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PROSITE entry PS51259


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS51259
Entry name [info] MHD2
Accession [info] PS51259
Entry type [info] MATRIX
Date [info] 01-OCT-2006 CREATED;
13-FEB-2019 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51258
Associated ProRule [info] PRU00588

Name and characterization of the entry

Description [info] Munc13-homology domain 2 (MHD2) profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=117;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=112;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.4859470; R2=0.0068047; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=16198.4453125; R2=10.1170406; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1031; H_SCORE=26629; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=737; H_SCORE=23655; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-11; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
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Post-processing [info]

PROMOTED_BY PS51258

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 20 in 20 different sequences
Number of true positive hits 20 in 20 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] MHD2
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
20 sequences

BAIP3_HUMAN (O94812), BAIP3_MOUSE (Q80TT2), GIT1_SCHPO  (Q9P7K5), 
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PDB
[Detailed view]
10 PDB

3SWH; 4Y21; 5UE8; 5UF7; 6A30; 7T7C; 7T7R; 7T7V; 7T7X; 7T81