PROSITE entry PS51265

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51265
Entry name [info]	ZF_DBF4
Accession [info]	PS51265
Entry type [info]	MATRIX
Date [info]	01-NOV-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51265
Associated ProRule [info]	PRU00600

Name and characterization of the entry

Description [info]

Zinc finger DBF4-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=50;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=45;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8617007; R2=0.0085572; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6242.0429688; R2=2.0071943; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=987; H_SCORE=8223; N_SCORE=10.3; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=543; H_SCORE=7332; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-16; D=-50; I=-50; B1=-200; E1=-200; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='Q';  M= -9,-45,-27,  9,-43, -1,-26,-17, 27,-23, 23,-23,  0, 50, 35, 11,-16,-22,-44,-33;
/M: SY='Q';  M=-17,-47, 43, 31,-46,-39, 23,-36, 20,-37, -4,-19,-35, 50, 28,-25,-28,  2,-50,-32;
/M: SY='K';  M=-20,-46,-28,  5,-40,-40,  5,-36, 45,  2,-27,-25, 45, 23, 27,-25, 15,-35,-45,-33;
/M: SY='K';  M=-10,-45,-25,-15,-46,-19,-25,-46, 64,-44,-33,  5,-35, 21, 53, -4, -4,-41,-44,-34;
/M: SY='P';  M=  1, 15,-26,  3,-49,  8,  5,-45, 29,-46,-36,-22, 52, 31,-21, 32,-22,-41,-47,-38;
/M: SY='G';  M=  0,-45,-32,-38,-52, 85,-37,-56,-34,-52,-41,-19,-37, 18,-41,-17,-35,-50,-42,-44;
/M: SY='Y';  M=-39,-50,-42,-43, 26,-47,-11,-22,-36,-21,-19,-42,-52,-32,-33,-36,-34, -3, 57,109;
/M: SY='C';  M=-30,142,-50,-50,-40,-45,-50,-47,-46,-38,-38,-36,-61,-53,-52,-32,-30,-35,-70,-51;
/M: SY='E';  M=-27, 40, -3, 88,-50,-42,-24,-52,-13,-45,-41,-25,-27, -6,-23,  3,-27,-44,-50,-42;
/M: SY='N';  M=-31, 75,-21,-36,-30,-32,-24, 28,-29,-30,-26, 77,-46,-30,-35,-23,-21, -3,-50, 15;
/M: SY='C';  M=-30,142,-50,-50,-40,-45,-50,-47,-46,-38,-38,-36,-61,-53,-52,-32,-30,-35,-70,-51;
/M: SY='R';  M=-33,  7,-27,  2,-37,-42,-22,-42, 44,-12,-28,  3,-40, 33, 65,-27,-30,-40,-40, 10;
/M: SY='V';  M=-27,-42, 23, 33,-32,-46,-35, 28,-12, -4,-19,-30,-38, 24,-31,-29, -2, 43,-51,-32;
/M: SY='K';  M=-13,-46,-18, 39,-48,-39,-25,-47, 70,-44,-35,-19,-31, 23, 25,-23, -3,-41,-43,-35;
/M: SY='Y';  M=-42,-45,-47,-47, 82,-49,-18,-21,-40,-15,-19,-43,-53,-42,-37,-39,-35,-26, -2, 90;
/M: SY='D';  M=-18,-44, 66, 48,-50,-33,-22,-48, -4,-47,-42, 31,-32,-15,-11,  6, 13,-43,-58,-39;
/M: SY='D';  M=-29,-42, 67,  1,-38,-32,  5, -2,-25,-37,-35, 42,-37,-23,-32, 16,  0,  0,-55,  5;
/M: SY='F';  M=-39,-40,-52,-47, 65,-53,-31, -8,-45, 55, -6,-48,-53,-43,-42,-43,-33,-15,-20, 44;
/M: SY='E';  M= -2,-45, 37, 62,-39,-36, 16,-46, 16,-43,-37,  1,-31,-12,-20,  2, -9,-41,-44, 21;
/M: SY='Q';  M= -3,-44, 24, 47,-43,-38,-26, -1,-18,-22,-28,  2,-34, 50, -6, -1, -5,  6,-49,-35;
/M: SY='H';  M=-38,-50,-22,-22,-36,-40,132,-55,-27,-37,-22,-11,-39,-16,-21,-27,-37,-54,-72, -5;
/M: SY='I';  M=-32,-41,-54,-49,-15,-56,-47, 63,-47, 45, -2,-48,-47,-43,-47,-42,-27, 34,-43,-25;
/M: SY='M';  M= -5,-41,-29, 20, 11,-18,-29,-19,  9,  7, 25,  5,-39, 19,  1,  0,-25, 20,-40, -1;
/M: SY='S';  M= -2,-35, -3, 23,-44,  7,-29,-42,-24,-44,-38,-15,-31,-18,-30, 69, 29,-34,-51,-37;
/M: SY='R';  M=  6,-45, 18, 42, -2,-37,-24,-46, 31,-42,-36,  7, -6,-13, 48,-13,-27,-40,-45,-32;
/M: SY='K';  M=-31,-47, 11, 19,-43,-40, 34,-41, 49, -8,-28,-19,-35, 45, 34,-24,  0,-39,-46,-30;
/M: SY='H';  M=-38,-50,-22,-22,-36,-40,132,-55,-27,-37,-22,-11,-39,-16,-21,-27,-37,-54,-72, -5;
/M: SY='R';  M=-33,-49,-30,  7, -5,-44,-24,-16, 19,-19,-29,-26,-41,  4, 84,-10,-31,-36,-42,-28;
/M: SY='R';  M=  3,-41,-23,  3,-42,-30,-24,-40, 31,-14,-31, 29,-36, 25, 41, 35,-20,-37,-47,-34;
/M: SY='F';  M=-42,-40,-52,-46,100,-51,-35,-18,  0,  5,-18,-43,-52,-50,-37,-41,-35,-23,-13,  9;
/I:         I=-15; MD=-77;
/M: SY='A';  M= 68,-34,-41,-34,-40,-27,-42,-26,-36, -5,-27,-35,-40,-33,-40,-16,  7,  6,-49,-40; D=-15;
/I:         I=-15; MI=-77; IM=-77; DM=-77;
/M: SY='M';  M=-11, 24,  1, 33,-37,-38,-28,  4, 27,-14, 37, -7,-34,-17, 10, 15,  8,-26,-48,-33;
/M: SY='N';  M=-30,-41, 33, 24,-48,-28,-18,-45, 21,-47,-37, 74,-35, 31,-18,-17, 12,-44,-56,-38;
/M: SY='D';  M= -1,-42, 68,  9,-50,-27,-23,-47,-14,-49,-43, 40, 15,-20,-30, 32, -6,-42,-59,-39;
/M: SY='E';  M= 17,-41, 24, 38,-42,-32, 14,-24,  1,-14,-32, 21,-35,-15, 24, 21,-22,-34,-50,-35;
/M: SY='N';  M=-32,-39,-14,-26, 13,-27, 42,-39, -7,-22,-31, 84,-42,  5,  9, -1,-21,-41,-48, -1;
/M: SY='W';  M=-41,-48,-49,-42, 75,-47,-25,-25,-38,-19,-22,-44,-51, 10,-36,-39,-38,-31, 93, 76;
/M: SY='Q';  M= 33,-41,-30,  7,-38,-35,-32, 15, 36, -6,-22,-28,-36, 45,-18,-22,-25,  6,-43,-33;
/M: SY='D';  M= 16, 34, 37, 20,-45,  2, 23,-37, 13,-37,  9,-20,-36, 29, -8,-14,-27, -5,-51,-34;
/M: SY='I';  M=-31,-39,-51,-46,-15,-54,-44, 52,-45, 50, -3,-45,-46,-41,-45,-39,  5, 29,-44,-25;
/M: SY='D';  M=-34,-47, 97, -3,-49,-33,-23,-46,-25,-12,-43, -7,-36,-24,-33,  3,-24,-45,-67,-37;
/M: SY='D';  M=  1,-40, 55,  6,-47,-28,-26,-44, -2,-45,-39,  1,-33, -1, 12, 45, 23,-37,-55,-36;
/M: SY='L';  M=-36,-39,-54,-47, 46,-54,-38, 26,-46, 60, 23,-49,-51,-42,-44,-44,-31,  0,-32,-13;
/M: SY='I';  M=-12,-43,-51,-48, 10, -2,-45, 67,-45, 25, 31,-42,-44,-41,-46,-38,-29, 11,-40,-23;
/M: SY='S';  M= 23,-40, 16, 27,-19,  5,-28,-25,-24, -8,  1, -5,-35, 30,-29, 34,-21,-31,-46,-33;
/M: SY='Q';  M=-26, 18,-25,  5,-41,-36, 36,-38,  3,-15, -2, -9,-36, 54, 33, 25, 24,-35,-49,-29;
/M: SY='L';  M=-29,-39,-48,-44, 25,-19,-39, 34,-42, 45, 26,-41,-46,-38,-43, 11,-26, 16,-39,-20;
/M: SY='Q';  M= 16,-42,  4, -9,-33, -2,-26,-20, 10, -9,-27,-23,-38, 41, 20, 14, -2,-13,-39, 22;
/M: SY='F';  M=-32, 19,  5,  0, 51,-41, 14,-32,-17,-19,-27, -4,-42, 30, 45, -3, -5,-14,-36,-16;
/M: SY='D';  M=-20,-47, 46, 19, -6,-36,  4,-37, 10,-39, -7,  5, 38,  6, 14,  0,-25, -8,-47, -8;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	12 in 12 different sequences
Number of true positive hits	12 in 12 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	DBF4-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

12 sequences

CHIF_DROME  (Q9NK54), DBF4A_CRIGR (Q99MU0), DBF4A_HUMAN (Q9UBU7),

DBF4A_MOUSE (Q9QZ41), DBF4A_XENLA (Q7ZZH7), DBF4A_XENTR (Q28FY7), 
DBF4B_HUMAN (Q8NFT6), DBF4B_XENLA (Q283Q6), DBF4_YEAST  (P32325), 
HIM1_SCHPO  (O59836), SPO6_SCHPO  (Q9Y7J1), ZDBF2_HUMAN (Q9HCK1)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

11 PDB

4F99; 4F9A; 4F9B; 4F9C; 6YA6; 6YA7; 6YA8; 7P5Z; 7PT6; 7PT7; 7V3V