PROSITE entry PS51312

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General information about the entry

Entry name [info]	SB
Accession [info]	PS51312
Entry type [info]	MATRIX
Date [info]	01-MAY-2007 CREATED; 10-MAY-2017 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51312
Associated ProRule [info]	PRU00644

Name and characterization of the entry

Description [info]

Steadiness box (SB) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=69;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=64;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.6496044; R2=0.0101444; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4203.4614258; R2=22.6153851; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=774; H_SCORE=21708; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=577; H_SCORE=17253; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-6; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D';  M=  4,  4,-34,  6,  6,-21,  1, -2, -3, -2,-10, -2,  5, -1,  3, -4,  4,  1, -4,-50,-21,  2;
/M: SY='P';  M=  2, -6,-26, -8, -7, -6, -8, -7,  3,-12, -4, -2, -5, 14, -7,-11, -1,  1,  0,-46,-14, -8;
/M: SY='L';  M= -3,-10,-35,-13, -9, -1,-11,-15, 20,-15, 28, 17,-12, -9, -9,-19, -9, -1, 25,-49,-18, -8;
/M: SY='Y';  M= -9, -7,-27, -9,-11, 14,-15,  8, -1,-13,  1, -1, -5,-12, -3,-10, -8, -9, -5,-21, 16, -8;
/M: SY='E';  M=  3, 10,-33, 11, 12,-35,  5,  1, -8,  6,-20, -7,  7,  2,  6,  5,  5,  4, -5,-48,-34,  7;
/M: SY='H';  M= -1, 15,-44, 15, 14,-39, -3, 25,-19, 15,-22, -8, 10,  1, 24, 16,  1,  1,-12,-33,-39, 16;
/M: SY='L';  M= -8,-16,-45,-15,-15,  9,-17,-15, 21,-14, 36, 23,-15,-10,-12,-20,-10, -3, 20,-38,-10,-11;
/M: SY='F';  M=-18,-25,-27,-31,-28, 46,-32,-13, 20,-27, 37, 19,-25,-27,-24,-31,-21,-14, 16,-20, 38,-24;
/M: SY='D';  M=  6, 13,-43, 19, 19,-37,  7,  5,-11,  6,-20,-11, 11,  0, 12,  0,  4,  1, -8,-58,-34, 16;
/M: SY='L';  M=-13,-20,-35,-20,-20,  8,-17,-17, 16,-18, 36, 20,-21,-14,-16,-25,-11, -6, 17,-34, -9,-16;
/M: SY='L';  M= -9,-14,-28,-18,-15, 15,-17, -8, 14,-17, 22, 13,-14,-13,-11,-18,-10, -6, 14,-33,  8,-12;
/M: SY='G';  M= 10, 10,-21, 10, 10,-32, 13,-10, -2,-10,-21,-11,  1,  9,  0,-11, 10, 10, -1,-61,-32,  0;
/M: SY='K';  M=  0, 10,-47, 15, 15,-42,  1,  9,-16, 16,-21, -8, 11, -1, 13, 12,  1,  0,-12,-41,-38, 15;
/M: SY='D';  M=  8, 13,-44, 21, 21,-37,  4,  4, -9,  4,-19,-13, 14, -2, 13, -4,  4,  0, -8,-66,-33, 15;
/M: SY='H';  M= -5,  7,-37,  8,  7,-23, -6, 19,-10,  9,-10, -2,  5, -2, 13, 10,  0, -3, -9,-28,-20,  9;
/M: SY='G';  M= 10,  9,-19,  9,  8,-32, 12, -9, -3, -8,-20,-10,  2,  9,  0, -9, 10, 10, -2,-57,-32,  0;
/M: SY='L';  M= -6,-22,-15,-22,-23, 14,-21,-19, 28,-21, 30, 18,-15,-12,-21,-23,-10, -3, 23,-42, -2,-21;
/M: SY='D';  M=  9, 18,-43, 25, 25,-45, 10,  7,-16,  8,-28,-17, 16,  1, 16,  0,  6,  1,-12,-65,-37, 20;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0, 10,  0,-20,-70,-40, 20;
/M: SY='V';  M=  7,  1,-20, -2,  1,-22,  5,-13,  8, -9, -3,  2, -3,  5, -3, -9,  5,  7, 11,-56,-27, -3;
/M: SY='L';  M= -9,-24,-38,-24,-24, 24,-24,-20, 36,-20, 48, 29,-19,-14,-20,-24,-14, -4, 30,-37,  0,-20;
/M: SY='Y';  M=-11, -8,-25,-11,-11, 23,-18,  1, -6,-15,-10, -9, -7,-20,-11,-16,-11,-12,-12,-21, 33,-13;
/M: SY='L';  M= -3, -6,-23, -9, -8, -1, -8, -7, 10,-12, 11,  8, -8, -6, -7,-13, -4, -1, 11,-39, -8, -7;
/M: SY='L';  M=-17,-27,-55,-28,-27, 25,-27,-19, 29,-18, 63, 39,-26,-18,-18,-26,-18, -8, 30,-26, -3,-18;
/M: SY='D';  M= 10, 14,-32, 18, 16,-43, 17,  1,-15,  1,-26,-16, 13,  3,  9, -5,  7,  6,-10,-60,-39, 12;
/M: SY='K';  M= -2,  9,-47, 12, 12,-39, -6, 15,-16, 20,-20, -6, 10, -2, 15, 19, -2, -1,-11,-27,-37, 16;
/M: SY='T';  M=  2, -1,-27, -1, -3,-16,  2,-10,  4,-10,  3,  3, -5,  1, -5,-14,  2,  5,  5,-43,-24, -5;
/M: SY='L';  M=-19,-28,-53,-30,-30, 38,-30,-19, 25,-24, 55, 30,-27,-21,-22,-30,-19,-12, 22,-17, 15,-23;
/M: SY='K';  M= -1, 14,-43, 17, 17,-41, -1, 17,-18, 20,-27,-10, 13,  0, 17, 20,  4, -1,-17,-35,-34, 16;
/M: SY='R';  M= -6,  4,-25,  5,  5,-40,-11, 14,-18, 22,-29, -9,  8, -1,  8, 26,  2, -2,-17,-16,-32,  8;
/M: SY='G';  M=  8, 13,-38, 16, 16,-49, 25, -1,-20,  1,-30,-18, 13,  0,  8, -8,  6,  6,-11,-62,-46, 11;
/M: SY='K';  M= -4,  4,-42,  3,  5,-30, -9,  8, -7, 15, -9,  2,  4, -2,  8, 15, -2,  0, -3,-28,-33,  7;
/M: SY='L';  M= -5,-19,-30,-22,-19, 16,-19,-20, 34,-20, 40, 25,-15,-12,-17,-22,-12, -2, 33,-46, -6,-17;
/M: SY='D';  M= 10, 10,-29, 14, 12,-39,  9,  1,-11,  4,-21,-11, 10,  9,  8,  0,  8,  6, -9,-55,-36, 10;
/M: SY='L';  M=-16,-28, -5,-32,-31, 21,-27,-21, 18,-29, 27, 12,-24,-19,-26,-30,-14,-11, 15,-34, 12,-28;
/M: SY='D';  M=  9, 18,-44, 26, 26,-46, 13,  7,-17,  7,-29,-18, 17,  1, 16, -2,  8,  2,-15,-66,-39, 17;
/M: SY='E';  M=  5,  6,-32,  8,  9,-30,  0,  1, -3,  2,-12, -5,  7,  3,  6, -1,  1,  2,  1,-52,-32,  8;
/M: SY='Y';  M=-28,-32,-11,-41,-41, 94,-47, -7,  8,-39, 13,  2,-28,-43,-37,-36,-28,-27,-10,  8,106,-40;
/M: SY='L';  M=-13,-23,-46,-26,-23, 20,-23,-19, 30,-18, 54, 34,-22,-16,-17,-24,-16, -6, 32,-34, -6,-17;
/M: SY='R';  M=-10,  6,-46,  6,  6,-46,-14, 14,-20, 40,-24,  0, 10,  0, 10, 44,  0,  0,-20, -4,-40, 10;
/M: SY='H';  M= -5, 12,-39, 12, 11,-37, -5, 24,-18, 20,-22, -6, 10,  1, 19, 23,  2, -1,-16,-28,-29, 14;
/M: SY='V';  M=  2, -9,-20,-16, -9, -4, -7,-18, 25,-16, 23, 16, -8, -6, -9,-16, -6,  2, 32,-57,-20, -9;
/M: SY='R';  M= -5,  4,-32,  4,  2,-37,-12, 15,-17, 30,-28, -3, 10,  2,  8, 37,  3,  2,-17, 13,-37,  8;
/M: SY='D';  M=  2,  7,-39, 11, 10,-29,  1,  1, -6,  4, -7, -3,  7, -2,  7, -2,  1,  0, -3,-50,-30,  8;
/M: SY='L';  M=-15,-25,-50,-27,-25, 22,-25,-20, 30,-20, 60, 35,-25,-17,-17,-27,-17, -7, 33,-30, -5,-17;
/M: SY='G';  M=  7,  5,  2,  5,  1,-35, 12, -9, -9,-10,-25,-15,  2,  5, -5,-11,  9,  7, -7,-54,-30, -5;
/M: SY='R';  M=-12, -3,-41, -4, -4,-25,-22, 15,-16, 31,-23,  1,  6, -4,  5, 40, -3, -3,-18, 23,-25,  4;
/M: SY='D';  M=  8, 18,-47, 26, 26,-47,  8, 10,-18, 10,-27,-17, 16,  1, 18,  3,  2,  1,-11,-64,-39, 24;
/M: SY='H';  M= -1, 19,-50, 19, 19,-41, -1, 28,-20, 12,-20, -9, 10,  0, 28, 12,  0,  0,-11,-48,-40, 19;
/M: SY='F';  M=-30,-39,-36,-49,-49,109,-50,-18, 18,-49, 28,  8,-30,-41,-40,-40,-30,-30, -2, 19,102,-49;
/M: SY='L';  M= -8,-13,-39,-15,-14, 13,-19, -9, 15,-10, 20, 16, -8,-13,-10,-10,-11, -6, 12,-36,  2,-11;
/M: SY='M';  M= -4, -1,-30, -1, -2,-14, -7, -1, -2,  1, -2,  2, -3, -3, -2,  0, -1,  0, -3,-35,-13, -3;
/M: SY='R';  M= -9,  1,-40,  0,  1,-39,-18, 15,-16, 35,-24,  2,  8, -1,  8, 43, -1,  0,-15, 13,-38,  8;
/M: SY='Y';  M= -4, -2,-24, -4, -4,  4, -9,  0,  1,-14, -6, -4, -7, -5, -4,-12, -2, -3, -3,-35,  7, -7;
/M: SY='L';  M=-10,-16,-48,-15,-15,  6,-16,-10, 15,-11, 37, 22,-16,-10, -8,-17,-10, -5, 16,-31,-10, -8;
/M: SY='F';  M= -5,-16,-23,-20,-19, 21,-17,-14, 21,-19, 20, 15,-10,-14,-17,-19,-10, -4, 16,-38, 10,-18;
/M: SY='D';  M=  0,  6,-38,  9,  6,-28, -2,  6, -9,  7, -7, -2,  6, -1,  8,  3,  1,  1, -6,-37,-30,  7;
/M: SY='R';  M=-11,  1,-44, -1,  0,-28,-16,  7,-12, 26,-14,  3,  4, -5,  4, 30, -4, -3,-13,-12,-25,  3;
/M: SY='I';  M= -4,-15,-12,-18,-16,  1,-16,-17, 24,-16, 19, 13,-11, -9,-16,-16, -8, -2, 22,-51,-10,-16;
/M: SY='R';  M=  1,  1,-25,  1,  0,-24, -2, -1, -2,  5,-10,  0,  2,  3,  0,  7,  4,  4, -3,-27,-28,  0;
/M: SY='D';  M=  1, 11,-40, 13, 13,-39,  0,  7,-11, 12,-19, -6,  8,  2, 11, 11,  3,  2, -8,-46,-36, 11;
/M: SY='G';  M=  4,  1,-29,  1,  1,-24, 10, -9, -1, -7, -5, -1, -1,  1, -3,-11,  5,  6,  1,-49,-29, -3;
/M: SY='L';  M= -7,-10,-42,-12,-11,  6,-14, -8, 13,-12, 23, 18,-12, -9, -7,-14, -8, -3, 13,-37, -8, -9;
/M: SY='G';  M=  1,  5,-20,  6,  6,-38,  7,  5,-16, -1,-24,-12,  5, -2,  6, -2,  4,  1,-11,-50,-32,  3;
/M: SY='L';  M= -4, -3,-48,  0,  0,-15, -6, -4,  3, -3, 12,  7, -3, -8,  0,-10, -7, -2,  7,-45,-23,  2;
/M: SY='K';  M=  2,  4,-30,  4,  4,-36, -1,  1, -8, 13,-15, -2,  6,  8,  5, 13,  5,  5, -7,-38,-36,  5;
/M: SY='D';  M=  5, 13,-37, 15, 14,-36,  7, 10,-12,  2,-18,-10, 10,  0, 14, -1,  3,  3, -7,-55,-36, 11;
/M: SY='L';  M=-10,-14,-32,-18,-15,  8,-15, -9, 10,-11, 18, 12,-12,-15,-12,-13,-11, -5, 12,-26, -2,-12;
/M: SY='W';  M=-15,-13, -1,-18,-18,-14,-18, -4,-19,-13,-27,-21,-10,-17,-15, -3, -5,-12,-20,  5, -3,-18;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	8 in 8 different sequences
Number of true positive hits	8 in 8 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Feature key [info]	DOMAIN
Feature description [info]	SB
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

8 sequences

ELCL_ARATH  (Q9FFY6), ELC_ARATH   (Q9LHG8), SST6_SCHPO  (Q7Z992),

STP22_YEAST (P25604), TS101_DICDI (Q54LJ3), TS101_HUMAN (Q99816), 
TS101_MOUSE (Q61187), TS101_RAT   (Q6IRE4)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

5 PDB

2CAZ; 2F66; 2F6M; 2P22; 6VME