;
/M: SY='R';  M=  36, -49,  -8, -18, -42,  10, -46,   6, -46, -42,  -2,  -6, -66, -37,  38,  13,  15,  17, -86, -38;
/M: SY='A';  M=  35, -42, -53, -59,   8, -47, -26,  33, -69,  -4,  29, -32, -25, -14,  -8, -16, -25,  33, -18,  29;
/M: SY='L';  M=   8,  -9, -88, -81,  30, -65, -76,  -6, -24,  71,  21, -84, -72, -71, -79, -59, -37,  -6, -76, -44;
/M: SY='R';  M=  13, -83, -39,  30, -83, -13, -16, -55,  14, -46, -25, -39, -47,  48,  64,   6,  -9, -30, -85, -67;
/M: SY='C';  M=  19,  56,  54,  18, -51, -17, -28, -73,   0, -38, -56,  35, -27,   7,   0,   1, -46, -57, -57, -22;
/M: SY='N';  M=  42,   2,  -4,  -4, -46, -33,  24, -41, -27, -10,  -8,  61, -67,   7,   6,  -5, -12, -40, -88, -26;
/M: SY='G';  M= -38, -64, -16, -60, -56,  91, -30, -44, -58, -55, -63,  25, -32, -32, -44, -40, -63, -50, -50, -70;
/I:         I=-32; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='Y';  M= -14,  -9, -39, -45,  65, -61,  46, -11, -57, -25,  38, -43, -73, -74, -51, -60, -34,  10,  66,  71;
/M: SY='E';  M= -31, -76,  56,  77, -70, -67,  -5, -71,   2, -70, -78,  12, -40,  14,   7, -18, -13, -67, -91, -50;
/M: SY='V';  M= -16,   1, -65, -76, -42, -73, -88,  35, -73, -20, -15, -56, -65, -81, -83, -36,   1,  86, -91, -53;
/M: SY='I';  M= -37, -64,  19, -20, -36, -52, -10,  59,   2, -30, -57, -45, -43,  -1,  15, -28,  -5,  42, -68, -24;
/M: SY='D';  M= -49, -83,  53, -31,  18, -78,  41,  31, -62,   6,  -5,  36, -49, -39, -60, -38, -45,  -6, -76,  52;
/M: SY='L';  M=  -9, -43, -38, -32, -10, -12, -40,  20, -61,  61,  14, -62, -40, -35, -23, -33,  -1,  -4, -79,  -6;
/I:         I=-11; MD=-9;
/M: SY='G';  M= -60, -88,  55,   1, -81,  77, -51, -80, -67, -81, -72,  -3,  14, -65, -48, -45, -37, -78, -90, -44; D=-11;
/I:         I=-11; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='I';  M=  -5, -42,  -6, -15, -31, -30,  41,  42, -40,  21, -35, -24, -26, -17, -16, -15, -15,  31, -85, -10;
/M: SY='M';  M= -23, -53,  37, -29,  13, -14,   5, -44,  16, -34,  53,  49, -12,  36,  16, -25, -37, -57, -27, -30;
/M: SY='V';  M= -16, -42,  11, -19, -60, -52, -15, -20, -37,  -1,  14, -17, -40,  52,  22, -37,   0,  55, -37, -47;
/M: SY='P';  M= -20, -64,   2, -24, -35, -23, -26, -40, -30, -38, -72, -21,  77, -33, -27,  44,  46, -62, -87, -23;
/M: SY='P';  M=   8,  16,  -9, -27, -39, -52, -24,  13, -39, -12, -35,  -6,  66, -14, -24, -18,   6,  28,  12, -34;
/M: SY='E';  M=  11, -42,  47,  71, -34, -28,  -2, -67, -15, -58, -25, -18,   3,  13, -16,  -3, -28, -72, -71, -64;
/M: SY='E';  M=   3, -72,  37,  63, -66, -46,  -5, -62,  27, -51, -23,  -1, -65,  34,   7, -17,  -6, -50, -39, -30;
/M: SY='I';  M= -15, -24, -28, -74,  28, -75, -74,  68, -74,  24,  -3, -57, -70, -76, -64, -39, -12,  34, -34, -12;
/M: SY='V';  M=  22, -62, -41, -26, -30, -71, -80,  37, -43,  33,  -7, -46, -40, -27, -25, -46, -47,  53, -45, -32;
/M: SY='E';  M=  21, -64,  37,  52, -56, -36, -27, -72,  17, -59, -53,   8, -60,  35,  23,  -4,  -6, -51, -58, -56;
/M: SY='A';  M=  54, -24, -16,  11, -36, -62,   2, -21,  11, -29, -41, -44, -48,  22,  15,  -3,  24, -30, -47, -35;
/M: SY='A';  M=  66, -26, -72, -65, -28, -63, -80,  38, -53,  20, -34, -66, -80, -29, -53, -63, -51,  27, -64, -19;
/M: SY='I';  M= -17, -58, -25,  21, -47, -65,   5,  40,  23,  17,  -8, -44, -79,  -1,  33, -47, -35,  10, -81,  -1;
/I:         I=-35; MI=0; MD=-30; IM=0; DM=-30;
/M: SY='E';  M=  18, -84,  28,  60, -70, -44, -28, -61,  20, -54, -51, -27, -61,  54,  23, -16, -22, -57, -61, -61;
/M: SY='E';  M= -17, -33, -29,  61,  13, -33,  60, -38, -15, -19, -48,  20, -51,  -3,  -3, -14, -10, -29,  24, -13;
/M: SY='D';  M= -22, -47,  61,  -1, -72,   4, -14, -87,  43, -74, -64,  34, -16,  39,  29, -26, -45, -77, -64, -75;
/M: SY='P';  M=  51, -16, -65, -70, -33, -68, -61, -34, -62, -66, -67, -78,  90, -74, -80, -53, -45,  37, -40, -13;
/M: SY='D';  M= -42, -61,  99,   0, -66, -47,  45, -61, -22, -56, -51, -20, -34,  24, -12, -48, -38, -44,-100, -54;
/M: SY='V';  M=  30,  12, -87, -83, -15, -13, -71,  51, -81,  21,  22, -80, -83, -79, -76, -70, -58,  52, -52, -62;
/M: SY='V';  M= -49, -79, -92, -87, -31, -90, -90,  72, -84,  17, -31, -86, -85, -83, -86, -73, -59,  72, -86, -47;
/M: SY='G';  M=  38,  34, -75, -79, -43,  81, -78, -70, -76, -13, -18, -57, -78, -67, -82, -24, -22, -50, -83, -79;
/I:         I=-26; MD=-22;
/M: SY='M';  M= -26, -34, -92, -87,  42, -50, -81,  50, -84,  44,  52, -85, -77, -82, -84, -64, -68,  33, -77, -58; D=-26;
/I:         I=-26; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='S';  M= -54, -85, -40, -77, -69, -54, -27, -58, -77, -86, -73, -43, -69, -58, -34,  86,  16, -41, -76, -66; D=-26;
/I:         I=-26; DM=-22;
/M: SY='S';  M=   6,  21, -68, -74, -32,  36, -66,   7, -68,  -2, -46, -46, -61, -64, -69,  60,  31, -10, -86, -40;
/M: SY='L';  M= -10,  31, -56, -76, -43, -37,  13, -13, -65,  56,  24, -10, -63,  -5, -76,  13,   3,  -7, -80,  22;
/M: SY='Y';  M=  -6, -45, -41, -68,  10, -66, -46,  27, -39,  15,  48, -33, -20,  22, -32,  26,   2, -38,  31,  49;
/M: SY='T';  M=  -5, -68,  -9, -45, -32,  41, -48,   0, -62, -19, -32, -32, -33, -26, -48,  -1,  69,   9, -87, -52;
/M: SY='W';  M=  13, -20, -53, -22, -37,  25,  15, -42,   0, -53, -38, -35,  55, -17, -32,  15,  25, -24,  69, -28;
/M: SY='H';  M= -13, -30, -43, -35, -50, -32,  94, -59, -60, -54, -14,  38, -38,  20, -33,  49,  29, -73, -23, -10;
/M: SY='M';  M=   3, -40, -47, -29,   0, -64,   4,  26, -14,  32,  55, -12, -50, -54, -17, -25,   0,  12, -14,  14;
/M: SY='P';  M=  -7, -41,  27,  45, -46, -33,  12, -34,  -8, -34, -25,   7,  46,  -3, -14, -31,  21, -17, -85,   7;
/M: SY='E';  M=   0, -38,  -7,  42,  14, -20,  -3, -18, -21,  16, -26,  18, -19,  10, -18, -24, -19, -16, -47,  28;
/M: SY='M';  M=  29,   5, -57, -78,  39, -42, -75,   5, -76,  -4,  85, -62, -81, -52, -78,  -5,   1,  32, -79, -55;
/M: SY='K';  M=  -8, -45, -45,   7, -41, -42, -10,   1,  42,   6, -28, -53,  35,  -2,  17, -37,  -7,  16, -81,   3;
/M: SY='E';  M=   7, -84,  25,  49, -28, -29,  39, -70,  18, -39, -33,   0, -63,  11,  28, -30, -27, -38, -80,  32;
/M: SY='V';  M= -30, -18, -73, -82,  -5, -87, -80,  39, -80,  46,  30,   3, -85, -78, -82, -66,  10,  51, -63, -41;
/M: SY='A';  M=  57, -13, -80, -59, -36, -51, -16,  33, -22,  16,   6, -39, -67, -51, -27, -20, -34,  25, -83, -19;
/M: SY='E';  M=   1, -60,  46,  47, -86, -34, -11, -83,  40, -76, -70, -16, -40,  24,  40, -11, -13, -64, -60, -44;
/M: SY='E';  M=  21, -81, -15,  51, -32, -39, -27,  -1, -15,  26,   8, -46, -65,  13,   7, -33, -10, -23, -43, -18;
/M: SY='M';  M=   6,  12, -89, -83,   3, -86, -77,  33, -80,  57,  66, -83, -86, -77, -74, -57, -40,  19, -80, -27;
/M: SY='K';  M= -22, -86, -21,  17, -84, -60,   6, -51,  70, -60, -48,   0, -67,  30,  62, -52, -36, -37, -84, -53;
/M: SY='E';  M=  26, -83,  -6,  59, -86, -52, -29, -55,  26, -60, -65,  -7, -67,  29,  48,  -5, -24, -56, -86, -75;
/M: SY='R';  M=  30, -51, -36,  16, -64, -60,   7,   8,  20,  10, -38, -12, -78,  25,  35, -36, -43,   7, -37, -25;
/M: SY='G';  M= -24,  -8,  16, -29, -36,  72,  12, -47, -23, -16, -21,  15, -54, -38,  -9, -11, -50, -50, -30, -14;
/I:         I=-32; MD=-27;
/M: SY='P';  M=  18, -73, -36, -47,   2, -22, -44,  15, -22,  11,   0, -42,  74, -64,   7, -37, -59, -18, -29, -21; D=-32;
/I:         I=-32; MD=-27;
/M: SY='D';  M= -12, -55,  47,  22, -47,  14,   7, -85,   7, -77, -65,  21,  -7, -12,  21,   2,   6, -83, -37, -65; D=-32;
/I:         I=-32; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='I';  M=  -2,  14, -86, -82, -20, -60, -84,  66, -49,  -5,   2, -79, -17, -57, -78, -31,  15,  48, -46, -13; D=-32;
/I:         I=-32; DM=-27;
/M: SY='P';  M= -26, -52, -54, -51,  -7, -70, -18,  10,  29,   7,   7, -52,  80, -21,   2, -57, -10,   2, -61, -35;
/M: SY='V';  M= -55, -56, -90, -85,   0, -92, -87,  60, -82,  26, -22, -83, -85, -82, -63, -63,   9,  68, -22, -64;
/M: SY='V';  M= -13, -38, -90, -85,  31, -31, -82,  46, -82,  27,  25, -83, -86, -73, -83, -75, -38,  58,   5,  -4;
/M: SY='V';  M=  10,  26, -87, -74,  13,  14, -67,  34, -81,  24,  20, -79, -84, -79, -83, -68, -47,  50,   6,  -9;
/M: SY='G';  M= -47, -84, -72, -83, -67, 103, -78, -97, -77, -81, -82, -58, -55, -75, -85, -41, -75, -85, -81, -59;
/M: SY='G';  M= -52, -84, -72, -77, -72, 103, -63, -97, -77, -85, -60, -31, -76, -61, -73, -57, -76, -91, -82, -74;
/M: SY='P';  M=  45, -67, -75, -58, -29,  10,  27,  20, -58, -46, -32, -18,  53, -38, -45, -23,   0,  18, -27, -18;
/M: SY='H';  M=  18, -52, -61,   9, -12,   3,  79,  29, -68, -23, -23, -24,   4, -26, -28, -11,  25, -23, -86, -22;
/I:         I=-23; MD=-20;
/M: SY='P';  M=  26, -12, -81, -67,  -6, -60, -82,  -3, -76,  -1, -61, -78,  70, -77, -82, -36,  28,  43, -87, -61; D=-23;
/I:         I=-23; MD=-20;
/M: SY='T';  M= -38, -47,  -7, -14, -83, -64, -54,  -3, -54, -73, -75,  19,   4, -25, -40,  60,  62, -37, -97, -79; D=-23;
/I:         I=-23; MI=0; MD=-20; IM=0; DM=-20;
/M: SY='H';  M=   6, -92, -17,   1,  49, -47,  60, -51, -60, -39, -54, -49, -62,   4, -56, -20, -43, -45, -63,  42; D=-23;
/I:         I=-23; DM=-20;
/M: SY='D';  M= -36, -10,  55,   5, -24, -49, -12, -25, -70, -11,  36, -27, -45, -31, -51, -44,  30,  14, -21, -18; D=-23;
/I:         I=-23; DM=-20;
/M: SY='P';  M=  40, -75,  -7, -12,   6, -18,  -7,   0, -59, -60, -65, -24,  52, -45, -39, -25, -49, -27,  26,  35; D=-23;
/I:         I=-23; DM=-20;
/M: SY='E';  M=  -7, -77,  23,  55, -55, -44,  -9, -48,   3, -42, -66, -11,  23,  24,  23, -35, -33,  11, -38, -33; D=-23;
/I:         I=-23; DM=-20;
/M: SY='E';  M= -22, -86,  36,  63, -14, -57,   0, -46,  30, -42, -38, -21, -30,  26,   1, -22,  -1, -69, -42, -15; D=-23;
/I:         I=-23; DM=-20;
/M: SY='I';  M= -12,  34, -64, -66,  10, -56, -52,  50, -82,  49,   7, -77, -45, -74, -66, -59,  -8,  21,   7, -43;
/M: SY='L';  M=  33, -38, -26,   3, -37, -39,   2, -29,   5,  44,  19, -33, -68, -10,  23, -29, -45, -36, -38,  -5;
/M: SY='P';  M=  12, -65,  24,  35, -67, -17, -38, -55,  25, -32, -53, -19,  41,  22,  27,   1, -11, -57, -86, -59;
/I:         I=-26; MD=-22;
/M: SY='H';  M= -10, -49,  -4,  27, -57, -66,  27, -48,  -5, -34,  -7,  14, -65,   9,  -1, -14, -23, -24, -94,  16; D=-26;
/I:         I=-26; MD=-22;
/M: SY='Y';  M= -39, -11, -53, -58,   3,  -1, -20, -23, -97, -46, -53, -24,-108, -42, -70, -70, -36, -81, -25,  69; D=-26;
/I:         I=-26; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='P';  M=   3, -85, -35,  -1,-105, -26, -49, -37, -60, -71, -93, -45,  55, -25,   6, -38, -50, -39,-108, -76; D=-26;
/I:         I=-26; DM=-22;
/M: SY='V';  M=  23,   0,  -4,  -4,  -7, -18,  16,   7, -45,  -5,  24, -25, -20,  -7, -39, -11, -17,  29,  22,  22;
/M: SY='G';  M=   5, -12, -74, -82,  22,  54, -25,  32, -78, -28, -44, -62, -18, -63, -56, -33, -52,  34, -52,  27;
/M: SY='D';  M=   4, -55,  79, -30, -16, -26,  25, -15, -66, -34, -56, -50, -33, -45, -74, -20, -44,  19,  13,  49;
/M: SY='Y';  M=  37,  32,  29, -55,  26, -14,  -9,  -9, -25, -37, -47, -69, -11, -38, -39, -30, -18,  29, -47,  38;
/M: SY='V';  M=  23, -26,  13,  -3, -45, -12, -54,  17,  -4, -14, -58, -17, -10, -31,  18, -46,  -9,  44, -87, -44;
/M: SY='V';  M= -11,  20,  51, -69, -44, -20, -71,  39, -34, -31, -19, -36, -81, -40, -68, -43, -27,  61,  -5, -31;
/M: SY='F';  M=  34, -34, -74, -41,  54, -18, -72,  17, -44,  -3,  -7, -68, -57, -29,  30, -40, -24,   7, -70,  30;
/M: SY='G';  M=  -4, -56, -39, -58,   8,  72, -64, -74, -70, -39, -12, -22,  -4, -31,  -3,  29,   9, -44, -82, -62;
/M: SY='E';  M= -38, -89,  45,  74, -89, -65, -30, -81, -30, -69, -69, -40,  57,   4,  28, -21, -40, -55, -37, -63;
/I:         I=-29; MD=-25;
/M: SY='G';  M=  31, -80, -77, -29, -70,  75, -54, -60, -18, -57, -11, -46, -59, -59, -79, -14, -52, -55, -88, -86; D=-29;
/I:         I=-29; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='E';  M= -12, -84,  21,  75, -80,   9, -49, -24, -44,  -3, -58, -47,  -6,  -2, -46, -21, -41,  15, -88, -76;
/M: SY='E';  M=   0, -81,  -4,  48,  -7,   9, -11, -10,  -6, -23, -25, -19, -13,  -2, -15, -12,  22,   2, -82,   0;
/M: SY='T';  M=  19, -12,  -8, -14, -15, -20, -32,   2, -45, -15,  28, -46,  14, -43, -47,  21,  49,  19, -87, -47;
/M: SY='M';  M=  35, -10, -48, -71,  44, -51, -78,  27, -73,  24,  46, -63, -24, -58, -67, -46, -11,  17,  24, -42;
/M: SY='P';  M=   2, -28,  20,   3, -44, -27,  -5, -39,   5,  -3, -25,  26,  26,   0,  21,   5,  -7,   2, -51,  -9;
/M: SY='E';  M=  15, -70,  47,  50, -66, -41,  -9, -64,  10, -19, -38,   5, -38,  35,  -2,  -6,  -3, -54, -45, -44;
/M: SY='L';  M= -23, -39, -65, -66,   4, -69, -79,  38, -83,  66,  19, -65, -58, -67, -82, -78, -28,  20,  -2, -12;
/M: SY='M';  M=   9,   2, -84, -69, -43, -57, -79,  35, -53,  45,  56, -49, -84, -53, -56, -33, -46,  43,  11, -65;
/M: SY='E';  M=  10, -67,  38,  48, -77, -12,  -6, -72,  13, -49, -12,  18, -37,  13,  23,  14,  -9, -55, -89, -59;
/M: SY='A';  M=  40,  -1,  28,  15,  -6, -13,  16, -54,   0, -38, -23, -25, -12,  -2,  25, -15, -20, -32,  21, -14;
/M: SY='L';  M= -11,   7, -23, -27,  -7, -39, -28,  38,   2,  47,  -1, -29, -71, -42, -38, -25, -27,  11,  11, -17;
/M: SY='R';  M=   8, -55,  12,  22, -45, -28,  -4, -11,   6,  -3, -51, -13, -10,  13,  48, -12, -10,  -7, -57, -22;
/M: SY='R';  M=  13, -75,  25,  16, -19,   7,  17, -60,  25, -53, -62,  22, -18,  20,  27,   3,  -6, -47, -54, -38;
/M: SY='G';  M=  -7, -50,  21,  28, -78,  45,   9, -50,  -2, -29, -47,  19,  -9,  10,   7,  -5, -19, -27, -31, -62;
/M: SY='R';  M=   3, -43,  -7,   7, -20,   5, -33, -22,  -3,   2,  12,   5, -15,   6,  34, -12,   4,   3, -56,  -3;
/M: SY='W';  M=   0, -61,  29,   5,   3,  -8,  -8, -29, -11,  -4, -15, -16,  30, -17,  13,   5,  -7, -19,  48,  -3;
/M: SY='P';  M=   8, -71,  23,  -2, -23, -28, -13,  -6,  14,   1, -13,  -6,  42,   7,  -1, -15, -20,  -9,   4,   0;
/M: SY='E';  M=  22, -68,  21,  32, -33, -14,   7, -21,   4, -22, -69,  -4,  16,   4,  28,   1, -10, -33, -61, -38;
/I:         E1=0; IE=-155; DE=-155;

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Post-processing [info]

PROMOTED_BY

PS51337

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	102 in 102 different sequences
Number of true positive hits	102 in 102 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	3
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	97.14 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	B12-binding
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

102 sequences

BCHE_CERS4  (Q9RFD3), BCHE_RHOCB  (P26168), BCHE_RUBGE  (Q7X2C7),

BCHE_SYNY3  (Q55373), BCHQ_CHLTE  (Q8KBK9), CARA_MYXXA  (Q50899), 
CARH_MYXXA  (Q50900), ECM_CERS4   (Q3IZ90), ECM_METEA   (Q49115), 
FOM3_STRWE  (Q56184), GMSS1_HALMA (Q5V467), GMSS2_HALMA (Q5V3F0), 
GMSS_CARHZ  (Q3AFA7), GMSS_CLOCO  (P80078), GMSS_CLOTE  (Q890S0), 
GMSS_CLOTT  (Q05488), GMSS_DESHY  (Q24SG7), GMSS_ECO57  (P58620), 
GMSS_FUSNN  (Q8RHY7), GMSS_HALSA  (Q9HN21), GMSS_SHIDS  (Q32IJ3), 
GMSS_TREDE  (P61191), GMSS_YERE8  (A1JSN5), HCMB_AQUTE  (I3VE74), 
HPNR_METCA  (Q60AV6), ICMF_CUPMC  (Q1LRY0), ICMF_GEOKA  (Q5KUG0), 
ICMF_NOCFA  (Q5Z110), ICMF_PARXL  (Q146L7), KAME_ACESD  (E3PRJ4), 
KAME_FUSNN  (Q8RHX8), MCM_CERS4   (Q3J4D7), MCM_RHIME   (O86028), 
METH_ALIF1  (Q5E814), METH_ALIFS  (Q9AJQ8), METH_BOVIN  (Q4JIJ3), 
METH_CAEBR  (A8XY95), METH_CAEEL  (Q09582), METH_DICDI  (Q54P92), 
METH_ECOLI  (P13009), METH_HUMAN  (Q99707), METH_MOUSE  (A6H5Y3), 
METH_MYCLE  (Q49775), METH_MYCTU  (O33259), METH_PSEAE  (Q9I2Q2), 
METH_RAT(Q9Z2Q4), METH_SALTY  (P37586), METH_SYNY3  (Q55786), 
METH_VIBCH  (Q9KUW9), METH_VIBPA  (Q87L95), METH_VIBVU  (Q8DCJ7), 
METH_VIBVY  (Q7MHB1), MGM_EUBBA   (Q59268), MTAC_METBF  (Q46EH4), 
MTBC1_METAC (Q8TTB0), MTBC1_METMA (P58979), MTBC2_METAC (Q8TS71), 
MTBC2_METMA (P58980), MTBC3_METAC (Q8TN69), MTBC3_METMA (P58981), 
MTBC_METBA  (O93657), MTBC_METTE  (Q9YGA3), MTGC_DESHY  (Q24SP8), 
MTMC1_METAC (P58867), MTMC1_METBA (O30641), MTMC1_METMA (P58977), 
MTMC2_METAC (P58868), MTMC2_METBA (Q9P9L5), MTMC2_METMA (P58978), 
MTQC_EUBLI  (P0DX07), MTSB_METBA  (Q48925), MTSB_METMA  (Q8PUA7), 
MTTC1_METAC (Q8TTA8), MTTC1_METMA (P58982), MTTC2_METAC (Q8TS74), 
MTTC2_METMA (P58983), MTTC_METBA  (O93659), MUTA_BOVIN  (Q9GK13), 
MUTA_CAEEL  (Q23381), MUTA_HUMAN  (P22033), MUTA_MACFA  (Q8HXX1), 
MUTA_MOUSE  (P16332), MUTA_PIG(Q8MI68), MUTA_PONAB  (Q5RFN2), 
MUTB_MYCBO  (P65488), MUTB_MYCTO  (P9WJK4), MUTB_MYCTU  (P9WJK5), 
MUTB_PORGI  (Q59677), MUTB_PROFR  (P11653), MUTB_STRVG  (Q05065), 
OAME_ACESD  (E3PY95), OXSB_PRIMG  (O24770), PCMB_XANP2  (A7IQE6), 
SCPA_ECOLI  (P27253), THNK_STREN  (Q83XP3), TOKK_STREV  (A0A6B9HEI0), 
TSRM_STRLU  (C0JRZ9), Y1042_HAEIN (Q57195), Y1487_METJA (Q58882), 
Y309_SYNY3  (Q55914), Y819_PYRHO  (O58549), YBCC_RHOCA  (P26166)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

3 sequences

CARH_THET8  (Q53W62), HPNP_RHOPT  (B3QHD1), YHGF_NEIGO  (Q51062)

PDB
[Detailed view]

58 PDB

1B1A; 1BE1; 1BMT; 1CB7; 1CCW; 1E1C; 1FMF; 1I9C; 1ID8; 1K7Y; 1K98; 1REQ;
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