PROSITE entry PS51330

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PURL: https://purl.expasy.org/prosite/signature/PS51330

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General information about the entry

Entry name [info]	DHFR_2
Accession [info]	PS51330
Entry type [info]	MATRIX
Date [info]	01-SEP-2007 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00072
Associated ProRule [info]	PRU00660

Name and characterization of the entry

Description [info]

Dihydrofolate reductase (DHFR) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=164;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=159;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.5709825; R2=0.0064342; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1077; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=456; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-97; D=-155; I=-155; B1=-1500; E1=-1500; MI=-325; MD=-325; IM=-325; DM=-325;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-325; BD=-325;
/M: SY='M';  M= -64,-260, -29,   5, -89, -58,   9, -52,  28, -86,  99,  -7,  12,  -9, -28, -10,  -4,-133,-264,-246;
/M: SY='I';  M=-107,-258,-270,-265,  10, -76,-262,  73, -94,  35, -10,-263,-264,-260,-108,-257,-106,  33,-257, -50;
/M: SY='S';  M= -14, -19, -91, -52,-254, -50, -33,  18,  36,-121, -71,  15,-253,  -9, -34,  43,  22,   1,-265, -61;
/M: SY='M';  M=  22,  -3,-264,-258, -10, -25, -50,  33,-257,  50,  57,-256,-261, -87,-258, -27,-244, -58,-257, -58;
/M: SY='I';  M=-246,-259,-270,-267,-235,-273,-269,  93,-262, -39, -32,-262,-261,-260,-265,-256,-241,  53,-262, -81;
/M: SY='W';  M=  20, -52,-269,-260,  23, -94,-265, -98,-257, -30, -13,-263,-262,-258,-259,-250, -93,  70, 112, -47;
/M: SY='A';  M=  99,  19,-253, -65,-260,-235,-255,-250,-248,-252,-246,-248,-252,-245,-253,-227,-238, -88,-262,-257;
/M: SY='M';  M=   7,  36,-252,   4, -63,-111, -21,  17,-118, -39,  69, -71,-256,  43, -10, -70, -34,  33,-262, -51;
/M: SY='D';  M=  36,  14,  76, -84,-261,   2,-246,-256,-243, -49,-253, -27,-251,-242,-250,  17,  36,-249,-271,-254;
/M: SY='E';  M= -13, -74, -17,  33,-256,-108,-244, -38,  33,  -7, -35, -10,  32,  22,  22, -22, -25, -23,-262,-251;
/I:         I=-21; MI=0; MD=-43; IM=0; DM=-43;
/M: SY='N';  M= -74,-256,  28,   6, -20, -62,  11,-258, -15,-260,-252,  96,-253,  15, -15, -20, -39, -59,-270,-249;
/M: SY='G';  M=-109, -53,-104,-250, -14,  64,  25,-103, -83, -27,   7,  32, -52, -55,  43, -62,-247,-256,  -1,  19;
/M: SY='V';  M=   2,  -1,-255, -29, -81,  50, -74, -24, -91,   0, -47, -70, -84,-252,-257,-242, -48,  60, -51,-249;
/M: SY='I';  M=-250,-261,-269,-268,  29,-273,-266, 105,-262, -43, -35, -51,-260,-260,-265,-258,-244,-127,-253,-235;
/M: SY='G';  M= -67,-260,-249,-260,-267, 103,-255,-274,-254,-270,-259,-235,-252,-251,-261,-102, -76,-267,-258,-262;
/M: SY='K';  M= -37,-258,   0,-115, -19,-254, -43,   6,  57,  -2, -41,  35,-255, -20,  25, -47, -42, -45,-255,  20;
/M: SY='N';  M= -47, -53,  62,  -5,-265,  26, -51,-265,  28,-115,-255,  65, -78,  27, -58, -72,-241,-262,-268, -75;
/M: SY='N';  M=-116,-257, -23, -41,-264,  66, -42,-265,-115,-138, -61,  89, -40,  -9, -95,-112, -25,-263,-268,-257;
/I:         I=-32; MI=0; MD=-68; IM=0; DM=-68;
/M: SY='Q';  M=  -5, -62,  37, -46,-260,  29, -11,-257,  23, -96, -55, -20, -67,  44, -36,   0,  27, -65, -19, -49;
/M: SY='M';  M=-249,-255,-267, -90,-229,-268,-252,  37,-259,  73,  83,-262,-263,-252,-258,-258, -61, -97,-257,-238;
/M: SY='P';  M=-131,-274, -74,-241,-265,-100, -63, -97,-248, -34, -55,-257, 125,-251,-259,-248,-243,-132,-263,-264;
/M: SY='W';  M=-259, -48,-285,-263,-225,-257,-284,-258,-256,-255,-258,-278,-263, -77,-259, -68,-270,-271, 178, -53;
/I:         I=-34; MI=0; MD=-72; IM=0; DM=-72;
/M: SY='H';  M= -86, -63, -45,-103, -75, -91, 111,-262,  -5,-125, -58,   2, -41, -27,  49,  14, -38,-260, -66,  18;
/M: SY='L';  M= -83,  15,-264,-103,-229,-267, -55,  62,-259,  62, -44, -35,-263,-254,-259, -45,-244, -30,-254,  20;
/M: SY='P';  M= -51,-266, -35,-235, -80,-251,-248, -64,  55, -87,-251,-244,  98, -54, -16,   2, -24,-256,-261, -98;
/M: SY='E';  M=  20,-258,   5,  68,-264,  -7, -67,-126,  19,-259,-252,  12,-247,  11, -37,  -2, -42, -54,-264,-254;
/M: SY='D';  M= -96,-265, 107,  59,-270,-252,-238, -68,-235,-265,-263,-225,-248,-232,-244,-240, -88,-263,-279,-255;
/M: SY='M';  M=-250,-255,-265,-256,  21,-265,-246, -36, -57,  64, 100, -70,-262,  -7, -70,-257,-246, -97, -44, -74;
/M: SY='K';  M=  27,-258, -67, -20,-260, -99, -17,-123,  71, -45, -26, -13,-250,  57,  11, -32,-110,-105,-260,-249;
/M: SY='H';  M=-115,-262,-247, -91,  47, -76,  93,-102,-238, -34,-238,  21,-261, -18,  39,-246,-249,-252,  23,  72;
/M: SY='F';  M=-259,-256, -59,-266, 123,-267,-251,-233,-262, -77, -62,-260,-270,-272,-260,-258,-251, -86,-226, -37;
/M: SY='K';  M= -23,-261,-243, -82, -89,-253, -44,-259,  87,-111, -51,-236,-251, -19,  57, -18, -40, -95,-256,  -9;
/M: SY='Q';  M=  23,-258,  -5,  35,-262,-118,-240,-258,  43,-257, -57,  -2,-249,  47,  32, -17,   0, -73,-262,-100;
/M: SY='T';  M= -33,-253,-252, -37,-241,-114,  -8,  13, -20,  30,  21, -54,-255, -26,  -4,-123,  57,  28,-263,-244;
/M: SY='T';  M=-236,-247,-243,-246,-250,-253,-253, -19,-243,-245, -66,-233, -86,-246,-251, -24, 115, -49,-271,-249;
/M: SY='M';  M= -28,-253, -71, -20,-244,-112,-247, -15,  19,  16,  61, -50,-251,   1, -90,   4,  60, -50,   0, -51;
/I:         I=-9; MI=0; MD=-20; IM=0; DM=-20;
/M: SY='G';  M=-241,-259, -20, -70, -50,  65,  -2, -25,  -4,-113, -41,  65,-254,  12,  -9, -50,-112, -58,-263,-100;
/M: SY='H';  M= -50, -44, -59, -78, -83, -29,  82,-262,  41,-260,-248,  77,-252,  31, -67,  -9, -16,-260,-269, -82;
/M: SY='P';  M=  36, -28, -56,-247,-251,-251, -40,   3, -66, -59, -31, -37,  66,-249,-254, -74,  39,  34, -31, -96;
/M: SY='V';  M=-242, -12,-268,-262,-235,-269,-263,  50,-260,  21,  33,-100,-262,-258,-261,-254, -92,  77,-265,-243;
/M: SY='I';  M=-242,-254,-267,-262,-232,-269,-265,  80,-259,  13, -54,-260,-260,-258,-261,-253,-238,  71,-261,-240;
/M: SY='M';  M=-122,-251,-265,-255, -15,-258,-237, -63,-249, -52, 150,-252,-253,-241,-247,-252,-242, -54, -28,-230;
/M: SY='G';  M=-231,-258,-246,-258,-265, 108,-253,-272,-251,-268,-257,-232,-250,-249,-259,-231,-250,-266,-255,-259;
/M: SY='R';  M= -20,-262,-245,-234, -83, -71,-235,-260, -10,-105,-245, -77,-255, -66, 113, -36, -96,-254,-255, -16;
/M: SY='K';  M= -60,-256,-236, -64,-257,-124,-238,-113,  94, -73,-245,  35, -90, -52,  39, -54,  -9, -57,-258,-247;
/M: SY='T';  M=-233, -36,-239,-242,-249,-249,-249,-241,-239,-245,-242, -75,-241,-243,-247, -24, 120,-120,-270,-247;
/M: SY='W';  M= -73,-263,-269,-261,  92,-259, -51,-239,-255,-100, -69,-262,-264,-257,-254,-256,-254,-246, 136,  70;
/M: SY='E';  M= -50,-260,  53,  94, -46,-253,-236,-257, -23, -33, -51,-233,-242,  19, -23,-237, -41,-124,-262,-249;
/M: SY='S';  M= -44, -74, -75, -44,-254, -19,-241,-253,-238,-256,-250, -72,-245, -81,-243, 106,  11,-101,-262, -55;
/M: SY='I';  M=-246,-253,-265,-260,  13,-266,-253,  78,-257,  56,  65,-258, -80,-252,-257,-255, -92, -57,-250,-231;
/M: SY='P';  M=-138,-264, -28,-240,-262,  55,-247,-114, -15, -66,-250,   0, 105,-243, -42, -73,-241,-123,-259,-258;
/I:         I=-19; MD=-40;
/M: SY='K';  M= -16, -37,   5,  -2, -65,  -4, -79, -81,  13, -34,-259, -29,   7, -12,  -9,   3, -44, -42,-275,-263; D=-19;
/I:         I=-19; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='R';  M=-130,-268, -99, -74, -68, -52, -65,-264,  61, -44, -49,-243,-259, -78,  87, -85,-251,-261,  13,-249; D=-19;
/I:         I=-19; DM=-40;
/M: SY='P';  M= -11, -65, -83,-239, -73, -63,-249, -19,  -4, -37, -42, -41, 111,-244, -65, -80,-108,  -2,-257, -26;
/M: SY='L';  M=-247,-250,-264,-256, -10,-266,-249, -64, -31,  94,-211,-262,-264,-250,-253,-256, -88, -90,-250,-232;
/M: SY='P';  M= -33,-264, -85, -31,-261,-116, -59, -96,  31, -91,-247, -36, 113, -35, -42, -27, -79, -36,-259,-256;
/M: SY='N';  M=-238,-254,  41,  -8, -88,  60, -61,-262,  11,-262, -78,  85,-249, -31, -80, -44,-237,-260,-264, -79;
/M: SY='R';  M=-247,   7,-244,-232,-256,-257, -47,-263, -97,-255,-244,-237,-256, -59, 121, -92,-246,-256,-257,-243;
/M: SY='I';  M= -53,-253, -33, -15, -63,-256,   2,  37,  18,  26, -39, -13, -29,  10,  12, -75,  34,   2,-256, -32;
/M: SY='N';  M= -95, -10,-225,-240, -41,-238,  58, -25,-234,-128, -10, 112, -92, -69,-240, -26,  11, -28,-269, -30;
/M: SY='I';  M= -51, -52, -76,-260, -19,-266,-259,  89,-256, -22, -37,-256,-257,-255,-258,-250,-238,  55, -24,  17;
/M: SY='V';  M=-234,-248,-263,-258,-233,-265,-264,  34,-255, -62, -36,-258,-258,-257,-257,-247, -73, 103,-265,-241;
/M: SY='L';  M=-110, -63,-265,-258,   4,-266,-254,  49,-257,  69,  -3,-260,-260,-253,-256,-253,-239,  45,-252,-233;
/M: SY='S';  M=-226, -53,-237,-239,-251, -63, -41,-246,-237,-250,-245,-226,-242,-234,-243,  91,  87, -90,-265,-246;
/M: SY='R';  M= -79, -55, -31,-232, -77,-121,  30,-258,  13,-118,-244, -27,-251, -92,  99,  28,  16,-252,-259,-241;
/I:         I=-13; MD=-26;
/M: SY='N';  M=-247,-261,  46, -71,-267, -88, -67,-104,  -5,-266, -35,  59, -30,  -7, -40,  38,  34,-260,-278,-258; D=-13;
/I:         I=-13; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='T';  M= -63, -24, -55, -35, -39,-274,  11, -96,  -8, -25, -44,-260, -16, -62, -21,  10,  30, -91,-282, -39; D=-13;
/I:         I=-13; DM=-26;
/M: SY='Q';  M= -55, -59, -29,   0, -13,-263, -91, -75,  18, -54, -75, -26,  10,  62,  15, -15, -50, -54,-267, -40; D=-13;
/I:         I=-13; DM=-26;
/M: SY='E';  M= -13,-257, -17,  46,-255, -52,   7,-116,  20, -36, -19,   3,  46,  15,  45, -18,   2,-249,-259, -78;
/M: SY='D';  M= -63,-255,  74,  40,-259,  23,   9, -68, -47,-109,-251,  48, -40, -49,-240,   9,  -9, -51, -40,-249;
/I:         I=-11; MD=-23;
/M: SY='Y';  M= -34, -40, -62, -16,  47,-103, -70,  -9, -69,   5, -55, -57, -26, -11,-252, -59, -54,  12,  66,  73; D=-11;
/I:         I=-11; MD=-23;
/M: SY='Q';  M= -14,-261,   6,   9,-102,-123,  -9, -43,  13, -58,  -2,  30,  20,  54,   4,  -6, -11, -45,-266,-251; D=-11;
/I:         I=-11; MD=-23;
/M: SY='A';  M=  36, -65, -15, -24,   1,  -3,  -5, -42, -17, -26, -77,  23,  20, -44,-116, -11,-244, -17,-264, -63; D=-11;
/I:         I=-11; MD=-23;
/M: SY='E';  M= -29,-269,  46,  55,-272, -49,-248,-131, -14, -92,-262,  31,  36,-240,-249, -35, -35,-112,-276, -92; D=-11;
/I:         I=-11; MD=-23;
/M: SY='N';  M= -84,-269,  14, -19,-271,  46,   0,-107, -25,-274,-265,  46, -35, -47,-257, -19,  -4,-270,-276, -30; D=-11;
/I:         I=-11; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='V';  M=  41,  48, -37,-251, -56, -50,-257,  17,-251, -46, -71,-250, -89,-251,-254, -58, -51,  79,-262, -83; D=-11;
/I:         I=-11; DM=-23;
/M: SY='H';  M= -82,-253,  -8,  24,   9, -68,  55,  11,  -7,  13, -24, -47, -11,   7, -20, -34,  18,  13, -38,  -2;
/I:         I=-40; MI=0; MD=-83; IM=0; DM=-83;
/M: SY='V';  M= -20, -62, -95,-116, -10, -82,   9,  43,-248,  -4, -76,-249,-254, -68, -22, -35,   2,  73,  36,   1;
/M: SY='C';  M=  34,  47,-250, -53,  30, -69,-247,  16, -71, -35,   9,  -8, -46, -71, -41, -18, -13,  46, -39,  21;
/M: SY='H';  M= -15, -37,  10, -29,-252,  -5,  77, -58,  17,-252,-243,  36,  24, -44,  -2,  31,  28,-249,-261, -21;
/M: SY='S';  M= -61, -29,  43, -46,-255,   4, -48,-104, -81, -98,-249,  22, -79, -51, -45,  90,   4,-248,-264,-247;
/M: SY='L';  M=-123,-252,-257, -24,  31, -82,-249,  52, -68,  57,  17,-255,  24,-248, -80,-250, -83,   6, -10,  -2;
/M: SY='E';  M=  -6,-256,  60,  67,-259, -15, -21, -62,   3,-254, -84, -30,  10,  22, -43,   3, -18, -72, -30,-248;
/I:         I=-43; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='E';  M=  21,-253,  56,  59, -97, -74, -29, -61, -20, -76, -77,  11, -80,  24,  -6,  18, -17, -81,-262,-247;
/M: SY='A';  M=  84, -19,-253,-246,   3, -84,-250, -10,-247,  15,-230,-247,-251,-244, -97, -57,-234,  17,-252, -41;
/M: SY='L';  M= -96,-251,-260, -72,  -6,-106, -52,  44, -37,  73, -14,-256,-258, -18,-251,-116, -56,  13,-250, -39;
/M: SY='E';  M=  23,-252,  19,  40,-105,-110, -57, -69,  32, -32,-243,  23, -21,  30,   3,  12,  15, -94,-259,-246;
/M: SY='W';  M=   3,-253, -27,  18,  28, -95,  30, -18, -21,  38,  -2, -29, -47, -11, -57, -22, -39, -25,  55,  20;
/M: SY='A';  M=  54,  15, -91,-109,   3, -65, -48,  -3,-121,  43, -54, -48, -44, -60,-119, -34, -38, -13,-245,  44;
/M: SY='K';  M=  11, -59,  10,  34, -49,  -8, -10, -82,  39, -73, -78,   9, -22,   4,  12,  27, -36, -52,-255,  -5;
/M: SY='N';  M= -10, -63,  29,  38,-109, -11, -19, -83,  27, -75, -57,  40,   2,  25, -20,  15,  19,-249,-261, -91;
/I:         I=-15; MI=0; MD=-31; IM=0; DM=-31;
/M: SY='H';  M= -67,-279,  12, -24, -89, -80,  33, -51, -11, -16, -86,  16, -15, -19, -43, -20, -36, -86,-286, -74; D=-15;
/I:         I=-15; DM=-31;
/M: SY='Q';  M= -67, -81,   2,  -6,-270,   7, -75, -52,  -8, -95,-259,  10,  14,  34, -41,  24, -21, -51, -55, -84; D=-15;
/I:         I=-15; DM=-31;
/M: SY='I';  M= -13, -42,  26,  18, -53, -46,   0,  29, -49, -47, -51,  -7, -33, -42, -49, -48,  -4,  22,-264,  -1; D=-15;
/I:         I=-15; DM=-31;
/M: SY='E';  M= -62,-261,  38,  60,-260,  -4, -54,-258,  17, -85,-251,  18, -18,  29, -26,  -6, -50, -41,-263, -24; D=-15;
/I:         I=-15; DM=-31;
/M: SY='E';  M= -65,-258,  50,  52,-258,-124,  13, -67,  33, -82, -23, -17, -16, -31,  21, -37,  31, -59,-265,-248; D=-15;
/I:         I=-15; DM=-31;
/M: SY='I';  M=  -9,   8,-261,-256, -98,-113,-258,  70,-254,  15, -15,-107, -82,-253,-256,-126, -23,  66,-257, -43;
/M: SY='F';  M= -31,  26,-103,-256,  95,-255,-242, -57,-100, -84,  36, -71,-260,-252,-250, -14, -51, -72,  91,  69;
/M: SY='V';  M=-119, -30,-263,-258,-104,-265,-262,  76,-255, -29, -22, -93,-256,-255,-257,-109,-233,  85,-259, -75;
/M: SY='I';  M=  -8,   3,-261,-258, -69, -93,-260, 102,-254, -38,  -2,-251,-253,-251,-258, -24, -31,  -7,-254,-237;
/M: SY='G';  M=-228,-255,-243,-255,-262, 111,-250,-270,-248,-265,-254,-229,-247,-246,-256,-228,-247,-263,-252,-257;
/M: SY='G';  M=-228,-255,-243,-254,-262, 110,-250,-269,-248,-265,-254,-229,-247,-246,-256, -67,-246,-263,-253,-256;
/M: SY='A';  M=  61, -77,-239,   9, -80,  48,-243,-249,  20, -76, -51, -83, -19, -58,-100,  31,-233, -42,-253, -35;
/M: SY='Q';  M= -19,-255, -23,  60, -93,  -4, -37,-254,   3,-137,-244, -50,-243,  79,  -3,  37, -20, -83,-253,  -2;
/M: SY='I';  M=-115,-250,-263,-258,-103,-265,-259,  84,-256,  40,-214,-256,-256,-253,-257, -93, -75,  58,-255,-236;
/M: SY='Y';  M= -71, -60,-254,-254,  61,-258,-224, -30,-248,  -2,-226,-253,-262,-245,-245,-247,-244,-120,-213, 126;
/M: SY='K';  M=  20,-252, -10,  46,-104, -90, -28,-251,  52, -75,-243,  23,-244,  25,  31,  -3,   8, -65,-256, -45;
/M: SY='Q';  M=  26,-253, -42,  58,-248,-120, -31, -67, -51,  20, -72, -36,-245,  80, -73,   9, -51, -61,-254, -38;
/M: SY='F';  M=  64,  -4, -86,-113,  68, -30, -37,-115,-247,  10, -19,-244,-252,-246,-249, -22,  10, -16, -22, -22;
/M: SY='M';  M= -32,-250, -96, -53,  -1,-260,-246,  42, -69,  70,  77, -83,-256, -70, -92,-250, -86, -75,  20, -80;
/I:         I=-43; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='P';  M= -43,-260,  57,  38,-261, -56, -65,-117, -30,-104, -72,  15,  95, -35, -51,   2,-235,-255,-262,-253;
/I:         I=-17; MI=0; MD=-35; IM=0; DM=-35;
/M: SY='Y';  M= -85,  -4, -72,   4,  13, -87,  33,  17,  20,  23,  28, -72,-253,  13,  18, -64,-241, -25,  15,  52; D=-17;
/I:         I=-17; DM=-35;
/M: SY='C';  M=  70,  79,-252,-247, -87,-243, -40,   6, -91,  -7, -39,-245, -45,-246,-250, -60,  -6,  35,-259, -80;
/M: SY='D';  M=-241,-256, 100,   0,-260, -69,  29,-257,   1, -81, -54, -13,-245,  -6, -29,   5,  15, -86,-271,-245;
/M: SY='R';  M= -38, -24, -23,  43, -79, -82,  11, -23,  41, -55, -74, -40,-247,  20,  69, -95,  -7, -21, -26, -33;
/M: SY='I';  M= -74, -18,-263,-257, -19,-264, -84,  64,-256,  64,  39,-258,-258, -88,-255,-252,-239,  28, -41,-233;
/M: SY='Y';  M=-119,-256, -95,  12,  38,-259,  61,  26,-245,   3, -76,-247,-256,-241,-106, -89, -86,  11,   4,  96;
/M: SY='L';  M= -91, -53,-260,-100,  -3,-263, -23,  55, -35,  57,  34,-255,-257,-248,  -4,-251,-239,  36, -21, -94;
/M: SY='T';  M= -77,-241,-236,-239,-248,-243,-245,-240,-236,-245,-241, -64,-239,-239,-244,  40, 117,-232,-266,-245;
/M: SY='R';  M=-129,-256, -53,  50, -19,-254,  50, -16,  27, -22, -44, -74,-247, -21,  61, -46,  -5,  10,  -8, -52;
/M: SY='I';  M=-239,-252,-262, -55, -54,-267,-262,  90,-255, -16, -20,-256,-255,-254,-258,-250,-235,  69,-257,-237;
/M: SY='H';  M= -26,-256,  50,   2, -30, -39,  88, -90,  15, -34,  32,  29,  -6,  -6, -19, -59,-106, -49, -51,  -8;
/M: SY='H';  M=  22, -73, -16,   5,-248,  15,  32, -21,  29, -13,  -6,   5, -44,   8,   0, -18, -10,  -2,-258, -66;
/M: SY='E';  M=  -7, -63,  46,  55,-253,-120, -13, -28,   2, -69, -53,  29,   8, -29, -24,  19,   5, -29,-262, -40;
/M: SY='F';  M=-117, -49, -39, -32,  77,-103,   5,   2, -86, -27, -37, -50,   9, -37, -65, -40, -21,  19,-232,  74;
/M: SY='E';  M= -31,-256,  49,  69, -75, -40, -48, -61,  10, -72,-246,  10,  45,  15, -38, -19, -19, -58, -32,-247;
/I:         I=-17; MI=0; MD=-36; IM=0; DM=-36;
/M: SY='C';  M=   9, 102, -85, -63, -19,  78,-249,-256, -94, -85,  -9, -78,-252, -40, -86, -44, -72,-249,-256, -34;
/M: SY='D';  M= -49, -70, 120, -51,-264,-242,-233,-261, -82,-261,-258,  -2, -45, -84,-241,-105, -22,-100, -47,-249;
/M: SY='T';  M=  25, -76,-245,-242,-242,-100,-249, -41, -64, -27,-232,-237, -79, -73,   2, -26,  87,  53,-262,-243;
/M: SY='F';  M= -86,-254,-253, -64,  98,-256,  18, -81, -17, -75,-231,-248,-259, -51, -11, -43, -36, -59,  36,  87;
/M: SY='F';  M= -17,-249, -72, -92, 105,-259,-245, -41,-253,  26,  40,-254,-260,-256, -93,-249,-242,   1,-230,  -4;
/M: SY='P';  M= -62,-265,  19, -41,-262, -80, -64, -96,  -2,-260,-249,  -9, 120, -51, -86, -41, -85,-255,-259, -70;
/M: SY='E';  M=  -4,-252,  14,  51,  12, -69, -24,  -6,  16,   2,  -9,  11,   0, -49, -25, -51,  -3,  -2, -23, -70;
/M: SY='I';  M= -91,-254,  24, -10,  39, -95, -28,  54, -37,  -2, -16, -28,   9, -35, -59, -19,  -8,   5,  50,   0;
/I:         I=-34; MD=-72;
/M: SY='D';  M= -68,-258,  75, -11,  -2, -22, -35, -55, -69,   0, -69,  35,  41, -84, -31, -37, -58, -32,-260,  -1; D=-34;
/I:         I=-34; MI=0; MD=-72; IM=0; DM=-72;
/M: SY='W';  M= -21,-256,  36,  43,  34, -45, -46, -50, -21,  11,  10,-240,   9, -17, -29, -92, -18, -93,  82,  26;
/M: SY='S';  M=  -4,-250,  38,  34,-254,   4,-235,-254,  14, -88,-247,  37,-124, -25,  -8,  51,  22,-248, -34, -29;
/I:         I=-23; MD=-49;
/M: SY='K';  M=  -2,-259,  15,  26,-261,  -6,  -9, -54,  38, -70, -54,  15, -59,  35, -43,   5, -29, -27,-265,-252; D=-23;
/I:         I=-23; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='W';  M=-133,-261,-268,-257,  93,-101,-253,-236, -57, -37, -70,-260, -84,-254, -83,-254, -73,-101, 146,  35;
/M: SY='K';  M= -30, -75,  -4,  44,-249,-247,  12, -46,  44, -52,-239,  21,-245,  20,  29,  -1,  18,   3,-256,  -8;
/M: SY='L';  M= -59, -22, -85,  42,-237,-126, -55, -13,  27,  48,  23, -57, -12, -11,  20, -53, -64,   9,-254, -62;
/M: SY='V';  M=  -8, -90,   1,   5,-239, -63,-247,  24, -43, -21,  -6, -16, -40, -25, -46, -18,  46,  56, -34, -29;
/M: SY='S';  M=   2, -28,  15,  31,   9, -20, -91, -30,   4,-113,-244,  -7, -32,  38, -27,  64, -46,-244,-254, -29;
/M: SY='E';  M= -35, -84, -66,  49,-251, -62,  11,   0,   6, -78, -45,  -8, -65,  29,  42,  24,  33, -14,-259,-243;
/I:         I=-11; MD=-24;
/M: SY='E';  M= -42, -37, -10,  47, -61, -50, -14,  14,   6, -59,-242, -52, -39,  42,-238,  40,   9,  -6,-262,-246; D=-11;
/I:         I=-11; MI=0; MD=-24; IM=0; DM=-24;
/M: SY='Y';  M= -33,-268, -13,  16, -15, -43,  -7, -14,  13, -99, -91, -42,  20, -17, -17,  -9, -41, -18, -48,  35; D=-11;
/I:         I=-11; DM=-24;
/M: SY='H';  M= -31, -55,  -3, -20,   9,  12,  67, -42, -20, -53,-246, -63, -53, -21,  24, -22, -66, -33, -56,  30; D=-11;
/I:         I=-11; DM=-24;
/M: SY='W';  M= -15,-257,   0,  40, -25, -17,  24, -24,  10,-102,-242, -23,  39,  -4,  18, -35,  19, -24,  43, -17;
/M: SY='K';  M=   8, -80, -32,  -4, -23,-250,  -9, -11,  45, -50, -87, -45,  24, -22,   7, -17,  34,  15, -16, -43;
/M: SY='D';  M= -99, -76,  67, -34,   4, -38, -35,   9,  -2, -33,-241,  -1, -57,  32,-112,   0,  -7, -17,   7,  23;
/M: SY='E';  M= -18,-257,  28,  75,-262, -14, -15,-257, -29,-257,-251, -25, -21,  12, -86,  20,  16, -38,-265,-252;
/M: SY='E';  M= -28,-261,  -8,  67, -88, -40,-241,-262,  64,-111,-252, -48, -33,  -5,   6, -25, -30,-129,-261,-252;
/I:         I=-30; MD=-64;
/M: SY='N';  M= -52,-261,   8,   0,-267,  10,  32,-269,  -2,-269,-258,  89,-258, -28, -61, -18, -78,-266,-277,-257; D=-30;
/I:         I=-30; MI=0; MD=-64; IM=0; DM=-64;
/M: SY='G';  M= -15,  -9,  23,  -7, -26,  41, -11,-258, -27, -71,-253,   5,  25,  -1, -40, -29, -32, -20,-266, -70; D=-30;
/I:         I=-30; DM=-64;
/M: SY='Y';  M= -68, -85,-259, -66,  18,-265,  -1,  35, -69,   3,-231, -47,  -4,-253,-255,-251,   0,  22, -34,  79;
/M: SY='P';  M=  11,-262,  15,  -3, -90, -72, -58,-117,  17, -71,-253,   5,  41, -18,   8,  13,   9, -69,-268, -66;
/M: SY='Y';  M=-107,   5,-264,-264,  61,-268,  19, -39,-259, -11, -24,-260,-271,-257,-257,-256, -30, -38, -29,  98;
/M: SY='T';  M=-106,-261,  16,  27,-259,-257, -42, -80,  -7,-138, -64,  -9,-255,  -5,  25,  22,  43,  -7,-269, -12;
/M: SY='F';  M= -91,-264, -88, -93,  97,-270, -19,  13,-261,-141, -22,-262,-271,-265, -50, -89,-118, -68, -24,  58;
/M: SY='C';  M=-115,  40, -42,  24, -71, -74, -38, -22,  -9,  -2,  -7, -29,-260,  40, -38, -30,   2,  13, -17, -39;
/M: SY='T';  M=-109,-261, -55,   1, -92,-101,   8,  16,  14, -29,   8, -40,-258, -36,  11, -35,  45,  12,-269, -87;
/M: SY='Y';  M=-262,-272,-269,-266,   7,-270,-242,-243, -88,  18, -78,-268,-273,-256, -58,-262,-259,-250,  98, 104;
/M: SY='E';  M= -56, -62, -29,  51, -89,-113, -52, -11,   6, -57, -71, -71,-257,  19,  15, -35,  -1,  17,-270, -94;
/M: SY='R';  M=-113, -79,-251, -84,-112,-263, -34,-266,  41, -85,-255, -15,  -1, -36,  86, -40,-116, -52,-268,-255;
/I:         E1=0; IE=-325; DE=-325;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	98 in 98 different sequences
Number of true positive hits	98 in 98 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	DHFR
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

98 sequences

DRTS1_ARATH (Q05762), DRTS2_ARATH (Q05763), DRTS_CRIFA  (Q23695),

DRTS_DAUCA  (P45350), DRTS_LEIAM  (P16126), DRTS_LEIMA  (P07382), 
DRTS_MAIZE  (O81395), DRTS_MIMIV  (Q5UQG3), DRTS_ORYSJ  (Q2QRX6), 
DRTS_PARTE  (Q27828), DRTS_PLABA  (Q27713), DRTS_PLACH  (P20712), 
DRTS_PLAFK  (P13922), DRTS_PLAVI  (O02604), DRTS_PLAVN  (P46103), 
DRTS_SOYBN  (P51820), DRTS_TOXGO  (Q07422), DRTS_TRYBB  (Q27783), 
DRTS_TRYCR  (Q27793), DYR10_ECOLX (Q04515), DYR13_ECOLX (Q59408), 
DYR15_ECOLX (P78218), DYR1_ECOLX  (P00382), DYR1_HALMA  (Q5V3R2), 
DYR2_HALMA  (Q5V600), DYR2_HUMAN  (Q86XF0), DYR3_SALTM  (P12833), 
DYR5_ECOLX  (P11731), DYR6_PROMI  (P95524), DYR7_ECOLX  (P27422), 
DYR8_ECOLX  (P0ABQ7), DYR8_SHISO  (P0ABQ8), DYR9_ECOLX  (Q59397), 
DYRA_HALVD  (P15093), DYRA_STAAU  (P13955), DYRB_HALVO  (Q9UWQ4), 
DYR_AEDAL   (P28019), DYR_BACSU   (P11045), DYR_BOVIN   (P00376), 
DYR_BPT4(P04382), DYR_BUCAI   (P57243), DYR_BUCAP   (Q8K9Z8), 
DYR_BUCBP   (Q89AV2), DYR_CAEEL   (Q93341), DYR_CANAX   (P22906), 
DYR_CHICK   (P00378), DYR_CITFR   (P31073), DYR_CRYNJ   (Q07801), 
DYR_DROME   (P17719), DYR_ECOL6   (P0ABQ5), DYR_ECOLI   (P0ABQ4), 
DYR_ENCCU   (O62583), DYR_ENTFC   (P00380), DYR_HAEIN   (P43791), 
DYR_HELVI   (Q9U8B8), DYR_HHV8P   (Q2HRC6), DYR_HUMAN   (P00374), 
DYR_KLEAE   (P31074), DYR_LACCA   (P00381), DYR_LACLA   (Q59487), 
DYR_MESAU   (P04753), DYR_MOUSE   (P00375), DYR_MYCBO   (P0A547), 
DYR_MYCGE   (P47470), DYR_MYCLE   (Q9CBW1), DYR_MYCPN   (P78028), 
DYR_MYCPU   (Q98Q32), DYR_MYCTO   (P9WNX0), DYR_MYCTU   (P9WNX1), 
DYR_NEIGO   (P04174), DYR_NEIMA   (Q9JSQ9), DYR_NEIMB   (Q9K168), 
DYR_PIG (P00377), DYR_PNECA   (P16184), DYR_RAT (Q920D2), 
DYR_SCHMA   (G4VJD6), DYR_SCHPO   (P36591), DYR_SHIFL   (P0ABQ6), 
DYR_SHV21   (P09503), DYR_SHV24   (P27421), DYR_SHV2C   (P22573), 
DYR_STAAC   (Q5HFZ7), DYR_STAAM   (P0A016), DYR_STAAN   (P99079), 
DYR_STAAR   (Q6GGY1), DYR_STAAS   (Q6G9D5), DYR_STAAU   (P0A017), 
DYR_STAAW   (Q8NWQ9), DYR_STAEP   (P0C0P0), DYR_STAEQ   (Q5HPB1), 
DYR_STAES   (P0C0P1), DYR_STAHA   (Q54277), DYR_STRPN   (Q54801), 
DYR_THEMA   (Q60034), DYR_UREPA   (Q9PR30), DYR_YEAST   (P07807), 
SCPA_MYCGA  (Q7NB76), SCPA_MYCPN  (P75478)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

476 PDB

1AI9; 1AO8; 1AOE; 1BOZ; 1BZF; 1CD2; 1CZ3; 1D1G; 1DAJ; 1DDR; 1DDS; 1DF7;
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